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Liver resection for early hepatocellular cancer: Comparison of centers in 3 different countries

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World Journal of Hepatology 2016年第31期8卷 1327-1335页

作者： Linda L Wong Brenda Y Hernandez Yurii B Shvetsov yoichi kawano Zhao-You Tang Jun-Fang Ji Cancer Center Department of Surgery John A Burns School of MedicineUniversity of Hawaii Department of Surgery Nippon Medical School Liver Cancer Institute and Zhongshan Hospital Fudan University Life Sciences Institute Zhejiang University

AIM To compare patients who underwent resection of early stage hepatocellular cancer(HCC) in three different countries. METHODS This retrospective study characterizes 573 stage Ⅰ/Ⅱ HCC patients treated with liver resection in 3 tertiaryreferral centers: Tokyo(n = 250), Honolulu(n = 146) and Shanghai(n = 177).RESULTS Shanghai patients were younger, predominantly male, hepatitis-B seropositive(94%) and cirrhotic(93%). Tokyo patients were older and more likely to have hepatitis-C(67%), smaller tumors, low albumin, and normal alpha-fetoprotein. The Honolulu cohort had the largest tumors and 30% had no viral hepatitis. Ageadjusted mortality at 1 and 5-years were lower in theTokyo cohort compared to Honolulu and there was no difference in mortality between Shanghai and Honolulu cohorts. Elevated alpha-fetoprotein, low albumin and tumor > 5 cm were associated with increased 1-year mortality. These factors and cirrhosis were independently associated with increased 5-year mortality. Independent risk factors of survival varied when examined separately by center. CONCLUSION The profile of early-stage HCC patients is strikingly different across countries and likely contributes to survival differences. Underlying differences in patient populations including risk factors/comorbidities influencing disease progression may also account for variation in outcomes.

关键词： Hepatocellular 癌症肝切除术病毒的肝炎

Potential Power of the Pyramidal Structure III: Discovery of Pyramid Effects with and without Seasonal Variation

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Natural Science 2020年第12期12卷 743-753页

作者： Osamu Takagi Masamichi Sakamoto Hideo yoichi Kimiko kawano Mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Since October 2007, we have been conducting rigorous scientific research on the unexplained “power” of a pyramidal structure (PS). From our research results so far, we could classify the pyramid effects by the PS into the following two types. (i) The pyramid effects in which the PS converted the test subject’s unexplained energy to affect biosensors when the test subject entered the PS and meditated. (ii) The pyramid effects in which the potential power of the PS affected biosensors if the test subject had not been inside the PS for at least 20 days and the test subject’s unexplained energy was excluded. In this paper, we report new results regarding (ii). As a result of dividing a year according to the four seasons of winter, spring, summer, and autumn and analyzing the pyramid effect of each period, the following points were found. 1) There was a pyramid effect without seasonal variation. The pyramid effect on the lower and upper layers was different throughout the year for the biosensors placed at the PS apex in two layers, regardless of the season. 2) There was a pyramid effect with seasonal variation. The value of the psi index, which indicates the magnitude of the pyramid effect, changed as the seasons changed, while different pyramid effects were maintained on the lower and upper layers. Regarding the change in the pyramid effect depending on the season, the psi index in summer was larger than that in winter in both the lower and upper layers. From these results, we found that there are two types of potential power at the PS apex: seasonal potential power and non-seasonal potential power.

关键词： Pyramid Potential Power Meditation Non-Contact Effect Seasonal Variation Biosensor Cucumis sativus Gas Psi Index

Potential Power of the Pyramidal Structure II

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Natural Science 2020年第5期12卷 248-272页

作者： Osamu Takagi Masamichi Sakamoto Hideo yoichi Kimiko kawano Mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Research on “pyramid power” began in the late 1930s. To date, many documents on “pyramid power” have been published. We have been conducting scientific research on the unexplained “power” of a pyramidal structure (PS) since October 2007. The research focuses on the detection of a non-contact effect of the unexplained “power” of the PS on biosensors (i.e., edible cucumber sections of Cucumis sativus “white spine type”) placed at the top of the PS. In this paper, in particular, we compared the non-contact effect of upper and lower biosensors placed in two layers on the PS apex, and we analyzed the difference of the non-contact effect due to the difference in the layers. The magnitude of the non-contact effect was represented by the calibrated psi index Ψ(E-CAL) calculated from gas concentrations emitted from the biosensors. A method to determine the presence or absence of the non-contact effect by analyzing the gas concentrations was developed by the International Research Institute (IRI). Ψ(E-CAL), which represents the magnitude of the non-contact effect, was the average value of the respective non-contact effect of the upper and lower biosensors stacked in two layers on the PS apex. We conducted the analysis on the assumption that the non-contact effect on the upper and lower biosensors might be different. Therefore, we considered that upper and lower biosensor calibration was required for Ψ(E-CAL), and we introduced a new calibrated psi index Ψ(E-CAL)Layer. Scientifically rigorous experiments to date have detected Ψ(E-CAL) with statistical significance and have demonstrated potential power of the PS (p = 6.0 × 10-3;Welch’s t-test, two-tails, the following p values are also the Welch’s t-test values). Based on data demonstrating the potential power of the PS, we analyzed the non-contact effects on the upper and lower biosensors of the PS apex. We obtained a surprising result that the non-contact effect on the upper biosensors (farther from the PS) was larger than th

关键词： Pyramid Potential Power Meditation Unconsciousness Non-Contact Effect Delay Biosensor Cucumis sativus Gas

Potential Power of the Pyramidal Structure

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Natural Science 2019年第8期11卷 257-266页

作者： Osamu Takagi Masamichi Sakamoto Hideo yoichi Kimiko kawano Mikio Yamamoto International Research Institute (IRI) Inage Chiba Japan Aquavision Academy Narita Chiba Japan

There have been various traditions and books which describe a so-called “pyramid power”, but there have been almost no reliable academic studies and no statistically significant data about it. We have continued scientifically rigorous experiments using biosensors to elucidate unexplained functions of a pyramidal structure (PS) since 2007. We used edible cucumber sections as biosensors and measured the concentrations of gas emitted from the sections by a technique developed by our group. From them we have demonstrated with high statistical accuracy the existence of the “pyramid power”, which was often recognized as having no scientific basis. We reached two conclusions from the work. 1) The PS converted the unconsciousness of a human (the test subject) more than 6 km away to energy detectable by the biosensors (1% significance). 2) The PS accumulated the influence that a human (the test subject) had when meditating within the PS. Then the PS converted the influence into the energy detectable by the biosensors (10-3% significance). These two conclusions showed that the functions of the PS were detected when “the PS and a human were related”. On the other hand, we hypothesized that the potential power of the PS could be detected even when “the PS and a human were not related”. In this paper, our purpose is to verify the existence of the potential power of the PS alone by experiment when “the PS and a human were not related”. The following three results were obtained by experiment. 1) The presence of the potential power of the PS was demonstrated with 1% significance. 2) The potential power of the PS changed in value between summer and winter, and it was clear that the non-contact effect on the biosensors was larger in summer and smaller in winter. 3) The potential power of the PS affected only the biosensors placed at the PS apex, and did not affect the biosensors placed at the calibration control point 8 m away from the PS. This paper is the first report in the world

关键词： Pyramid Potential Power Meditation Unconsciousness Non-Contact Effect Delay Biosensor Cucumber Gas

Clinical Outcomes of Patients Who Perform High-Load Activities after Total Hip Arthroplasty in Snowy Agricultural Areas

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Surgical Science 2018年第8期9卷 248-255页

作者： Tetsuya kawano Hiroaki Kijima Toshiaki Aizawa Shin Yamada Natsuo Konishi Hitoshi Kubota Hiroshi Tazawa Takayuki Tani Norio Suzuki Keiji Kamo Yoshihiko Okudera Ken Sasaki Masashi Fujii Yosuke Iwamoto Itsuki Nagahata Takanori Miura Naohisa Miyakoshi yoichi Shimada Department of Orthopedic Surgery Kita-Akita Municipal Hospital Akita Japan Akita Hip Research Group Akita Japan Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan

Background: In snowy agricultural areas, weeding and snow shoveling are essential activities, and sports activities are common recreational activities. Clarifying the relationships between the degrees of these activities after total hip arthroplasty (THA) and the clinical outcomes may enable us to predict the results of THA for high-load activity patients. Methods: The subjects were 227 post-THA patients who were followed up between 2012 and 2014. Patient-reported outcomes were investigated by the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) and a questionnaire on postoperative activity. In addition, the Japanese Orthopaedic Association Hip Score (JOA score) was used to quantify hip function. Results: Patients who resumed activities had significantly higher JOA and JHEQ scores than patients who had given up their activities. However, 25.8% of patients had not resumed weeding with a squatting posture. Furthermore, 20% had not resumed sports activities. The most common reason for giving up these activities was fear of implant failure. Conclusions: If the patients were informed that there is no problem restarting their activities after THA, the patients could resume activities and their clinical outcomes may be improved.

关键词： Total Hip Arthroplasty Postoperative Activities Weeding Snow Shoveling