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苏铁羽叶褐斑病病原菌鉴定及其化学防治药剂的筛选

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热带作物学报 2024年第8期45卷 1677-1684页

作者：覃茜丁丽琼池昭锦陆祖正单彬谢振兴黄歆怡许恬广西壮族自治区亚热带作物研究所广西南宁530001 南宁植物园广西南宁530029

本研究旨在分离并鉴定造成苏铁属植物羽叶褐斑病的病原真菌,筛选出对该病原真菌具有强烈抑制作用的化学防治药剂,为苏铁的保护提供理论依据。首先,通过病斑组织分离、纯化后回接滇南苏铁叶片,根据科赫氏法完成其致病性验证。其次,对其... 详细信息

本研究旨在分离并鉴定造成苏铁属植物羽叶褐斑病的病原真菌,筛选出对该病原真菌具有强烈抑制作用的化学防治药剂,为苏铁的保护提供理论依据。首先,通过病斑组织分离、纯化后回接滇南苏铁叶片,根据科赫氏法完成其致病性验证。其次,对其进行形态鉴定;再应用SSU、LSU、GAPDH、tef1、rpb2、Alt、OPA10-2、ITS 8个基因序列,构建多基因进化树进一步鉴定病原真菌。最后,通过平板抑菌试验,从7种化学药剂中筛选出高效的抗菌药剂。本研究发现,形态学鉴定与多基因联合进化分析表明,该病原菌为链格孢属的巴斯基链格孢(Alternariaburnsii);在7种化学药剂平板抑菌试验中,氟酰羟·苯甲唑效果最佳,其浓度在0.67 mg/L时抑菌率达到73.48%。

关键词：苏铁褐斑病病原鉴定巴斯基链格孢平板抑菌试验

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多光谱法与分子模拟研究亥茅酚苷与人血清白蛋白的结合特性

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化学研究与应用 2024年第7期36卷 1521-1528页

作者：洪传彬刘桂明郑彭予迟雪婷周佳李丽许佳明黄晓巍长春中医药大学药学院吉林长春130117 长春师范大学化学学院吉林长春130032 长春中医药大学东北亚中医药研究院吉林长春130117

本实验利用荧光光谱法、紫外光谱法及圆二色光谱法,结合分子对接和动力学模拟研究亥茅酚苷(SOG)与人血清白蛋白(HSA)相互作用。结果表明SOG静态猝灭人血清白蛋白固有荧光且伴随非辐射能量转移,同时通过疏水作用、氢键和静电力与HSA结合... 详细信息

本实验利用荧光光谱法、紫外光谱法及圆二色光谱法,结合分子对接和动力学模拟研究亥茅酚苷(SOG)与人血清白蛋白(HSA)相互作用。结果表明SOG静态猝灭人血清白蛋白固有荧光且伴随非辐射能量转移,同时通过疏水作用、氢键和静电力与HSA结合形成复合物,与HSA的主要结合位为IIA亚域。随着SOG与HSA反应地进行,HSA的二级结构α-螺旋含量减少,肽键伸展,疏水基团裸露,构象发生变化。分子对接及分子动力学模拟证明,SOG与HSA形成的复合物体系紧密稳定。

关键词：人血清白蛋白亥茅酚苷分子对接动力学模拟

罗氏602与雅培iSR2000全自动生化分析仪部分肿瘤项目比对分析

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中国医疗器械信息 2024年第12期30卷 25-27页

作者：廖思钦廖美艳池青黄光秀邹文毕佛山市三水区人民医院检验科广东佛山528100

目的:探讨本科室两台不同全自动生化分析仪对癌胚抗原(CEA)、甲胎蛋白(AFP)检测结果的可比性和一致性。方法:随机收集60例患者血清样本,分别在罗氏602和雅培iSR2000全自动生化分析仪上进行检测,并对结果进行相关性分析,求出回归方程和... 详细信息

目的:探讨本科室两台不同全自动生化分析仪对癌胚抗原(CEA)、甲胎蛋白(AFP)检测结果的可比性和一致性。方法:随机收集60例患者血清样本,分别在罗氏602和雅培iSR2000全自动生化分析仪上进行检测,并对结果进行相关性分析,求出回归方程和相关系数,最后采用Bland-Altman(BA)分析法对两台仪器的一致性进行评价。结果:两台全自动生化分析仪各项目的变异系数CV均≤3.5%,稳定性较好,CEA和AFP的结果相关性良好,r2分别为0.982和0.997;采用Bland-Altman法对两种仪器检测结果的一致性进行分析,CEA和AFP的一致性界限内的点为96.67%和95.00%。结论:两台仪器检测结果的一致性良好,两台仪器的结果可以通用。实验室内的生化仪器之间的比对是保证结果可比性的关键因素。

关键词：全自动生化分析仪一致性 Bland-Altman法

Temporary coronary sinus pacing to improve ventricular dyssynchrony with cardiogenic shock: A case report

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World Journal of Clinical Cases 2021年第20期9卷 5562-5567页

作者： Teressa Reanne Ju Hsin Tseng Hsin-Ti Lin Alexander Lee Wang chi Chan Lee Yi-ching Lai Department of Internal Medicine NewYork-Presbyterian Queens HospitalQueensNY 11355United States School of Medicine China Medical UniversityTaichung City 40447Taiwan Department of Critical Care Medicine Guam Regional Medical CityDededo 96929Guam Department of Cardiology Division of Internal MedicineChina Medical University HospitalTaichung City 40447Taiwan

BACKGroUND Temporary transvenous pacing through the coronary sinus is a novel approach rarely used in treating unstable *** modality could provide cardiac pacing while achieving better ventricular *** present a case who received cardiac pacing through the coronary sinus and provide a summary of evidence in the current *** SUMMARY A 55-year-old woman with a history of advanced heart failure was admitted to the rehabilitation ward after a recent *** hospitalization,she had paroxysmal atrial fibrillation with rapid ventricular response resulting from fluid *** atrial fibrillation was spontaneously reversed to sinus rhythm after diuresis,she developed multiple episodes of polymorphic ventricular tachycardia along with sinus bradycardia and prolonged QTc *** became hypotensive despite appropriate medical *** through her implantable cardioverter-defibrillator was attempted but worsened her *** dyssynchrony was *** transvenous atrial pacing through the coronary sinus was performed,which stabilized her blood pressure and improved end-organ perfusion.A permanent biventricular pacemaker was later implanted,and she was safely discharged to a nursing *** Temporary transvenous pacing through the coronary sinus,a novel approach to treat unstable bradycardia,may reduce ventricular dyssynchrony.

关键词： Cardiac resynchronization Artificial pacemaker Coronary sinus Heart failure Cardiogenic shock Case report

On-Surface Synthesis of Na-Porphyrins Using NaCl as a Convenient Na Source

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Precision Chemistry 2023年第4期1卷 226-232页

作者： Zewei Yi chi Zhang Zhaoyu Zhang Rujia Hou Yuan Guo Wei Xu Interdisciplinary Materials Research Center School of Materials Science and EngineeringTongji UniversityShanghai 201804P.R.China

Metallo-porphyrins with different metal centers display unique properties and are essential in various biological and chemical *** efforts have been devoted to enriching the family of metallo-porphyrins on surfaces mainly through metalation processes within porphyrins and exogenous pure metals or intrinsic surface adatoms,which have focused on transition ***,less attention has been paid to the synthesis of alkali-metal-based porphyrins on a ***,by a combination of scanning tunneling microscopy(STM)imaging/manipulations and density functional theory(DFT)calculations,we report the fabrication of Na-porphyrins on Au(111)by introducing NaCl,i.e.,two double-layered Na-centered ***,the interconversion between them was realized by precise STM *** results demonstrate the feasibility of metalation by applying inorganic salt,which would serve as a promising strategy to embed intramolecular metal components into porphyrins for further functionalization and modification.

关键词： metallo-porphyrin alkali metal on-surface chemistry scanning tunneling microscopy density functional theory

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变压器热量回收的半焊式板式换热器优化设计

变压器 2024年第9期61卷 11-15页

作者：朱司丞谢英男陆云凤冯驰金烨国网浙江省电力有限公司湖州供电公司浙江湖州313000

工业和信息化部发布的《工业能效提升行动计划》中提到,应持续提高用能设备系统能效,进一步提高工业领域能源利用率,推动优化能源资源配置。为响应国家对实施变压器能效提升行动的号召,同时为利用电网中的变压器产生的大量热能,本文作... 详细信息

工业和信息化部发布的《工业能效提升行动计划》中提到,应持续提高用能设备系统能效,进一步提高工业领域能源利用率,推动优化能源资源配置。为响应国家对实施变压器能效提升行动的号召,同时为利用电网中的变压器产生的大量热能,本文作者设计了一种用于变压器热量回收的半焊式板式换热器。首先文章对不同种板式换热器的结构和特点进行论述,根据使用条件,选择适用于变压器油与水换热的换热器类型。然后根据蜂窝长宽比等技术参数进行优化,制定了其具体的设计参数。

关键词：变压器半焊式板式换热器热量回收

Benefits of the Seattle biopsy protocol in the diagnosis of Barrett's esophagus in a chinese population

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World Journal of Clinical Cases 2018年第14期6卷 753-758页

作者： Shou-Wu Lee Han-Chung Lien chi-Sen Chang Ming-Xian Lin Chung-Hsin Chang Chung-Wang Ko Division of Gastroenterology Department of Internal Medicine Taichung Veterans General Hospital Taichung 40705 Taiwan Department of Internal Medicine Chung Shan Medical University Taichung 40201 Taiwan Department of Internal Medicine National Yang-Ming University Taipei 11221 Taiwan

AIMTo investigate the benefits of the Seattle protocol in the diagnosis of chinese individuals with Barrett’s *** enrolled were patients from one center with endoscopically-suspected esophageal metaplasia. These patients first received narrow-band imaging-targeted biopsy, and later, the Seattle protocol-guided biopsy, within a period from October 2012 to December 2014. Those cases without initial pathologic patterns of intestinal metaplasia （IM） and then appearance or loss of IM tissue were designated as Group A or B, respectively. Those with initial pathologic patterns ofIM, which then persisted or were lost were designated as Group C or D, *** number of cases for each group was as follows： A： 20, B： 78, C： 31 and D： 14. The distribution of the Prague criteria M levels of Group A was significantly higher than Group B （ P = 0.174）. Among these groups, Group C had the highest proportions of hiatus hernia （54.8%）, long segment Barrett’s esophagus （29%）, and also the highest Prague criteria M levels. The sensitivity of IM detection was 69.2% for the narrow-band imaging-targeted biopsy and 78.5% for the Lee SW et al . Seattle protocol for Barrett’s esophagusSeattle protocol-guided biopsy. The difference was not signifcant （P = 0.231）. The number of detectable dysplasias increased from one case via the NBI-target biopsy to five cases via the Seattle protocol-guided biopsy, including one case of *** Seattle protocol improved the IM detection in our subjects with higher Prague criteria M levels and disclosed more cases with dysplastic tissues.

关键词： Barrett’s esophagus Dysplasia Intestinal metaplasia Seattle protocol chinese

Gene expression profile of peripheral blood in colorectal cancer

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World Journal of Gastroenterology 2014年第39期20卷 14463-14471页

作者： Yu-Tien Chang chi-Shuan Huang Chung-Tay Yao Sui-Lung Su Harn-Jing Terng Hsiu-Ling Chou Yu-ching Chou Kang-Hua Chen Yun-Wen Shih chian-Yu Lu ching-Huang Lai Chen-En Jian chiao-Huang Lin chien-Ting Chen Yi-Syuan Wu Ke-Shin Lin Thomas Wetter chi-Wen Chang chi-Ming Chu Division of Biomedical Statistics and Informatics School of Public Health National Defense Medical Center Division of Colorectal Surgery Cheng Hsin Rehabilitation Medical Center Department of Surgery Cathay General Hospital Department of Epidemiology School of Public Health National Defense Medical Center Advpharma Inc. Department of Nursing Far Eastern Memorial Hospital and Oriental Institute of Technology Department of Nursing School of Medicine Chang Gung University Air Force Combatant Command National Defense Ministry Institute of Medical Biometry and Informatics Heidelberg University Germany Department of Biomedical Informatics and Medical Education University of Washington Seattle United States

AIM: Optimal molecular markers for detecting colorectal cancer (CRC) in a blood-based assay were evaluated.

关键词： Colorectal cancer Gene expression Microarray Internet

Glypican-3: A molecular marker for the detection and treatment of hepatocellular carcinoma

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Liver Research 2020年第4期4卷 168-172页

作者： Tsung-chieh Shih Lijun Wang Hsiao-chi Wang Yu-Jui Yvonne Wan Department of Biochemistry and Molecular Medicine University of California DavisSacramentoCAUSA Department of Pathology and Laboratory Medicine University of California DavisSacramentoCAUSA Department of Internal Medicine University of California DavisDavisCAUSA

Hepatocellular carcinoma(HCC)is a malignant tumor with a fairly poor prognosis(5-year survival of less than 50%).Using sorafenib,the only food and drug administration(FDA)-approved drug,HCC cannot be effectively treated;it can only be controlled at most for a couple of *** is a great need to develop efficacious treatment against this debilitating ***-3(GPC3),a member of the glypican family that attaches to the cell surface by a glycosylphosphatidylinositol anchor,is overex-pressed in HCC cases and is elevated in the serum of a large proportion of patients with ***3 expression contributes to HCC growth and ***,several different types of antibodies targeting GPC3 have been *** aim of this review is to summarize the current literatures on the GPC3 expression in human HCC,molecular mechanisms of GPC3 regulation and antibodies targeting GPC3.

关键词： Glypican-3(GPC3) Wnt signaling Hepatocellular carcinoma(HCC)