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PDA-BPs integrated mussel-inspired multifunctional hydrogel coating on PPENK implants for anti-tumor therapy,antibacterial infection and bone regeneration

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Bioactive Materials 2023年第9期27卷 546-559页

作者： yizheng li Chengde liu Xitong Cheng Jinyan Wang Yue Pan Cheng liu Shouhai Zhang Xigao Jian State Key Laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian116024China Department of Polymer Science and Engineering Dalian University of TechnologyDalian116024China State Key Laboratory of Fine Chemicals Department of Pharmaceutical SciencesSchool of Chemical EngineeringDalian University of TechnologyDalian116024China liaoning Province Engineering Research Centre of High-Performance Resins Dalian116024China

Currently,many cancer patients with bone defects are still threatened by tumor recurrence,postoperative bacterial infection,and massive bone loss.Many methods have been studied to endow bone implants with biocompatibility,but it is difficult to find an implant material that can simultaneously solve the problems of anticancer,antibacterial and bone promotion.Here,a multifunctional gelatin methacrylate/dopamine methacrylate adhesive hydrogel coating containing 2D black phosphorus(BP)nanoparticle protected by polydopamine(pBP)is prepared by photocrosslinking to modify the surface of poly(aryl ether nitrile ketone)containing phthalazinone(PPENK)implant.The multifunctional hydrogel coating works in conjunction with pBP,which can deliver drug through photothermal mediation and kill bacteria through photodynamic therapy at the initial phase followed by promotion of osteointegration.In this design,photothermal effect of pBP control the release of doxorubicin hydrochloride loaded via electrostatic attraction.Meanwhile,pBP can generate reactive oxygen species(ROS)to eliminate bacterial infection under 808 nm laser.In the slow degradation process,pBP not only effectively consumes excess ROS and avoid apoptosis induced by ROS in normal cells,but also degrade into PO43􀀀to promote osteogenesis.In summary,nanocomposite hydrogel coatings provide a promising strategy for treatment of cancer patients with bone defects.

关键词： Poly(aryl ether nitrile ketone) Nanocomposite hydrogel coating Black phosphorus Antitumor and PDT antibacterial therapy Osteogenesis

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Super-Resolution Displacement Spectroscopic Sensing over a Surface“Rainbow”

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Engineering 2022年第10期17卷 75-81页

作者： Lyu Zhou Nan Zhang Chang Chieh Hsu Matthew Singer Xie Zeng yizheng li Haomin Song Josep Jornet Yun Wu Qiaoqiang Gan Department of Electrical Engineering The State University of New York at BuffaloBuffaloNY 14260USA Department of Biomedical Engineering The State University of New York at BuffaloBuffaloNY 14260USA Department of Electrical and Computer Engineering Northeastern UniversityBostonMA 02115USA Material Science Engineering Program King Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia

Subwavelength manipulation of light waves with high precision can enable new and exciting applications in spectroscopy,sensing,and medical imaging.For these applications,miniaturized spectrometers are desirable to enable the on-chip analysis of spectral information.In particular,for imaging-based spectroscopic sensing mechanisms,the key challenge is to determine the spatial-shift information accurately(i.e.,the spatial displacement introduced by wavelength shift or biological or chemical surface binding),which is similar to the challenge presented by super-resolution imaging.Here,we report a unique"rainbow"trapping metasurface for on-chip spectrometers and sensors.Combined with super-resolution image processing,the low-setting 4×optical microscope system resolves a displacement of the resonant position within 35 nm on the plasmonic rainbow trapping metasurface with a tiny area as small as0.002 mm2.This unique feature of the spatial manipulation of efficiently coupled rainbow plasmonic resonances reveals a new platform for miniaturized on-chip spectroscopic analysis with a spectral resolution of 0.032 nm in wavelength shift.Using this low-setting 4×microscope imaging system,we demonstrate a biosensing resolution of 1.92×109exosomes per milliliter for A549-derived exosomes and distinguish between patient samples and healthy controls using exosomal epidermal growth factor receptor(EGFR)expression values,thereby demonstrating a new on-chip sensing system for personalized accurate bio/chemical sensing applications.

关键词： Rainbow trapping Metasurface Surface plasmon polaritons Super-resolution displacement On-chip biosensing

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Polystyrene nanoplastics aggravated ecotoxicological effects of polychlorinated biphenyls in on zebrafish(Danio rerio)embryos

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Geoscience Frontiers 2022年第3期13卷 168-176页

作者： yizheng li Shulin liu Qiuping Wang Yanling Zhang Xikun Chen Lei Yan Muhammad Junaid Jun Wang College of Marine Sciences South China Agricultural UniversityGuangzhou 510642China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 528478China Institute of Eco-Environmental Research Guangxi Academy of SciencesNanning 530007China

In view of the accumulation of nanoplastics(NPs)in the food chain of environment and animals,and the good adsorption properties of nano-plastics to toxic substances,it is necessary to explore the influence of NPs in living organisms.In this study,single and joint toxicological effects of polystyrene nanoplastics(PS-NPs,size 80 nm)and polychlorinated biphenyls(PCBs),were explored in freshwater aquatic animal model zebrafish(Danio rerio).Our study found that exposure to single PS-NPs induced mild acute toxicity,albeit the combined exposure of PS-NPs and polychlorinated biphenyls aggravated the toxicity of PCBs in a dose-dependent manner.Results from gene expression profiling showed that NPs exposure could activate detoxification process,resulting in a slight up-regulation of antioxidant genes(sod1,gstp1),bone development genes(bmp2,bmp4)and cardiac gene(tbx20);while PCBs suppressed the detoxification through down-regulation of these genes,and the addition of NPs will exacerbate the impact of PCBs on gene suppression.Importantly,the results of in vivo purification experiments found that NPs showed prolonged retention in liver,intestine and gills of zebrafish and they might have crossed biological barrier and accumulate in lipid-rich tissues and excretion does not appear as the significant pathway for their elimination.In conclusion,the toxic effects of polychlorinated biphenyls on chorionic protected embryos were not significant as zebrafish chorion plays an important role in resisting the invasion of pollutants;PCBs can seriously damage the bone and heart development of zebrafish,while the presence of NPs significantly enhanced the toxicity of PCBs in zebrafish,which is an alarming concern for growing NPs levels and ecological safety in aquatic environment.

关键词： Nanoplastics Zebrafish embryos Polychlorinated biphenyls(PCBs) Joint toxicity Gene expression

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小麦去甲基化酶基因DME-5B克隆与鉴定

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分子植物育种 2024年第5期22卷 1403-1409页

作者：朱明一李一政穆红梅郭尚敬聊城大学农学院聊城252000

小麦DME蛋白和水稻中ROS1是一同类DNA去甲基化酶,ROS1对水稻糊粉层数有限制作用,DME在小麦中是否有相似功能未见报道。本研究采用同源克隆技术,在小麦中克隆出TraesDME-5B基因,并对其编码蛋白的理化性质及结构特征进行生物学特性分析,... 详细信息

小麦DME蛋白和水稻中ROS1是一同类DNA去甲基化酶,ROS1对水稻糊粉层数有限制作用,DME在小麦中是否有相似功能未见报道。本研究采用同源克隆技术,在小麦中克隆出TraesDME-5B基因,并对其编码蛋白的理化性质及结构特征进行生物学特性分析,为研究去甲基化酶DME对小麦种子发育中糊粉层的影响进行初步探索。结果显示,TraesDME-5B全长5862 bp,编码1953个氨基酸,预测DME-5B蛋白为疏水蛋白,该蛋白的二级结构主要含有α-螺旋、无规卷曲等,其中无规则卷曲所占比例为60.73%,是DME-5B二级结构中最主要的构成元件,并且三级结构与二级结构预测结果高度一致。保守结构域分析显示,DME家族在禾本科植物进化过程中含有RRM_DME、ENDO3c superfamily和Perm-CXXC 3个保守结构域。结果表明,TraesDME-5B是小麦中一类DNA去甲基化酶,能够发挥DNA去甲基化作用。

关键词： DNA去甲基化小麦同源克隆 TraesDME-5B

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一种基于数据补全的大象流检测方法

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小型微型计算机系统 2024年第1期45卷 139-144页

作者：许艺凡李宜铮王光耀段靖海王科翔陶军东南大学网络空间安全学院南京211189 中航工业沈阳飞机设计研究所沈阳110036 中国航空研究院北京100029 网络通信与安全紫金山实验室南京211189

由于在网络测量中存在不可避免的数据损失,网络监测数据通常是不完备的甚至是稀疏的,这使得大象流的精确检测成为一个具有挑战性的问题.本文提出了一种基于数据补全的离线大象流检测方法.为实现对于大象流的精准检测,首先实现了一个基... 详细信息

由于在网络测量中存在不可避免的数据损失,网络监测数据通常是不完备的甚至是稀疏的,这使得大象流的精确检测成为一个具有挑战性的问题.本文提出了一种基于数据补全的离线大象流检测方法.为实现对于大象流的精准检测,首先实现了一个基于矩阵分解的数据补全算法,将流量数据补全问题转化为一个低秩矩阵奇异值分解问题.其次,在此基础上进行高阶扩展,引申出张量补全模型,利用张量CP分解实现数据补全,将原问题转化为通过最小化张量秩来恢复缺失条目的张量补全问题.最后对上面使用的矩阵补全算法和张量补全算法进行了仿真实验,对比了各算法精准度,评估了超参数,并展示了张量补全算法的时间开销.实验结果证明该方法取得了较好的效果.

关键词：大象流检测数据补全矩阵分解张量

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颈内动脉闭塞患者预后相关因素研究

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广州医药 2024年第3期55卷 255-261页

作者：韦英秀蒙喜斯崔伟彭定天李奕铮黄俏丽广西医科大学附属武鸣医院神经内科广西南宁530199

目的探讨影响颈内动脉闭塞(ICAO)患者预后的相关因素,为临床改善ICAO患者预后提供理论依据。方法回顾性分析2017—2022年广西医科大学附属武鸣医院因ICAO入住神经内科的131例患者,根据ICAO发病时间分为急性颈内动脉闭塞(AICAO)和慢性颈... 详细信息

目的探讨影响颈内动脉闭塞(ICAO)患者预后的相关因素,为临床改善ICAO患者预后提供理论依据。方法回顾性分析2017—2022年广西医科大学附属武鸣医院因ICAO入住神经内科的131例患者,根据ICAO发病时间分为急性颈内动脉闭塞(AICAO)和慢性颈内动脉闭塞(CICAO),根据预后的不同,分为预后良好和预后不良组,比较两组的基本信息(性别、年龄等)、既往病史(包括高血压、糖尿病、冠心病等)、发病时神经功能损害程度(美国国立卫生研究院卒中神经功能缺损评分NIHSS评分)、侧支循环代偿评分、介入手术开通治疗、出血转化之间的差异,分析影响患者预后的相关因素。结果CICAO患者总体预后良好,AICAO预后良好组患者发病时NIHSS评分0.05)。结论CIACO较AICAO总体预后良好,发病时NIHSS评分<6分、侧支循环代偿良好、无出血转化是IACO预后良好的相关因素。发病时NIHSS评分高、侧支循环代偿不良、出血转化是ACAO预后不良的危险因素。

关键词：颈内动脉闭塞侧支循环代偿评分 NIHSS评分闭塞颈内动脉再通出血转化

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The effect of matrine against biofilm formation in Escherichia coli

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广西医科大学学报 2017年第6期34卷 801-805页

作者： Yuming Huang Xi Peng yizheng li He Zhao Ju Qin Yashan Song Qiaoyuan Wu Yunhua liao Renal Division Department of MedicalThe First Affiliated Hospital of Guangxi Medical University Department of Nephrology The Affiliated Hospital of Guilin Medical College

Objective:To investigate the effect of matrine against biofilm formation of Escherichia coli(E.coli)in the early stage.Methods:Biofilms of E.coli(ATCC25922)was induced by using a peritoneal dialysis catheter in 96-well plates.After treatment with matrine for 24 h,the formation of biofilm on the catheters was observed by scanning electron microscope.The expressions of the flagellar gene(fliC)and motility genes(motA and motB)were determined by qPCR,and the protein expression of fliC was detected by western blotting.Results:The biofilm formation of E.coli was suppressed by different concentrations(less than the minimal inhibitory concentration)of matrine,and the mRNA levels of motA and motB as well as the mRNA and protein expression levels of fliC were decreased in a dose-dependent manner.Conclusion:Matrine could inhibit biofilm formation of E.coli via downregulating the expression of motA,motB and fliC.

关键词： matrine Escherichia coli peritoneal dialysis catheter biofilm

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Intelligent Recognition Using Ultralight Multifunctional Nano‑Layered Carbon Aerogel Sensors with Human‑like Tactile Perception

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Nano-Micro Letters 2024年第1期16卷 172-186页

作者： Huiqi Zhao yizheng Zhang Lei Han Weiqi Qian Jiabin Wang Heting Wu Jingchen li Yuan Dai Zhengyou Zhang Chris RBowen Ya Yang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro‑Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400People’s Republic of China Tencent Robotics X Shenzhen 518054People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Department of Mechanical Engineering University of BathBath BA27AKUK Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004People’s Republic of China

Humans can perceive our complex world through multi-sensory fusion.Under limited visual conditions,people can sense a variety of tactile signals to identify objects accurately and rapidly.However,replicating this unique capability in robots remains a significant challenge.Here,we present a new form of ultralight multifunctional tactile nano-layered carbon aerogel sensor that provides pressure,temperature,material recognition and 3D location capabilities,which is combined with multimodal supervised learning algorithms for object recognition.The sensor exhibits human-like pressure(0.04–100 kPa)and temperature(21.5–66.2℃)detection,millisecond response times(11 ms),a pressure sensitivity of 92.22 kPa^(−1)and triboelectric durability of over 6000 cycles.The devised algorithm has universality and can accommodate a range of application scenarios.The tactile system can identify common foods in a kitchen scene with 94.63%accuracy and explore the topographic and geomorphic features of a Mars scene with 100%accuracy.This sensing approach empowers robots with versatile tactile perception to advance future society toward heightened sensing,recognition and intelligence.

关键词： Multifunctional sensor Tactile perception Multimodal machine learning algorithms Universal tactile system Intelligent object recognition

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An Improved Method of linear Encoding Representation-A Cell linear Quadtree

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哈尔滨工业大学学报 1990年第3期22卷 28-31页

作者： He Yu Zhang Qianren Ye yizheng li Zhongrong (Department of Computer science) DepartmentofComputerscience

The linear encoding of a quadtree is an efficient way to represent the quadtree. In this paper, an improved linear quadtree, a cell linear quadtree, is proposed, in which its redundant storage is eliminated and the co... 详细信息

关键词：分支树图像处理图像编码层状数据结构编码表达法

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Bioinformatics Data Distribution and Integration via Web Services and XML

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Genomics, Proteomics & Bioinformatics 2003年第4期1卷 299-303页

作者： Xiao li and yizheng ZhangCollege of life Science, Sichuan University/Sichuan Key Laboratory of Molecular Biology and Biotechnology,Chengdu 610064, China. College of life Science Sichuan University/Sichuan Key Laboratory of Molecular Biology and Biotechnology Chengdu 610064 China.

It is widely recognized that exchange, distribution, and integration of biological data are the keys to improve bioinformatics and genome biology in post-genomic era. However, the problem of exchanging and integrating biological data is not solved satisfactorily. The extensible Markup Language (XML) is rapidly spreading as an emerging standard for structuring documents to exchange and integrate data on the World Wide Web (WWW). Web service is the next generation of WWW and is founded upon the open standards of W3C (World Wide Web Consortium) and IETF (Internet Engineering Task Force). This paper presents XML and Web Services technologies and their use for an appropriate solution to the problem of bioinformatics data exchange and integration .

关键词： biological data integration extensible Markup Language (XML) web services extensible Stylesheet Language (XSL)

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