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Improved performance of naringenin herbosomes over naringenin in streptozotocin- induced diabetic rats: In vitro and in vivo evaluation

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Asian Pacific Journal of Tropical Biomedicine 2021年第9期11卷 385-393页

作者： Ruthvika Joshi Ankit P.Laddha yogesh A.Kulkarni Sarika Wairkar Shobhaben Pratapbhai Patel School of Pharmacy&Technology Management SVKM's NMIMSV.L.Mehta RoadVile Parle(W)Mumbai.Maharashtra-400056India

Objective:To prepare naringenin herbosome and evaluate its antidiabetic ***:Herbosomes were prepared by the solvent evaporation *** vitro parameters like particle size,polydispersity index,zeta potential,and entrapment efficiency were estimated and in vitro diffusion study was *** in vivo studies were also performed in streptozotocin-induced diabetic male Sprague Dawley rats to evaluate blood glucose,total cholesterol,triglyceride,blood urea nitrogen,total protein,albumin level,aspartate aminotransferase,and alanine aminotransferase ***:The optimized herbosome batch showed a particle size of 564.4 nm,a polydispersity index of 0.412,and zeta potential of−39.3 *** percentage entrapment of this formulation was 84.04%,with complete drug release within 8 *** of diabetic rats with naringenin herbosomes for 28 d significantly reduced the elevated level of plasma glucose as compared to plain *** biochemical parameters,the treatment showed a significant decrease in total cholesterol,triglyceride,and blood urea nitrogen;while elevated levels of aspartate aminotransferase and alanine aminotransferase were returned to *** naringenin and herbosome formulation at high dose increased the total protein whereas albumin level significantly increased in naringenin herbosomes at the highest dose but not in the pure naringenin treatment ***:Naringenin herbosomes could improve the metabolic profile of diabetic rats,indicating enhanced antidiabetic activity of herbosome formulation.

关键词： Naringenin Herbosomes Blood glucose level Biochemical parameters Antidiabetic activity

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Automatic License Plate Recognition System for Vehicles Using a CNN

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Computers, Materials & Continua 2022年第4期71卷 35-50页

作者： Parneet Kaur yogesh Kumar Shakeel Ahmed Abdulaziz Alhumam Ruchi Singla Muhammad Fazal Ijaz Department of Computer Science Chandigarh Group of CollegesLandran140307India Department of Computer Science College of Computer Sciences and Information TechnologyKing Faisal UniversityAl-AhsaSaudi Arabia Department of Research InnovationsSponsored Projects&EntrepreneurshipChandigarh Group of CollegesLandran140307India Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea

Automatic License Plate Recognition(ALPR)systems are important in Intelligent Transportation Services(ITS)as they help ensure effective law enforcement and *** systems play a significant role in border surveillance,ensuring safeguards,and handling vehicle-related *** most effective approach for implementing ALPR systems utilizes deep learning via a convolutional neural network(CNN).A CNN works on an input image by assigning significance to various features of the image and differentiating them from each *** are popular for license plate character ***,little has been reported on the results of these systems with regard to unusual varieties of license plates or their success at *** present an efficient ALPR system that uses a CNN for character recognition.A combination of pre-processing and morphological operations was applied to enhance input image quality,which aids system *** system has various features,such as the ability to recognize multi-line,skewed,and multifont license *** also works efficiently in night mode and can be used for different vehicle *** overall accuracy of 98.13%was achieved using the proposed CNN technique.

关键词： Deep learning intelligent transportation services morphological convolutional neural network accuracy

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Machine learning and evolutionary prediction of superhard BC-N compounds

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npj Computational Materials 2021年第1期7卷 1034-1041页

作者： Wei-Chih Chen Joanna N.Schmidt Da Yan yogesh K.Vohra Cheng-Chien Chen Department of Physics University of Alabama at BirminghamBirminghamALUSA Department of Computer Science University of Alabama at BirminghamBirminghamALUSA

We build random forests models to predict elastic properties and mechanical hardness of a compound,using only its chemical formula as *** model training uses over 10,000 target compounds and 60 features based on stoichiometric attributes,elemental properties,orbital occupations,and ionic bonding *** the models,we construct triangular graphs for B-C-N compounds to map out their bulk and shear moduli,as well as hardness *** graphs indicate that a 1:1 B-N ratio can lead to various superhard *** also validate the machine learning results by evolutionary structure prediction and density functional *** study shows that BC_(10)N,B_(4)C_(5)N_(3),and B_(2)C_(3)N exhibit dynamically stable phases with hardness values>40 GPa,which are superhard materials that potentially could be synthesized by low-temperature plasma methods.

关键词： prediction moduli occupation

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All-optical active THz metasurfaces for ultrafast polarization switching and dynamic beam splitting

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Light(Science & Applications) 2018年第1期7卷 766-774页

作者： Longqing Cong yogesh Kumar Srivastava Huifang Zhang Xueqian Zhang Jiaguang Han Ranjan Singh Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University21 Nanyang LinkSingapore 637371Singapore Centre for Disruptive Photonic Technologies The Photonics InstituteNanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Center for Terahertz Waves and College of Precision Instrument and Optoelectronics Engineering Key Laboratory of Optoelectronic Information TechnologyMinistry of EducationTianjin University300072 TianjinPeople’s Republic of China

Miniaturized ultrafast switchable optical components with an extremely compact size and a high-speed response will be the core of next-generation all-optical devices instead of traditional integrated circuits,which are approaching the bottleneck of Moore’s *** have emerged as fascinating subwavelength flat optical components and devices for light focusing and holography ***,these devices exhibit a severe limitation due to their natural passive *** we introduce an active hybrid metasurface integrated with patterned semiconductor inclusions for all-optical active control of terahertz *** modulation of polarization states and the beam splitting ratio are experimentally demonstrated on a time scale of 667 *** scheme of hybrid metasurfaces could also be extended to the design of various free-space all-optical active devices,such as varifocal planar lenses,switchable vector beam generators,and components for holography in ultrafast imaging,display,and high-fidelity terahertz wireless communication systems.

关键词： polarization optical beam

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The incidence of sporadic viral hepatitis in North India:a preliminary study

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Hepatobiliary & Pancreatic Diseases International 2007年第6期6卷 596-599页

作者： Subrat Kumar Radha Kanta Ratho yogesh Kumar Chawla Anuradha Chakraborti Department of Virology Department of Hepatology Department of Experimental Medicine and Biotechnology

BACKGROUND: Viral hepatitis is one of the major causes of mortality and morbidity in developing countries. Hepatitis E virus (HEV) among the major etiological agents is responsible for both sporadic and epidemic outbreaks. The epidemic outbreak is water-borne whereas the sporadic outbreak is possibly through contact. Various diagnostic tools at times fail to pinpoint the cause of viral hepatitis. This study was carried out to evaluate the utility of ELISA and nRT-PCR (nested reverse transcriptase polymerase chain reaction) for the diagnosis of sporadic and acute viral hepatitis (AVH) caused by HEV in an endemic situation in North India. METHODS: Serum samples were collected from all the affected and suspected persons and subjected to serological detection of HAV IgM, HBsAg, HCV antibody and HEV IgM. The samples that were positive for HEV IgM were further processed for the detection of HEV RNA by nRT-PCR. RESULTS: A total of 843 samples were collected from 685 patients with AVH, 70 patients with fulminant hepatic failure (FHF), 53 patients with chronic liver disease (CLD), 11 patients with antituberculosis therapy (ATT)-induced jaundice, and 24 pregnant women. The percentage of positivity for anti-HEV IgM was 58.3% in the pregnant women, 41.4% in the paients with FHF, 38.6% in the patients with AVH, 9.4% in the patients with CLD and 18.2% in the patients with ATT induced jaundice. 9.4% of HBsAg carriers were positive for anti-HEV IgM. Males outnumbered females (62.8% vs. 37.1%). Furthermore, the rates of fulminant and acute outbreaks of hepatitis with HEV RNA positivity were 41.4% and 9.4%, respectively. CONCLUSION: Serological and molecular analysis should be combined for the diagnosis of viral infections, especially in endemic areas.

关键词： viral hepatitis fulminant liver failure pregnancy

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Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome

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World Journal of Gastroenterology 2014年第40期20卷 14934-14941页

作者： Radha K Dhiman Swastik Agrawal Tarana Gupta Ajay Duseja yogesh Chawla Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh 160012 India

AIM: To compare the utility of the Chronic Liver Failure-Sequential Organ Failure Assessment (CLIF-SOFA) and Asia-Pacific Association for the Study of Liver (APASL) definitions of acute-on-chronic liver failure (ACLF)... 详细信息

关键词： Cirrhosis Acute decompensation Mortality Prognosis Acute on chronic liver failure

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Nonalcoholic steatohepatitis in Asian Indians is neither associated with iron overload nor with HFE gene mutations

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World Journal of Gastroenterology 2005年第3期11卷 393-395页

作者： Ajay Duseja Reena Das Mohit Nanda Ashim Das Gurjeewan Garewal yogesh Chawla Department of Hepatology Department of Hematology Department of Histopathology

AIM: The pathogenesis of occurrence of liver inflammation and fibrosis in patients with nonalcoholic steatohepatitis (NASH) is not completely understood. Other than insulin resistance, iron abnormalities have been thought to be one of the triggering factors. Therefore, our aim was to study the role of iron abnormalities and HFE gene mutations in patients with NASH. METHODS: Thirty-one patients of NASH diagnosed on the basis of clinical examination biochemistry, ultrasonography and liver biopsy (n = 14) were included in the study. Serum iron parameters (n = 23) (iron, ferritin, total iron-binding capacity and transferrin saturation), Perls' iron staining on liver biopsies (n = 14) and HFE gene mutations (C282Y and H63D) (n = 16) were studied in these patients. The association between iron staining, necroinflammatory activity and fibrosis stage on liver biopsies was also determined. RESULTS: Elevated serum iron, ferritin and transferrin saturation above 55% were observed in 4.3% of patients. On histology, 71% of the patients had negative iron staining, 21.4% had 1+ staining, 7.2% had 2+ staining and none had 3+ or 4+ staining. There was no association between the degree of iron staining and necroinflammatory activity (P=0.55) and fibrosis stage (P= 0.09) on histology. None of the patients had C282Y HFE gene mutation and four patients (25%) were found to be heterozygotes for H63D gene mutation. CONCLUSION: Our study does not favor iron overload and HFE gene mutations as major factors in the pathogenesis of NASH in Asian Indians.

关键词： Nonalcoholic steatohepatitis Iron overload HFE gene Mutation

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Towards a systematic understanding of blockchain governance in proposal voting: A dash case study

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Blockchain(Research and Applications) 2022年第3期3卷 89-99页

作者： Lawrence Mosley Hieu Pham Xiaoshi Guo yogesh Bansal Eric Hare Nadia Antony Omni Analytics Group AmesIA50014USA College of Business The University of Alabama in HuntsvilleHuntsvilleAL35899USA Department of Industrial and Manufacturing Systems Engineering Iowa State UniversityAmesIA50014USA Omni Analytics Innovative Technologies Initiative AmesIA50014USA

The transparent and immutable nature of blockchain provides incentives for organizations wishing to create and implement an open,decentralized governance *** members exercise their voting rights,a fault-tolerant record accumulates on the blockchain that can be analyzed to diagnose and intercept potential threats to the governing *** date,there has not been a systematic study of on-chain governance with respect to *** this paper,we provide an analysis of blockchain governance through a case study of the first cryptocurrency to adopt on-chain voting,*** analysis introduces the key characteristics of blockchain governance,steps through a data-driven exploration of Dash's on-chain voting system,and highlights exploitable attack vectors and vulnerabilities for the subversion of Dash's on-chain voting system via a novel network analysis *** then conclude with guidelines for other organizations looking to implement similar blockchain governance solutions while maintaining integrity in their operations.

关键词： Decentralized governance Blockchain Voting systems Data mining Network analysis

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Effects of the COVID-19 pandemic on semen quality in male partners of infertile couples: a hospitalbased observational study

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Asian Journal of Andrology 2023年第2期25卷 240-244页

作者： Tribhuwan Kumar Kamlesh Jha Md Zabihullah Kumari Neelu yogesh Kumar Kumar Siddharth Department of Physiology All India Institute of Medical SciencesPatna 801507BiharIndia Akshat Spandan Clinic Patna 801507BiharIndia

The effects of the coronavirus disease 2019(COVID-19)pandemic on male fertility have received considerable attention because human testes contain high levels of angiotensin-converting enzyme-2 receptors,through which severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can *** studies showed decreases in semen quality during and after recovery from ***,no semen quality studies have examined the effects of widespread subclinical and mild disease,as well as changes in lifestyle,psychosocial behavior,intake of dietary supplements,and *** cross-sectional study compared semen quality parameters in male partners of infertile couples between men who underwent semen analysis before the COVID-19 pandemic(prepandemic group)and men who underwent semen analysis during the pandemic period(pandemic group);the analysis sought to clarify the overall effects of the *** participants in the pandemic group had experienced clinically overt *** the 239 participants,mean body weight(P=0.001),mean body mass index(P<0.001),median sperm concentration(P=0.014),total sperm count(P=0.006),and total percentages of motile(P=0.013)and abnormal cells(P<0.001)were significantly greater in the pandemic group(n=137)than those in the prepandemic group(n=102).Among abnormal cells,the percentages of cells with excess residual cytoplasm(P<0.001),head defects(P<0.001),and tail defects(P=0.015)were significantly greater in the pandemic group than those in the prepandemic *** the exception of morphology,the overall semenogram results were better in the pandemic group than those in the prepandemic group.

关键词： coronavirus disease 2019 pandemic male infertility SARS-CoV-2 semen analysis

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Ecological variables influencing the diversity and distribution of macrolichens colonizing Quercus leucotrichophora in Uttarakhand forest

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Journal of Mountain Science 2018年第2期15卷 307-318页

作者： Shashi UPADHYAY Arun K.JUGRAN yogesh JOSHI Renu SUYAL Ranbeer S.RAWAL Lichenology laboratory S.S.J.Campus Kumaun University Biodiversity Conservation & Management Ecosystem Services and Climate Change Group G.B.Pant National Institute of Himalayan Environment and Sustainable Development G.B.Pant National Institute of Himalayan Environment and Sustainable Development Garhwal Unit

Ecological variables play a significant role in determining the diversity and distribution of any living organism on earth. Lichens are not exceptional and are quite sensitive in comparison to other organisms; hence the present study focuses on the impact of ecological variables on the diversity and distribution of epiphytic macrolichens colonizing Quercus leucotrichophora across eight different sites(50 m × 50 m) in Thal Ke Dhar forest, Kumaun Himalaya, Uttarakhand, India. For sampling of macrolichens, 200 trees(25 trees from each site) of *** were selected from each site and five quadrats of 5 cm × 10 cm(1000 quadrats in totality) were drawn at the tree trunk. From all the sampled trees, a total of 54 species of epiphytic macrolichens belonging to 18 genera and five families were recorded. Various ecological variables, namely altitude, aspect, slope, diameter at breast height(DBH), and lopping percent(partial cutting of the twigs as disturbance), were also analyzed to investigate their influence on macrolichen species composition and distribution pattern in the study area. For the determination of relationships between these variables, statistical analysis, namely Pearson's Correlation Coefficient, Polynomial regression analysis and Principal Component Analysis(PCA)were performed. Out of all variables, lopping was significantly correlated to species richness of epiphytic macrolichens(0.712~*, p<0.05) and it was confirmed by Pearson's Correlation *** of having high anthropogenic pressure or impact through lopping, the maximum number of macrolichen species was recorded at elevation 2267 meter above sea level(m asl). The present study revealed that besides other ecological variables,lopping practices can act as a key parameter incontrolling the diversity and distribution not only of epiphytic macrolichens but also of other life forms such as bryophytes, pteridophytes, insects, birds *** can be either negatively or positively correla

关键词： Conservation Epiphytic macrolichens Kumaun Himalaya Lopping Quercus Banj oak

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