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Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2936-2952页

作者： Liang Zhao yizhen Pang Yangfan Zhou Jianhao Chen Hao fu Wei Guo Weizhi Xu Xin Xue Guoqiang Su Long Sun Hua Wu Jingjing Zhang Zhanxiang Wang Qin Lin Xiaoyuan Chen Haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Radiation Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Colorectal Tumor Surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Cardiothoracic Surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Neurosurgery and Department of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key Laboratory of Rare Earth Photoelectric functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor *** radionuclide therapy delivers radiation directly to tumor ***1004 is a fibroblast activation protein(FAP)-targeting radiopharmaceutical,conjugated with the albumin binder Evans Blue,which has demonstrated enhanced tumor uptake and retention in previous preclinical and clinical ***,we demonstrate that^(68)Ga/^(177)Lu-labeled LNC1004 exhibits increased uptake and prolonged retention in MC38/NIH3T3-FAP and CT26/NIH3T3-FAP tumor *** therapy with^(177)Lu-LNC1004 induced a transient upregulation of PD-L1 expression in tumor *** combination of^(177)Lu-LNC1004 and anti-PD-L1 immunotherapy led to complete eradication of all tumors in MC38/NIH3T3-FAP tumor-bearing mice,with mice showing 100%tumor rejection upon ***,single-cell RNA sequencing(scRNA-seq),and TCR sequencing revealed that combination therapy reprogrammed the tumor microenvironment in mice to foster antitumor immunity by suppressing malignant progression and increasing cell-to-cell communication,CD8^(+)T-cell activation and expansion,M1 macrophage counts,antitumor activity of neutrophils,and T-cell receptor diversity.A preliminary clinical study demonstrated that^(177)Lu-LNC1004 was well-tolerated and effective in patients with refractory ***,scRNA-seq of peripheral blood mononuclear cells underscored the importance of addressing immune evasion through immune checkpoint blockade *** was emphasized by the observed increase in antigen processing and presentation juxtaposed with T cell *** conclusion,our data supported the efficacy of immunotherapy combined with^(177)Lu-LNC1004 for cancer patients with FAP-positive tumors.

关键词： immunity retention holds

MicrobMatcher: a microbial comparison software based on matrix-assisted laser desorption/ionization with time-of-flight mass spectrometry

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Journal of Biomedical Science and Engineering 2011年第5期4卷 403-409页

作者： yizhen fu Feng Liu Yalu Ye 不详

Matrix-assisted Laser Desorption/Ionization with Time-of-flight Mass Spectrometry (MALDI-TOFMS) was investigated as a method for the rapid identifica-tion of species. Current demand in microbial identi-fication is how to compare unknown strains to the known one quickly, semi-automatically and accurately. In this paper, we present a software tool that allows flexibly microbial matching in a user-friendly way, by letting the users to customize comparison parameters including: in vitro transcription enzyme, mass tolerance,minimum fragment length, intensity threshold and corresponding weights. We provide three spectral scoring functions to compute the affin-ity between the species. Therefore, the precision of microbial comparison increases. To test and verify this tool, we employed experimental spectral data based on MALDI-TOFMS and the gene sequences of *** and Salmonella. This software is written in Java for cross-platform intention.

关键词： microbial Comparison Matrix-Assisted Laser Desorption/Ionization with Time-of-Flight Mass Spectrometry

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肝细胞癌综合治疗进展

临床肝胆病杂志 2020年第10期36卷 2179-2183页

作者：傅毅振徐立中山大学肿瘤防治中心肝脏外科广州510060

原发性肝癌是全球范围内最常见的恶性肿瘤之一,其中肝细胞癌占据了约90%的病例。包括手术、消融、介入、靶向和免疫治疗在内的多学科综合治疗是肝癌治疗的有效策略。近年来,肝癌的综合治疗取得了令人惊喜的进展,特别是中晚期肝癌的联合... 详细信息

原发性肝癌是全球范围内最常见的恶性肿瘤之一,其中肝细胞癌占据了约90%的病例。包括手术、消融、介入、靶向和免疫治疗在内的多学科综合治疗是肝癌治疗的有效策略。近年来,肝癌的综合治疗取得了令人惊喜的进展,特别是中晚期肝癌的联合治疗以及药物研发的进步,使肝癌患者的整体预后得到大幅改善,靶向药物和免疫治疗的进步更有望改变肝癌的综合治疗模式。现就局部治疗和系统治疗两个大方向系统性地对近期肝癌综合治疗的进展进行论述。

关键词：癌,肝细胞治疗学

Mechanisms and regulation of defensins in host defense

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3985-4014页

作者： Jie fu Xin Zong Mingliang Jin Junxia Min fudi Wang yizhen Wang Key Laboratory of Molecular Animal Nutrition Ministry of EducationCollege of Animal SciencesZhejiang UniversityHangzhouChina Key Laboratory of Animal Nutrition and Feed Science in Eastern China Ministry of AgricultureHangzhouZhejiang ProvinceChina The First Affiliated Hospital Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310058China The Second Affiliated Hospital School of Public HealthState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhouChina The First Affiliated Hospital Basic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyangChina

As a family of cationic host defense peptides,defensins are mainly synthesized by Paneth cells,neutrophils,and epithelial cells,contributing to host *** biological functions in innate immunity,as well as their structure and activity relationships,along with their mechanisms of action and therapeutic potential,have been of great interest in recent *** highlight the key research into the role of defensins in human and animal health,we first describe their research history,structural features,evolution,and antimicrobial ***,we cover the role of defensins in immune homeostasis,chemotaxis,mucosal barrier function,gut microbiota regulation,intestinal development and regulation of cell ***,we discuss their clinical relevance and therapeutic potential in various diseases,including infectious disease,inflammatory bowel disease,diabetes and obesity,chronic inflammatory lung disease,periodontitis and ***,we summarize the current knowledge regarding the nutrient-dependent regulation of defensins,including fatty acids,amino acids,microelements,plant extracts,and probiotics,while considering the clinical application of such ***,the review summarizes the various biological functions,mechanism of actions and potential clinical significance of defensins,along with the challenges in developing defensins-based therapy,thus providing crucial insights into their biology and potential clinical utility.

关键词： immunity homeostasis lung

新工科建设背景下塑料模具设计课程思政教学案例设计

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模具制造 2023年第2期23卷 87-89页

作者：王文生李迎春李洁叶新明付一政中北大学材料科学与工程学院山西太原030051

立德树人是高校人才培养的首要任务,而课程思政既是落实立德树人的重要途径,也是新工科背景下专业课程教学改革的重要内容。以塑料模具设计中设备选择及浇注系统设计为例,具体探讨了课前-课中-课后如何将思政元素与专业知识深度融合,通... 详细信息

立德树人是高校人才培养的首要任务,而课程思政既是落实立德树人的重要途径,也是新工科背景下专业课程教学改革的重要内容。以塑料模具设计中设备选择及浇注系统设计为例,具体探讨了课前-课中-课后如何将思政元素与专业知识深度融合,通过课程的教学实践,实现了价值塑造、知识传授和能力培养的三元统一。

关键词：课程思政模具设计教学设计浇注系统

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2019年原发性肝癌治疗进展

肿瘤综合治疗电子杂志 2020年第2期6卷 86-89页

作者：傅毅振陈敏山中山大学肿瘤防治中心肝脏外科广州510060

原发性肝癌是全球范围内最常见的恶性肿瘤之一,其中约90%为肝细胞癌(以下简称“肝癌”)。中国是肝癌大国,肝癌的防治关系到国民的健康,包括手术、消融、介入、靶向和免疫治疗在内的多学科综合治疗是肝癌治疗的有效策略。2019年,在肝癌... 详细信息

原发性肝癌是全球范围内最常见的恶性肿瘤之一,其中约90%为肝细胞癌(以下简称“肝癌”)。中国是肝癌大国,肝癌的防治关系到国民的健康,包括手术、消融、介入、靶向和免疫治疗在内的多学科综合治疗是肝癌治疗的有效策略。2019年,在肝癌治疗各个领域的研究均取得了令人惊喜的成果,特别是中晚期肝癌的联合治疗和免疫治疗极大地改善了肝癌患者的预后,有望改变肝癌的治疗模式。本文将从局部治疗和系统治疗两个方向系统性地对2019年肝癌治疗进展展开综述。

关键词：原发性肝癌肝细胞癌综合治疗免疫治疗进展

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中国平安竹研究进展与发展对策

世界竹藤通讯 2024年第2期22卷 98-102页

作者：付艳茹程平丁慧金贤姜揭东海彭逸珍王海霞江西省林业科学院南昌330032

平安竹秆形奇特,是一种珍贵的观赏竹种,推广应用前景广阔。为推动平安竹的产业化开发和城市园林绿化应用,文章从生物学特性、抗性、形态学形成机理及繁育技术等方面总结分析了平安竹在中国的研究进展,并从生长规律、关键功能基因及遗传... 详细信息

平安竹秆形奇特,是一种珍贵的观赏竹种,推广应用前景广阔。为推动平安竹的产业化开发和城市园林绿化应用,文章从生物学特性、抗性、形态学形成机理及繁育技术等方面总结分析了平安竹在中国的研究进展,并从生长规律、关键功能基因及遗传转化、矮化技术、快繁技术和观赏应用价值等方面对平安竹的后续研究方向进行展望,以期为平安竹的进一步研究、种质资源创新和运用提供参考。

关键词：平安竹观赏竹种质资源园林应用中国

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黄金无氰电铸金盐制备工艺分析

福建冶金 2021年第6期50卷 17-19页

作者：陈秀华陈春发田亚辉傅义振德诚珠宝集团有限公司福建福州350208 福建晶坤尚检测技术有限公司福建福州350208

以硝基盐酸溶解黄金原料,加入氨水沉淀制取用于配制无氰电铸液所用雷酸金盐的工艺,与常规的电解法工艺相比,有以下优点:其生产设备简单,相对投入更少;同等人力条件下,由于工艺的不同,硝基盐酸法生产效率明显提高,同时避免了电解法金离... 详细信息

以硝基盐酸溶解黄金原料,加入氨水沉淀制取用于配制无氰电铸液所用雷酸金盐的工艺,与常规的电解法工艺相比,有以下优点:其生产设备简单,相对投入更少;同等人力条件下,由于工艺的不同,硝基盐酸法生产效率明显提高,同时避免了电解法金离子在阴极析出产生的金料浪费;由于省去了电解过程,更加节能。

关键词：无氰电铸硝基盐酸雷酸金

Rice3K56 is a high-quality SNP array for genome-based genetic studies and breeding in rice(Oryza sativa L.)

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The Crop Journal 2023年第3期11卷 800-807页

作者： Chaopu Zhang Min Li Lunping Liang Jun Xiang Fan Zhang Chenyang Zhang yizhen Li Jing Liang Tianqing Zheng Fanlin Zhang Hua Li Binying fu Yingyao Shi Jianlong Xu Bingchuan Tian Zhikang Li Wensheng Wang College of Agronomy Anhui Agricultural UniversityHefei 230036AnhuiChina Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572024HainanChina Higentec Co. Ltd.Changsha 410000HunanChina

Single nucleotide polymorphism(SNP)genotyping arrays provide an optimal high-throughput platform for genetic research and molecular breeding programs in both animals and *** this study,a highquality and custom-designed Rice3K56 SNP array was developed with the resequencing data of 3024 rice accessions worldwide,which was then tested extensively in 192 representative rice *** on the Gene Titan chips of Affymetrix Axiom each containing 56,606 SNP markers,the Rice3K56 array has a high genotyping reliability(99.6%),high and uniform genome coverage(an average of 6.7-kb between adjacent SNPs),abundant polymorphic information and easy automation,compared with previously developed rice SNP *** applied in rice varietal differentiation,population diversity analysis,gene mapping of 13 complex traits by a genome-wide association study analysis(GWAS),and genome selection experiments in a recombinant inbred line and a multi-parent advanced generation inter-cross populations,these properties of the Rice3K56 array were well demonstrated for its power and great potential to be a highly efficient tool for rice genetic research and genomic breeding.

关键词： Rice3K56 SNP array Genotyping Genetic analysis Molecular breeding