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A Study on Visual Diversity of Japanese Residential Streetscapes

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Journal of Civil Engineering and Architecture 2015年第5期9卷 626-634页

作者： Garu Muni Wathsala Lakpriya Gunawardena Kubota yoichi Kiyotaka Fukahori Graduate School of Science and Engineering Saitama University Saitama-shi 338-8570 Japan

This study was conducted to find out the available visual diversity in Japanese residential streetscapes. The visual diversity occurs when the visual elements on streetscapes are different to each other. In this study, a field survey as a subjective method and the entropy as an objective method were used as measures of visual diversity. Data were collected from 80 residential streetscapes from four sites in the Saitama Prefecture, Japan. The sequential perspective views of streetscapes were analyzed for eight visual elements： shape of houses, shape of roofs, shape of windows, positions of the main openings of houses, availability of the ornaments on houses, height, color and the appearance of the boundary walls of premises to calculate the entropy. A field survey with multicultural subjects was used to find out the correlation between entropy and the human perception on the visual diversity. According to the results, the residential streetscapes displayed high diversity variations largely due to the shape of the roofs, shape of the windows and the appearance of the boundary walls of the premises. Moreover, the results concluded that the residential streetscapes at the study area are neither visually diverse nor visually uniform in considering the visual diversity aspect.

关键词： Entropy streetscapes visual diversity visual elements.

Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection

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World Journal of Gastrointestinal Surgery 2022年第7期14卷 670-684页

作者： Yuzuru Sakamoto Shingo Shimada Toshiya Kamiyama Ko Sugiyama Yoh Asahi Akihisa Nagatsu Tatsuya Orimo Tatsuhiko Kakisaka Hirofumi Kamachi yoichi M Ito Akinobu Taketomi Department of Gastroenterological Surgery Hokkaido University Graduate School of MedicineSapporo 060-8638HokkaidoJapan Data Science Center Promotion UnitInstitute of Health Science Innovation for Medical CareHokkaido University HospitalSapporo 060-8648HokkaidoJapan

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common malignancies ***,the number of patients with chronic kidney disease(CKD)is on the rise because of the increase in lifestyle-related *** To establish a tailored management strategy for HCC patients,we evaluated the impact of comorbid renal dysfunction(RD),as stratified by using the estimated glomerular filtration rate(EGFR),and assessed the oncologic validity of hepatectomy for HCC patients with *** We enrolled 800 HCC patients who underwent hepatectomy between 1997 and 2015 at our university *** categorized patients into two(RD,EGFR<60 mL/min/1.73 m^(2);non-RD,EGFR≥60 mL/min/1.73 m^(2))and three groups(severe CKD,EGFR<30 mL/min/1.73 m^(2);mild CKD,30≤EGFR<60 mL/min/1.73 m2;control,EGFR≥60 mL/min/1.73 m^(2))according to renal function as defined by the *** survival(OS)and recurrence-free survival(RFS)were compared among these groups with the log-rank test,and we also analyzed survival by using a propensity score matching(PSM)model to exclude the influence of patient *** mean postoperative observation period was 64.7±53.0 *** The RD patients were significantly older and had lower serum total bilirubin,aspartate aminotransferase,and aspartate aminotransferase levels than the non-RD patients(P<0.0001,P<0.001,P<0.05,and P<0.01,respectively).No patient received maintenance hemodialysis after *** the overall postoperative complication rates were similar between the RD and non-RD patients,the proportions of postoperative bleeding and surgical site infection were significantly higher in the RD patients(5.5%vs 1.8%;P<0.05,3.9%vs 1.8%;P<0.05,respectively),and postoperative bleeding was the highest in the severe CKD group(P<0.05).Regardless of the degree of comorbid RD,OS and RFS were comparable,even after PSM between the RD and non-RD groups to exclude the influence of patient characteristics,liver function,and other causes of dea

关键词： Hepatocellular carcinoma Hepatectomy Renal dysfunction Estimated glomerular filtration rate

Rheumatoid Arthritis with High Serum KL-6 Complicating Malignant Tumor: Two Case Reports

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Open Journal of Orthopedics 2015年第3期5卷 41-45页

作者： Hiroyuki Tsuchie Seiya Miyamoto yoichi Kataoka Seietsu Senma Yuichiro Narita Yuji Hatakeyama Moto Kobayashi Kana Sasaki yoichi Shimada Division of Orthopedic Surgery Nakadori General Hospital Akita Japan Joto Orthopedic Clinic Akita Japan Division of Orthopedic Surgery Hiraka General Hospital Yokote Japan Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan

Interstitial pneumonia develops not only as a rheumatoid arthritis (RA) manifestation, but also due to the side effects of drugs for its treatment, leading to the necessity of regular examinations. Krebs von den Lungen-6 (KL-6) is often used to check the activity of interstitial pneumonia in RA patients. However, this marker is also produced by some malignant tumors, and a high level of serum KL-6 has been reported in cancer patients. We describe herein 2 cases of RA with the complication of a malignant tumor not involving the lung, although there is no lesion in the lung regardless of the high level of serum KL-6.

关键词： KL-6 Malignant Tumor Rheumatoid Arthritis SP-D

Discharge Simulation in a Data-Scarce Basin Using Reanalysis and Global Precipitation Data: A Case Study of the White Volta Basin

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Journal of Water Resource and Protection 2014年第14期6卷 1316-1325页

作者： yoichi Fujihara Yukiyo Yamamoto Yasuhiro Tsujimoto Jun-Ichi Sakagami Faculty of Bioresources and Environmental Sciences Ishikawa Prefectural University Nonoichi Japan Japan International Research Center for Agricultural Sciences Tsukuba Japan Faculty of Agriculture Kagoshima University Kagoshima Japan

Basins in many parts of the world are ungauged or poorly gauged, and in some cases existing measurement networks are declining. The purpose of this study was to examine the utility of reanalysis and global precipitation datasets in the river discharge simulation for a data-scarce basin. The White Volta basin of Ghana which is one of international rivers was selected as a study basin. NCEP1, NCEP2, ERA-Interim, and GPCP datasets were compared with corresponding observed precipitation data. Annual variations were not reproduced in NCEP1, NCEP2, and ERA-Interim. However, GPCP data, which is based on satellite and observed data, had good seasonal accuracy and reproduced annual variations well. Moreover, five datasets were used as input data to a hydrologic model with HYMOD, which is a water balance model, and with WTM, which is a river model;thereafter, the hydrologic model was calibrated for each datum set by a global optimization method, and river discharge were simulated. The results were evaluated by the root mean square error, relative error, and water balance error. As a result, the combination of GPCP precipitation and ERA-Interim evaporation data was the best in terms of most evaluations. The relative errors in the calibration and validation periods were 43.1% and 46.6%, respectively. Moreover, the results for the GPCP precipitation and ERA-Interim evaporation were better than those for the combination of observed precipitation and ERA-Interim evaporation. In conclusion, GPCP precipitation data and ERA-Interim evaporation data are very useful in a data-scarce basin water balance analysis.

关键词： Reanalysis Data Global Precipitation Data Ungauged Basin Hydrologic Model Discharge Simulation Africa

High level of serum cholesteryl ester transfer protein inactive hepatitis C virus infection

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World Journal of Hepatology 2016年第5期8卷 291-300页

作者： Kenichi Satoh Tomohisa Nagano Nobuyoshi Seki yoichi Tomita Yuta Aida Tomonori Sugita Munenori Itagaki Satoshi Sutoh Hiroshi Abe Yoshio Aizawa Department of Gastroenterology and Hepatology Internal Medicine of Jikei University Katsushika Medical CenterKatsushikakuTokyo 125-8506Japan

AIM: To determine the significance of cholesteryl ester transfer protein(CETP) in lipoprotein abnormalities in chronic hepatitis C virus(HCV) ***: We evaluated the significance of the serum concentration of CETP in 110 Japanese patients with chronic HCV infection. Fifty-five patients had active HCV infection, and HCV eradication had been achieved in 55. The role of CETP in serum lipoprotein abnormalities, specifically, in triglyceride(TG) concentrations in the four major classes of lipoproteins, was investigated using Pearson correlations in conjunction with multiple regression analysis and compared them between those with active HCV infection and those in whom eradication had been achieved. RESULTS: The serum CETP levels of patients with active HCV infection were significantly higher than those of patients in whom HCV eradication was achieved(mean ± SD, 2.84 ± 0.69 μg/m L vs 2.40 ± 1.00 μg/m L, P = 0.008). In multiple regression analysis, HCV infection status(active or eradicated) was an independent factor significantly associated with the serum CETP level. TG concentrations in low-density lipoprotein(mean ± SD, 36.25 ± 15.28 μg/m L vs 28.14 ± 9.94 μg/m L, P = 0.001) and high-density lipoprotein(HDL)(mean ± SD, 25.9 ± 7.34 μg/m L vs 17.17 ± 4.82 μg/m L, P < 0.001) were significantly higher in patientswith active HCV infection than in those in whom HCV eradication was achieved. The CETP level was strongly correlated with HDL-TG in patients with active HCV infection(R = 0.557, P < 0.001), whereas CETP was not correlated with HDL-TG in patients in whom HCV eradication was achieved(R =-0.079, P = 0.56). CONCLUSION: Our results indicate that CETP plays a role in abnormalities of lipoprotein metabolism in patients with chronic HCV infection.

关键词： Hepatitis C virus Cholesteryl ester transferprotein High-density lipoprotein triglyceride Casecontrol study Lipoprotein metabolism

FRAX and Exercise: Should Exercise Be Categorized as a Risk Factor in Osteoporotic Patients

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Open Journal of Orthopedics 2013年第2期3卷 133-136页

作者： Akira Horikawa Naohisa Miyakoshi yoichi Shimada Hiroyuki Kodama Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan. South Akita Orthopedic Clinic Katagami Japan

Although FRAX (WHO Fracture Risk assessment Tool), developed by the WHO, is a well-validated tool for determining the probability of a major osteoporotic fracture in the next 10 years, it doesn’t include a number of other impact factors such as exercise and nutrition. The purpose of this study was to compare the differences in FRAX between subjects with and without exercise habits or intake of calcium/coffee. A significant difference in FRAX was observed between the groups with respect to exercise (p < 0.001). There were no significant differences in FRAX, however, between the groups with and without intake of calcium/coffee. Although exercise habits are not included in FRAX, our findings suggest that exercise status influenced other factors included in FRAX. Since exercise is reported to prevent falls and fall-related osteoporotic fractures, including exercise status in FRAX may be more effective for estimating the possibility of future fractures. Further investigation should be conducted to determine whether exercise status is an important risk factor, independent of FRAX, for osteoporotic fractures.

关键词： FRAX Exercise Osteoporosis

初始不可切除胰腺导管腺癌转化手术的现状与展望

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中华消化外科杂志 2018年第4期17卷 329-332页

作者： Sohei Satoi Tomohisa Yamamoto Kentaro Inoue yoichi Matsui 日本关西医科大学外科日本大阪市573-1010

胰腺导管腺癌预后一直不佳，患者5年生存率〈5%，化疗领域的进展将不可切除胰腺导管腺癌中位生存时间延长。不可切除胰腺导管腺癌的治疗仍充满挑战，需多学科团队共同制订治疗方案。令人欣慰的是，近期研究结果显示：局部晚期和远处转... 详细信息

胰腺导管腺癌预后一直不佳，患者5年生存率〈5%，化疗领域的进展将不可切除胰腺导管腺癌中位生存时间延长。不可切除胰腺导管腺癌的治疗仍充满挑战，需多学科团队共同制订治疗方案。令人欣慰的是，近期研究结果显示：局部晚期和远处转移的胰腺导管腺癌对化疗良好的反应性及转化手术率的增高。近期几项研究结果显示：对初始不可切除胰腺导管腺癌行转化治疗后，外科手术可获得更高的切除率（20%-61%）、更高的R0切除率（27%-89%）和淋巴结阴性率（29%-86%），且多数研究中的手术死亡率和术后并发症发生率均在可控制范围内。不可切除胰腺导管腺癌患者行转化手术后中位生存时间可达24-56个月，显著优于无法行外科手术的患者。此外，关于最佳化疗方案的选择、残留肿瘤体积的测量、外科手术指征、最佳手术时间及切除范围仍是研究热点。对初始不可切除胰腺导管腺癌患者，转化手术治疗是目前改善其预后的重要方法，亦需多学科团队医师共同努力；临床尚需更多设计优良的临床研究确认转化治疗在不可切除胰腺导管腺癌中的应用价值。

关键词：胰腺肿瘤胰腺导管腺癌不可切除转化医学手术治疗新辅助治疗远处器官转移: 局部晚期肿瘤标志物

E1A, E1B double-restricted adenovirus enhances the cytotoxicity and antitumor activity of gemcitabine to renal cell carcinoma

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Chinese Medical Journal 2011年第7期124卷 1082-1087页

作者： WANG Hua Makoto Satoh CHEN Gui-ping LI De-chuan Hirofumi Hamada yoichi Arai Department of Urology Zhejiang Cancer Hospital Hangzhou Zhejiang 310022 China Department of Urology Se-en Hospital Tagajyo Japan Department of Molecular Medicine Sapporo Medical University Sapporo Japan Division of Urology Chair of Surgery Tohoku University Graduate School of Medicine Sendai Japan

Background Our previous studies have demonstrated potent oncolysis efficacy of the E1A, E1B double-restricted replication-competent oncolytic adenovirus AxdAdB-3 for treatment of bladder cancer. Here, we reported the ... 详细信息

关键词： oncolysis adenovirus gemcitabine renal cell carcinoma

Potential Power of the Pyramidal Structure III: Discovery of Pyramid Effects with and without Seasonal Variation

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Natural Science 2020年第12期12卷 743-753页

作者： Osamu Takagi Masamichi Sakamoto Hideo yoichi Kimiko Kawano Mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Since October 2007, we have been conducting rigorous scientific research on the unexplained “power” of a pyramidal structure (PS). From our research results so far, we could classify the pyramid effects by the PS into the following two types. (i) The pyramid effects in which the PS converted the test subject’s unexplained energy to affect biosensors when the test subject entered the PS and meditated. (ii) The pyramid effects in which the potential power of the PS affected biosensors if the test subject had not been inside the PS for at least 20 days and the test subject’s unexplained energy was excluded. In this paper, we report new results regarding (ii). As a result of dividing a year according to the four seasons of winter, spring, summer, and autumn and analyzing the pyramid effect of each period, the following points were found. 1) There was a pyramid effect without seasonal variation. The pyramid effect on the lower and upper layers was different throughout the year for the biosensors placed at the PS apex in two layers, regardless of the season. 2) There was a pyramid effect with seasonal variation. The value of the psi index, which indicates the magnitude of the pyramid effect, changed as the seasons changed, while different pyramid effects were maintained on the lower and upper layers. Regarding the change in the pyramid effect depending on the season, the psi index in summer was larger than that in winter in both the lower and upper layers. From these results, we found that there are two types of potential power at the PS apex: seasonal potential power and non-seasonal potential power.

关键词： Pyramid Potential Power Meditation Non-Contact Effect Seasonal Variation Biosensor Cucumis sativus Gas Psi Index