检索结果-南通市图书馆

Optical and Physical Analysis of Nd3. Doped Borosilicate Glasses

材料科学与工程（中英文B版） 2015年第11期5卷 406-417页

作者： yogesh kumar Sharma Priyanka Goyal Sudha Pal Umesh Chandra Bind Department of Physics S.B.S. Govt. P. G. College Rudrapur (Kumaun University Nainital)-263153 Uttarakhand India Centre of Nano Technology Indian Institute of Technology Roorkee India

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Day case paediatric microlaryngobronchosocopy:A prospective study

引用

World Journal of Otorhinolaryngology 2017年第1期7卷 1-4页

作者： Arwa El-Sheemy Jagdeep Singh Virk Jay Ahmed Eleni Nikolopoulou Sahar kazmi yogesh Bajaj ENT Department Barts Childrens and Royal London Hospital

AiM To assess the feasibility and parental acceptance of diagnostic microlaryngobronchoscopy(MLB) as day case *** A prospective study was performed over a 26 moperiod at a tertiary paediatric ENT centre. Patients were selected in clinic using set criteria. All MLBs were performed using a standardised anaesthetic protocol and patients monitored post-operatively. Six weeks following surgery, parents underwent questionnaire *** Ninety-four out of 101 MLBs was successfully performed as day case surgery over the set period. Seven patients required an overnight stay for further observation. Fiftyseven parents took part in the questionnaire of which 68.4% were highly satisfied with same day discharge. CONCLUSiON MLB is feasible, safe and acceptable as day case surgery in carefully selected patients.

关键词： Child Laryngoscopy Anaesthetics General Microlaryngoscopy Ambulatory surgical procedure Microlaryngobronchoscopy Bronchoscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacokinetics/Pharmacodynamics study of Fixtral SB as compared to supra bioavailable itraconazole and conventional itraconazole

引用

World Journal of Pharmacology 2023年第1期12卷 1-11页

作者： Syed Mujtaba Hussain Naqvi Monil yogesh Neena Gala Snehal Muchhala Anand Arumugam Dhananjay Panigrahi Dipak Patil Rahul Rathod Amey Mane Medical Affairs Dr Reddy’s LaboratoriesHyderabad 500016India Global Clinical Management Dr Reddy’s LaboratoriesHyderabad 500016India Formulation Development Dr Reddy’s LaboratoriesHyderabad 500016India

BACkGROUND itraconazole is a broad-spectrum triazole antifungal inhibiting fungal growth by inhibiting ergosterol synthesis and exhibits a nonlinear pharmacokinetic *** absorption pattern with wide fluctuations in blood levels causes inconsistent and unpredictable clinical behaviour of this drug despite its low minimum inhibitory concentration(MiC)as compared to other antifungal *** To compare the oral bioavailability and bioequivalence of Fixtral SB(supra bioavailable itraconazole)with reference product R2(supra bioavailable 2×50 mg itraconazole).METHODS The study population consisted of 54 healthy volunteers,aged between 18-45 years and randomized to receive a single oral dose of either test[T;Fixtral SB(supra bioavailable itraconazole)100 mg]or reference product(R1;Sporanox 100 mg×2 capsules and R2;Lozanoc capsules 50 mg×2 capsules).Blood samples were taken pre-dose and post-dose up to 96 *** study evaluated bioequivalence by comparing the oral bioavailability of the test product with reference product *** pharmacodynamic characteristics of the drug were evaluated by comparing the test product with reference product ***(Pk)-PD comparative analysis[area under the concentration-time curve(AUC)/minimum inhibitory concentration(MiC)>25]was performed for conventional itraconazole 100 mg and supra bioavailable itraconazole 50 *** events(AEs)assessments were performed in each study period and post-study *** Statistical analysis of primary Pk variables revealed bioequivalence,with confidence intervals being completely inside the acceptance criteria of 80%-125%.The peak concentration levels of itraconazole were achieved at 10 h(T)and 8.5 h(R2),*** parameter assessment showed that AUC/MiC for R1 are comparable to Fixtral SB 100mg for MiC levels up to 16mcg/mL(P>0.05 and observed P=0.3196).Six AEs were observed that were mild to moderate in severity and *** severe AE was reported.

关键词： Supra-Bioavailable itraconazole Conventional itraconazole Oral bioavailability Pharmacodynamics Efficacy Adverse events

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

打造未来的供应链(三)

引用

石油石化物资采购 2012年第4期 87-87页

作者： yogesh Malik Alex Niemeyer Brian Ruwadi 樊晓武（译）麦肯锡克利夫兰分公司迈阿密分公司《石油石化物资采购》编辑部

如果公司对多供应链进行动态的考察,着眼于整个供应链在各种情况下的弹性能力,就会发现多供应链的优势极具价值。

关键词：供应链企业供销管理成本结构

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy and Safety of Tinefcon^® Tablets in Subjects with Plaque Psoriasis: An Open Label, Non-Comparative, Multicenter, Phase iV Trial

引用

Journal of Cosmetics, Dermatological Sciences and Applications 2016年第2期6卷 55-66页

作者： Somesh Sharma kailash Bhatia Meetesh Agarwal Sandesh Gupta Leelavathi Budamakuntla Sudhakar Grandhi Vinod Titarmare Sushil Pande Ranjan Rawal Aruna Samarth Rizwan Haq Vikrant Saoji D. V. S. pratap L. M. kansal D. G. Saple Shatrughan Sahay Parag kalyani Puneet Goyal Sharmila Patil A. J. kanwar Bhavesh Swarnakar Sujay kulkarni Abhijeet Morde Hitesh khandagale yogesh Dound Nitin Jadhav Sanjeev Hegde Murlidhara Padigaru Ashish C. Suthar Piramal Enterprises Limited Mumbai India Bhatia Skin Center Bima Nagar Indore India Agrawal Path LAB Vijaynagar Indore India Skin & Laser Center Krishna Nagar New Delhi India Diabetes and Shirdi Skin Care Centre Karnataka India Medipoint Hospitals Pvt. Ltd. Pentagon Research Pvt. Ltd. Pune India Skin Care Clinic Nagpur India NkP Salve institute and Lata Mangeshkar Hospital Nagpur India Department of Dermatology Sheth VS General Hospital Ahmedabad India Sai Skin Care Clinic Hyderabad India Radiance Skin Care Clinic Nagpur India Dr. Vikrant Saoji’s Clinic Ramdaspeth Nagpur India Durgabai Deshmukh Hospital & Research Center Hyderabad India kansal Cosmetic & Skin Care Clinic Jaipur India Dr. Saple’s Clinic Dadar (East) Mumbai India Sri Skin Care & Laser Clinic Lucknow UP India Ruby Hall Clinic Pune India Renova Skin & Laser Clinic Sector-9 Mansarovar Jaipur India Dr. D. Y. Patil Medical College and Hospital Nerul Navi Mumbai India Department of Dermatology Venerology & Leprology Postgraduate Institute of Medical Education and Research Chandigarh India Swarnakar Superspeciality Centre Indore India Clinical Research and Development Piramal Enterprises Limited Mumbai India

importance: This post-marketing surveillance study was conducted to evaluate real-world information about the efficacy and safety of oral Tinefcon? tablets (Sphaeranthus indicus based) in plaque psoriasis patients. Materials and Methods: Patients aged at least 18 years and older with clinical diagnosis of plaque psoriasis, were enrolled in this open label, non-comparative, multicenter trial. All eligible subjects received four 700 mg Tinefcon? tablets/day for 12 weeks. The primary outcome measure was percent change in Psoriasis Area Severity index (PASi) score from baseline to week 12. The secondary outcome measures were Physician Global Assessment (PGA), Nail Psoriasis Severity index (NAPSi), Psoriatic Arthritis Evaluation and Gene Expression Profiling and immunohistochemistry. Results: After completion of Tinefcon? treatment at 12 weeks, more than half of subjects (52%) achieved PASi 50 response;PASi 75 response was attained in 68 (23%) subjects and PASi 90 response in 22 (7%) subjects. Five subjects with severe psoriasis achieved PASi 90 without receiving any concomitant medication. Reduction in severity as assessed by PGA was observed in more than half of patients with moderate disease. Histopathological evaluation revealed that epidermal thickness was considerably reduced in 66% of subjects. The expression of inflammatory marker S100A9 protein was(meaningfully reduced in 60% patients with non-significant reduction of keratin 10 protein expression. Gene expression analysis showed increase down regulation of SERPiNB4;Pi3 and kRT16 genes after a 12-week treatment period in subjects with higher PASi scores. Conclusion: Oral Tinefcon? tablets showed good efficacy and had a favorable safety profile in plaque psoriasis patients.

关键词： Psoriasis Tinefcon® Tablet Sphaeranthus indicus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：