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Characterization of particle size and settling velocity of cohesive sediments affected by a neutral exopolymer

International Journal of Sediment Research 2012年第4期27卷 473-485页

作者： Xiao-ling TAN Guo-ping ZHANG Hang YIN Allen H.REED yoko furukawa Graduate Research Assistant Department of Civil ＆ Environmental EngineeringLouisiana State University Department of Civil & Environmental Engineering Louisiana State University Graduate Research Assistant Department of Civil & Environmental EngineeringLouisiana State University Research Scientist Seafloor Sciences BranchNaval Research LaboratoryStennis Space Center

In natural waters,exopolymers or extracellular polymeric substances(EPS) exuded by microorganisms interact with clay particles,resulting in the flocculation of clays and hence alteration to the properties of suspended cohesive *** investigate and further understand how neutral EPS affect cohesive sediment transport and the final sediment yield,an experimental study was conducted on laboratory-prepared clay and guar gum(used as an analog for neutral EPS) suspensions to characterize EPS-induced flocculation and the settling velocity of resultant *** different clays consisting of kaolinite,illite,Ca-montmorillonite,and Na-montmorillonite were studied to examine the influence of different layer charges on clay flocculation induced by neutral *** size was determined by a laser particle size analyzer,and settling velocity estimated by analyzing the time-series floc settling images captured by an optical *** indicate that neutral EPS promote clay-EPS flocculation for all four clays with the particle/floc size significantly increased from～0.1-60μm to as large as～600μ***' layer charge has a profound influence on the clay-EPS *** the same floc size,the settling velocity of clay-EPS flocs is typically smaller than that of pure clay flocs,which is attributed to the reduced density of flocs caused by the EPS. However,for flocs of the same composition(*** clay or hybrid clay-EPS mixture),the settling velocity increases with *** fractal dimension of these clay-EPS flocs estimated from settling velocity ranges from 1.39 to 1.47,which are smaller than that of pure clay flocs,indicating that these flocs are less compacted than the pure clay flocs.

关键词： Clay Exopolymer Flocculation Fractal dimension Particle size Settling velocity

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Enzyme-linked immunosorbent assay of 3 Screen Islet Cell Autoantibody in patients with autoimmune thyroid disease

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World Journal of Diabetes 2024年第5期15卷 935-944页

作者： Eiji Kawasaki Hidekazu Tamai Takahiro Fukuyama yoko Sagara Ryutaro Hidaka Aira Uchida Masayuki Tojikubo Narihito Tatsumoto Yuko Akehi Yuji Hiromatsu The Diabetes Thyroid and Endocrine CenterShin-Koga HospitalKurume 830-8577Japan

BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes(T1D).While it has been established that 20%-30%of T1D patients suffer from autoimmune thyroid disease(AITD),there is limited available data regarding the presence of anti-islet autoantibodies in AITD *** commercially available anti-islet autoantibodies,glutamic acid decarboxylase 65 autoantibodies(GADAs)are often the first marker measured in general clinical *** To investigate the frequency of anti-islet autoantibodies in AITD *** Our study involved four hundred ninety-five AITD patients,categorized into three distinct groups:AITD with T1D(n=18),AITD with phenotypic type 2 diabetes(T2D)(n=81),and AITD without diabetes(n=396),and the enzyme-linked immunosorbent assay(ELISA)was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody(3 Screen ICA),GADA,insulinoma-associated antigen-2 autoantibodies(IA-2As),and zinc transporter 8 autoantibodies(ZnT8As)within these *** The frequency of 3 Screen ICA in AITD patients with T1D,T2D,and those without diabetes were 88.9%,6.2%,and 5.1%,respectively,with no significant difference seen between the latter two ***,the frequency of 3 Screen ICA was 11.1%higher in AITD patients with T1D,1.3%higher in AITD patients with T2D,and 1.1%higher in AITD patients without diabetes compared to GADA,***,12.5%,20.0%,and 20.0%of the 3 Screen ICA-positive patients were negative for ***,1.3%of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual *** the 3 Screen ICA-positive patients,there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D com

关键词： Anti-islet autoantibodies Autoimmune thyroid disease Real-world practice Retrospective study Type 1 diabetes

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Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

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World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru yoko yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

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Usefulness of Newly Devised Clomiphene Citrate Administration Method Compared with the Conventional Method in Ovulation and Pregnancy

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 637-649页

作者： Makoto Kawamura Misaki Akiyama Remi Nakajima Eri Satoi yoko Ogaki Rieko Kanda Department of Obstetrics and Gynecology Kohseichuo General Hospital Tokyo Japan

Objective: Since not all women wish to conceive a child through aggressive treatment, we investigated the usefulness of modified repeated intracyclic clomiphene citrate (CC) therapy (repeated CC therapy) as a newly devised administration method. Methods: We evaluated the effects of CC administration on menstrual cycle length and retrospectively compared ovulation and pregnancy in 220 women who received CC at our hospital. Patients in the conventional method group received 50 mg per day for five days, starting on the fifth day of menstruation (withdrawal bleeding). Groups with and without menstrual cycle shortening after conventional CC administration were compared. The repeated CC therapy group was also compared with the non-shortened group. Repeated CC therapy was administered for the first five days as in the conventional method, and a second five-day repeat treatment was administered after an interval of five to seven days. Pregnancy rates, including indirect pregnancies, were evaluated by three different methods. Results: Ovulation and pregnancy rates were significantly better in the shortened group than in the non-shortened group (P < 0.001 and P = 0.010, respectively). Even in the non-shortened group, ovulation and pregnancy rates including indirect pregnancies were significantly improved when ovulation was observed with repeated CC therapy (P < 0.001 and P = 0.022, respectively). Conclusions: For patients whose menstrual cycle was not improved or shortened, repeated CC therapy as the newly devised CC administration method is useful as the next step after the conventional CC administration method.

关键词： Clomiphene Citrate Infertility Menstrual Cycle Ovulation Induction

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Six Amino Acids among Natural Moisturizing Factors Responsible for Skin Hydration: Improvement and Anti-Aging of Skin by Galactomyces Ferment Filtrate-PiteraTM Containing Skin Moisturizer

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第2期14卷 113-127页

作者： Kukizo Miyamoto yoko Munakata Keisuke Fujii Wang Summer Ley Yang Suda Sudarsana Masutaka Furue Research and Development Kobe Innovation Center Procter and Gamble Innovation GK Kobe Japan Global Scientific Communications P & G Guangzhou Ltd. Guangzhou China Department of Dermatology Graduate School of Medical Sciences Kyushu University Fukuoka Japan

Background: Natural moisturizing factors (NMFs) are filaggrin-derived components in the cornified layer that are critical for maintaining healthy skin moisturization and barrier function. However, studies have reported conflicting findings on the relationship between NMF levels and aging, while few studies have investigated this relationship clinically. To fill this research gap, we determined the levels of major NMF components such as free amino acids, pyrrolidone carboxylic acid, and urocanic acids, and individually verified their relationships with skin hydration, barrier function, age, and skin aging. Purpose: The objective of this study was to clinically investigate the relationship between NMF components levels and skin aging in facial skin. The main NMF components were obtained from facial skin and quantified. We then selected NMF components showing strong relationships to skin hydration, and analyzed the relationships of the levels of these selected NMF components with signs of skin aging, namely, texture, pores, wrinkles, and dullness (L-value). We also examined the efficacy of treatment with a skin care formula (SK-II Facial Treatment Essence, called SK-II FTE hereafter) including Galactomyces ferment filtrate (GFF, PiteraTM) on the selected NMF component levels associated with skin hydration and barrier function, and the signs of skin aging of texture, pores, wrinkles, and dullness (L-value). Method: We conducted two clinical trials in this research. In Study 1, we measured 23 NMF components using tape-stripped cornified layer to quantify them via an HPLC method in 196 Asian females aged 20 to 59 (mean S.D., 38.6 9.4). Facial visual aging parameters [texture, pores, wrinkles, and dullness (L-value)], as well as elasticity (R7), skin hydration, and TEWL, were quantified using facial skin imaging and skin physical property measurement devices. Study 2 was performed to evaluate whether the facial application of SK-II FTE affects the NMF levels and skin aging

关键词： NMF Amino Acid Visual Aging Parameter Hydration Aging Texture Pore Wrinkle Dullness Galactomyces Ferment Filtrate PiteraTM SK-II Facial Treatment Essence

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Quantification of In Vivo Epidermal Keratinocyte Architecture Associated with the Signs of Skin Aging and the Skin Benefit Evaluation by Application of Galactomyces Ferment Filtrate (Pitera)-Containing Skin Care Product

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 12-28页

作者： Kukizo Miyamoto yoko Munakata Keisuke Fujii Chenlu Lei Ley Yang Suda Sudarsana Masutaka Furue Research and Development Kobe Innovation Center Procter and Gamble Innovation GK Kobe Japan Global Scientific Communications P & G Guangzhou Ltd. Guangzhou China Department of Dermatology Graduate School of Medical Sciences Kyushu University Fukuoka Japan

Background: Aged skin exhibits visual alterations such as wrinkles, rough texture, pore dilation, and dull skin tone, as well as physiological aging, namely, decreased hydration and increased transepidermal water loss (TEWL). Recent advances in coherence tomography have also revealed that skin aging affects in vivo epidermal keratinocyte architecture. However, the interconnectivity between spatial architectural aging and visual/physiological aging parameters remains largely unknown. Purpose: To elucidate whether the tomographic keratinocyte architectural aging is correlated with visual and physiological skin aging parameters and to quantitatively evaluate the improvements of the architectural, visual, and physiological aging parameters by the daily treatment of the skin care formula containing Galactomyces Ferment Filtrate (GFF, 8X PiteraTM). Method: We measured the in vivo keratinocyte cellular architecture with two-photon stereoscopic tomography obtaining by-layer epidermal section images in 78 Asian females of various ages. Visual aging parameters were analyzed using a portable image capture system. Hydration and TEWL were also assessed. The anti-aging effects of GFF-containing skin moisturizer (SK-II LXP CreamTM) were also examined in two studies after twice-daily application for 2 (N = 35) and 4 (N = 32) weeks. Results: As for the keratinocyte cellular architecture, skin aging was significantly associated with decreased cell density and increased cell uniformity. These architectural aging parameters were significantly correlated with visual and physiological aging parameters, namely, rough texture, wrinkles, pore dilation, dull skin tone, dehydration, and increased TEWL. The strong interconnectivity allowed us to develop formulae to estimate the keratinocyte architecture from visual aging parameters. Moreover, twice-daily application of SK-II significantly improved the keratinocyte architecture associated with multiple skin aging visual an

关键词： Facial Skin Aging In Vivo Keratinocyte Cellular Architecture Visual Aging Pa-rameter Dehydration Interconnectivity New Trajectory Galactomyces Fer-ment Filtrate PiteraTM SK-II LXP CreamTM

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最新综述执行摘要:终末期患者抗菌药物的使用

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中国感染控制杂志 2024年第8期23卷 1044-1046页

作者：刘婷谭彩霞(译) 吴安华(审校) Karlin D Pham C furukawa D 中南大学湘雅医院医院感染控制中心湖南长沙410008 不详

对于仍然坚定致力于提供以患者为中心的医疗服务,并同时参与共同决策促进抗菌药物管理的感染性疾病(ID)医生来说,在患者终末期如何使用抗菌药物是一项挑战。在住院和门诊环境中为难治性或复发性感染患者提供连续治疗的感染性疾病医生可... 详细信息

对于仍然坚定致力于提供以患者为中心的医疗服务,并同时参与共同决策促进抗菌药物管理的感染性疾病(ID)医生来说,在患者终末期如何使用抗菌药物是一项挑战。在住院和门诊环境中为难治性或复发性感染患者提供连续治疗的感染性疾病医生可以在患者生命特别脆弱的时刻提供周到的、精准的指导。

关键词：姑息治疗抗菌药物抗菌药物管理临终关怀

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Characteristics of glucose change in diabetes mellitus generalized through continuous wavelet transform processing:A preliminary study

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World Journal of Diabetes 2023年第10期14卷 1562-1572页

作者： Yoichi Nakamura Shinya furukawa Cardiovascular Medicine&Diabetology Specified Clinic of Soyokaze CardioVascular Medicine and Diabetes CareMatsuyama 790-0026EhimeJapan Health Services Center Ehime UniversityMatsuyama 790-8577EhimeJapan

BACKGROUND The continuous glucose monitoring(CGM)system has become a popular evaluation tool for glucose fluctuation,providing a detailed description of glucose change *** hypothesized that glucose fluctuations may contain specific information on differences in glucose change between type 1 diabetes mellitus(T1DM)and type 2 diabetes mellitus(T2DM),despite similarities in change patterns,because of different *** Fourier transform,continuous wavelet transform(CWT)is able to simultaneously analyze the time and frequency domains of oscillating *** To investigate whether CWT can detect glucose fluctuations in *** The 60-d and 296-d glucose fluctuation data of patients with T1DM(n=5)and T2DM(n=25)were evaluated *** data obtained every 15 min for 356 d were *** were assessed by CWT with Morlet form(n=7)as the mother *** methodology was employed to search for limited frequency glucose fluctuation in the daily glucose *** frequency and enclosed area(0.02625 scalogram value)of 18 emerged signals were *** specificity for T1DM was evaluated through multiple regression analysis using items that demonstrated significant differences between them as explanatory *** The high frequency at midnight(median:75 Hz,cycle time:19 min)and middle frequency at noon(median:45.5 Hz,cycle time:32 min)were higher in T1DM vs T2DM(median:73 and 44 Hz;P=0.006 and 0.005,respectively).The area of the>100 Hz zone at midnight to forenoon was more frequent and larger in T1DM vs *** a day,the lower frequency zone(15-35 Hz)was more frequent and the area was larger in T2DM than in *** threedimensional scatter diagrams,which consist of the time of day,frequency,and area of each signal after CWT,revealed that high frequency signals belonging to T1DM at midnight had a loose distribution of wave cycles that were 17-24 *** analysis revealed that the high frequency signal at midnight could c

关键词： Continuous glucose monitoring Pathophysiology Fourier,Pseudo-frequency Contour map Scalogram matrix

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Resistance to energy metabolism-targeted therapy of AML cells residual in the bone marrow microenvironment

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Cancer Drug Resistance 2023年第1期6卷 138-150页

作者： yoko Tabe Marina Konopleva Department of Laboratory Medicine Juntendo UniversityTokyo 112-8421Japan Department of Medicine(Oncology)and Molecular Pharmacology Albert Einstein College of MedicineBronxNY 10461USA Department of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

In response to the changing availability of nutrients and oxygen in the bone marrow microenvironment,acute myeloid leukemia(AML)cells continuously adjust their metabolic *** meet the biochemical demands of their increased proliferation,AML cells strongly depend on mitochondrial oxidative phosphorylation(OXPHOS).Recent data indicate that a subset of AML cells remains quiescent and survives through metabolic activation of fatty acid oxidation(FAO),which causes uncoupling of mitochondrial OXPHOS and facilitates *** targeting these metabolic vulnerabilities of AML cells,inhibitors of OXPHOS and FAO have been developed and investigated for their therapeutic *** experimental and clinical evidence has revealed that drug-resistant AML cells and leukemic stem cells rewire metabolic pathways through interaction with BM stromal cells,enabling them to acquire resistance against OXPHOS and FAO *** acquired resistance mechanisms compensate for the metabolic targeting by *** chemotherapy/targeted therapy regimens in combination with OXPHOS and FAO inhibitors are under development to target these compensatory pathways.

关键词： Bone marrow microenvironment acute myeloid leukemia mitochondria oxidative phosphorylation fatty acid oxidation energy metabolism

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Successful resection of colonic metastasis of lung cancer after colonic stent placement:A case report and review of the literature

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1549-1558页

作者： yoko Nakayama Minekazu Yamaguchi Keisuke Inoue Shunichi Hamaguchi Yoshitsugu Tajima Department of Surgery Oda Municipal HospitalOda 694-0063ShimaneJapan Department of General Medicine Shimane University Faculty of MedicineIzumo 693-8501Japan Department of Digestive and General Surgery Shimane University Faculty of MedicineIzumo 693-8501Japan

BACKGROUND Lung cancer is the leading cause of cancer deaths *** lung cancer can metastasize to various organs such as the liver,lymph nodes,adrenal gland,bone,and brain,metastases to the digestive organs,especially the colon,are *** SUMMARY An 83-year-old man diagnosed with lung cancer received radiation and chemoimmunotherapy,resulting in a complete clinical *** year after the initial lung cancer diagnosis,the patient presented with obstructive ileus caused by a tumor in the descending *** elective left hemicolectomy was successfully performed after the endoscopic placement of a self-expandable metallic stent(SEMS).Pathologically,the tumor of the descending colon was diagnosed as lung cancer *** postoperative course was uneventful,and the patient is in good condition 13 mo after surgery,with no signs of *** previous 23 cases of surgical resection of colonic metastasis from lung cancer were reviewed using PubMed to characterize their clinicopathological features and *** SEMS is useful for obstructive colonic metastasis as a bridge to surgery to avoid emergency operations.

关键词： Colonic metastasis Colonic obstruction Lung cancer Self-expandable metallic stent Surgical resection Case report

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