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Background diseases and the number of previous intravitreal aflibercept injections on immediate intraocular pressure increase and vitreous reflux rate in phakic eyes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 545-550页

作者： Tetsuya muto Shigeki Machida Shinichiro Imaizumi Department of Ophthalmology Dokkyo Medical University Saitama Medical CenterKoshigaya 343-8555Japan Imaizumi Eye Hospital Koriyama 963-8877Japan Fukushima Medical University Fukushima 960-1295Japan

●AIM:To evaluate the effect of background diseases and number of previous intravitreal aflibercept injections(IVAIs)on immediate intraocular pressure(IOP)increase and vitreous reflux(VR)rate and to evaluate the correlation of both age and axial length with immediate IOP increase and VR rate.●METHODS:This study included 105 patients with cystoid macular edema secondary to retinal vein occlusion,35 patients with diabetic macular edema,69 patients with neovascular age-related macular degeneration(nAMD),and 12 patients with myopic choroidal neovascularization,which underwent first-time *** correlation of immediate IOP increase and VR rates with the four background diseases was ***,the correlation of age with immediate IOP increase and VR rate as well as correlation of axial length with immediate IOP increase and VR rate were ***,54 patients with nAMD were treated with IVAI>10 times(multiple IVAIs).Moreover,the correlation of immediate IOP increase and VR rates with first-time and multiple IVAIs in nAMD was determined.●RESULTS:The immediate IOP increase(P=0.16)and VR rates(P=0.50)were almost similar among the four background *** immediate postinjection IOP and age,VR rate and age,immediate postinjection IOP and axial length,or VR rate and axial length were not correlated in the four background *** immediate IOP increase(P=0.66)and VR rates(P=0.28)did not significantly differ between first-time and multiple IVAIs in nAMD.●CONCLUSION:Background diseases and number of previous IVAIs have no effect on immediate IOP increase and VR ***,age and axial length have no correlation on immediate IOP increase and VR rate.

关键词： aflibercept intraocular pressure vitreous reflux intravitreal injection

The deterministic condition for the ground reaction force acting point on the combined knee valgus and tibial internal rotation moments in early phase of cutting maneuvers in female athletes

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Journal of Sport and Health Science 2024年第3期13卷 376-386页

作者： Issei Ogasawara Ken Ohta Gajanan S.Revankar Shoji Konda yohei Shimokochi Hideyuki Koga Ken Nakata Department of Health and Sport Sciences Graduate School of MedicineOsaka UniversityToyonaka 560-0043Japan Sports Sensing Co. LTD.Fukuoka 815-0035Japan Department of Neurology Graduate School of MedicineOsaka UniversitySuita 565-0871Japan Department of Health and Sport Management Osaka University of Health and Sport SciencesSennan-gun 590-0496Japan Department of Joint Surgery and Sports Medicine Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8519Japan

Background:Combined knee valgus and tibial internal rotation(VL+IR)moments have been shown to stress the anterior cruciate ligament(ACL)in several in vitro cadaveric *** utilize this knowledge for non-contact ACL injury prevention in sports,it is necessary to elucidate how the ground reaction force(GRF)acting point(center of pressure(CoP))in the stance foot produces combined knee VL+IR moments in risky maneuvers,such as ***,the effects of the GRF acting point on the development of the combined knee VL+IR moment in cutting are still ***:We first established the deterministic mechanical condition that the CoP position relative to the tibial rotational axis differentiates the GRF vector’s directional probability for developing the combined knee VL+IR moment,and theoretically predicted that when the CoP is posterior to the tibial rotational axis,the GRF vector is more likely to produce the combined knee VL+IR moment than when the CoP is anterior to the tibial rotational ***,we tested a stochastic aspect of our theory in a lab-controlled in vivo *** females performed 60˚cutting under forefoot/rearfoot strike conditions(10 trials each).The positions of lower limb markers and GRF data were measured,and the knee moment due to GRF vector was *** trials were divided into anterior-and posterior-CoP groups depending on the CoP position relative to the tibial rotational axis at each 10 ms interval from 0 to 100 ms after foot strike,and the occurrence rate of the combined knee VL+IR moment was compared between trial ***:The posterior-CoP group showed significantly higher occurrence rates of the combined knee VL+IR moment(maximum of 82.8%)at every time point than those of the anterior-CoP trials,as theoretically predicted by the deterministic mechanical ***:The rearfoot strikes inducing the posterior CoP should be avoided to reduce the risk of non-contact ACL injury associated with the com

关键词： Center of pressure Deterministic condition Foot strike pattern Injury mechanism Moment of ground reaction force

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大尺度自成因机制与自成因地层学

地质学报 2024年第7期98卷 1977-2000页

作者：王俊辉 Tetsuji muto 鲜本忠油气资源与工程全国重点实验室中国石油大学(北京)北京102249 中国石油大学(北京)地球科学学院北京102249 长崎大学环境科学部日本长崎852-8521

在海平面升降、构造活动、沉积物供给等外部驱动作用下,沉积地层的叠置受自成因和他成因两种机制的控制。近年的认识表明,自成因机制可发生在沉积过程的各个时空尺度。不同于小尺度自成因机制仅发生在沉积系统的局部,大尺度自成因机制... 详细信息

在海平面升降、构造活动、沉积物供给等外部驱动作用下,沉积地层的叠置受自成因和他成因两种机制的控制。近年的认识表明,自成因机制可发生在沉积过程的各个时空尺度。不同于小尺度自成因机制仅发生在沉积系统的局部,大尺度自成因机制可在盆地范围内系统性地控制地层的发育,能够修饰甚至改变他成因过程。要想准确地探究地层的叠置样式与外部驱动条件之间的关系,必须有效地鉴别大尺度自成因与他成因过程。基于对大尺度自成因过程的认识,逐渐建立与发展了自成因地层学。它提出的自成因与他成因观、平衡响应与非平衡响应观为解析地层叠置样式与外部驱动条件之间的关系提供了新的视角。自成因地层学一方面对外部驱动条件分为稳定的(速率等作用方式保持不变)与不稳定的(速率等作用方式发生改变),由前者形成的地层叠加样式(或过程)称为自成因的,后者形成的地层叠加样式(或过程)称为他成因的。另一方面也将地层叠置样式分为稳定的(加积速率与进积速率的比值R_(agg)/R_(pro)保持不变)与不稳定的(R_(agg)/R_(pro)发生改变)。若稳定的外部驱动条件形成稳定的地层叠加样式,称为平衡响应,是自成因过程;稳定的外部驱动条件形成不稳定的地层叠加样式称为自成因的非平衡响应。此外,不稳定的外部驱动条件也可能形成稳定的地层叠加样式,称为他成因的非平衡响应。自成因地层学认为,由于自成因非平衡响应机制的普遍存在,地层的叠加过程通常表现得不稳定。相比而言,稳定的地层叠加样式仅在特殊情况下才能发生。传统成因地层学应当重视大尺度的自成因机制。

关键词：自成因地层学自成因与他成因平衡响应与非平衡响应海岸线自动后退三角洲海侵与非三角洲海侵基准面

In Vivo Improvements in Facial Appearance and in Vitro Changes in Gene Expression Using a Topical Formulation Designed to Repair Environmentally Induced DNA Damage

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第2期14卷 141-173页

作者： Amaryllis Aganahi Richard Parker yohei Tanaka RATIONALE Kyneton Australia Clinica Tanaka Plastic Reconstructive Surgery and Anti-aging Center Matsumoto Japan

Background: While sunscreen has been accepted as a mainline defence against photodamage from ultraviolet, visible light and near-infrared radiation, there appears to be a lack of research into photorepair. The concept of protecting the skin during the day and repairing cellular damage at night is intuitive, yet specific strategies revolving around combinations of proven reparative active ingredients remain unelucidated. Purpose: To investigate the efficacy of a solar repair Formulation following ultraviolet and environmental exposure in order to improve overall skin health and appearance through three hypotheses: The Formulation increases expression of DNA repair mechanisms markers;The Formulation enhances overall skin appearance through reducing signs of inflammation, elevating hydration, reinforcing skin firmness and amplifying radiance;In-Vivo efficacy test results are aligned with measured gene expression changes. Methods: The Formulation (#6NIC1.V1.1-1) was tested for: In-vitro LDH cytotoxicity activity, In-vitro qPCR gene expression with and without ultraviolet exposure on a reconstructed 3-dimensional skin model, and In-Vivo efficacy study on a panel of 22 participants objectively and subjectively. Results: Skin radiance, firmness, hydration, redness, and inflammation are significantly improved after In-Vivo skin exposure to the Formulation and environmental challenges such as ultraviolet radiation. These outcomes were confirmed by in-vitro genetic testing on a reconstructed human skin model. Conclusion: The studies allowed us to identify and group results in four main skin functions that were significantly enhanced following the application of the Formulation: firmness, hydration, radiance and soothing.

关键词： Photoprotection Photorepair DNA Repair Anti-Photoaging Gene Expression Antioxidant Rejuvenation

Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2024年第14期30卷 2006-2017页

作者： Kazuhiro Takahashi Masahiko Gosho Yoshihiro Miyazaki Hiromitsu Nakahashi Osamu Shimomura Kinji Furuya Manami Doi yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Tsuyoshi Enomoto Shinji Hashimoto Tatsuya Oda Department of Gastrointestinal and Hepatobiliary-Pancreatic Surgery University of TsukubaTsukuba 3058-575IbarakiJapan Department of Biostatistics University of TsukubaTsukuba 3058-575IbarakiJapan

BACKGROUND The success of liver resection relies on the ability of the remnant liver to *** of the knowledge regarding the pathophysiological basis of liver regeneration comes from rodent studies,and data on humans are ***,there is limited knowledge about the preoperative factors that influence postoperative *** To quantify postoperative remnant liver volume by the latest volumetric software and investigate perioperative factors that affect posthepatectomy liver *** A total of 268 patients who received partial hepatectomy were *** were grouped into right hepatectomy/trisegmentectomy(RH/Tri),left hepa-tectomy(LH),segmentectomy(Seg),and subsegmentectomy/nonanatomical hepatectomy(Sub/Non)*** regeneration index(RI)and late rege-neration rate were defined as(postoperative liver volume)/[total functional liver volume(TFLV)]×100 and(RI at 6-months-RI at 3-months)/RI at 6-months,*** lower 25th percentile of RI and the higher 25th percentile of late regeneration rate in each group were defined as“low regeneration”and“delayed regeneration”.“Restoration to the original size”was defined as regeneration of the liver volume by more than 90%of the TFLV at 12 months *** The numbers of patients in the RH/Tri,LH,Seg,and Sub/Non groups were 41,53,99 and 75,*** RI plateaued at 3 months in the LH,Seg,and Sub/Non groups,whereas the RI increased until 12 months in the RH/Tri *** to our multivariate analysis,the preoperative albumin-bilirubin(ALBI)score was an independent factor for low regeneration at 3 months[odds ratio(OR)95%CI=2.80(1.17-6.69),P=0.02;per 1.0 up]and 12 months[OR=2.27(1.01-5.09),P=0.04;per 1.0 up].Multivariate analysis revealed that only liver resection percentage[OR=1.03(1.00-1.05),P=0.04]was associated with delayed ***,multivariate analysis demonstrated that the preoperative ALBI score[OR=2.63(1.00-1.05),P=0.02;per 1.

关键词： Liver regeneration Albumin-bilirubin score Liver resection percentage Partial hepatectomy Human Regeneration index

Seismic assessment of two multi-tiered pagodas damaged by the 2015 Nepal earthquake

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Earthquake Engineering and Engineering Vibration 2021年第2期20卷 453-469页

作者： yohei Endo Toshikazu Hanazato Department of Architecture Shinshu University4-17-1 WakasatoNagano 380-8553Japan Department of Architecture Mie University1577 Kurimamachiya-chōTsuMie 514-8507MieJapan

A seismic assessment of two multi-tier pagodas by numerical analysis is presented *** Changu Narayan temple and the Kumbeshwar temple in Nepal are used as the case *** pagodas are built of brick masonry in earthen mortar,with timber columns and *** Changu Narayan temple is a two-tier pagoda,and was seriously damaged during the 2015 Gorkha *** Kumbeshwar temple is a five-tier pagoda,and its top-tier collapsed due to the Gorkha earthquake.A seismic assessment was carried out using finite element(FE)*** FE models were prepared,and dynamic identification tests and penetrometer tests were *** analysis and nonlinear dynamic analysis were performed as part of the seismic *** main shock of the 2015 Gorkha earthquake was considered as the input *** behavior between the two pagodas was compared with the collapse mechanisms and damage patterns observed in the actual *** comparison suggested common structural features of multi-tier *** study is dedicated to providing a better understanding of the seismic behavior of multi-tier pagoda-type structures and provides suggestions for their effective analysis.

关键词： masonry multi-tier pagoda seismic assessment nonlinear dynamic analysis FEM analysis

Evolution of the “Neutral” : Diverse Forms of Wide-Compatibility Haplotypes at the Locus for Reproductive Isolation

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Molecular Plant 2020年第4期13卷 539-540页

作者： yohei Koide Research Faculty of Agriculture Hokkaido UniversityKita 9 Nishi 9SapporoHokkaido 060-8589Japan

One of the biggest questions in evolutionary biology is how biological species *** biological species are groups of interbreeding natural populations reproductively isolated from other such groups(Mayer,1942),reproductive isolation is the key process of the *** various isolating barriers,postzygotic barriers ranging from maladaptation to inviability or sterility in the offspring have attracted biologists’attention because of the problem of the evolution of the“unfit”offspring.A clear model to solve this problem is the Dobzhansky-Muller(DM)model(Figure 1;Coyne and Orr,2004),in which incompatibilities are generally caused by an interaction between the genes that have functionally diverged in each population without selection opposing any intermediate step(Coyne and Orr,2004).

关键词： Figure Forms breeding

Prototyping of Ultra Micro Centrifugal Compressor-Influence of Meridional Configuration

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Journal of Thermal Science 2011年第4期20卷 312-317页

作者： Toshiyuki Hirano Tadataka muto Hoshio Tsujita Production Systems Engineering Course Tokyo Metropolitan College of Industrial Technology Graduate School of Engineering Hosei University3-7-2KajinochoKoganei-shiTokyo184-8584Japan Department of Mechanical Engineering Faculty of Science and EngineeringHosei University

In order to investigate the design method for a micro centrifugal compressor, which is the most important component of an ultra micro gas turbine, two types of centrifugal impeller with 2-dimensional blade were designed, manufactured and tested. These impellers have different shapes of hub on the meridional plane with each other. Moreover, these types of impeller were made for the 5 times and the 6 times size of the final target centrifugal impeller with the outer diameter of 4ram in order to assess the similitude for the impellers. The comparison among the performance characteristics of the impellers revealed the influence of the meridional configuration on the performance and the similitude of the compressors.

关键词： Ultra Micro Centrifugal Compressor Performance Characteristics Impeller Meridional Configuration

Synthesis and sintering of samarium rich SmS_x and its electrical property

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Journal of Rare Earths 2016年第10期34卷 1042-1047页

作者： Liang Li Shinji Hirai yohei Tasaki Department of Materials Science and Engineering Muroran Institute of Technology

Non-stoichiometric samarium monosulfide（SmS_x, 0.55≤x≤1.2） was synthesized from Sm_2S_3 and SmH_3 at 1273 K for 3 h under vacuum. The influence of reaction ratio of Sm_2S_3 to SmH_3 on the fabrication of SmS_x was investigated. The fabrication of SmS required the molar ratio of Sm_2S_3 to SmH_3 above 1. Lattice parameter of synthetic SmS_x increased firstly and then decreased to saturate following with the addition of SmH_3 content. SmS_x compact was sintered at 1373 K by spark plasma sintering. Density of synthetic SmS_x was about 99% of theory density. Seebeck coefficient of n-type semiconductor Sm Sx decreased as temperature rose. The absolute value was distributed between 170–280 μV/K. The electrical resistivity of SmS_x（0.86≤x≤1.07） decreased with temperature increasing and showed similar temperature dependence. The surplus Sm which randomly distributed in the SmS_x（0.55≤x≤0.75） matrix led to a remarked reduction of electrical resistivity. The optimized power factor for SmS_（0.6） and Sm S_（0.75） could reach 1500 μW/（K^2·m） at 600 K.

关键词： samarium monosulfide SmH_3 Seebeck coefficient electrical resistivity rare earths