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Endometrial response to conceptus-derived estrogen and interleukin-1β at the time of implantation in pigs

Journal of Animal Science and Biotechnology 2018年第3期9卷 531-547页

作者： Hakhyun Ka Heewon Seo yohan choi Inkyu Yoo Jisoo Han Department of Biological Science and Technology Yonsei University Department of Veterinary Integrated Biosciences Texas A&M University College Station Department of Obstetrics and Gynecology University of Kentucky College of Medicine

The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines,interleukin-1β2(IL1 B2), interferon-γ(IFNG), and IFN-δ(IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response. Conceptus-derived estrogens act as a signal for maternal recognition of pregnancy by changing the direction of prostaglandin(PG) F2αfrom the uterine vasculature to the uterine lumen. Estrogens also induce the expression of many endometrial genes,including genes related to growth factors, the synthesis and transport of PGs, and immunity. IL1 B2, a pro-inflammatory cytokine, is produced by the elongating conceptus. The direct effect of IL1 B2 on endometrial function is not fully understood. IL1 B activates the expression of endometrial genes, including the genes involved in IL1 B signaling and PG synthesis and transport. In addition, estrogen or IL1 B stimulates endometrial expression of IFN signaling molecules,suggesting that estrogen and IL1 B act cooperatively in priming the endometrial function of conceptus-produced IFNG and IFND that, in turn, modulate endometrial immune response during early pregnancy. This review addresses information about maternal-conceptus interactions with respect to endometrial gene expression in response to conceptus-derived factors, focusing on the roles of estrogen and IL1 B during early pregnancy in pigs.

关键词： Conceptus Endometrium Estrogen Interleukin-1β Pig Uterus

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Effects of dietary supplementation of bacteriophage cocktail on health status of weanling pigs in a non-sanitary environment

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1661-1677页

作者： yohan choi Abdolreza Hosseindoust Sang Hun Ha Joeun Kim YeJin Min YongDae Jeong JunYoung Mun SooJin Sa JinSoo Kim Swine Science Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000Republic of Korea Department of Animal Industry Convergence Kangwon National UniversityChuncheon 24341Republic of Korea

Background The study evaluated the effects of bacteriophage cocktail(BP)and ZnO administered during weaning time for piglets exposed to a non-sanitary *** bacteriophages were designed to eliminate Escherichia coli(K88,K99 and F41),Salmonella(typhimurium and enteritidis),and Clostridium perfreingens(types A and C).Forty 21-day-old crossbreed piglets were assigned to four treatments,including the PC(sanitary environment),NC(nonsanitary environment),BP(NC plus 108 pfu/kg BP),and ZO(NC plus 2,500 mg/kg ZnO).Piglets in the NC,BP and ZO were kept in a non-sanitary environment for 14 d,which was contaminated with the feces of infected *** Pigs in the BP and ZO treatments had a higher final body weight compared with the *** NC treatment showed the highest concentration of inflammatory cytokines including interleukin(IL)-1β,IL-6 and tumor necrosis factor-αin the *** administration of BP and ZO showed lower myeloperoxidase concentrations compared with the *** NC treatment showed a lower concentration of superoxide dismutase in serum compared with the *** the treatments in non-sanitary environment,the NC treatment showed a higher concentration of malondialdehyde compared with the *** PC treatment showed a lower concentration of butyric acid in the feces compared with the BP *** non-sanitary treatments,the villus height in the duodenum was greater in the BP and ZO compared with the *** lower abundance of Proteobacteria phylum was observed in the BP and PC treatments compared with the *** highest relative abundance of Eubacterium was recorded in the BP *** abundance of Megasphaera and Schwartzia was higher in the NC pigs compared with the BP *** abundance of Desulfovibrio was lower in the supplemented treatments(BP and ZO)compared with non-supplemented(NC and PC).The abundance of Cellulosilyticum genera was higher in the BP and ZO treatments rather than in the *** piglets in the NC treatment had the

关键词： Antioxidant Cytokines Diarrhea Fecal score Inflammation Microbiota Proteobacteria

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Multi-objective optimization of the cathode catalyst layer micro-composition of polymer electrolyte membrane fuel cells using a multi-scale,two-phase fuel cell model and data-driven surrogates

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Journal of Energy Chemistry 2023年第6期81卷 28-41,I0003页

作者： Neil Vaz Jaeyoo choi yohan Cha Jihoon Kong Yooseong Park Hyunchul Ju Department of Mechanical Engineering Inha University100 Inha-ro Michuhol-GuIncheon 22212Republic of Korea

Polymer electrolyte membrane fuel cells(PEMFCs)are considered a promising alternative to internal combustion engines in the automotive *** commercialization is mainly hindered due to the cost and effectiveness of using platinum(Pt)in *** cathode catalyst layer(CL)is considered a core component in PEMFCs,and its composition often considerably affects the cell performance(V_(cell))also PEMFC fabrication and production(C_(stack))*** this study,a data-driven multi-objective optimization analysis is conducted to effectively evaluate the effects of various cathode CL compositions on Vcelland *** essential cathode CL parameters,i.e.,platinum loading(L_(Pt)),weight ratio of ionomer to carbon(wt_(I/C)),weight ratio of Pt to carbon(wt_(Pt/c)),and porosity of cathode CL(ε_(cCL)),are considered as the design *** simulation results of a three-dimensional,multi-scale,two-phase comprehensive PEMFC model are used to train and test two famous surrogates:multi-layer perceptron(MLP)and response surface analysis(RSA).Their accuracies are verified using root mean square error and adjusted R^(2).MLP which outperforms RSA in terms of prediction capability is then linked to a multi-objective non-dominated sorting genetic algorithmⅡ.Compared to a typical PEMFC stack,the results of the optimal study show that the single-cell voltage,Vcellis improved by 28 m V for the same stack price and the stack cost evaluated through the U.S department of energy cost model is reduced by$5.86/k W for the same stack performance.

关键词： Polymer electrolyte membrane fuel cell Surrogate modeling Multi-layer perceptron(MLP) Response surface analysis(RSA) Non-dominated sorting genetic algorithmⅡ(NSGAⅡ)

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Microstructural evolution and mechanical properties of binary Mg-xBi(x=2,5,and 8 wt%)alloys

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Journal of Magnesium and Alloys 2021年第3期9卷 983-994页

作者： Hui Yu Shaoda Fan Shuaiju Meng Jae Ok choi Zhongjie Li yohan Go Young Min Kim Weimin Zhao Bong Sun You Kwang Seon Shin School of Materials Science and Engineering Hebei University of TechnologyXiping Road 5340Tianjin 300130China

The microstructures and mechanical properties of Mg-x Bi(x=2,5,and 8 wt%)were investigated compared with pure *** ascast Mg-Bi billets consist of dendriticα-Mg grain matrix,divorced eutectic Mg_(3)Bi_(2) phase and secondary precipitated Mg_(3)Bi_(2) *** homogenization,secondary precipitated Mg_(3)Bi_(2) particles were all dissolved into the matrix,while most of the divorced eutectic Mg_(3)Bi_(2) intermetallic compounds *** the as-extruded samples exhibit fully dynamic recrystallization(DRX)and the average grain size decreases and the amount of nano-scale Mg_(3)Bi_(2) precipitates increases with increasing Bi ***,Bi alloying has little influence on the texture of the as-extruded pure Mg,with all the samples showing typical basal *** the results of grain refinement and precipitation hardening,the strengths of the as-extruded samples increase under both tensile and compressive ***,the yield asymmetry significantly decreases with Bi ***,all the as-extruded samples represent similar ductility under compression,while the tensile elongation first increases and then decreases with more Bi *** as-extruded Mg-5Bi alloy demonstrates good combination of strength and ***,Mg-8Bi alloy displays lower tensile ductility than that of Mg-5Bi alloy due to the presence of abundant undissolved coarse Mg_(3)Bi_(2) particles,which act as cracking sources during tensile ***,the strain hardening rate,strain hardening exponent n,and hardening capacity Hc are greatly reduced by Bi addition,mainly owing to the enhanced synergy effects of grain refinement and numerous Mg_(3)Bi_(2) precipitates.

关键词： Mg-Bi Mechanical properties Microstructure Strain hardening

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