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Potential Maintenance Mechanism in Atrial Fibrillation Patients Subject to Different Treatment Procedures： A Preliminary Study Based on a Human Atrial Model

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Current Medical Science 2018年第3期38卷 422-426页

作者： Zhao-lian OUYANG Li-ping SUN Hui chi Ling XIA Ying-lan GONG Yu-bo FAN Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing 100083 China Institute of Medical Information (IMI) Chinese Academy of Medical Sciences (CAMS) Beijing 100020 China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang University Beijing 102402 China Department of Cardiology Beijing Shijitan Hospital Capital Medical University Beijing 100038 China Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China National Research Center for Rehabilitation Technical Aids Beijing 100176 China

Two clinical ablation protocols, 2C3L and stepwise, have been routinely used in our group to treat atrial fibrillation （AF）, but with a less than 60% long-term arrhythmia-free outcome achieved in patients. The goal of this study was to examine the underlying mechanism of low success in clinical outcome. MRI images from one patient were used to reconstruct a human atrial anatomical model, and fibrotic tissue was manually added to represent the arrhythmia substrate. AF was induced with standard protocols used in clinical practice. 2C3L and stepwise were then used to test the efficacy of arrhythmia termination in our model. The results showed that re-entries induced in our model could not be terminated by using either 2C3L or the stepwise protocol. Although some of the induced re-entries were terminated, others emerged in new areas. Ablation using only the 2C3L or stepwise method was not sufficient to terminate all re-entries in our model, which may partially explain the poor long-term arrhythmiafree outcomes in clinical practice. Our findings also suggest that computational heart modelling is an important tool to assist in the establishment of optimal ablation strategies.

关键词： computational modelling atrial fibrillation atrial ablation 2C3L stepwise

Generation of Tunable Amplitude-Squeezed Light by Injection Locking of a Laser Diode

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chinese Physics Letters 2000年第6期17卷 422-424页

作者： WANG Jun-Min HE Ling-Xiang ZHANG Tian-Cai XIE Chang-De PENG Kun-chi Institute of Opto-electronics Shanxi UniversityTaiyuan 030006

Tunable amplitude squeezing around the D_(2)line of cesium has been experimentally accomplished at room temperature in a quantum-well laser diode with light injection from a single-mode distributed Bragg-Reflector laser *** the master laser frequency is tuned,amplitude squeezing of the output light from the slave laser can be maintained at about 0.9dB throughout a tunabIe range of~l.7 GHz around the cesium D_(2)line.

关键词： Tunable laser diode

血清同型半胱氨酸水平与HFpEF患者NT-proBNP水平及凝血功能的相关性

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中外医学研究 2024年第2期22卷 65-68页

作者：黄光秀廖思钦廖美艳池青罗冰邹文毕佛山市三水区人民医院广东佛山528100

目的:探讨血清同型半胱氨酸(Hcy)水平与射血分数保留的心力衰竭(HFpEF)患者N末端B型脑钠肽前体(NT-proBNP)水平及凝血功能的相关性。方法:选取2021年10月—2022年10月佛山市三水区人民医院收治的120例HFpEF患者为HFpEF组,选取同期正常... 详细信息

目的:探讨血清同型半胱氨酸(Hcy)水平与射血分数保留的心力衰竭(HFpEF)患者N末端B型脑钠肽前体(NT-proBNP)水平及凝血功能的相关性。方法:选取2021年10月—2022年10月佛山市三水区人民医院收治的120例HFpEF患者为HFpEF组,选取同期正常体检的120例患者为对照组,比较两组血清Hcy、凝血功能[凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)]及NT-proBNP水平。采用Pearson相关性分析血清Hcy水平与HFpEF患者凝血功能、NT-proBNP水平的相关性。结果:HFpEF组NT-proBNP、Hcy、FIB、APTT、PT、TT均高于对照组,差异有统计学意义(ProBNP、FIB、APTT、PT、PT呈正相关,差异有统计学意义(r=0.707、0.662、0.721、0.661、0.489,ProBNP、凝血功能水平呈正相关。

关键词：血清同型半胱氨酸 N末端B型脑钠肽前体射血分数保留的心力衰竭凝血功能相关性

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新型固砂剂在渤海油田的防砂效果及影响因素研究

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石油化工应用 2024年第5期43卷 47-51页

作者：黄文奥彭正强田延妮韩放郭靖池伸中海油田服务股份有限公司天津300459

渤海油田油水井出砂现象明显,导致部分油井停井无产出。化学防砂工艺成本低,见效快,近年来大受欢迎。利用新型化学固砂技术能较好的固结砂体,达到控砂目的,完成出砂井的治理。从油藏动静态参数入手,分析已治理井各项数据,应用灰色关联... 详细信息

渤海油田油水井出砂现象明显,导致部分油井停井无产出。化学防砂工艺成本低,见效快,近年来大受欢迎。利用新型化学固砂技术能较好的固结砂体,达到控砂目的,完成出砂井的治理。从油藏动静态参数入手,分析已治理井各项数据,应用灰色关联度理论对化学防砂效果与多项因素的相关性进行研究,判断泥质含量、储层斜厚、地层温度、作业前含水率等参数均在较大程度上影响新型固砂剂作业成功率,且在化学防砂成功作业的前提下,延长化学防砂有效期主要优选指标为泥质含量、地层压力、地层温度、含水率等。该成果在渤海油田A井得到了成功应用,实施后控砂增产效果明显,对后续出砂井治理选井选层提供了参考依据。

关键词：灰色关联度分析化学防砂选井选层油藏增产

New discovery of fossil cycad-like plants from the Middle Jurassic of West Liaoning,china

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Science Bulletin 2005年第16期 134-137页

作者： SAIKI Keni’chi Natural History Museum and Institute Japan chiba 260-8086

Combined detection of serum tumor markers for differential diagnosis of solid lesions located at the pancreatic head

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Hepatobiliary & Pancreatic Diseases International 2007年第6期6卷 641-645页

作者： Liao, Quan Zhao, Yu-Pei Yang, Ying-chi Li, Li-Jun Long, Xiao Han, Shao-Mei Beijing Union Med Coll Hosp Dept Gen Surg Beijing 100730 Peoples R China

BACKGroUND: The differential diagnosis of solid lesions located at the pancreatic head is very important for choosing therapies and setting up surgical tactics. This study was designed to evaluate the clinical significance of combined measurement of multiple serum tumor markers and the application of the receiver-operating characteristic (roC) curves in the differential diagnosis of solid lesions located at the pancreatic head. METHODS: The serum levels of CA19-9, CA242, CA50 and carcinoembryonic antigen (CEA) in 112 patients with carcinoma of the pancreatic head and 38 patients with focal chronic pancreatitis in the pancreatic head were measured with ELISA. The sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of the four serum tumor markers were calculated. The roC curves for the four serum tumor markers were constructed and the area under the curve (AUC) was calculated. RESULTS: The AUCs of CA19-9, CA242, CA50 and CEA were 0.805, 0.749, 0.738 and 0.705; the PLRs were 1.91, 3.43, 5.09 and 5.46; and the NLRs were 0.41, 0.56, 0.59 and 0.71, respectively. Combined measurements increased the diagnostic specificity, and parallel combined testing increased the diagnostic sensitivity. CONCLUSIONS: Combined measurement of serum tumor markers CA19-9, CA242, CA50 and CEA is valuable in differential diagnosis of solid lesions located at the pancreatic head, and CA19-9 has the best diagnostic ability. Combined measurements can increase the specificity of diagnosis. Evaluation with the roC curve is better than the sensitivity or specificity alone and the results are more integrated and objective.

关键词： pancreatic neoplasm tumor markers roC curve differential diagnosis

Higher risk of type 2 diabetes in young women with polycystic ovary syndrome: A 10-year retrospective cohort study

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World Journal of Diabetes 2022年第3期13卷 240-250页

作者： Wan-Ting Liao Jing-Yang Huang Ming-Tsung Lee Yu-Cih Yang Chun-chi Wu Institute of Medicine Chung-Shan Medical UniversityTaichung 402Taiwan chinese Medicine Department Show Chwan Memorial HospitalChanghua 500Taiwan Research Center for Health Data Science Chung Shan Medical University HospitalTaichung 402Taiwan National Center for Geriatrics and Welfare Research National Health Research InstitutesYunlin 632Taiwan Clinical Trial Research Center China Medical University HospitalTaichung 404Taiwan

BACKGroUND Polycystic ovary syndrome(PCOS)is a common disorder in women of reproductive *** the last few decades,research studies have revealed that PCOS is strongly associated with metabolic disorders,including metabolic syndrome,obesity,insulin resistance and *** observation has shown that women with PCOS are expected to have an increased risk of developing type 2 diabetes(T2DM)in the *** To assess the hazard ratio(HR)of T2DM between women with/without *** This population-based,retrospective cohort study evaluated data retrieved from the National Health Insurance Research *** subjects were women with PCOS(n=2545)identified on the basis of diagnosis,testing,or treatment codes,and women without PCOS as controls(n=2545).The HR of T2DM between women with or without PCOS was the main outcome measure *** Our study found that, during a 10-year follow-up period, the overall incidence of T2DM was 6.25per 1000 person-years in the PCOS group compared with 1.49 in the control group. Afteradjustment for potential confounding variables, the overall incidence of T2DM was higher in thePCOS group vs the control group (HR = 5.13, 95%CI: 3.51-7.48, P roup, 5.28 in the 25-29-year age group, and 4.06 in the 29-34-year age ***, no such significant association was noted in women older than 35 *** findings highlight the importance of prompting a more aggressive treatment to preventdiabetes in women diagnosed with PCOS at a young age, and, in contrast, the lessened importanceof this type of intervention in women diagnosed with PCOS at a late reproductive age.

关键词： Polycystic ovary syndrome Diabetes Incidence Hazard ratio Population-based cohort study

A 1,3-dipolar cycloaddition protocol to porphyrin- functionalized reduced graphene oxide with a push-pull motif

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Nano Research 2015年第3期8卷 870-886页

作者： Aijian Wang Wang Yu Zhengguo Xiao Yinglin Song Lingliang Long Marie P. Cifuentes Mark G. Humphrey chi Zhang china-Australia Joint Research Center for Functional Molecular Materials School of Chemical and Material Engineering Jiangnan University Wuxi 214122 China china-Australia Joint Research Center for Functional Molecular Materials Scientific Research Academy Jiangsu University Zhenjiang 212013 China School of Physical Science and Technology Soochow University Suzhou 215006 China Research School of Chemistry Australian National University Canberra ACT0200 Australia

Reduced graphene oxide （RGO） has been covalently functionalized with porphyrin moieties by two methods： A straightforward Prato reaction （i.e. a 1,3-dipolar cycloaddition） with sarcosine and a formyl-containing porphyrin, and a stepwise method that involves a 1,3-dipolar cycloaddition to the RGO surface using 4-hydroxybenzaldehyde, followed by nucleophilic substitution with an appropriate porphyrin. The chemical bonding of porphyrins to the RGO surface has been confirmed by ultraviolet/visible absorption, fluorescence, Fourier-transform infrared, and Raman spectroscopies, X-ray powder diffraction and X-ray photoelectron specfroscop）~ transmission electron and atomic force microscopy, and thermogravimetric analysis; this chemical attachment assures efficient electron/energy transfer between RGO and the porphyrin, and affords improved optical nonlinearities compared to those of the RGO precursor and the pristine porphyrin.

关键词： porphyrin cycloaddition reduced graphene oxide nonlinear optics

Numerical simulation study on monoblock casting process of ultra-slender structural components and experimental validation

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china Foundry 2017年第5期14卷 449-455页

作者： Xu-liang Zhang Xiu-mei chi Bo-dong Zeng Hao Sun Jia-yun Chen Xian-fei Wang Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

Substrate, a typical ultra-slender aluminum alloy structural components with a large aspect ratio and complex internal structure, was traditionally manufactured by re-assembly and sub-welding. In order to realize the monoblock casting of the substrate, the Pro/E software was utilized to carry out three-dimensional(3D) modeling of the substrate casting, and the filling and solidification processes were calculated, as well as the location and types of casting defects were predicted by the casting simulation software Anycasting. Results of the filling process simulation show that the metal liquid is distributed into each gap runner evenly and smoothly. There is no serious vortex phenomenon in the mold cavity, and the trajectory of the virtual particles is clear. Results of the solidification process simulation show that shrinkage cavities mainly appear at the junction of gap runners and the rail surface of the substrate. The average deformation is 0.6 mm in X direction, 3.8 mm in Y direction, and 8.2 mm in Z direction. Based on the simulation results, the casting process of the substrate was optimized, and qualified castings were successfully produced, which will provide a reference for the casting process design of other ultraslender aluminum alloy structural components.

关键词： aluminum alloy structural component numerical simulation defect prediction