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初始不可切除胰腺导管腺癌转化手术的现状与展望

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中华消化外科杂志 2018年第4期17卷 329-332页

作者： Sohei Satoi Tomohisa Yamamoto Kentaro Inoue yoichi Matsui 日本关西医科大学外科日本大阪市573-1010

胰腺导管腺癌预后一直不佳，患者5年生存率〈5%，化疗领域的进展将不可切除胰腺导管腺癌中位生存时间延长。不可切除胰腺导管腺癌的治疗仍充满挑战，需多学科团队共同制订治疗方案。令人欣慰的是，近期研究结果显示：局部晚期和远处转... 详细信息

胰腺导管腺癌预后一直不佳，患者5年生存率〈5%，化疗领域的进展将不可切除胰腺导管腺癌中位生存时间延长。不可切除胰腺导管腺癌的治疗仍充满挑战，需多学科团队共同制订治疗方案。令人欣慰的是，近期研究结果显示：局部晚期和远处转移的胰腺导管腺癌对化疗良好的反应性及转化手术率的增高。近期几项研究结果显示：对初始不可切除胰腺导管腺癌行转化治疗后，外科手术可获得更高的切除率（20%-61%）、更高的R0切除率（27%-89%）和淋巴结阴性率（29%-86%），且多数研究中的手术死亡率和术后并发症发生率均在可控制范围内。不可切除胰腺导管腺癌患者行转化手术后中位生存时间可达24-56个月，显著优于无法行外科手术的患者。此外，关于最佳化疗方案的选择、残留肿瘤体积的测量、外科手术指征、最佳手术时间及切除范围仍是研究热点。对初始不可切除胰腺导管腺癌患者，转化手术治疗是目前改善其预后的重要方法，亦需多学科团队医师共同努力；临床尚需更多设计优良的临床研究确认转化治疗在不可切除胰腺导管腺癌中的应用价值。

关键词：胰腺肿瘤胰腺导管腺癌不可切除转化医学手术治疗新辅助治疗远处器官转移: 局部晚期肿瘤标志物

High level of serum cholesteryl ester transfer protein inactive hepatitis C virus infection

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World Journal of Hepatology 2016年第5期8卷 291-300页

作者： Kenichi Satoh Tomohisa Nagano Nobuyoshi Seki yoichi Tomita Yuta Aida Tomonori Sugita Munenori Itagaki Satoshi Sutoh Hiroshi Abe Yoshio Aizawa Department of Gastroenterology and Hepatology Internal Medicine of Jikei University Katsushika Medical CenterKatsushikakuTokyo 125-8506Japan

AIM: To determine the significance of cholesteryl ester transfer protein(CETP) in lipoprotein abnormalities in chronic hepatitis C virus(HCV) ***: We evaluated the significance of the serum concentration of CETP in 110 Japanese patients with chronic HCV infection. Fifty-five patients had active HCV infection, and HCV eradication had been achieved in 55. The role of CETP in serum lipoprotein abnormalities, specifically, in triglyceride(TG) concentrations in the four major classes of lipoproteins, was investigated using Pearson correlations in conjunction with multiple regression analysis and compared them between those with active HCV infection and those in whom eradication had been achieved. RESULTS: The serum CETP levels of patients with active HCV infection were significantly higher than those of patients in whom HCV eradication was achieved(mean ± SD, 2.84 ± 0.69 μg/m L vs 2.40 ± 1.00 μg/m L, P = 0.008). In multiple regression analysis, HCV infection status(active or eradicated) was an independent factor significantly associated with the serum CETP level. TG concentrations in low-density lipoprotein(mean ± SD, 36.25 ± 15.28 μg/m L vs 28.14 ± 9.94 μg/m L, P = 0.001) and high-density lipoprotein(HDL)(mean ± SD, 25.9 ± 7.34 μg/m L vs 17.17 ± 4.82 μg/m L, P < 0.001) were significantly higher in patientswith active HCV infection than in those in whom HCV eradication was achieved. The CETP level was strongly correlated with HDL-TG in patients with active HCV infection(R = 0.557, P < 0.001), whereas CETP was not correlated with HDL-TG in patients in whom HCV eradication was achieved(R =-0.079, P = 0.56). CONCLUSION: Our results indicate that CETP plays a role in abnormalities of lipoprotein metabolism in patients with chronic HCV infection.

关键词： Hepatitis C virus Cholesteryl ester transferprotein High-density lipoprotein triglyceride Casecontrol study Lipoprotein metabolism

Micro RNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6

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World Journal of Gastrointestinal Oncology 2016年第7期8卷 532-542页

作者： Toshihiro Tadano yoichi Kakuta Shin Hamada Yosuke Shimodaira Masatake Kuroha Yoko Kawakami Tomoya Kimura Hisashi Shiga Katsuya Endo Atsushi Masamune Seiichi Takahashi Yoshitaka Kinouchi Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Community Gastroenterology (Iwaki Kyoritsu Hospital) Tohoku University Graduate School of Medicine Health Administration Center Center for the Advancement of Higher Education Tohoku University

AIM: To investigate the microR NA(miR NA) expression during histological progression from colorectal normal mucosa through adenoma to carcinoma within a lesion. METHODS: Using microarray, the sequential changes in miR NA expression profiles were compared in colonic lesions from matched samples; histologically, nonneoplastic mucosa, adenoma, and submucosal invasive carcinoma were microdissected from a tissue sample. Cell proliferation assay was performed to observe the effect of miR NA, and its target genes were predicted using bioinformatics approaches and the expression profile of SW480 transfected with the miR NA mimics. mR NA and protein levels of the target gene in colon cancer cell lines with a mimic control or miR NA mimics were measured using qR TPCR and Western blotting. The expression levels of miR NA and target gene in colorectal tissue samples were also ***: Microarray analysis identified that the miR-320 family, including miR-320 a, miR-320 b, miR-320 c, miR-320 d and miR-320 e, were differentially expressed in adenomaand submucosal invasive carcinoma. The mi R-320 family, which inhibits cell proliferation, is frequently downregulated in colorectal adenoma and submucosal invasive carcinoma tissues. Seven genes including CDK6 were identified to be common in the results of gene expression array and bioinformatics analyses performed to find the target gene of the miR-320 family. We confirmed that mR NA and protein levels of CDK6 were significantly suppressed in colon cancer cell lines with miR-320 family mimics. CDK6 expression was found to increase from non-neoplastic mucosa through adenoma to submucosal invasive carcinoma tissues and showed an inverse correlation with miR-320 family ***: MiR-320 family affects colorectal tumor proliferation by targeting CDK6, plays important role in its growth, and is considered to be a biomarker for its early detection.

关键词： CDK6 Colorectal cancer Mi R-320 family Colorectal adenoma Laterally spreading type

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面向对象的分布式环境OZ的认证系统研究

计算机应用研究 1999年第3期16卷 4-5,12页

作者：王丽娜 yoichi HAMAZAKI 东北大学日本工业技术院电子技术综合研究所

本文针对面向对象的分布式环境ＯＺ的通信安全要求，应用密码学技术，设计了基于公开钥算法的安全认证系统，进行ｃａｌｌｅｒ与ｃａｌｌｅｅ之间的身份认证。在面向对象的分布式环境ＯＺ中，提供认证安全服务，不仅可以避免不正确的存... 详细信息

本文针对面向对象的分布式环境ＯＺ的通信安全要求，应用密码学技术，设计了基于公开钥算法的安全认证系统，进行ｃａｌｌｅｒ与ｃａｌｌｅｅ之间的身份认证。在面向对象的分布式环境ＯＺ中，提供认证安全服务，不仅可以避免不正确的存取、更改、盗窃、中途攻击，而且能有效地管理密钥。采用面向对象（ｏｒｉｅｎｔｅｄ－ｏｂｊｅｃｔ）策略、使用最先进的Ｊａｖａ语言实现了这个认证子系统。

关键词：面向对象分布式环境 OZ 认证系统全球网络

E1A, E1B double-restricted adenovirus enhances the cytotoxicity and antitumor activity of gemcitabine to renal cell carcinoma

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Chinese Medical Journal 2011年第7期124卷 1082-1087页

作者： WANG Hua Makoto Satoh CHEN Gui-ping LI De-chuan Hirofumi Hamada yoichi Arai Department of Urology Zhejiang Cancer Hospital Hangzhou Zhejiang 310022 China Department of Urology Se-en Hospital Tagajyo Japan Department of Molecular Medicine Sapporo Medical University Sapporo Japan Division of Urology Chair of Surgery Tohoku University Graduate School of Medicine Sendai Japan

Background Our previous studies have demonstrated potent oncolysis efficacy of the E1A, E1B double-restricted replication-competent oncolytic adenovirus AxdAdB-3 for treatment of bladder cancer. Here, we reported the ... 详细信息

关键词： oncolysis adenovirus gemcitabine renal cell carcinoma

Potential Power of the Pyramidal Structure III: Discovery of Pyramid Effects with and without Seasonal Variation

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Natural Science 2020年第12期12卷 743-753页

作者： Osamu Takagi Masamichi Sakamoto Hideo yoichi Kimiko Kawano Mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Since October 2007, we have been conducting rigorous scientific research on the unexplained “power” of a pyramidal structure (PS). From our research results so far, we could classify the pyramid effects by the PS into the following two types. (i) The pyramid effects in which the PS converted the test subject’s unexplained energy to affect biosensors when the test subject entered the PS and meditated. (ii) The pyramid effects in which the potential power of the PS affected biosensors if the test subject had not been inside the PS for at least 20 days and the test subject’s unexplained energy was excluded. In this paper, we report new results regarding (ii). As a result of dividing a year according to the four seasons of winter, spring, summer, and autumn and analyzing the pyramid effect of each period, the following points were found. 1) There was a pyramid effect without seasonal variation. The pyramid effect on the lower and upper layers was different throughout the year for the biosensors placed at the PS apex in two layers, regardless of the season. 2) There was a pyramid effect with seasonal variation. The value of the psi index, which indicates the magnitude of the pyramid effect, changed as the seasons changed, while different pyramid effects were maintained on the lower and upper layers. Regarding the change in the pyramid effect depending on the season, the psi index in summer was larger than that in winter in both the lower and upper layers. From these results, we found that there are two types of potential power at the PS apex: seasonal potential power and non-seasonal potential power.

关键词： Pyramid Potential Power Meditation Non-Contact Effect Seasonal Variation Biosensor Cucumis sativus Gas Psi Index

Effects of L-carnitine and Branched-Chain Amino Acids on Energy Metabolism,Body Composition,and Delayed-Onset Muscle Soreness after Exercise in Healthy Subjects

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Journal of Nutritional Oncology 2018年第1期3卷 25-33页

作者： yoichi Sakurai Yumi Hasegawa Yuka Kurosaka Hideyuki Nanba Satoshi Odo Department of Ecology Wayo Women’s University Graduate SchoolChibaJapan Department of Surgery Chiba-ken Saiseikai Narashino HospitalChibaJapan Department of Clinical Nutrition Matsudo Municipal HospitalChibaJapan College of Science and Technology Nihon University Lonza Japan Ltd TokyoJapan

Background Specific nutrients combined with exercise may prevent a loss of lean body mass and consequently prevent *** examined the effects of 2 weeks of supplementation with L-carnitine and a single dose of branched-chain amino acids(BCAAs)on energy metabolism and body composition before and after exercise and on post-exercise muscle soreness in healthy *** A total of 12 young,untrained,healthy women were randomly assigned to two groups who received either 2 weeks of supplementation with L-carnitine(1000 mg/day)and a single dose of BCAAs plus 200 kcal energy(LCAR+BCAA group,n=6)or 200 kcal energy alone(control group,n=6)before 60 min of *** substrate metabolism and body composition by bio-impedance were examined before and after ***-onset muscle soreness(DOMS)was evaluated by using a visual analogue scale for 3 days after *** Serum concentrations of free and acyl-L-carnitine in the LCAR+BCAA group were not significantly different from those in the control *** were no significant differences in body composition before or after exercise between the two *** serum free fatty acid levels 120 min after the oral ingestion of BCAAs were significantly lower in the LCAR+BCAA group than in the control group,there were no significant differences in serum free fatty acid levels immediately after and 60 min after *** for 3 days after exercise was lower in the LCAR+BCAA group than in the control group,but this difference was not *** Continuous supplementation with L-carnitine combined with a dose of BCAAs in young,untrained,healthy subjects caused a blunted response of stimulated lipolysis after exercise.

关键词： Sarcopenia L-carnitine Branched-chain amino acids Exercise Oxidative stress Delayed-onset muscle soreness

Influence of Sowing Season and Host Crop Identity on the Community Structure of Arbuscular Mycorrhizal Fungi Colonizing Roots of Two Different Gramineous and Leguminous Crop Species

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Advances in Microbiology 2015年第2期5卷 107-116页

作者： Masao Higo Katsunori Isobe Yukiya Matsuda Mio Ichida yoichi Torigoe College of Bioresource Sciences Nihon University Fujisawa Japan

Introduction of cover crops may improve the diversity of arbuscular mycorrhizal fungi (AMF) in roots and soil under crop rotational systems;therefore, it is necessary to determine the potential for AMF communities to improve sustainable food production. We investigated the impact of cover crops, including wheat (Triticum aestivum L.), barley (Hordeum vulgare L.), pea (Pisum sativum L.), and hairy vetch (Vicia villosa Roth.), on the AMF communities in their roots in autumn and spring sowing seasons with PCR-DGGE analysis. Although all four cover crops impacted the AMF community structure in roots, the diversity of AMF communities was unchanged among crop type or sowing season. Redundancy analysis (RDA) demonstrated that AMF communities within crop type were significantly different. However, the AMF community structures were not influenced by growing season, suggesting that growth stage in crops may be more responsive to shaping AMF community structure in crop roots than host crop identity.

关键词： Arbuscular Mycorrhizal Fungi Community Structure Crop Identity Host Selectivity Sowing Season

Potential Power of the Pyramidal Structure

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Natural Science 2019年第8期11卷 257-266页

作者： Osamu Takagi Masamichi Sakamoto Hideo yoichi Kimiko Kawano Mikio Yamamoto International Research Institute (IRI) Inage Chiba Japan Aquavision Academy Narita Chiba Japan

There have been various traditions and books which describe a so-called “pyramid power”, but there have been almost no reliable academic studies and no statistically significant data about it. We have continued scientifically rigorous experiments using biosensors to elucidate unexplained functions of a pyramidal structure (PS) since 2007. We used edible cucumber sections as biosensors and measured the concentrations of gas emitted from the sections by a technique developed by our group. From them we have demonstrated with high statistical accuracy the existence of the “pyramid power”, which was often recognized as having no scientific basis. We reached two conclusions from the work. 1) The PS converted the unconsciousness of a human (the test subject) more than 6 km away to energy detectable by the biosensors (1% significance). 2) The PS accumulated the influence that a human (the test subject) had when meditating within the PS. Then the PS converted the influence into the energy detectable by the biosensors (10-3% significance). These two conclusions showed that the functions of the PS were detected when “the PS and a human were related”. On the other hand, we hypothesized that the potential power of the PS could be detected even when “the PS and a human were not related”. In this paper, our purpose is to verify the existence of the potential power of the PS alone by experiment when “the PS and a human were not related”. The following three results were obtained by experiment. 1) The presence of the potential power of the PS was demonstrated with 1% significance. 2) The potential power of the PS changed in value between summer and winter, and it was clear that the non-contact effect on the biosensors was larger in summer and smaller in winter. 3) The potential power of the PS affected only the biosensors placed at the PS apex, and did not affect the biosensors placed at the calibration control point 8 m away from the PS. This paper is the first report in the world

关键词： Pyramid Potential Power Meditation Unconsciousness Non-Contact Effect Delay Biosensor Cucumber Gas