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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 852-862页

作者： Zhoujun Ma yizhou Zhou Yuping Zheng Li Yang Zhinong Wei the College of Energy and Electrical Engineering Hohai UniversityNanjing 211100China State Grid Jiangsu Electric Power Co. Ltd.Nanjing 210019China State Key Laboratory ofSmart Grid Protection and Control NARI Group CorporationNanjing 211106China

This paper proposes a distributed robust optimal dispatch model to enhance information security and interaction among the operators in the regional integrated energy system(RIES).Our model regards the distribution network and each energy hub(EH)as independent operators and employs robust optimization to improve operational security caused by wind and photovoltaic(PV)power output uncertainties,with only deterministic information exchanged across *** paper also adopts the alternating direction method of multipliers(ADMM)algorithm to facilitate secure information interaction among multiple RIES operators,maximizing the benefit for each ***,the traditional ADMM algorithm with fixed step size is modified to be adaptive,addressing issues of redundant interactions caused by suboptimal initial step size settings.A case study validates the effectiveness of the proposed model,demonstrating the superiority of the ADMM algorithm with adaptive step size and the economic benefits of the distributed robust optimal dispatch model over the distributed stochastic optimal dispatch model.

关键词： Regional integrated energy system(RIES) distributed optimization robust optimization operation security energy hub(EH)

Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp^(3.)and C(sp)-C(sp^(2))bonds

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Chinese Chemical Letters 2024年第7期35卷 253-258页

作者： Lei Wan yizhou Tong Xi Lu Yao Fu Hefei National Research Center for Physical Sciences at the Microscale iChEMCAS Key Laboratory of Urban Pollutant ConversionAnhui Province Key Laboratory of Biomass Clean EnergyUniversity of Science and Technology of ChinaHefei 230026China Key Laboratory of Precision and Intelligent Chemistry School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China

Transition-metal-catalyzed cross-electrophile coupling has emerged as a reliable method for constructing carbon–carbon ***,we report a general method,cobalt-catalyzed reductive alkynylation,to construct C(sp)-C(sp^(3.)and C(sp)-C(sp^(2))*** presented reaction has a broad substrate scope,enabling the efficient cross-electrophile coupling between alkynyl bromides with alkyl halides and aryl or alkenyl(pseudo)*** presented reaction is conducted under mild conditions,tolerating many functional groups,thus suitable for the modification and synthesis of biologically active molecules.

关键词： Cobalt-catalysis Cross-electrophile coupling Carbon-carbon bond formation Reductive alkynylation Alkyne synthesis

METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs

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International Journal of Oral Science 2024年第3期16卷 528-538页

作者： yizhou Jin Xiao Han Yuejun Wang Zhipeng Fan Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina Research Unit of Tooth Development and Regeneration Chinese Academy of Medical SciencesBeijingChina

Bisphosphonate-related osteonecrosis of jaw(BRONJ)is characterized by impaired osteogenic differentiation of orofacial bone marrow stromal cells(BMSCs).Corin has recently been demonstrated to act as a key regulator in bone development and orthopedic ***,the role of corin in BRONJ-related BMSCs dysfunction remains unclarified.A m6A epitranscriptomic microarray study from our group shows that the CORIN gene is significantly upregulated and m6A hypermethylated during orofacial BMSCs osteogenic *** knockdown inhibits BMSCs osteogenic differentiation,whereas corin overexpression or soluble corin(sCorin)exerts a promotion ***,corin expression is negatively regulated by bisphosphonates(BPs).Corin overexpression or sCorin reverses BPs-impaired BMSCs differentiation ***,we find altered expression of phos-ERK in corin knockdown/overexpression BMSCs and BMSCs under sCorin ***98059(a selective ERK inhibitor)blocks the corin-mediated promotion *** regard to the high methylation level of corin during osteogenic differentiation,we apply a non-selective m6A methylase inhibitor,Cycloleucine,which also blocks the corin-mediated promotion ***,we demonstrate that METTL7A modulates corin m6A modification and reverses BPs-impaired BMSCs function,indicating that METTL7A regulates corin expression and thus contributes to orofacial BMSCs differentiation *** conclude,our study reveals that corin reverses BPs-induced BMSCs dysfunction,and METTL7A-mediated corin m6A modification underlies corin promotion of osteogenic differentiation via the ERK *** hope this brings new insights into future clinical treatments for BRONJ.

关键词： impaired cor mediated

Revealing the Void Formation Mechanism during Superplastic Deformation of a Fine-Grained Ni-Co-Base Superalloy

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 915-920页

作者： Rashad AAl-Hammadi Rui Zhang Chuanyong Cui Zijian Zhou yizhou Zhou Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

The mechanism behind void formation during superplasticity remains a subject of *** study presented a novel insight into the void formation in a fine-grained Ni-Co-based superalloy during *** was observed that the dissolution ofγ′-particles resulted in the creation of vacancies due to differences in atomic size between the matrix and the *** vacancies acted as inclusions,leading to the formation of ***,excessive void formation correlated with higher particle dissolution was experimentally observed,highlighting a direct relationship between void formation and particle dissolution.

关键词： Superplasticity Void formation Ni-Co-based superalloy Microstructure

From atomistic modeling to materials design:computation-driven material development in lithium-ion batteries

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Science China Chemistry 2024年第1期67卷 276-290页

作者： Xiangrong Li Xiang Chen Qiang Bai Yifei Mo yizhou Zhu Research Center for Industries of the Future and School of Engineering Westlake UniversityHangzhou 310030China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Materials Science and Engineering University of MarylandCollege Park 20742United States

As an advanced energy storage system,lithium-ion batteries play an essential role in modern *** their ubiquitous success,there is a great demand for continuous improvements of the battery performance,including higher energy density,lower safety risk,longer cycling life,and lower *** performance improvement requires the design and development of novel electrode and electrolyte materials that exhibit desirable properties and satisfy strict *** modeling can provide a unique perspective to fundamentally understand and rationally design battery *** this paper,we review a few recent successful examples of computation-driven discovery and design in electrode and electrolyte ***,we highlight how atomistic modeling can reveal the underlying mechanisms,predict the important properties,and guide the design and engineering of electrode and electrolyte *** have a conclusion with a discussion of the unique capability of atomistic modeling in battery material development and provide a perspective on future challenges and directions for computation-driven battery material developments.

关键词： materials design computation modeling batteries electrolyte electrode

Design of low-frequency circular metastructure isolators with high-load-bearing capacity

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Chinese Journal of Aeronautics 2024年第10期37卷 207-220页

作者： Ning CHEN Zhichun YANG Te YANG yizhou SHEN Wei TIAN Yanlong XU School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China National Key Laboratory of Strength and Structural Integrity Xi’an 710065China State Key Laboratory for Strength and Vibration of Mechanical Structures Xi’an 710049China

Traditional vibration isolation structures cannot work effectively for low-frequency vibration under heavy loads,due to the inherent contradiction between the high-static and lowdynamic stiffness of these *** the challenge can be effectively addressed by introducing a negative stiffness mechanism,the existing structures inevitably have complex ***,a class of man-made structures with both extraordinary mechanical properties and simple configurations,provide a new insight for low-frequency vibration isolation *** this paper,circular metastructure isolators consisting of some simple beams are designed for low-frequency vibration,including a single-layer isolator and a double-layer isolator,and their static and dynamic characteristics are studied,*** the static characteristic,the force–displacement and stiffness–displacement curves are obtained by finite element simulation;for the dynamic characteristic,the vibration transmissibility curves are obtained analytically and *** result shows that the circular nonlinear single-layer isolator has excellent lowfrequency isolation performance,and the isolation frequency band will decrease about 20 Hz when the isolated mass is fixed at 1.53. kg,compared with a similar circular linear *** static and dynamic properties are well verified through *** work provides an innovative approach for the low-frequency vibration isolation and has wide potential applications in aeronautics.

关键词： Isolator Low-frequency Curved beam Metastructure Stiffness

Security Constrained Distributed Transaction Model for Multiple Prosumers

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 834-843页

作者： Haiteng Han Sichen Shen Zhinong Wei Mohammed Olama Haixiang Zang Guoqiang Sun yizhou Zhou School of Electrical and Power Engineering Hohai UniversityNanjing 211100China Oak Ridge National Laboratory Oak RidgeTN 37831 USA

Massive access of renewable energy has prompted demand-side distributed resources to participate in regulation and improve flexibility of power systems. With large-scale access of massive, decentralized, and diverse distributed resources, demand-side market members have transformed from traditional “consumers” to “prosumers”. To explore the distributed transaction model of prosumers, in this paper, a multi-prosumer distributed transaction model is proposed, and the Conditional Value-at-Risk (CVaR) theory is applied to quantify potential risks caused by the stochastic characteristics inherited from renewable energy. First, a prosumer model under constraints of the distribution network including photovoltaic units, fuel cells, energy storage system, central air conditioning and flexible loads is established, and a multi-prosumer distributed transaction strategy is proposed to achieve power sharing among multiple prosumers. Second, a prosumer transaction model based on CVaR is constructed to measure risks inherited from the uncertainty of PV output within the prosumer and ensure safety of system operation in extreme PV output scenarios. Then, the alternating direction multiplier method (ADMM) is utilized to solve the constructed model efficiently. Finally, distributed transaction costs of prosumers are distributed fairly based on the generalized Nash equilibrium to maximize social benefits. Simulation results show the multi-prosumer distributed transaction mechanism established under the proposed generalized Nash equilibrium method can encourage power sharing among prosumers, increasing their own income and social benefits. Also, the CVaR can assist decision making of prosumers in weighting the risks and benefits, improving system resilience through energy management of prosumers.

关键词： Alternating direction multiplier method Conditional Value-at-Risk distributed transaction generalized Nash equilibrium prosumer

STGNN-LMR:A Spatial–Temporal Graph Neural Network Approach Based on sEMG Lower Limb Motion Recognition

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Journal of Bionic Engineering 2024年第1期21卷 256-269页

作者： Weifan Mao Bin Ma Zhao Li Jianxing Zhang yizhou Lu Zhuting Yu Feng Zhang Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Beijing 101408China University of Science and Technology of China Hefei 230026China Shanghai Zhongyan Jiuyi Technology Co. Ltd.Shanghai 201821China Academy of Military Science Bejing 100091China

Lower limb motion recognition techniques commonly employ Surface Electromyographic Signal(sEMG)as input and apply a machine learning classifier or Back Propagation Neural Network(BPNN)for ***,this artificial feature engineering technique is not generalizable to similar tasks and is heavily reliant on the researcher’s subject *** contrast,neural networks such as Convolutional Neural Network(CNN)and Long Short-term Memory Neural Network(LSTM)can automatically extract features,providing a more generalized and adaptable approach to lower limb motion *** this approach overcomes the limitations of human feature engineering,it may ignore the potential correlation among the sEMG *** paper proposes a spatial–temporal graph neural network model,STGNN-LMR,designed to address the problem of recognizing lower limb motion from multi-channel ***-LMR transforms multi-channel sEMG into a graph structure and uses graph learning to model spatial–temporal *** 8-channel sEMG dataset is constructed for the experimental stage,and the results show that the STGNN-LMR model achieves a recognition accuracy of 99.71%.Moreover,this paper simulates two unexpected scenarios,including sEMG sensors affected by sweat noise and sudden failure,and evaluates the testing results using hypothesis *** to the experimental results,the STGNN-LMR model exhibits a significant advantage over the control models in noise scenarios and failure *** experimental results confirm the effectiveness of the STGNN-LMR model for addressing the challenges associated with sEMG-based lower limb motion recognition in practical scenarios.

关键词： Lower limb motion recognition Exoskeleton sEMG.Graph neural network Noise Sensor failure

Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing

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National Science Review 2024年第6期11卷 285-293页

作者： Qiubing Chen Xuebin Wang yizhou Zhang Ming Tian Junyi Duan Ying Zhang Hao Yin Departments of Urology and Laboratory Medicine Frontier Science Center for Immunology and Metabolism Medical Research InstituteZhongnan Hospital of Wuhan UniversityWuhan University State Key Laboratory of Virology Tai Kang Center for Life and Medical Sciences Tai Kang Medical SchoolWuhan University Department of Rheumatology and Immunology Zhongnan Hospital of Wuhan UniversityWuhan University Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical Sciences RNA Institute Wuhan University

Lipid nanoparticles(LNPs) have gained clinical approval as carriers for both siRNA and mRNA. Among the crucial components of LNPs, ionizable lipids play a pivotal role in determining the efficiency of RNA delivery. In this study, we synthesized a series of ionizable lipids, denoted as HTO, with a higher count of hydroxyl groups compared to SM-102. Remarkably, LNPs based on HTO12 lipid demonstrated comparable mRNA delivery efficiency and biosafety to those based on SM-102. However, the former reduced the ratio of ionizable lipid/total lipids to mRNA in LNPs by 2.5 times compared to SM-102. The HTO12 LNP efficiently encapsulated adenine base editor mRNA and sgRNA targeting Pcsk9, leading to substantial gene editing within the liver of mice and effective reduction of the target protein. Our study underscores that ionizable lipids with multiple hydroxyl groups may facilitate an improved lipid-to-mRNA ratio to minimize the dosage of ionizable lipids for in vivo delivery.

关键词： ionizable lipid lipid nanoparticle mRNA delivery base editor delivery Pcsk9

Peak structure in the interlayer conductance of Moirésuperlattices

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Chinese Physics B 2024年第10期33卷 376-380页

作者： yizhou Tao Chao Liu Mingwen Xiao Henan Fang College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Physics Nanjing UniversityNanjing 210093China

We investigate the peak structure in the interlayer conductance of Moirésuperlattices using a tunneling theory wedeveloped *** theoretical results predict that,due to the resonance of two different partial waves,the doublepeakstructure can appear in the curve of the interlayer conductance versus twist ***,we study the influencesof the model parameters,i.e.,the chemical potential of electrodes,the thickness of Moirésuperlattice,and the strength ofinterface potential,on the peak structure of the interlayer *** particular,the parameter dependence of the peakstructure is concluded via a phase diagram,and the physical meanings of the phase diagram is ***,thepotential applications of the present work is discussed.

关键词： Moirésuperlattice interlayer conductance electronic transport twistronics