检索结果-南通市图书馆

环鄱阳湖城市群土地利用碳排放传导效应及预测

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水土保持研究 2024年第2期31卷 342-353页

作者：胡宜之余敦江西农业大学国土资源与环境学院南昌330045

[目的]量化地类转化视角下土地利用碳传导效应,预测环鄱阳湖城市群未来土地利用碳排放趋势,并为区域低碳土地利用管理提供决策依据。[方法]基于2000—2020年环鄱阳湖城市群土地利用碳排放变化结果,构建碳传导效应测度模型揭示土地利用... 详细信息

[目的]量化地类转化视角下土地利用碳传导效应,预测环鄱阳湖城市群未来土地利用碳排放趋势,并为区域低碳土地利用管理提供决策依据。[方法]基于2000—2020年环鄱阳湖城市群土地利用碳排放变化结果,构建碳传导效应测度模型揭示土地利用转移内部碳排放变化情况,并借助FLUS-Markov模型和GM-Markov模型对未来土地利用碳排放进行了预测。[结果]2000—2020年环鄱阳湖城市群共有1.01×10^(4)km^(2)土地发生转化,耕地与林地间的相互转化以及耕地转为建设用地最为活跃。2000—2020年环鄱阳湖城市群土地利用净碳排放由8.79×10^(6)t增至3.63×10^(7)t,碳源/碳汇比值逐年上升,其中,建设用地为主要碳源,林地为主要碳汇。不同时期土地利用碳传导效应均表现为碳排放,且呈先增后减态势,研究期间共产生4.05×10^(7)t碳排放,主要由耕地、林地和水域向建设用地转化引致。2025年、2030年、2035年环鄱阳湖城市群土地利用碳排放预测结果为4.13×10^(7)t,4.69×10^(7)t和5.39×10^(7)t。[结论]未来环鄱阳湖城市群土地利用碳排放仍会持续增加,减排重心应集中在减少建设用地碳源和增加林地碳汇两方面。

关键词：土地利用碳排放碳传导效应 FLUS-Markov模型 GM-Markov模型环鄱阳湖城市群

CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-γ production by CD4^(+) T cells

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2018年第3期15卷 260-271页

作者： Chenhong Zheng Shulei Yin Yang Yang yizhi yu Xiaohua Xie Department of Comprehensive Surgery Clinical Division of South BuildingChinese PLA General HospitalBeijing100853China National Key Laboratory of Medical Immunology and Institute of Immunology Second Military Medical UniversityShanghai200433China

The T-cell-mediated immune response is implicated in many clinical hepatic injuries, such as autoimmune hepatitis and acute virus hepatitis. CD24 is widely expressed by different immune cells and plays an important role in the pathogenesis of many autoimmune diseases. However, the role of CD24 in T-cell-mediated liver injury has not been elucidated until now. Here we showed that CD24 deficiency protects mice from concanavalin A (ConA)-induced fulminant liver injury by reducing serum interferon-γ (IFN-γ) levels. CD24 expression by hepatic T cells was markedly increased following ConA challenge. Moreover, decreased IFN-γ production by hepatic CD4^(+) T cells in CD24-deficient mice was detected, which was correlated with downregulated phosphorylation of STAT1 in hepatic tissue. In vitro experiments also supported the conclusion that CD24 deficiency impaired IFN-γ production by CD4^(+) T cells following ConA, CD3/CD28 and phorbol myristate acetate/ionomycin stimulation. Our study suggests that CD24 deficiency confers hepatoprotection by decreasing CD4^(+) T-cell-dependent IFN-γ production in vivo, which suggests that CD24 might be a potential target molecule for reducing clinical hepatitis.

关键词： CD24 CD4^(+)T cells concanavalin A(ConA) heat-stable antigen hepatitis interferon-γ liver injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

规划管控约束下耕地细碎化评价与整治分区

农业工程学报 2024年第3期40卷 283-293,F0003页

作者：魏鹏余敦胡宜之胡海洋孙聪康江西农业大学国土资源与环境学院南昌330045 江西省国土空间调查规划研究院南昌330025

科学评估耕地细碎化治理的适宜性与必要性,并进行合理的整治分区有利于耕地资源的高效利用与空间布局,促进三生空间协调发展。该研究以典型山区县及资源型城市江西省德兴市为例,基于村域尺度,从生产适宜性、空间集聚性、管控约束性3个... 详细信息

科学评估耕地细碎化治理的适宜性与必要性,并进行合理的整治分区有利于耕地资源的高效利用与空间布局,促进三生空间协调发展。该研究以典型山区县及资源型城市江西省德兴市为例,基于村域尺度,从生产适宜性、空间集聚性、管控约束性3个视角构建评价体系,采用多因素综合叠加评价法对耕地细碎化进行评价,借助三维魔方空间分类法开展整治分区研究。结果表明:1)各村耕地资源生产适宜性良好,均值为0.558;空间集聚性一般,均值为0.350;管控约束性标准差大于均值,各村差异较大;耕地细碎化治理适宜性较高,均值为0.711。2)统筹评价结果将德兴市划分为高质保障区、综合整治区、设施优化区、集约整合区以及现状维持区5区,基于各区生产适宜性、空间集聚性与管控约束性差异制定差别化整治措施与治理策略。研究结果可为耕地细碎化整治提供有益的参考借鉴。

关键词：整治分区耕地细碎化规划管控德兴市三维魔方空间

Roles of organelle-specific autophagy in hepatocytes in the development and treatment of non-alcoholic fatty liver disease

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2022年第14期135卷 1673-1681页

作者： yizhi Zhang yu Chen Fourth Department of Liver Disease(Difficult and Complicated Liver Diseases and Artificial Liver Center) Beijing You’an Hospital Affiliated to Capital Medical UniversityBeijing 100069China Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research Beijing 100069China

Non-alcoholic fatty liver disease(NAFLD)is a disorder of lipid metabolism.The lipotoxic intermediates of lipid metabolism cause mitochondrial dysfunction and endoplasmic reticulum stress.Organelle-specific autophagy is responsible for the removal of dysfunctional organelles to maintain intracellular homeostasis.Lipophagy contributes to lipid turnover by degrading lipid droplets.The level of autophagy changes during the course of NAFLD,and the activation of hepatocyte autophagy might represent a method of treating NAFLD.

关键词： Autophagy Lipophagy Mitophagy Reticulophagy Non-alcoholic fatty liver disease

在线全文

学校读者我要写书评

暂无评论

γδT细胞识别机制研究进展

中国肿瘤生物治疗杂志 2024年第3期31卷 277-282页

作者：陈怡宁(综述) 唐玲于益芝(审阅) 上海理工大学健康科学与工程学院上海200093 海军军医大学第一附属医院中医外科上海200433 海军军医大学基础医学院免疫学教研室暨免疫与炎症全国重点实验上海200433

γδT细胞在肿瘤免疫治疗中具有重要潜力,其识别抗原的特异性和MHC非依赖性使其成为治疗的有力工具。然而,γδT细胞在肿瘤发生发展过程中发挥着复杂多样的双向作用,包括产生促进肿瘤生长的IL-17。近期的研究进一步揭示了γδT细胞的识... 详细信息

γδT细胞在肿瘤免疫治疗中具有重要潜力,其识别抗原的特异性和MHC非依赖性使其成为治疗的有力工具。然而,γδT细胞在肿瘤发生发展过程中发挥着复杂多样的双向作用,包括产生促进肿瘤生长的IL-17。近期的研究进一步揭示了γδT细胞的识别机制,包括Vγ9Vδ1 TCR对EphA2的识别机制、Vγ9Vδ2 T细胞激活依赖于磷酸抗原(pAg)介导的BTN2A1-BTN3A1蛋白相互作用,以及TCR链介导的Vδ3亚群识别机制。这些发现为肿瘤免疫治疗提供了新思路,例如通过促进EphA2的表达来增强Vδ1T细胞的杀伤作用,通过干预BTN3A1-BTN2A1相互作用来控制Vγ9Vδ2 T细胞的异常活化等。随着对γδT细胞识别机制研究的不断深入,将为深入理解它们在免疫监视中的角色、优化肿瘤免疫治疗策略提供了新视角和有力支持。

关键词： γδT细胞识别机制肿瘤治疗

Cloning and Characterization of DULP,a Novel Ubiquitin-Like Molecule from Human Dendritic Cells

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2009年第1期6卷 27-33页

作者： Guoyan Liu Shuxun Liu Ping Li Ling Tang Yanmei Han Huazhang An Jiangyan Li Xiankun Dai Nan Li Xuetao Cao yizhi yu Institute of Immunology and State Key Laboratory of Medical Immunology Second Military Medical University Shanghai 200433 China Guoyan Liu and Shuxun Liu contributed equally to this study

We identified a novel ubiquitin-like molecule DULP from human dendritic cells. DULP contains a domain that shares 26% identity and 34% similarity with ubiquitin, and it possesses the corresponding Ile-44 hydrophobic patch used by mono- or poly-ubiquitin to interact with a ubiquitin-interaction motif （UIM） or ubiquitin-associated domain （UBA）. Lysine residue corresponding to 6 of ubiquitin, which is involved in the formation of a multi-ubiquitin chain that can bind proteasomal subunit Rpn10/S5a, is also conserved in its ubiquitin-homology domain. However, DULP does not possess the highly conserved C-terminus Gly-Gly required for ubiquitin conjugation or the Lys-48 required for the formation of polyubiquitin chain to target substrates for degradation, suggesting it might be a novel ubiquitin-domain protein （UDP）. DULP was found widely expressed in many cells and the ubiquitin-homology domain was not cleaved. We also confirmed that DULP expression was enriched in the nucleus and much weaker in the cytosol. Besides, we found that overexpression of DULP in 293T cells induced apoptosis, which might not be associated with the mitochondrial or proteasome pathway, with the specific mechanism remain unclear. Further investigations are needed to identify the precise biological functions of DULP. Cellular ＆ Molecular Immunology.

关键词： ubiquitin-like protein dendritic cell molecular cloning apoptosis

Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2013年第4期10卷 330-337页

作者： yuejuan Zheng Yang Yang yuhu Li Limin Xu Yi Wang Ziyi Guo Haiyan Song Muyi Yang Beier Luo Aoxiang Zheng Ping Li Yan Zhang Guang Ji yizhi yu Department of Immunology and Microbiology Shanghai University of Traditional Chinese Medicine Shanghai 201203 China National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University Shanghai 200433 China Institute of Digestive Disease Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200032 China

Approaches for controlling inflammatory responses and reducing the mortality rate of septic patients remain clinically ineffective; new drugs need to be identified that can induce anti-inflammatory responses. Ephedrine hydrochloride （EH） is a compound that is widely used in cardiovascular diseases, especially to treat hypotension caused by either anesthesia or overdose of antihypertensive drugs. In this study, we reported that EH also plays an important role in the control of the inflammatory response. EH increased IL-IO and decreased proinflammatory cytokine （IL-6, tumor-necrosis factor （TNF）-a, IL-12 and IL-11~） expression in primary peritoneal macrophages and Raw264.7 cells treated with peptidoglycan （PGN）, a Gram-positive cell wall component. The anti-inflammatory role of EH was also demonstrated in an experimental mouse model of peritonitis induced by intraperitoneal PGN injection. The phosphatidylinositol 3-kinase （PI3K）/Akt pathway was found to be responsible for the EH-mediated increase in IL-IO production and decrease in IL-6 expression. Therefore, our results illustrated that EH can help maintain immune equilibrium and diminish host damage by balancing the production of pro- and anti-inflammatory cytokines after PGN challenge. EH may be a new potential anti-inflammatory drug that can be useful for treating severe invasive Gram-positive bacterial infection.

关键词： anti-i nflammation EH ephedrine hydroch Ioride I L- 10 peptidoglycan PG N phosphatidylinositol 3-ki nase PI3K

氧化铈纳米酶-甲基丙烯酸酐化明胶水凝胶在小鼠全层皮肤缺损感染创面修复中的作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华烧伤与创面修复杂志 2024年第2期40卷 131-140页

作者：顾雅男徐翔昊王彦平李宇韬梁振余州彭毅志宋保强西安医学院西安710021 空军军医大学第一附属医院整形科西安710032 陆军军医大学(第三军医大学)第一附属医院全军烧伤研究所创伤与化学中毒全国重点实验室重庆400038

目的探讨氧化铈纳米酶-甲基丙烯酸酐化明胶(GelMA)水凝胶(以下简称复合水凝胶)在小鼠全层皮肤缺损感染创面修复中的作用。方法该研究为实验研究。采用水热法制备粒径为(116±9)nm的氧化铈纳米酶,同时制备具有多孔网状结构且成胶性能良好... 详细信息

目的探讨氧化铈纳米酶-甲基丙烯酸酐化明胶(GelMA)水凝胶(以下简称复合水凝胶)在小鼠全层皮肤缺损感染创面修复中的作用。方法该研究为实验研究。采用水热法制备粒径为(116±9)nm的氧化铈纳米酶,同时制备具有多孔网状结构且成胶性能良好的GelMA水凝胶。筛选出25μg/mL氧化铈纳米酶可明显促进人皮肤成纤维细胞增殖和具有较高的超氧化物歧化酶活性,将其加入GelMA水凝胶中制备复合水凝胶。计算用磷酸盐缓冲液(PBS)浸泡3、7 d后复合水凝胶中氧化铈纳米酶的释放百分比。将小鼠红细胞悬液分为用相应溶液处理的PBS组、Triton X-100组、氧化铈纳米酶组、GelMA水凝胶组及复合水凝胶组,利用酶标仪检测处理1 h后红细胞的溶血情况。测定用PBS、氧化铈纳米酶、GelMA水凝胶及复合水凝胶培养耐甲氧西林金黄色葡萄球菌(MRSA)和大肠埃希菌2 h后的细菌浓度。以上实验样本数均为3。取24只8周龄雄性BALB/c小鼠,在背部对称位置各制备1个用MRSA感染的全层皮肤缺损创面。将小鼠分为不进行药物干预的对照组及滴加相应溶液的氧化铈纳米酶组、GelMA水凝胶组和复合水凝胶组,每组6只小鼠。观察伤后3、7、14 d创面愈合情况并测量伤后3、7 d剩余创面面积(样本数为5)。取小鼠伤后3 d创面分泌物,检测MRSA的浓度(样本数为3),采用激光散斑血流成像系统观测小鼠伤后5 d创面血流灌注量(样本数为6)。伤后14 d,取小鼠创面组织,行苏木精-伊红染色观察新生上皮情况,行Masson染色观察胶原情况(样本数均为3)。结果浸泡3、7 d后,复合水凝胶中氧化铈纳米酶释放百分比分别约为39%、75%。处理1 h后,与Triton X-100组比较,PBS组、GelMA水凝胶组、氧化铈纳米酶组及复合水凝胶组红细胞溶血程度均明显下降(P0.05)。伤后3 d,复合水凝胶组小鼠创面MRSA浓度明显低于对照组、氧化铈纳米酶组、GelMA水凝胶组(P值均<0.05)。伤后5 d,复合水凝胶组小鼠创面血液灌注量明显大于对照组、氧化铈纳米酶组、GelMA水凝胶组(P值均<0.05)。伤后14 d,复合水凝胶组小鼠创面基本完成上皮化,上皮化情况明显优于其他3组;复合水凝胶组小鼠创面胶原含量较其他3组明显增多,排列也更为有序。结论复合水凝胶具有良好的生物相容性和体内外抗菌效果,可持续缓释氧化铈纳米酶,改善早期创面血流灌注,促进创面再上皮化及胶原合成,从而促进小鼠全层皮肤缺损感染创面愈合。

关键词：生物相容性材料水凝胶感染氧化铈纳米酶甲基丙烯酸酐化明胶创面修复

Innate immune imprints in SARS-CoV-2 Omicron variant infection convalescents

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第12期7卷 4392-4404页

作者： Zhiqing Li Xiaosu Chen Junyan Dan Tianju Hu Ye Hu Shuxun Liu Yangyang Chai Yansong Shi Jian Wu Hailai Ni Jiaqi Zhu Yanfeng Wu Nan Li yizhi yu Zhongfang Wang Jincun Zhao Nanshan Zhong Xianwen Ren Zhongyang Shen Xuetao Cao National Key Laboratory of Medical Immunology Institute of ImmunologyNaval Medical UniversityShanghai200433China Frontier Research Center for Cell Response Institute of ImmunologyCollege of Life SciencesNankai UniversityTianjin300071China Department of Immunology Institute of Basic Medical ResearchPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing100005China The Health Care Department Shanghai Changhai HospitalShanghai200433China Department of Cardiology Shanghai Changhai HospitalShanghai200433China Guangzhou Laboratory Guangzhou510300China Changping Laboratory Beijing102206China Organ Transplant Center Tianjin First Central HospitalNankai UniversityTianjin300192China

SARS-CoV-2 Omicron variant infection generally gives rise to asymptomatic to moderate COVID-19 in vaccinated people.The immune cells can be reprogrammed or“imprinted”by vaccination and infections to generate protective immunity against subsequent challenges.Considering the immune imprint in Omicron infection is unclear,here we delineate the innate immune landscape of human Omicron infection via single-cell RNA sequencing,surface proteome profiling,and plasma cytokine quantification.We found that monocyte responses predominated in immune imprints of Omicron convalescents,with IL-1β-associated and interferon(IFN)-responsive signatures with mild and moderate symptoms,respectively.Low-density neutrophils increased and exhibited IL-1β-associated and IFN-responsive signatures similarly.Mild convalescents had increased blood IL-1β,CCL4,IL-9 levels and PI3+neutrophils,indicating a bias to IL-1βresponsiveness,while moderate convalescents had increased blood CXCL10 and IFN-responsive monocytes,suggesting durative IFN responses.Therefore,IL-1β-or IFN-responsiveness of myeloid cells may indicate the disease severity of Omicron infection and mediate post-COVID conditions.

关键词： infection protective immunity