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Evaluation of antiplasmodial properties in 15 selected traditional medicinal plants from India

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Journal of Integrative Medicine 2020年第1期18卷 80-85页

作者： yogesh Subhash Biradar Swathi Bodupally Harish Padh Department of Pharmacognosy and Phytochemistry Bharat School of PharmacyMangalpallyIbrahimpatnamHyderabad 501510TelanganaIndia Department of Pharm D Bharat School of PharmacyMangalpallyIbrahimpatnamHyderabad 501510TelanganaIndia Department of Biotechnology B.V.Patel Pharmaceutical Education and Research Development CentreThaltej-Gandhinagar HighwayThaltejAhmedabad 380054GujaratIndia

Objective:The objective of this study was to evaluate the in vitro antiplasmodial properties against malaria parasite in 15 plants mentioned in Indian traditional medicine ***:In vitro antiplasmodial activity of methanolic extracts obtained from Indian traditional medicinal plants was evaluated on Plasmodium falciparum of FCK2 and INDO strains using schizont maturation inhibition assay and parasite lactate dehydrogenase inhibition ***:Methanolic extracts of Adhatoda zeylanica,Embelia ribes,Piper nigrum and Plumbago zeylanica exhibited more than 50%inhibition in both the stains in schizont maturation inhibition *** extracts of seven medicinal plants exhibited antiplasmodial activity at half maximal inhibitory concentration(IC50)<100 mg/m L,and methanolic extracts of five medicinal plants exhibited antiplasmodial activity at IC50<50 mg/m L in *** lactate dehydrogenase(PfLDH)inhibition ***,*** and *** exhibited promising antiplasmodial activity in PfLDH inhibition *** and *** exhibited improved activity against resistant in comparison to sensitive ***:*** and *** were the most promising extracts from this study and deserve further investigation of their antiplasmodial properties.

关键词： Medicinal plants Plasmodium falciparum Schizont maturation inhibition assay Lactate dehydrogenase inhibition assay Cytotoxicity

Protective effect of Polyalthia longifolia *** leaves on ethanol and ethanol/HCl induced ulcer in rats and its antimicrobial potency

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Asian Pacific Journal of Tropical Medicine 2011年第9期4卷 673-679页

作者： Sumitra Chanda yogesh Baravalia Mital Kaneria Phytochemical Pharmacological and Microbiological LaboratoryDepartment of BiosciencesSaurashtra UniversityRajkot-360 005GujaratIndia

Objective:To explore antiulcer and antimicrobial properties of methanolic extract of Polyalthia longifolia ***:Gastroprotective potential of Polyalthia longifolia was studied on ethanol and ethanol/HCl induced ulcers at 2 different doses(270 and 540 mg/kg/body weight). Antimicrobial efficacy of Polyalthia longifolia(25 mg/mL) was also studied against six gram positive,seven gram negative bacteria and five fungi by agar well diffusion *** inhibitory concentration was determined by agar well diffusion method in two fold serial dilution, in the range of 97-25 000μg/***:The reduction of ulcer index in Polyalthia longifolia treated animals was found to be statistically significant with respect to control *** Polyalthia longifolia exhibited ulcer protection activity in dose dependent manner and was also better than the *** antimicrobial activity,gram positive bacteria were more susceptible to Polyalthia longifolia than gram negative bacteria and fungal ***:Results obtained confirm the antiulcer and antimicrobial potential of the Polyalthia longifolia.

关键词： Polyalthia longifolia Antimicrobial activity Antiulcer activity Ulcer index Methanol extract

Photometric studies of two W UMa type variables in the field of distant open cluster NGC 6866

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Research in Astronomy and Astrophysics 2016年第4期16卷 87-96页

作者： yogesh Chandra Joshi Rukmini Jagirdar Santosh Joshi Aryabhatta Research Institute of Observational Sciences Manora PeakNainital 263002India Center for Advanced Study in Astronomy Osmania UniversityHyderabad 500007India

We present photometric analysis of the two W UMa type binaries identified in the field of distant open star cluster NGC 6866. Although these systems, namely ID487 and ID494, were reported by Joshi et al., a detailed study of these stars has not been carried out before. The orbital periods of these stars are found to be 0.415110±0.000001 day and 0.366709±0.000004 day, respectively. Based on the photometric and infrared colors, we find their respective spectral types to be K0 and K3. The photometric light vari- ations of both stars show the O＇Connell effect which can be explained by employing a dark spot on the secondary components. The V and I band light curves are analyzed using the Wilson-Devinney （WD） code and relations given by Gazeas which yield radii and masses for the binary components of star ID487 of R1 = 1.24 ± 0.01R,R2 = 1.11 4- 0.02Re, and M1 = 1.24 ± 0.02Me, M2 = 0.96 ±0.05Me and for star ID494 of R1 = 1.22 ± 0.02Re, R2 = 0.81 4- 0.01 Re, and M1 = 1.20 4- 0.06 Me, M2 = 0.47 4- 0.01 Me.

关键词： methods: observational -- techniques: photometric -- binaries: eclipsing -- stars: fundamen-tal parameters

Resonant magnetoelastic microstructures for wireless actuation of liquid flow on 3D surfaces and use in glaucoma drainage implants

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Microsystems & Nanoengineering 2015年第1期1卷 26-34页

作者： Venkatram Pepakayala Joshua Stein yogesh Gianchandani Center for Wireless Integrated MicroSensing and Systems(WIMS2) Department of Electrical Engineering and Computer ScienceUniversity of MichiganAnn ArborMIUSA Department of Ophthalmology and Visual Sciences University of MichiganAnn ArborMIUSA

Magnetoelastic resonators made from metal alloy foils are widely used for miniature wireless anti-theft tags and have also been explored for use in various sensing *** annealing within three-dimensional(3D)molds,these foils can be formed into curved ***,magnetoelastic materials present an opportunity for the development of a new class of wireless,actuators that have small form factors and low surface profiles and that can conform to curved *** paper describes passive,wireless,resonant magnetoelastic actuators intended for the generation of fluid flow on the surfaces of implantable Ahmed glaucoma drainage *** actuators are remotely excited to resonance using a magnetic field generated by external *** fluid flow is intended to limit cellular adhesion to the surface of the implant,as this adhesion can ultimately lead to implant encapsulation and *** actuators are micromachined from planar 29-μm-thick foils of Metglas 2826MB(Fe_(40)Ni_(38)Mo_(4)B_(18)),an amorphous magnetoelastic alloy,using photochemical *** 10.3×5.6 mm^(2),the planar structures are annealed in 3D molds to conform to the surface of the drainage device,which has an aspherical *** actuator designs are described,with varying shapes and resonant mode *** resonant frequencies for the different designs vary from 520 Hz to 4.7 *** velocities of up to 266μm s^(−1) are recorded at a wireless activation range of 25–30 mm,with peak actuator vibration amplitudes of 1.5μ*** actuators such as those described here have the potential to greatly enhance the effectiveness of glaucoma drainage devices at lowering eye pressure and may also be useful in other areas of medicine.

关键词： actuator fibrosis glaucoma magnetostriction Metglas

Petrogenesis of the Neoarchean zincian chromite within ultramafic xenoliths,Bastar Craton,India

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Acta Geochimica 2023年第3期42卷 471-487页

作者： Arpita Karmakar Tushar Meshram Mohammad Asif yogesh Pandey Geological Survey of India Vasudha BhawanKumarswamy LayoutBangalore 560111India Geological Survey of India NagpurIndia Geological Survey of India RaipurIndia

The present study reports and discusses the genesis of zincian chromite in the ultramafic xenoliths from the Dongripali area,Bastar craton,Central *** zincian chromite is in the ultramafic xenoliths of Bengpal supracrustal rock hosted by Neoarchaean Bundeli *** zincian chromite shows a range of Cr_(2)O_(3)(39.69 to 51.66 wt%),Al_(2)O_(3)(05.30 wt%to 08.71 wt%),FeO(21.74 wt%to 27.51 wt%),Fe_(2)O_(3)(10.19 wt%to 19.36wt%)with higher ZnO content ranging from 1.73 wt%to 4.08 wt%.Accordingly,their Cr#[Cr/(Cr+Al)]varies in a narrow range from 0.83 to *** calculated melt composition supports metamorphic or post-magmatic nature rather than common occurrences such as inclusion in diamonds,meteorites,and association with any sulfide-rich mineralised *** reveals that the post-magmatic processes play a vital role in transforming chromite to zincian *** empirical thermometric calculation from chromite,amphibole,and pyroxene support their metamorphic origin and formed during low-P and high-T amphibolite grade facies of metamorphism(~700℃).The Neoarchaean granitic magmatism has a significant role in generating and transferring the heat during contact metamorphism with hydration of ultramafic xenoliths and further alteration,i.e.,*** olivine is a major repository for Mn,Zn,and Co in peridotite/ultramafic;these elements get mobilised during the metamorphism and *** is a possible reason for the mobilisation of zinc and incorporation in the chromite within altered *** a result,chromiterich ultramafic xenolith subjected to metamorphic process gets enrichment of Zn and Fe due to elemental *** converts common chromite into zincian chromite,as reported in altered ultramafics elsewhere.

关键词： Zincian chromite Ultramafic Neoarchaean granitic magmatism High-grade metamorphism

Approach to a patient with cardiac amyloidosis

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Journal of Geriatric Cardiology 2019年第7期16卷 567-574页

作者： Christopher Strouse Alexandros Briasoulis Rafael Fonseca yogesh Jethava Department of Internal Medicine Division of HematologyOncologyand Blood and Marrow TransplantationUniversity of IowaIowa CityIAUSA Cardiomyopathy Section Cardiology DivisionUniversity of IowaIowa CityIowaUSA Bone Marrow Transplant Program Mayo ClinicPhoenixArizonaUSA

1 Introduction Cardiac amyloid(CA)is characterized by inexorably progressive heart failure making early diagnosis and treatment *** article will review the pathophysiology,clinical presentation,diagnosis,prognostication and treatment of patients with CA.2 Pathophysiology CA is the result of extracellular deposition of a misfolded protein into cardiac tissue,forming insoluble aggregations of rigid,nonbranching 10 nm wide *** causes impaired cardiac function by disrupting cardiac architecture,direct myotoxicity and ischemic injury secondary to infiltration of intramyocardial vessels.

关键词： Cardiac amyloidosis Heart failure The elderly

Population I Cepheids and understanding star formation history of the Small Magellanic Cloud

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Research in Astronomy and Astrophysics 2016年第4期16卷 71-78页

作者： yogesh Chandra Joshi Auro Prasad Mohanty Santosh Joshi Aryabhatta Research Institute of Observational Sciences Manora PeakNainital 263002India National Institute of Technology Rourkela 769008India

In this paper, we study the age and spatial distributions of Cepheids in the Small Magellanic Cloud （SMC） as a function of their ages using data from the OGLE III photometric catalogue. A period - age relation derived for Classical Cepheids in the Large Magellanic Cloud （LMC） has been used to find the ages of Cepheids. The age distribution of the SMC Classical Cepheids is found to have a peak at log（Age）： 8.40 ± 0.10 which suggests that a major star formation event might have occurred in the SMC about 250 4- 50 Myr ago. It is believed that this star forming burst had been triggered by close interactions of the SMC with the LMC and/or the Milky Way. A comparison of the observed spatial distributions of the Cepheids and open star clusters has also been carried out to study the star formation scenario in the SMC.

关键词： stars: Cepheids -- star type: Pop I (classical) -- galaxies: SMC -- methods: statistical

Numerical Investigation of Sound Generation due to Laminar Flow Past Elliptic Cylinders

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Numerical Mathematics(Theory,Methods and Applications) 2020年第1期13卷 27-62页

作者： Bikash Mahato Naveen Ganta yogesh G.Bhumkar Scientific Computing Laboratory School of Mechanical SciencesIndian Institute of Technology BhubaneswarOdishaIndia

Numerical investigation of sound generation due to unsteady laminar flow past elliptic cylinders has been carried out using direct numerical simulation(DNS)approach at a free-stream Mach number of *** of aspect ratio(0.6≤AR≤1.0)and Reynolds number(100≤Re≤160)on the characteris-tics of radiated sound fields are ***-dimensional compressible fluid flow equations are solved on a refined grid using high resolution dispersion relation pre-serving(DRP)*** present DNS data,equivalent noise sources as given by various acoustic analogies are *** and frequencies associated with these noise sources are further related to characteristics of disturbance pressure *** pressure fields are intensified with increase in Reynolds number and aspect ***,radiated sound power increases with increase in Reynolds number and aspect *** various cases studied here,minimum and max-imum values of radiated sound power are found at Re=120&AR=0.6 and Re=160&AR=1.0,*** patterns show that the generated sound fields are dominated by the lift dipole for all ***,proper orthogonal decomposition(POD)technique has been implemented for decomposing distur-bance pressure *** POD modes associated with the lift and the drag dipoles have been *** analyses also clearly display that the radiated sound fields are dominated by the lift dipole ***,acoustic and hydrodynamic modes obtained using Doak’s decomposition method have confirmed the patterns of radiated sound field intensities.

关键词： Computational aeroacoustics acoustic analogies aeolian tones proper orthogonal decomposition Doak’s decomposition

Anthropogenic disturbances and status of forest and wildlife in the dry deciduous forests of Chhattisgarh state in India

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Journal of Forestry Research 2012年第1期23卷 45-52页

作者： Chandra Prakash Kala yogesh Dubey Ecosystem & Environment Management Indian Institute of Forest Management P.B. No. 357 Nehru Nagar Bhopal - 462 003 Madhya Pradesh INDIA

The advent of modem forces and the changes in socio- economic patterns of forest dwellers have increased the pressures on the forests. In order to mitigate such pressures and also to protect the forests and wildlife the model of protected areas networks has shifted and en- hanced such pressures in the unprotected natural forests due to several reasons. Being a low profile category of protected status and continuous human settlements, the present study highlights the case of dry deciduous forests of Sarguja district of Chhattisgarh state of India. The major objec- tives of this study were to quantify the status of forests and wildlife and also to determine the extent of anthropogenic disturbances faced by the dry deciduous forests of central India. Transect and silent drive count methods were used for sampling wildlife and quadrat method was used for sampling vegetation. Besides, the local uses of various forest pro- duces were also studied in view of understanding the people dependency on forests. The forest vegetation, in the study area, was pre-dominated by Shorea robusta, which had Madhuca indica, Diospyrus melanoxylon and Buchnania lanzan as the major companion species. The forest had either the high girth class mature tree species or the saplings. The low vegeta- tion cover and density were due to the high anthropogenic pressures mainly in the form of heavy livestock grazing and collection of etlmo- botanically important species. The study though reveals that the area is not rich in wildlife and the forest is fragmented, the area still supports some important species, which include many rare and endangered plants and animals. The findings of this study have been discussed in view of the management and conservation of the forest and wildlife in the dry deciduous forests.

关键词： dry deciduous forest central India wildlife anthropogenicdisturbances biodiversity conservation