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Roles of organelle-specific autophagy in hepatocytes in the development and treatment of non-alcoholic fatty liver disease

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Chinese Medical Journal 2022年第14期135卷 1673-1681页

作者： yizhi zhang Yu Chen Fourth Department of Liver Disease(Difficult and Complicated Liver Diseases and Artificial Liver Center) Beijing You’an Hospital Affiliated to Capital Medical UniversityBeijing 100069China Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research Beijing 100069China

Non-alcoholic fatty liver disease(NAFLD)is a disorder of lipid metabolism.The lipotoxic intermediates of lipid metabolism cause mitochondrial dysfunction and endoplasmic reticulum stress.Organelle-specific autophagy is responsible for the removal of dysfunctional organelles to maintain intracellular homeostasis.Lipophagy contributes to lipid turnover by degrading lipid droplets.The level of autophagy changes during the course of NAFLD,and the activation of hepatocyte autophagy might represent a method of treating NAFLD.

关键词： Autophagy Lipophagy Mitophagy Reticulophagy Non-alcoholic fatty liver disease

Photocatalyzed[2+1]cyclization of alkenes and silylated trifluorodiazoethanes:facile entry into(difluoromethylene)cyclopropanes

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Science China Chemistry 2023年第11期66卷 3141-3147页

作者： Suo Chen yizhi zhang Shanshan Liu Xiao Shen The Institute for Advanced Studies Engineering Research Center of Organosilicon Compounds&MaterialsMinistry of EducationWuhan UniversityWuhan 430072China Shenzhen Research Institute of Wuhan University Shenzhen 518057China

Methylenecyclopropanes are among the most robust building blocks in synthetic chemistry,but the study on(difluoromethylene)-cyclopropanes is rather limited,because of the difficulty in the synthesis of these compounds.Herein,we report the invention of a novel carbene precursor,(1-diazo-2,2,2-trifluoroethyl)dimethyl(phenyl)silane(1a)and its application in the synthesis of(difluoromethylene)cyclopropanes.The reaction proceeds through photocatalyzed[2+1]cyclization of readily available alkenes and diazo compound 1a followed by the work-up of the reaction through the elimination of silyl fluoride.Both aromatic and aliphatic alkenes are tolerated by the mild reaction conditions,affording various(difluoromethylene)cyclopropanes in 44%–82%yield(>30 examples).Gram scale reaction and diversified downstream transformations highlight the synthetic potential of this methodology.The experimental and DFT calculations suggest the involvement of triplet carbene intermediate.

关键词： triplet carbene cyclopropanation methylenecyclopropanes (difluoromethylene)cyclopropanes

Over-limit risk assessment method of integrated energy system considering source-load correlation

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Global Energy Interconnection 2023年第6期6卷 661-674页

作者： Ying Wang Xiaojun Wang yizhi zhang Yigang zhang Zekai Xu School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044P.R.China

In an integrated energy system,source-load multiple uncertainties and correlations lead to an over-limit risk in operating state,including voltage,temperature,and pressure over-limit.Therefore,efficient probabilistic energy flow calculation methods and risk assessment theories applicable to integrated energy systems are crucial.This study proposed a probabilistic energy flow calculation method based on polynomial chaos expansion for an electric-heat-gas integrated energy system.The method accurately and efficiently calculated the over-limit probability of the system state variables,considering the coupling conditions of electricity,heat,and gas,as well as uncertainties and correlations in renewable energy unit outputs and multiple types of loads.To further evaluate and quantify the impact of uncertainty factors on the over-limit risk,a global sensitivity analysis method for the integrated energy system based on the analysis of covariance theory is proposed.This method considered the source-load correlation and aimed to identify the key uncertainty factors that influence stable operation.Simulation results demonstrated that the proposed method achieved accuracy to that of the Monte Carlo method while significantly reducing calculation time.It effectively quantified the over-limit risk under the presence of multiple source-load uncertainties.

关键词： Probabilistic energy flow Polynomial chaos expansion Correlation Risk assessment Analysis of covariance

Visible-Light-Induced[4+1]Cyclization-Aromatization of Acylsilanes andα,β-Unsaturated Ketones

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CCS Chemistry 2023年第2期5卷 325-333页

作者： Zhihong Zhu Weilu zhang yizhi zhang Shanshan Liu Xiao Shen Institute for Advanced Studies Engineering Research Center of Organosilicon Compounds and MaterialsMinistry of EducationWuhan UniversityWuhan 430072

Herein we report the first[4+1]cyclization-aromatization reaction of acylsilanes andα,β-unsaturated ketones.The unprecedented visible-light-induced reaction proceeded through mild conditions without addition of any catalyst or additive,affording a variety of furans with broad substrate scope and good functional-group tolerance.The synthetic utility of the method was demonstrated by various downstream transformations of the otherwise difficult-to-access sulfone-containing silyl furans.The mechanism study reveals that 1,4-diketones are not likely to be the intermediates of the reaction.

关键词： acylsilane α β-unsaturated ketone carbene photo chemistry cyclization-aromatization furan

2D profiling of tumor chemotactic and molecular phenotype at single cell resolution using a SERS-microfluidic chip

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Nano Research 2022年第5期15卷 4357-4365页

作者： yizhi zhang Lei Wu Kuo Yang Shenfei Zong Zhuyuan Wang Yiping Cui Advanced Photonics Center School of Electronic Science and EngineeringSoutheast UniversityNanjing 210096China Department of Biomedical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Emerging single-cell technologies create new opportunities for unraveling tumor heterogeneity.However,the development of high-content phenotyping platform is still at its infancy.Here,we develop a microfluidic chip for two-dimensional(2D)profiling of tumor chemotactic and molecular features at single cell resolution.Individual cells were captured by the triangular micropillar arrays in the cell-loading channel,facilitating downstream single-cell analysis.For 2D phenotyping,the chemotactic properties of tumor cells were visualized through cellular migratory behavior in microchannels,while their protein expression was profiled with multiplex surface enhanced Raman scattering(SERS)nanovectors,in which Raman reporter-embedded gold@silver core-shell nanoparticles(Au@Ag REPs)were modified with DNA aptamers targeting cellular surface proteins.As a proof of concept,breast cancer cells with diverse phenotypes were tested on the chip,demonstrating the capability of this platform for simultaneous chemotactic and molecular analysis.The chip is expected to provide a powerful tool for investigating tumor heterogeneity and promoting clinical precision medicine.

关键词： gold@silver nanoparticles surface enhanced Raman spectroscopy microfluidic chip single cell analysis two-dimensional(2D)phenotype profiling

A generalized synthesis method for freestanding multiferroic twodimensional layered supercell oxide films via a sacrificial buffer layer

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Nano Research 2023年第7期16卷 10559-10566页

作者： Jianan Shen Benson Kunhung Tsai Ke Xu Anyu Shang James PBarnard yizhi zhang Rahul Tripathi Zhihong Chen Xinghang zhang Haiyan Wang School of Materials Engineering Purdue UniversityWest LafayetteIndiana 47907USA Elmore Family School of Electrical and Computer Engineering Purdue UniversityWest LafayetteIndiana 47907USA Birck Nanotechnology Center Purdue UniversityWest LafayetteIndiana 47907USA

Multiferroics are an intriguing family of materials due to the simultaneous presence of two ferroic orderings,namely,ferroelectricity and ferromagnetism.They are scientifically and technologically important and have numerous potential applications,such as four-state logic memories and multiferroic tunneling junctions.However,the growth of epitaxial singlephase multiferroic thin films typically requires single crystalline oxide substrates,which hinders their future integration with Sibased devices.In this study,we report a generalized synthesis method that uses the polydimethylsiloxane(PDMS)-assisted wetetching method with an Sr_(3)Al_(2)O_(6)(SAO)sacrificial layer to transfer freestanding single-phase multiferroic Bi_(2)NiMnO_(6)(BNMO)films from conventional SrTiO_(3)(STO)substrates onto a Si wafer.The structures and properties of the films have been characterized before and after the transfer.These transferred films possess good multiferroic properties on Si wafers,indicating full compatibility with modern Si technology.This method can be generally applicable to other Bi-based multiferroic materials as well.Lastly,the original STO substrates after the transfer process have been recycled for preparing new batches of freestanding BNMO films,indicating a low-cost and sustainable method for manufacturing large-volume freestanding complex oxide thin films.

关键词： multiferroics freestanding films wet-transfer SAO sacrificial layer recyclable substrates sustainable

Natural overlaying behaviors push the limit of planar cyclic deformation performance in few-layer MoS_(2) nanosheets

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InfoMat 2023年第9期5卷 64-77页

作者： Peifeng Li Guangjie zhang Zhuo Kang Xin Zheng Yong Xie Chunyuan Liang yizhi zhang Xiaoyang Fang Rong Sun Zhiquan Liu Yeqiang Bu Yang Lu Yue zhang Shenzhen Institute of Advanced Electronic Materials Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenthe People's Republic of China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingthe People's Republic of China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Advanced Energy Materials and TechnologiesUniversity of Science and Technology BeijingBeijingthe People's Republic of China State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijingthe People's Republic of China College of Chemistry and Materials Engineering Zhejiang A&F UniversityHangzhouthe People's Republic of China Center for X-mechanics School of Aeronautics and AstronauticsZhejiang UniversityHangzhouPeople's Republic of China Department of Mechanical Engineering The University of Hong KongHong Kongthe People's Republic of China

As a typical two-dimensional(2D)transition metal dichalcogenides(TMDCs)material with nonzero band gap,MoS_(2)has a wide range of potential applications as building blocks in the field of nanoelectronics.The stability and reliability of the corresponding nanoelectronic devices depend critically on the mechanical performance and cyclic reliability of 2D MoS_(2).Although an in situ technique has been used to analyze the mechanical properties of 2D materials,the cyclic mechanical behavior,that is,fatigue,remains a major challenge in the practical application of the devices.This study was aimed at analyzing the planar cyclic performance and deformation behavior of three-layer MoS_(2)nanosheets(NSs)using an in situ transmission electron microscopy(TEM)variable-amplitude uniaxial low-frequency and cyclic loading-unloading tensile acceleration test.We also elucidated the strengthening effect of the natural overlaying affix fragments(other external NSs)or wrinkle folds(internal folds from the NS itself)on cycling performances and service life of MoS_(2)NSs by delaying the whole process of fatigue crack initiation,propagation,and fracture.The results have been confirmed by molecular dynamics(MDs)simulations.The overlaying enhancement effect effectively ensures the long-term reliability and stability of nanoelectronic devices made of few-layer 2D materials.

关键词： cyclic deformation performance few-layer MoS_(2) in situ TEM nanomechanics natural overlays strengthening effect

Genomic Selection for Frogeye Leaf Spot Resistance in Soybean

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Journal of Northeast Agricultural University(English Edition) 2024年第1期31卷 11-19页

作者： Yao Lanning Chen yizhi Li Haochen zhang Yue Xia Mingyu Ning Shicheng Ning Hailong College of Arts and Sciences Northeast Agricultural UniversityHarbin 150030China College of Life Sciences Northeast Agricultural UniversityHarbin 150030China College of Economics and Management Northeast Agricultural UniversityHarbin 150030China College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Soybean Biology Ministry of EducationKey Laboratory of Soybean Biology and Breeding/GeneticsMinistry of AgricultureCollege of AgricultureNortheast Agricultural UniversityHarbin 150030China Zhongnongfa Wudalianchi Agricultural Technology Co. LtdWudalianchi 164100HeilongjiangChina

Soybean frogeye leaf spot(FLS) disease is a global disease affecting soybean yield, especially in the soybean growing area of Heilongjiang Province. In order to realize genomic selection breeding for FLS resistance of soybean, least absolute shrinkage and selection operator(LASSO) regression and stepwise regression were combined, and a genomic selection model was established for 40 002 SNP markers covering soybean genome and relative lesion area of soybean FLS. As a result, 68 molecular markers controlling soybean FLS were detected accurately, and the phenotypic contribution rate of these markers reached 82.45%. In this study, a model was established, which could be used directly to evaluate the resistance of soybean FLS and to select excellent offspring. This research method could also provide ideas and methods for other plants to breeding in disease resistance.

关键词： LASSO regression stepwise regression genomic selection model soybean frogeye leaf spot(FLS)disease

Progress on diagnostic and prognostic markers of pancreatic cancer

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Oncology Research 2023年第2期31卷 83-99页

作者： HONG YANG WAN LI LIWEN REN YIHUI YANG yizhi zhang BINBIN GE SHA LI XIANGJIN ZHENG JINYI LIU SEN zhang GUANHUA DU BO TANG HONGQUAN WANG JINHUA WANG The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing100050China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin300060China

Pancreatic cancer is a malignant disease characterized by low survival and high recurrence rate,whose patients are mostly at the stage of locally advanced or metastatic disease when first diagnosed.Early diagnosis is particularly important because prognostic/predictive markers help guide optimal individualized treatment regimens.So far,CA19-9 is the only biomarker for pancreatic cancer approved by the FDA,but its effectiveness is limited by low sensitivity and specificity.With recent advances in genomics,proteomics,metabolomics,and other analytical and sequencing technologies,the rapid acquisition and screening of biomarkers is now possible.Liquid biopsy also occupies a significant place due to its unique advantages.In this review,we systematically describe and evaluate the available biomarkers that have the greatest potential as vital tools in diagnosing and treating pancreatic cancer.

关键词： Pancreatic cancer Biomarkers Liquid biopsy Systematic review