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Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer

World Journal of Gastroenterology 2015年第9期21卷 2683-2692页

作者： Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh yoichi yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto First Department of Internal Medicine Faculty of MedicineUniversity of YamanashiYamanashi 409-3898Japan First Department of Surgery Faculty of MedicineUniversity of YamanashiYamanashi 409-3898Japan Department of Pathology Faculty of MedicineUniversity of YamanashiYamanashi 409-3898Japan Department of Surgery Yamanashi Prefectural Central HospitalYamanashi 400-8506Japan Department of Pathology Yamanashi Prefectural Central HospitalYamanashi 400-8506Japan Department of Surgery Social Insurance Yamanashi HospitalYamanashi 400-0025Japan Department of Pathology Social Insurance Yamanashi HospitalYamanashi 400-0025Japan Department of General Surgery Kofu Kyoritsu HospitalYamanashi 400-0034Japan Department of Pathology Kofu Kyoritsu HospitalYamanashi 400-0034Japan Department of Surgery Kofu Municipal HospitalYamanashi 400-0832Japan Department of Pathology Kofu Municipal HospitalYamanashi 400-0832Japan Department of Surgery Yamanashi Kosei HospitalYamanashi 405-0033Japan Department of Surgery Kanoiwa General HospitalYamanashi 405-0018Japan Department of Pathology Kanoiwa General HospitalYamanashi 405-0018Japan Department of Surgery Social Insurance Kajikazawa HospitalYamanashi 400-0601Japan Department of Surgery Kofu National HospitalYamanashi 400-0006Japan Department of Surgery Fujiyoshida Municipal Medical CenterYamanashi 403-0005Japan Division of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyo 180-0023Japan

AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk ***:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined *** clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining ***:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate *** preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent *** to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk ***:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size *** these factors,LI was the most significantly correlated factor.

关键词： Undifferentiated-type early gastric cancer Lymph n

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Spectroscopic Determination of C,N,and O Abundances of Solar-analog Stars Based on the Lines of Hydride Molecules

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Research in Astronomy and Astrophysics 2023年第2期23卷 107-120页

作者： yoichi Takeda 11-2 Enomachi Naka-kuHiroshima-shi730-0851Japan

Photospheric C,N,and O abundances of 118 solar-analog stars were determined by applying the synthetic-fitting analysis to their spectra in the blue or near-UV region comprising lines of CH,NH,and OH molecules,with an aim of clarifying the behaviors of these abundances in comparison with[Fe/H].It turned out that,in the range of-0.6■[Fe/H]■+0.3,[C/Fe]shows a marginally increasing tendency with decreasing[Fe/H]with a slight upturn around[Fe/H]~0,[N/Fe]tends to somewhat decrease toward lower[Fe/H],and[O/Fe]systematically increases (and thus[C/O]decreases) with a decrease in[Fe/H].While these results are qualitatively consistent with previous determinations mostly based on atomic lines,the distribution centers of these[C/Fe],[N/Fe],and[O/Fe]at the near-solar metallicity are slightly negative by several hundredths of dex,which is interpreted as due to unusual solar abundances possibly related to the planetary formation of our solar ***,clear anomalies are not observed in the[C,N,O/Fe]ratios of planet-host *** out of four very Be-deficient stars were found to show anomalous[C/Fe]or[N/Fe]which may be due to mass transfer from the evolved companion,though its relation to the Be depletion mechanism is still unclear.

关键词： Galaxy evolution-planet-star interactions-stars abundances-stars atmospheres-stars solar-type

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Now and future of mouse mutagenesis for human disease models

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Journal of Genetics and Genomics 2010年第9期37卷 559-572页

作者： yoichi Gondo Mutagenesis and Genomics Team RIKEN Bio Resource Center

One of the major objectives of the Human Genome Project is to understand the biological function of the gene and genome as well as to develop clinical applications for human diseases. For this purpose, the experimental validations and preclinical trails by using animal models are indispensable. The mouse （Mus musculus） is one of the best animal models because genetics is well established in the mouse and embryonic manipulation technologies are also well developed. Large-scale mouse mutagenesis projects have been conducted to develop various mouse models since 1997. Originally, the phenotype-driven mutagenesis with N-ethyl-N-nitrosourea （ENU） has been the major efforts internationally then knockout/conditional mouse projects and gene-driven mutagenesis have been following. At the beginning, simple monogenic traits in the experimental condition have been elucidated. Then, more complex traits with variety of environmental interactions and gene-to-gene interactions （epistasis） have been challenged with mutant mice. In addition, chromosomal substitution strains and collaborative cross strains are also available to elucidate the complex traits in the mouse. Altogether, mouse models with mutagenesis and various laboratory strains will accelerate the studies of functional genomics in the mouse as well as in human.

关键词： mutagenesis functional genomics reverse genetics model animal quantitative trait epistasis

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Measurements of the Ca II infrared triplet lines of young stellar objects

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Research in Astronomy and Astrophysics 2013年第10期13卷 1189-1201页

作者： yoichi Itoh Keiko Moto'oka yoichi Itoh The Saga Prefecture Space & Science Museum 16351 Nagashima Takeo Takeo Saga 843-0021 Japan Nishi-Harima Astronomical Observatory Center for Astronomy University of Hyogo 407-2 Nishigaichi Sayo Hyogo 679-5313 Japan yitoh @nhao.jp

Equivalent widths and line widths of Ca II infrared triplet emission lines were measured in the high-resolution optical spectra of 39 young stellar *** found that the equivalent widths of the emission lines decrease with stellar *** has often been claimed that strong chromospheric activity is generated by a dynamo process caused by fast rotation of the ***,we found no clear correlation between the strength of the Ca II lines and the stellar rotation ***,we found that the objects with high mass accretion rates had stronger Ca II emission *** correlation supports the turbulent chromosphere model or the magnetic accretion theory for classical T Tauri *** also noticed that the equivalent widths of Ca II lines in transitional disk objects are one-tenth of those in classical T Tauri stars,even if the masses of the circumstellar disks are comparable.

关键词： stars:pre-main sequence stars:emission lines

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Degradation behaviors of nonylphenol ethoxylates by isolated bacteria using improved isolation method

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Journal of Environmental Sciences 2008年第9期20卷 1025-1027页

作者： Hideyuki Tamaki yoichi Kamagata Institute for Biological Resources and Functions National Institute of Advanced Industrial Science and Technology

Nonylphenol ethoxylate (NPEO)-degrading bacteria were isolated from activated sludge using an improved isolation method, and the corresponding degradation behaviours were investigated. Eight NPEO-degrading strains distributed in genera Pseudomonas, Sphingomonas, Sphingobium, Cupriavidus, Ralstonia, Achromobacter, and Staphylococcus were acquired. The latter five genera have never been reported for the degradation of NPEOs. Four degradation patterns were observed for the eight pure strains. In pattern A, NPE...

关键词： nonylphenol ethoxylate (NPEO) biodegradation ssolation method

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Cultivating the unseen:Lessons from James Tiedje

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mLife 2023年第3期2卷 217-223页

作者： yoichi Kamagata National Institute of Advanced and Industrial Science and Technology(AIST) TsukubaJapan

In recounting *** ***'s outstanding research achievements spanning the past 55 years,it is easy to overlook his early and mid-career ***,his contribution to the aerobic degradation of pesticides and other chemicals,as well as methanogenic degradation of those compounds retains their *** researchers in environmental microbiology have gained invaluable knowledge from these studies,which have been applied to the elucidation of previously uncultivated microorganisms.

关键词： cultivated gained pesticides

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Numerical analysis of surface plasmons excited on a thin metal grating

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第1期7卷 55-70页

作者： OKUNO yoichi SUYAMA Taikei Graduate School of Science and Technology Kumamoto University Kumamoto 860-8555 Japan Department of Electrical and Computer Engineering Kumamoto University Kumamoto 860-8555 Japan

The authors numerically investigated the characteristics of surface plasmons excited on a thin metal grating placed in planer or conical mounting. After formulating the problem, the solution method, Yasuura＇s method （a modal expansion approach with least-squares boundary matching） was described. Although the grating is periodic in one direction, coupling between TE and TM waves Occurs because arbitrary incidence is assumed. This requires the employment of both TE and TM vector modal functions in the analysis. Numerical computations showed：（l） the excitation of surface plasmons with total or partial absorption of incident light; （2） the resonance character of the coefficient of an evanescent order that couples the plasmon surface wave; （3） the field profile and Poynting＇s vector. The plasmons excited on the surfaces of a thin metal grating are classified into three types： SISP, SRSP, and LRSP, different from each other in the feature of field profile and energy flow. In addition, the eigenvalue of a plasmon mode was obtained by solving a sequence of diffraction problems with complex-valued angles of incidence and using the quasi-Newton algorithm to predict the real angle of incidence at which the absorption occurs.

关键词： Thin metal grating Plasmon modes Resonance absorption Numerical analysis

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Storage-efficient reconstruction framework for planar contours

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Geo-Spatial Information Science 2017年第1期20卷 14-28页

作者： Hiroyuki Goto yoichi Shimakawa Department of industrial and system engineering Hosei UniversitytokyoJapan Department of computer science and technology salesian polytechniquetokyoJapan

A storage-efficient reconstruction framework for cartographic planar contours is *** a smaller number of control points,we aim to calculate the area and perimeter as well as to reconstruct a smooth *** input data forms an oriented contour,each control point of which consists of three values:the Cartesian coordinates(x,y)and tangent angleθ.Two types of interpolation methods are developed,one of which is based on an arc spline while the other one is on a cubic Hermite *** arc spline-based method reconstructs a G1 continuous curve,with which the exact area and perimeter can be *** benefit of using the Hermite spline-based method is that it can achieve G2 continuity on most control points and can obtain the exact area,whereas the resulting perimeter is *** a numerical experiment for analytically defined curves,more accurate computation of the area and perimeter was achieved with a smaller number of control *** another experiment using a digital elevation model data,the reconstructed contours were smoother than those by a conventional method.

关键词： Oriented contour arc spline cubic Hermite spline geometric continuity storage efficient

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High-Resolution Spectroscopy of Winds Associated with T Tauri Stars

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Research in Astronomy and Astrophysics 2016年第2期16卷 89-96页

作者： Naoto Iguchi yoichi Itoh Graduate School of Science Kobe University1-1 Rokkodai-choNada-kuKobeHyogo 657-8501Japan Nishi-Harima Astronomical Observatory Center for AstronomyUniversity of Hyogo407-2NishigaichiSayoHyogo 679-5313Japan

We carried out optical high-resolution spectroscopy of T Tauri stars using the Subaru Telescope. Using archived data from the Keck Telescope and the Very Large Telescope, we detected forbidden lines of [S II] at 4069A, in addition to those of [O I] at 5577 A and 6300A, for 13 T Tauri stars. We consider that low-velocity components of these forbidden lines emanate from the wind associated with T Tauri stars. Using two flux ratios of the three lines, we simultaneously determined the hydrogen density and temperature of the winds. The winds ofT Tauri stars have a hydrogen density of 2.5 × 106 cm^-3 - 2.5 × 10^9 cm^-3 and a temperature of 10 800 -18 000 K. The mass loss rates by the wind are estimated to lie in the range from 2.0 × 10^-10 M⊙ yr-1 to 1.4× 10^-9 M⊙ yr-1. The mass loss rates are found to increase with increasing mass accretion rates. The ratio of the mass loss rate to the mass accretion rate is 0.001-0.1 for classical T Tauri stars and 0.1-1 for transitional disk objects.

关键词： stars pre-main sequence -- stars emission lines

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Unsteady Flow at Low Flow-rate Region in a Semi-open Propeller Fan (Velocity Fluctuation outside of Blade Tip)

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Journal of Thermal Science 2011年第3期20卷 218-223页

作者： Norimasa SHIOMI yoichi KINOUE Toshiaki SETOGUCHI Department of Mechanical Engineering Saga UniversityHonjo-machi 1Saga-shiSaga840-8502Japan

In order to clarify the unsteady flow fields at low flow-rate region with positive gradient on pressure-flow-rate curve,the experimental investigation was carried out at rotor inlet and outside of rotor blade tip without casing in a semi-opened propeller fan using a hot-wire anemometer.A single I-type hot-wire probe was used,and the data obtained were processed by the use of phase-locked averaging,ensemble averaging and FFT *** flow fields at rotor inlet and outside of rotor blade tip were discussed mainly using the results from distributions of velocity fluctuations and power spectrum *** was found from these results that there are the two types of different periodical fluctuations and both of those frequencies were not the same of rotor rotating frequency(RRF;15Hz).One was observed at relatively high flow-rate region at relatively downstream area in measurement and its frequency was approximately 7Hz(47% of RRF).The other was observed at relatively low flow-rate region at relatively upstream area in measurement and its frequency was approximately 10Hz(67% of RRF)".As the velocity fluctuations with the flow fields are rapidly increased by the former fluctuation,it is thought that its fluctuation is the trigger of blade stall.

关键词： Semi-opened fan Propeller fan Unsteady flow measurement and FFT analysis

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