检索结果-南通市图书馆

Biotransformation,multifunctional recycling mechanism of nanostructures,and evaluation of the safety of nanoscale materials

引用

Particuology 2023年第11期82卷 76-86页

作者： Debjyoti Talukdar Parveen kumar Benu Chaudhary Deepak Sharma Nishant Yadav Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Waleed Hassan Almalki Sami IAlzarea Imran Kazmi Ashutosh Pareek Gaurav gupta Madan Mohan gupta Department of Medical Research Armenian Russian International University“Mkhitar Gosh”YerevanArmenia Shri Ram College of Pharmacy KarnalHaryanaIndia Guru Gobind Singh College of Pharmacy YamunanagarHaryanaIndia Department of Pharmaceutical Technology SOMSAdamas UniversityBarasat-Barracpore RoadKolkataWest BengalIndia B.S.Anangpuria Institute of Pharmacy FaridabadHaryanaIndia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl Kharj11942Saudi Arabia Department of Pharmacology College of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyJouf UniversitySakakaAl-JoufSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacy Banasthali VidyapithBanasthali-RajasthanIndia School of Pharmacy Suresh Gyan Vihar UniversityJagatpura302017Mahal RoadJaipurIndia Department of Pharmacology Saveetha Dental CollegeSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia Uttaranchal Institute of Pharmaceutical Sciences Uttaranchal UniversityDehradunIndia School of Pharmacy Faculty of Medical SciencesThe University of the West IndiesSt.AugustineTrinidad and Tobago

Current evidence of concept analyses recommending nanotechnology for biomedical uses abounds in recent research. The area of biotechnology interfaces with nanostructures, reconfigures their composition, and alters their characteristics;which influences the dispersion of the particles, the biotransformation they cause, and their potential toxic effect. It is vital to link the idea of the lifecycle of nanostructures to the biological impacts and use methodologies to identify, estimate, and track the gradual bioprocessing of nanostructures in vivo, from a body-wide level to a nanoscopic size. This is necessary because understanding how nanostructures processing, degradation, persistence, and recycling predict potential exposure risks. The safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding of the recycling and transformations of nanomaterials in a living organism. Long-term fate in the body is crucial, as it governs potential environmental risks to human health. Strategies may be used to manage the long-term outcome of nanostructures in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. The lifespan of nanoparticles, a flexible and biocompatible category of nanostructures that have made it into clinical trials, is the subject of this article. Strategies may be used to manage the long-term outcome of nanoparticles in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. This review explained the safety of nanoscale materials, biotransformation, and the multifunctional recycling mechanism of nanostructures.

关键词： Nanostructure Nanoparticle Biotransformation Toxiceffect Environmental risk

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alteration of somatostatin receptor subtype 2 gene expression in pancreatic tumor angiogenesis

引用

World Journal of Gastroenterology 2004年第1期10卷 132-135页

作者： Manoj kumar gupta Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

AIM: To explore the difference of somatostatin receptor subtype 2 (SST2R) gene expression in pancreatic cancerous tissue and its adjacent tissue, and the relationship between the change of SST2R gene expression and pancreatic tumor angiogenesis related genes. METHODS: The expressions of SST2R, DPC4, p53 and ras genes in cancer tissues of 40 patients with primary pancreatic cancer, and the expression of SST2R gene in its adjacent tissue were determined by immunohistochemiscal LSAB method and EnVisionTM method. Chi-square test was used to analyze the difference in expression of SST2R in pancreatic cancer tissue and its adjacent tissue, and the correlation of SST2R gene expression with the expression of p53, ras and DPC4 ***: Of the tissue specimens from 40 patients with primary pancreatic cancer, 35 (87.5%) cancer tissues showeda negative expression of SST2R gene, whereas 34 (85%) a positive expression of SST2R gene in its adjacent tissues. Five (12.5%) cancer tissues and its adjacent tissues simultaneously expressed SST2R. The expression of SST2R gene was markedly higher in pancreatic tissues adjacent to cancer than in pancreatic cancer tissues (P0.05). CONCLUSION: There was a significant difference of SST2R gene expression in pancreatic cancer tissues and its adjacent tissues, which might be one cause for the different therapeutic effects of somatostatin and its analogs on pancreatic cancer patients. There were abnormal expressions of SST2R, DPC4, p53 and ras genes in pancreatic carcinogenesis, and moreover, the loss or decrease of SST2R gene expression was significantly negatively correlated with the overexpression of tumor angiogenesis correlated p53 and ras genes, suggesting that SST2R gene togethe

关键词：胰腺癌肿瘤血管生成生长抑制素受体亚型2 免疫组织化学肿瘤病理学

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expression of TREM-1 mRNA in acute pancreatitis

引用

World Journal of Gastroenterology 2004年第18期10卷 2744-2746页

作者： Manoj kumar gupta Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030Hubei ProvinceChina

AIM: To explore the expression of triggering receptor expressed on myeloid cells (TREM-I) mRNA in acute pancreatitis (AP).METHODS: Using the reverse transcription polymerase chain reaction (RT-PCR), we examined the expression of TREM-1 mRNA in 10 cases of mild acute pancreatitis (MAP), 8 cases of severe acute pancreatitis (SAP), and 10 cases of healthy control subjects. And we also examined the expression of TREM-1 mRNA in 14 cases of AP (including 10 MAP and 4 SAP) before treatment, after successful therapy and clinically ***: The expression of TREM-1 mRNA in the groups of MAP, SAP patients and healthy control subjects was 0.771±0.274, 1.092±0.331 and 0.459±0.175, respectively;there was a significant difference among the three groups (P<0.05). And there was also a significant difference between the AP patients (0.914±0.341) and healthy control subjects (0.459+0.175) (P<0.05). Moreover, in the 14 cases of AP, before treatment, after successful therapy and clinically cured, the expression of TREM-1 mRNA was 0.905±0.226,0.739±0.169 and 0.633±0.140, respectively, and there was a significant difference among the three stages (P<0.05).CONCLUSION: The expression of TREM-1 mRNA in the patients with AP increases obviously, and correlates with the degree of AP. Furthermore, the expression of TREM-1 mRNA is distinctly different at the different stages of AP. It indicates TREM-1 may play an important role in the occurrence and development of AP.

关键词：基因表达 TREM-1 mRNA 急性胰腺炎消化系统

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanism and its regulation of tumor-induced angiogenesis

引用

World Journal of Gastroenterology 2003年第6期9卷 1144-1155页

作者： Manoj kumar gupta Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030Hubei ProvinceChina

Tumor angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. The process of angiogenesis plays an important role in many physiological and pathological conditions. Solid tumors depend on angiogenesis for growth and metastasis in a hostile environment. In the prevascular phase, the tumor is rarely larger than 2 to 3 mm3 and may contain a million or more cells. Up to this size, tumor cells can obtain the necessary oxygen and nutrient supplies required for growth and survival by simple passive diffusion. The properties of tumors to release and induce several angiogenic and antiangiogenic factors which play crucial roles in regulating endothelial cell (EC) proliferation, migration, apoptosis or survival, cell-cell and cell-matrix adhesion through different intracellular signaling are thought to be the essential mechanisms during tumor-induced angiogenesis. Tumor angiogenesis actually starts with tumor cells releasing molecules that send signals to surrounding normal host tissue. This signaling activates certain genes in the host tissue that, in turn, make proteins to encourage growth of new blood vessels. In this review, we focus the mechanisms of tumor-induced angiogenesis, with an emphasis on the regulatory role of several angiogenic and anti-angiogenic agents during the angiogenic process in tumors. Advances in understanding the mechanisms of tumor angiogenesis have led to the development of several most effective antiangiogenic and anti-metastatic therapeutic agents and also have provided several techniques for the regulation of cancer's angiogenic switch. The suggestion is made that standard cytotoxic chemotherapy and angiogenesis inhibitors used in combination may produce complementary therapeutic benefits in the treatment of cancer.

关键词：肿瘤血管生成发病机理病因学治疗

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

喷雾热解法制备高产率石墨／炭纳米纤维及其特征研究

引用

新型炭材料 2008年第2期23卷 116-120页

作者： Bipin kumar gupta O. N. Srivastava National Physical Laboratory Dr. K.S. Krishnan Road New Delhi 110012 India Department of Physics Banaras Hindu University Varanasi-221005 India

基于石墨／炭纳米纤维（GNFs）的克量级（〉1g）制备及其特征表征，通过苯的喷雾热解制备了GNFs，并采用XRD，TEM及SEM对GNFs进行了表征。结果表明：高产率GNFs的最佳生长条件是：喷管内径～0．52mm，苯液流量～5mL／min，反应温度-750... 详细信息

基于石墨／炭纳米纤维（GNFs）的克量级（〉1g）制备及其特征表征，通过苯的喷雾热解制备了GNFs，并采用XRD，TEM及SEM对GNFs进行了表征。结果表明：高产率GNFs的最佳生长条件是：喷管内径～0．52mm，苯液流量～5mL／min，反应温度-750℃，载气H2流量-1500mL／min。所制GNFs的典型长度和直径分别为～60μm和-250nm，大部分GNFs样品呈现螺圈／螺旋纤维状。喷雾热解生长模式中GNFs的产率为克量级（1．45g）／产程。

关键词：炭纳米纤维石墨碳 XRD TEM SEM

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

IoT-Based Women Safety Gadgets (WSG): Vision, Architecture, and Design Trends

引用

Computers, Materials & Continua 2023年第7期76卷 1027-1045页

作者： Sharad Saxena Shailendra Mishra Mohammed Baljon Shamiksha Mishra Sunil kumar Sharma Prakhar Goel Shubham gupta Vinay Kishore Department of Computer Science and Engineering Thapar Institute of Engineering and TechnologyPatialaPunjab147001India Department of Computer Engineering College of Computer&Information ScienceMajmaah UniversityMajmaah11952Saudi Arabia Department of Computer Science and Engineering National Institute of TechnologyJamshedpur831001India

In recent years,the growth of female employees in the commercial market and industries has *** a result,some people think travelling to distant and isolated locations during odd hours generates new threats to women’s *** exponential increase in assaults and attacks on women,on the other hand,is posing a threat to women’s growth,development,and *** the time of the attack,it appears the women were immobilized and needed immediate *** self-defense isn’t sufficient against abuse;a new technological solution is desired and can be used as quickly as hitting a switch or *** proposed Women Safety Gadget(WSG)aims to design a wearable safety device model based on Internet-of-Things(IoT)and Cloud *** is designed in three layers,namely layer-1,having an android app;layer-2,with messaging and location tracking system;and layer-3,which updates information in the cloud *** can detect an unsafe condition by the pressure sensor of the finger on the artificial nail,consequently diffuses a pepper spray,and automatically notifies the saved closest contacts and police station through messaging and location *** has a response time of 1000 ms once the nail is pressed;the average time for pulse rate measure is 0.475 s,and diffusing the pepper spray is 0.2–0.5 *** average activation time is 2.079 s.

关键词： Perpetrator safety IoT women security GPS tracking GSM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Detection of Behavioral Patterns Employing a Hybrid Approach of Computational Techniques

引用

Computers, Materials & Continua 2022年第7期72卷 2015-2031页

作者： Rohit Raja Chetan Swarup Abhishek kumar Kamred Udham Singh Teekam Singh Dinesh gupta Neeraj Varshney Swati Jain Department of Information Technology Guru Ghasidas VishwavidyalayaBilaspur495009India Department of Basic Science College of Science&Theoretical StudiesSaudi Electronic University13316Saudi Arabia Department of Computer Science&IT JAIN(Deemed to be University)Bangalore560069India Computer Science and Information Science Cheng Kung University621301Taiwan School of Computer Science University of Petroleum and Energy StudiesDehradun248007India Department of CSE I K Gujral Punjab Technical UniversityJalandhar144603India Department of Computer Engineering and Applications GLA UniversityMathura281406India Department of Computer Science Government J Yoganandam Chhattisgarh CollegeRaipur492001India

As far as the present state is concerned in detecting the behavioral pattern of humans(subject)using morphological image processing,a considerable portion of the study has been conducted utilizing frontal vision data of human *** present research work had used a side vision of human-face data to develop a theoretical framework via a hybrid analytical model *** this example,hybridization includes an artificial neural network(ANN)with a genetic algorithm(GA).We researched the geometrical properties extracted from side-vision human-face *** additional study was conducted to determine the ideal number of geometrical characteristics to pick while *** close vicinity ofminimum distance measurements is done for these clusters,mapped for proper classification and decision process of behavioral *** identify the data acquired,support vector machines and artificial neural networks are utilized.A method known as an adaptiveunidirectional associative memory(AUTAM)was used to map one side of a human face to the other side of the same *** behavioral pattern has been detected based on two-class problem classification,and the decision process has been done using a genetic algorithm with best-fit *** developed algorithm in the present work has been tested by considering a dataset of 100 subjects and tested using standard databases like FERET,Multi-PIE,Yale Face database,RTR,CASIA,*** complexity measures have also been calculated under worst-case and best-case situations.

关键词： Adaptive-unidirectional-associative-memory technique artificial neural network genetic algorithm hybrid approach

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spectrum, Manifestations and Outcomes of Dengue Infection in Individuals with and without Liver Disease

引用

Journal of Clinical and Translational Hepatology 2019年第2期7卷 106-111页

作者： Anand VKulkarni Ashok K.Choudhury Madhumita Premkumar Priyanka Jain Ekta gupta Shiv kumar Sarin Department of Hepatology and Transplant Institute of Liver and Biliary SciencesNew DelhiIndia Department of Virology Institute of Liver and Biliary SciencesNew DelhiIndia Department of Statistics Institute of Liver and Biliary SciencesNew DelhiIndia

Background and Aims:Dengue infection is a major health burden,which can result in mild self-limited febrile illness to highly fatal hemorrhagic *** is paucity of literature describing the manifestations of dengue in patients with underlying liver *** studied and compared the manifestations of this tropical infection in patients with and without liver ***:Patients with serologically-confirmed dengue infection were included in this retrospective study,obtained for over a period of 1 *** and laboratory variables were compared for the individuals with no underlying liver disease(Group A,n=71),chronic hepatitis(Group B,n=12),and cirrhosis(Group C,n=12).Results:Males predominated the study population(61%),with a higher mean age in the cirrhotic *** most common clinical manifestation was classical dengue fever,seen in 89 *** presented as dengue hemorrhagic fever(1 each in Group A and Group B),1 presented as acute liver failure,and 3 as acute-on-chronic liver *** was less evident in Group C as compared to Group A and Group B(p<0.001).Patients in Group C had significantly prolonged International Normalized Ratio(INR)and enhanced thrombocytopenia compared to patients in Group A and Group *** in Group C also required prolonged hospital stay(Group A:4.83±2.88,Group B:7.33±2.3,Group C:13±5 days;p<0.001).Three patients expired in Group C compared to the 1 in Group A and none in Group B(p=0.01).On univariate analysis,hemoglobin,albumin,INR,and bilirubin predicted development of liver *** multivariate analysis,INR and bilirubin predicted development of liver ***:Dengue infection can have varied manifestations,ranging from simple fever to acute-on-chronic liver failure and acute liver *** patients lack classical features of dengue and have relatively poor *** should be suspected as a cause of liver failure in endemic areas,where no etiological ca

关键词： Dengue Cirrhosis Acute-on-chronic liver failure Acute liver failure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways

引用

Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 214-221页

作者： Swati gupta Kamla Prasad Mishra Paban kumar Dash Manmohan Parida Lilly Ganju Shashi Bala Singh Defence Institute of Physiology & Allied Sciences Defence Research and Development Establishment

Objective: To investigate the therapeutic efficacy of andrographolide, a plant derived compound, against chikungunya virus(CHIKV) infection. Methods: Using flow cytometry and immunoblotting assay, in vitro viral protein expression was studied in THP-1 cells line. In Balb/c mouse neonates, viral RNA copy number was determined by real time PCR. Results:The results showed reduced CHIKV protein expression on andrographolide treatment in CHIKV-infected human peripheral blood mononuclear cells, Vero cells and THP-I cell *** vivo, andrographolide treatment to CHIKV-infected neonates reduced viral RNA copy number. Further. andrographolide also increased cytotoxic T lymphocytes both in vitro and in vivo. Andrographolide also activated host innate immune pathways, viz., protein kinase *** eukaryotic initiation factor 2 α, retinoic acid inducible gene-Ⅰ and interferon regulatory factor 3/7, thereby increasing IFN-a secretion. CHIKV-induced nuclear factor κlight chain enhancer of activated B cells and tumor necrosis factor-a was also reduced on andrographolide treatment. Conclusion: Andrographolide inhibits CHIKV by suppressing viral protein expression and up-regulating host innate immunity and hence could be an effective therapeutic agent against CHIKV infection.

关键词： Chikungunya virus Andrographolide Interferon α Protein kinase R Retinoic acid inducible gene-I Tumor necrosis factor α

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chronic hepatitis E–an emerging disease in an immunocompromised host

引用

Gastroenterology Report 2018年第2期6卷 152-155,I0003页

作者： Amitabh Singh Rachna Seth Anand gupta Shalimar Baibaswata Nayak Subrat kumar Acharya Prasenjit Das Department of Paediatrics All India Institute of Medical SciencesNew DelhiIndia Department of Gastroenterology All India Institute of Medical SciencesNew DelhiIndia Department of Pathology All India Institute of Medical SciencesNew DelhiIndia

Chronic hepatitis E virus(HEV)infection is increasingly being reported in immunosuppressed individuals with HIV,patients with haematological malignancy and transplant *** diagnosis of cirrhosis and liver failure post chronic HEV is controversial due to lack of standard diagnostic *** treatment benefits of ribavirin in chronic HEV of genotype 1 are not well *** report a case of chronic HEV infection of genotype 1 leading to chronic liver disease in a child cured of acute *** report also highlights the successful use of ribavirin for eradicating chronic HEV infection and its subsequent survival *** hepatitis E may be an emerging disease of immunosuppressed patients and should be suspected in the presence of cryptogenic *** is an effective therapy for controlling HEV.

关键词： chronic hepatitis E immunosuppression chronic liver disease ribavirin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：