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Prevalence of Adverse Drug Reactions to Second Line Anti Tuberculosis Drugs in Nigeria: A Cross-Sectional Study

Journal of Tuberculosis Research 2021年第2期9卷 90-102页

作者： Abideen Adedayo Ganiyu yohanna kambai avong Akinwumi Akinyede Olusoji Mayowa Ige Osman El tayeb Fatai Taleatu Ayobami Omayeka Victor Babawale Ibrahim Oreagba Department of Pharmacology Therapeutics and Toxicology College of Medicine University of Lagos Lagos Nigeria Government Chest Hospital Ibadan Nigeria Institute of Human Virology of Nigeria (IHVN) Abuja Nigeria University of Technology Sydney Ultimo Australia University College Hospital Ibadan Nigeria Damien Foundation Belgium Nigeria Office Ibadan Nigeria National Tuberculosis and Leprosy Control Programme (NTBLCP) Abuja Nigeria

Introduction: Multidrug resistant tuberculosis (MDR-TB) is treated with second line antituberculosis drugs. These drugs are notorious for inflicting serious adverse drug reactions (ADRs), which many studies have shown causes a wide range of economic and health problems including death. Aim: The study examined the prevalence of ADRs, associated risk factors, socio-demographic association and outcomes among patients treated for MDR-TB at a comprehensive tuberculosis treatment center in Nigeria. Method: The study was conducted at the Government Chest Hospital, Jericho, Ibadan. We applied a retrospective assessment of patient treatment data and ADRs reports stored at the study site from March 2013 and February 2016. Subsequently, a prospective study of ADRs was conducted on patients admitted into the same hospital. Causality relationship between the drugs and the reported ADRs was determined with a specially validated tool. The outcomes assessed include recovery from the ADRs, death and permanent deafness from the ADRs. Extracted data were analyzed using SPSS version 22.0. Risk Ratio was calculated for the influence of risk factors for adverse drug reactions. Logist

关键词： Multidrug Resistant Tuberculosis ADR Risk Factors Prevalence

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