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Channel Attention GAN-Based Synthetic Weed Generation for Precise Weed Identification

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Plant Phenomics 2024年第2期6卷 257-268页

作者： Tang Li Motoaki Asai yoichiro Kato Yuya Fukano Wei Guo Graduate School of Agricultural and Life Sciences The University of TokyoTokyo 188-0002Japan Institute for Plant Protection National Agriculture and Food Research OrganizationFukushima 960-2156Japan Graduate School of Horticulture Chiba UniversityChiba 271-0092Japan

Weed is a major biological factor causing declines in crop ***,widespread herbicide application and indiscriminate weeding with soil disturbance are of great concern because of their environmental ***-specific weed management(SSWM)refers to a weed management strategy for digital agriculture that results in low energy *** learning is crucial for developing SSWM,as it distinguishes crops from weeds and identifies weed ***,this technique requires substantial annotated data,which necessitates expertise in weed science and agronomy.

关键词： identification attention generation channel gan-based precise synthetic weed

In situ observation of the Rayleigh–Taylor instability of liquid Fe and Fe–Si alloys under extreme conditions: Implications for planetary core formation

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Matter and Radiation at Extremes 2021年第5期6卷 23-30页

作者： Hidenori Terasaki Tatsuhiro Sakaiya Keisuke Shigemori Kosaku Akimoto Hiroki Kato yoichiro Hironaka Tadashi Kondo Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Department of Earth Sciences Graduate School of Science and TechnologyOkayama UniversityOkayama 700-8530Japan Institute of Laser Engineering Osaka UniversitySuitaOsaka 565-0871Japan

Rayleigh–Taylor(RT)instability,which occurs when a heavy fluid overlies a light fluid in a gravitational field,is an important scenario for planetary core formation,especially beneath the planetary magma *** process has been discussed based on numerical simulations and experiments using analog ***,experiments on the RT instability using the core-forming melt have not been performed at high *** this study,we perform in situ observation of the RT instability of liquid Fe and Fe–Si(Si10 and 20 wt.%)alloys under high pressure using a high-power laser-shock *** observed perturbation on the Fe–Si surface grows exponentially with time,while there is no obvious growth of perturbations on the Fe in the measured time ***,the growth rate of the RT instability increases with Si *** timescale of the initial growth of the RT instability in planetary interiors is likely to be much faster(by more than two orders of magnitude)than the 30–403106 year timescale of planetary core formation.

关键词： alloys technique. materials.

Cell competition and its implications for development and cancer

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Journal of Genetics and Genomics 2011年第10期38卷 483-495页

作者： yoichiro Tamori Department of Biological Science Florida State UniversityTallahasseeFL 32306-4370USA

Cell competition is a struggle for existence between cells in heterogeneous tissues of multicellular organisms. Loser cells, which die during cell competition, are normally viable when grown only with other loser cells, but when mixed with winner cells, they are at a growth disadvantage and undergo apoptosis. Intriguingly, several recent studies have revealed that cells bearing mutant tumor-suppressor genes, which show overgrowth and tumorigenesis in a homotypic situation, are frequently eliminated, through cell competition, from tissues in which they are surrounded by wild-type cells. Here, we focus on the regulation of cellular competitiveness and the mechanism of cell competition as inferred from two different categories of mutant cells：（1） slower-growing cells and （2） structurally defective cells. We also discuss the possible role of cell competition as an intrinsic homeostasis system through which normal cells sense and remove aberrant cells, such as precancerous cells, to maintain the integrity and normal development of tissues and organs.

关键词： Cell competition Canalization Competition-dependent cell death Drosophila models Cellular proliferation Cellular growth Tumor-suppressor genes

Hepatectomy for gallbladder-cancer with unclassified anomaly of right-sided ligamentum teres: A case report and review of the literature

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World Journal of Hepatology 2018年第7期10卷 523-529页

作者： Toru Goto Hiroaki Terajima Takehito Yamamoto yoichiro Uchida Department of Gastroenterological Surgery and Oncology Tazuke Kofukai Medical Research Institute Kitano Hospital

Right-sided ligamentum teres(RSLT) is a congenital anomaly in which the right umbilical ligament becomes dominant and anomalous ramifications of the hepatic vessels and biliary system are present. A male patient in his 70 s was diagnosed with advanced gallbladder cancer directly infiltrating the right hepatic duct(RHD), together with RSLT. Preoperative three-dimensional simulation of the liver based on multiple detector computed tomography images after cholangiography revealed ramifications of all segmental portal veins from the portal trunk and discordance of the arterial and biliary branching patterns of segment 8. Fusion analysis of the biliary architecture and segmental volumetry showed that the RHD drained segments 1 r, 5, 6, and 7. We successfully performed a modified right-sided hepatectomy sparing segment 8(i.e., resection of the RHD drainage territory), with negative surgical margins. This report is the first to describe major hepatectomy for advanced gallbladder cancer with RSLT.

关键词： Right-sided ligamentum teres Hepatectomy Gallbladder cancer Preoperative liver simulation Anomaly of the portal vein

Red algae-derived isofloridoside activates the sweet taste receptor T1R2/T1R3

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Food Bioscience 2022年第6期50卷 1876-1881页

作者： Miku Akishino Yuko Aoki Hajime Baba Makio Asakawa yoichiro Hama Susumu Mitsutake Graduate School of Advanced Health Sciences Saga UniversitySagaJapan Graduate School of Agriculture Saga UniversitySagaJapan Department of Applied Biochemistry and Food Science Faculty of AgricultureSaga UniversitySagaJapan Department of Food Science Faculty of EducationKumamoto UniversityKumamotoJapan The United Graduate School of Agricultural Sciences Kagoshima UniversityKagoshimaJapan

Isofloridoside (IF) is a naturally occurring galactosylglycerol compound with a refreshing sweet taste. It is found in red algae, where it acts as a photosynthetic intermediate. However, the mechanism by which IF elicits sweetness has not been determined. In this study, we investigate the interaction between IF and the sweet taste receptor T1R2/T1R3. We show that IF causes an increase in intracellular Ca2+ concentration and an increase in Erk phosphorylation in T1R2/T1R3-expressing HEK293T cells, indicating that IF interacts with T1R2/T1R3. IF also activates endogenously expressed T1R2/T1R3 in mouse small intestinal endocrine L-cells, and promotes the secretion of the incretin glucagon-like peptide-1 (GLP-1). In silico docking simulations of IF and T1R2/T1R3 predict that IF forms hydrogen bonds with Tyr103 in the extracellular Venus flytrap domain of T1R2. This result is consistent with the binding mode of many other sweet-tasting molecules. We found that IF have the potential as a new alternative sweetener.

关键词： GPCR Taste receptor T1R2 T1R3 Floridoside Pyropia yezoensis

Gangliocytic paraganglioma: An overview and future perspective

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World Journal of Clinical Oncology 2019年第9期10卷 300-302页

作者： yoichiro Okubo Department of Pathology Kanagawa Cancer CenterYokohamaKanagawa 241-8515Japan

Gangliocytic paraganglioma(GP) is rare neuroendocrine tumor(NET) with a good prognosis that commonly arising from duodenum. Although the tumor is characterized by its unique triphasic cells(epithelioid, spindle, and ganglion-like cells), the proportions of these three tumor cells vary widely from case to case,and occasionally, morphological and immunohistochemical similarities are found between GP and NET G1(carcinoid tumors). Further, GP accounts for a substantial number of duodenal NETs. Therefore, GP continues to be misdiagnosed, most often as NET G1. However, GP has a better prognosis than NET G1, and it is important to differentiate GP from NET G1. In this article, I wish to provide up-to-date clinicopathological information to help oncologists gain better insight into the diagnosis and clinical management of this tumor.

关键词： Neuroendocrine tumor Gangliocytic paraganglioma Progesterone receptor Pancreatic polypeptide Literature survey

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Advances in Aging Research 2022年第5期11卷 117-134页

作者： yoichiro Sato Akito Kawaguchi Department of Physical Therapy Faculty of Health Sciences Hokkaido University of Science Sapporo Japan IMS Sapporo Internal Medicine Rehabilitation Hospital Sapporo Japan

This study aimed to investigate the characteristics of the coupling of the center of pressure (COP) movement and toes in older adults during one-legged standing (OLS). Participants were community dwelling older and younger adults. Toe vertical force during the OLS was recorded using a plantar-pressure distribution system, and the vertical forces in the hallux, little toe, and the first and fifth metatarsophalangeal (MP) joints were analyzed. A cross-correlation function was performed to examine the coordination between toes and between COP movement and four regions of the foot. The cross-correlation functions showed no significant difference in coefficients between toes. The OLS duration in the older adults was significantly correlated with the coefficient between the medial-lateral component of the COP and the first MP region. This study suggests that it is important to press the first MP region appropriately relative to COP movement to maintain the OLS.

关键词： One-Legged Stance Coordination Coupling Toe Older

Autism-Spectrum Quotient Is Associated with Observational Skill Acquisition in Healthy Young Adults

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Journal of Behavioral and Brain Science 2020年第4期10卷 179-190页

作者： yoichiro Sato Kento Kageyama Department of Physical Therapy Faculty of Health Sciences Hokkaido University of Science Sapporo Japan Department of Rehabilitation Asahikawa Medical University Hospital Asahikawa Japan

Although observational motor learning is one method of skill acquisition, this type of motor learning is not equally effective for all individuals. To clarify factors associated with the effectiveness of motor learning, we examined the association between model-observational skill acquisition and the Autism-Spectrum Quotient (AQ), which is reportedly associated with motor learning via visual information. Twenty healthy adults performed the Kendama task. The participants practiced under three conditions: using their own methods (self), following observation of model actions (model-observation), and following observation of their own actions (self-observation). Measurement trials were performed 20 times prior to self-practice sessions and after each practice session. Success ratios were calculated for each measurement trial. All participants completed the AQ. The difference in success ratios for measurement sessions following practices between the self and model-observation conditions was significantly negatively correlated with AQ scores. Individuals with low AQ values can more easily acquire skills via model-observational motor learning than those with relatively higher AQ values.

关键词： Observational Motor Learning Autism-Spectrum Quotient Motor Imagery Healthy Individual

Long-Term Outcomes of Systemic-to-Pulmonary Artery Shunt in Patients with Functional Single Ventricle and Heterotaxy Syndrome

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Congenital Heart Disease 2023年第4期18卷 399-411页

作者： Shota Kawai Takashi Kido Yuta Teguri Koji Miwa Tomomitsu Kanaya yoichiro Ishii Hisaaki Aoki Futoshi Kayatani Sanae Tsumura Department of Cardiovascular Surgery Osaka Women’s and Children’s HospitalIzumiOsakaJapan Department of Pediatric Cardiology Osaka Women’s and Children’s HospitalIzumiOsakaJapan

Objectives: We sought to determine the long-term outcomes and mortality-associated factors after systemic-topulmonaryartery shunt (SPS) in patients with heterotaxy syndrome. Methods: We retrospectively analyzed allpatients with a functional single ventricle and heterotaxy syndrome who underwent SPS at our center from January2001 to April 2022. Results: This study involved 84 patients. Restrictive pulmonary blood flow requiringearly modulation was presented in 34 (40%) patients. Compared with patients without restrictive pulmonaryblood flow (N = 50 [60%]), the postnatal survival of these 34 patients was significantly lower at 10 years (log rank:p = 0.04), but the statistical significance disappeared at 20 years (log rank: p = 0.18). Among 31 patients whounderwent SPS, 11 (35%) had extracardiac total anomalous pulmonary venous connection (TAPVC). The survivalrate after SPS was 80% at 10 years. Cox regression analysis showed that extracardiac TAPVC (hazard ratio6.44, 95% confidence interval 1.23–33.7, p = 0.03) and pulmonary venous obstruction (PVO) at TAPVC repair(hazard ratio 11.2, 95% confidence interval 2.13–58.5, p = 0.004) were significantly associated with death. In25 patients who underwent bidirectional cavopulmonary shunt (BCPS), surgical interventions on the pulmonaryartery (PA) were performed after SPS in 7 of 9 patients with PA coarctation, 3 of 4 with non-confluent PAs, and4 of 12 with normal PAs. At SPS, primary central PA plasty was performed in three patients with PA coarctationand 2 with non-confluent PAs. There was no significant difference in the PA index before BCPS between patientswith and without primary central PA plasty (p = 0.49). Among 20 patients who underwent total cavopulmonaryconnection (TCPC), adverse events occurred in 7 (35%) patients, including death in 1 (5%), intervention for pulmonaryarteriovenous malformation (PAVM) in 3 (15%), and surgical intervention for PVO in 3 (15%). TheB-type natriuretic peptide concentration was significant

关键词： Heterotaxy syndrome single ventricle total anomalous of pulmonary venous connection pulmonary artery coarctation