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Inhalable metal–organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2281-2297页

作者： Chongzheng Yan Ying liu Guozhi Zhao Huatian Yang Huaiyou Lv Genju li Yuhan li Yaqing Fu Fengqin Sun Yafei Feng yizhe li Zhongxi Zhao Department of Pharmaceutics Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesCheelloo College of MedicineShandong UniversityJinan 250012China Key University Laboratory of Pharmaceutics&Drug Delivery Systems of Shandong Province School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Cuproptosis shows enormous application prospects in lung metastasis ***,the glycolysis,Cu^(+)efflux mechanisms,and insufficient lung drug accumulation severely restrict cuproptosis ***,an inhalable poly(2-(N-oxide-N,N-diethylamino)ethyl methacrylate)(OPDEA)-coated copper-based metal–organic framework encapsulating pyruvate dehydrogenase kinase 1 siRNA(siPDK)is constructed for mediating cuproptosis and subsequently promoting lung metastasis immunotherapy,namely *** inhalation,OMP shows highly efficient lung accumulation and long-term retention,ascribing to the OPDEA-mediated pulmonary mucosa *** tumor cells,OMP is degraded to release Cu2+under acidic condition,which will be reduced to toxic Cu^(+)to induce cuproptosis under glutathione(GSH)***,siPDK released from OMP inhibits intracellular glycolysis and adenosine-5ʹ-triphosphate(ATP)production,then blocking the Cu^(+)efflux protein ATP7B,thereby rendering tumor cells more sensitive to OMP-mediated ***,OMP-mediated cuproptosis triggers immunogenic cell death(ICD)to promote dendritic cells(DCs)maturation and CD8^(+)T cells ***,OMP-induced cuproptosis up-regulates membrane-associated programmed cell death-ligand 1(PD-L1)expression and induces soluble PD-L1 secretion,and thus synergizes with anti-PD-L1 antibodies(aPD-L1)to reprogram immunosuppressive tumor microenvironment,finally yielding improved immunotherapy ***,OMP may serve as an efficient inhalable nanoplatform and afford preferable efficacy against lung metastasis through inducing cuproptosis and combining with aPD-L1.

关键词： Cuproptosis Immunogenic cell death PD-L1 checkpoint blockade Copper-based metal-organic framework Immunotherapy Tumor microenvironment Transmucosal deliveryLung metastasis

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Experimental Research on a Feasible Building Insulation Material Based Reed in China

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Journal of Thermal Science 2025年第1期34卷 176-187页

作者： liU Tiantian PENG yizhe liU lifang CAI Chenghan WANG Shuang li Hongqiang College of Civil Engineering Hunan University College of Civil Engineering Hunan University of Science and Technology School of Energy and Power Jiangsu University of Science and Technology National Center for International Research Collaboration in Building Safety and Environment (NCIRCBSE) Hunan University Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education Hunan University

The seemingly useless reeds are prepared as thermal insulation materials,which not only meet the requirements of environmental sustainability but also enhance the added value of reeds,creating new economic *** hydrophobicity of raw biomass surfaces leads to problems such as weak bonding strength and non-dense structure in the formed materials,as well as issues related to the residual insect infestations on the *** this study,reed straw was used as the raw material,and foamed geopolymer was used as the binder to prepare building insulation materials based *** improve the interfacial adhesion performance between reed straw and foamed geopolymer,a thermochemical modification method-thermal carbonization,was *** this study,the mechanical properties and hydraulic properties of the studied materials with different degrees of surface thermal modification were tested,especially the fire resistance performance,and weathering resistance performance rarely found in published *** the surface thermal modification condition of reed straw was 250℃（30 min）,the comprehensive performance of reed-based building insulation materials was the best,when the studied material density was 321.3 kg/m3;the compressive strength was 0.59 MPa;the thermal conductivity was 0.101 W/（m·K）;the pH was 11.27;the moisture absorption rate was 25.1%,and the compressive strength loss rate in wet-dry cycles was 18.5%.In addition,it had excellent fire resistance performance and weathering resistance *** new material can be widely used to improve the thermal insulation of traditional buildings and as sandwich filler in prefabricated buildings,such as preparing insulating walls.

关键词： building insulation material based reed fire resistance performance interface adhesion properties pre-treatment of reeds weathering resistance performance

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The Current Status and Prospects of China’s Low- Carbon Economic Development

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Proceedings of Business and Economic Studies 2023年第6期6卷 50-54页

作者： yizhe li Northwest Normal University Lanzhou 730070Gansu ProvinceChina

This paper aims to explore the importance of developing a low-carbon economy in China and presents a series of key ***,it emphasizes the adverse impact of economic development on the natural environment and highlights the unsustainable nature of China’s previous pursuit of economic growth at the expense of its ecological ***,the paper provides specific recommendations in response to the pressing resource and environmental challenges in current economic and social development,along with the urgent need to accelerate the transition towards a greener,low-carbon economy to achieve carbon peak and carbon neutrality *** key recommendations include continually enhancing the legal framework for a low-carbon economy,optimizing the energy structure,improving energy efficiency,and optimizing the industrial *** proposals aim to offer concrete actions to support the development of a low-carbon economy in China,encompassing legal support,energy transformation,and industrial ***,this paper underscores China’s potential in developing a low-carbon economy and calls for resolute actions to strengthen legal frameworks,foster technological innovation,and promote industrial *** actions will guide China towards a more sustainable and environmentally conscious economic future,aligning its growth trajectory with the global imperative to reduce carbon footprints.

关键词： Low-carbon economics Green development Chinese economy

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Exploring Effective Ways of Green Printing to Reduce Harmful Volatile Organic Compounds Emissions

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Proceedings of Business and Economic Studies 2024年第1期7卷 199-203页

作者： yizhe li Yao Wang Northwest Normal University Lanzhou 730070Gansu ProvinceChina

This paper delves into the transformative shift in the printing industry from traditional petroleum-based inks to sustainable alternatives,focusing on soy ***,it examines the environmental and health hazards associated with conventional printing,highlighting the detrimental impact of volatile organic compounds(VOCs)and toxic substances in *** emergence of soy ink as an eco-friendly solution is then *** from soybeans,soy ink significantly reduces the release of harmful VOCs and enhances the recyclability of printed *** paper discusses not only the environmental benefits of soy ink but also its operational and economic advantages,such as improved deinking capabilities and waste reduction.A notable development in soy ink technology is the use of soy methyl ester,which addresses the challenges of slow drying and penetration associated with traditional *** paper concludes by emphasizing the need for continued innovation in sustainable practices within the printing industry,positioning soy ink as a key player in aligning economic goals with environmental *** shift to soy-based inks exemplifies a broader trend towards sustainability,pivotal for the future health of the planet.

关键词： Soy ink Sustainable printing Environmental impact Soy methyl ester Green innovation

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Pressure-induced photoluminescence enhancement and ambient retention in confined carbon dots

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Nano Research 2022年第3期15卷 2545-2551页

作者： Qing Lou Xigui Yang Kaikai liu Zhongzheng Ding Jinxu Qin yizhe li Chaofan Lv Yuan Shang Yuewen Zhang Zhuangfei Zhang Jinhao Zang lin Dong Chong-Xin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China Supercomputer Center Zhengzhou UniversityZhengzhou 450001China

Piezochromic luminescent materials have shown great potential in advanced optoelectronic ***,most of luminescent materials usually undergo emission quenching under external ***,we demonstrate for the first time that the photoluminescence of carbon dots(CDs)confined within sodium hydroxide can be enhanced when high pressure is *** exhibit a 1.6-fold fluorescence enhancement compared with pristine ***,the enhanced fluorescence intensity can be retained after the release of pressure to ambient conditions.A combination of experimental analysis and theoretical simulations indicates that such an enhanced emission is mainly attributed to the strong conﬁnement resulting from the sodium hydroxide matrix,which can separate the CDs spatially and restrict the nonradiative *** results provide a rational strategy for manipulating the optical properties of CDs with enhanced and retainable photoluminescence(PL)performance,thus opening up a venue for designing luminescent CDs-based materials.

关键词： carbon nanodots high pressure piezochromic fluorescence confinement effect emission enhancement

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Current Status and Perspectives of Dual-Atom Catalysts Towards Sustainable Energy Utilization

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Nano-Micro Letters 2024年第7期16卷 402-440页

作者： yizhe li Yajie li Hao Sun liyao Gao Xiangrong Jin Yaping li Zhi LV lijun Xu Wen liu Xiaoming Sun State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science EngineeringCollege of ChemistryBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China Xinjiang Coal Mine Mechanical and Electrical Engineering Technology Research Center Xinjiang Institute of EngineeringUrumqi 830023Xinjiang Uygur Autonomous RegionPeople’s Republic of China

The exploration of sustainable energy utilization requires the imple-mentation of advanced electrochemical devices for efficient energy conversion and storage,which are enabled by the usage of cost-effective,high-performance ***,heterogeneous atomically dispersed catalysts are considered as potential candidates for a wide range of *** to conventional cata-lysts,atomically dispersed metal atoms in carbon-based catalysts have more unsatu-rated coordination sites,quantum size effect,and strong metal-support interactions,resulting in exceptional catalytic *** these,dual-atomic catalysts(DACs)have attracted extensive attention due to the additional synergistic effect between two adja-cent metal *** have the advantages of full active site exposure,high selectiv-ity,theoretical 100%atom utilization,and the ability to break the scaling relationship of adsorption free energy on active *** this review,we summarize recent research advancement of DACs,which includes(1)the comprehensive understanding of the synergy between atomic pairs;(2)the synthesis of DACs;(3)characterization meth-ods,especially aberration-corrected scanning transmission electron microscopy and synchrotron spectroscopy;and(4)electrochemical energy-related *** last part focuses on great potential for the electrochemical catalysis of energy-related small molecules,such as oxygen reduction reaction,CO_(2) reduction reaction,hydrogen evolution reaction,and N_(2) reduction *** future research challenges and opportunities are also raised in prospective section.

关键词： Dual-atom catalysts Synergetic effect Electrocatalysis Oxygen reduction reaction CO_(2)reduction reaction Hydrogen evolution reaction N2 reduction reaction

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荷兰Venlo型温室结构抗震性能分析

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农业工程学报 2021年第19期37卷 243-249页

作者：李一哲骈超中国建材国际工程集团有限公司上海200063

为了研究地震作用对依据荷兰规范设计的Venlo温室结构安全性的影响,该研究以荷兰公司设计的山东某Venlo型温室为例,利用有限元软件MIDASGen,采用振型分解反应谱法对设防烈度分别为7度(0.10g)、7度(0.15g)、8度(0.20 g)和8度(0.30 g)的... 详细信息

为了研究地震作用对依据荷兰规范设计的Venlo温室结构安全性的影响,该研究以荷兰公司设计的山东某Venlo型温室为例,利用有限元软件MIDASGen,采用振型分解反应谱法对设防烈度分别为7度(0.10g)、7度(0.15g)、8度(0.20 g)和8度(0.30 g)的温室整体结构进行模拟计算,对结构的周期、振型、应力和位移进行了分析探讨。结果显示,温室整体的最长自振周期为1.75 s,表现为较柔性的结构体系,前2阶振型分别为Y、X向的平动,在2个主轴方向上具有相近的抗震性能。不同设防烈度下,结构的承载力最大值均为216.96 MPa,由风荷载控制,最大应力小于构件屈服强度。当设防烈度为8度(0.30 g)时,X向地震作用对构件的拉、压应力最大,分别为211.95和196.02 MPa。无地震参与的荷载组合中X向风荷载产生的位移最大,达到31.80 mm。在地震参与的荷载组合中,柱顶最大位移为61.84 mm,结构变形主要受地震荷载的影响,Y向地震作用超过同工况下X向地震作用约11.6%。结论表明,引进的荷兰温室在地震设防烈度不高于8度(0.30 g)时,构件始终处于弹性范围内,满足规范要求,但最大变形超过了中国建筑抗震设计对弹性层间位移角1/250的要求。最后,该文对中国农业温室结构设计标准的编制提出了一些建议。

关键词：温室结构地震设防烈度有限元 Venlo

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X80管线钢的氢脆性能

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腐蚀与防护 2021年第1期42卷 25-29页

作者：李一哲中车青岛四方机车车辆股份有限公司青岛262111

制备了单边缺口拉伸(SENT)试样,在0.5mol/L H_(2)SO_(4)+3g/L NH4SCN溶液中,以10mA/cm^(2)的电流密度充氢4h,采用拉伸试验和三点弯曲试验考察了氢脆对X80管线钢断裂韧性的影响。结果显示:充氢SENT试样的断裂韧性和承载力显著低于母材SEN... 详细信息

制备了单边缺口拉伸(SENT)试样,在0.5mol/L H_(2)SO_(4)+3g/L NH4SCN溶液中,以10mA/cm^(2)的电流密度充氢4h,采用拉伸试验和三点弯曲试验考察了氢脆对X80管线钢断裂韧性的影响。结果显示:充氢SENT试样的断裂韧性和承载力显著低于母材SENT试样的,使用三点弯曲试验测定的断裂韧性结果较为保守;充氢SENT试样的裂纹比较尖锐,呈现非稳态扩展特征,其塑性变形主要集中于裂纹尖端的局部区域;氢的存在会降低裂纹起裂和扩展所需的能量,促进韧性撕裂过程向脆性断裂转化。

关键词： X80管线钢氢脆断裂韧性裂纹尖端

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老年人网络健康信息检索行为实验研究

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图书情报工作 2014年第12期58卷 102-108页

作者：吴丹李一喆武汉大学信息管理学院

采用用户检索实验的方法,从检索工具选择、检索式构造、检索结果浏览和选择4个阶段分析老年人网络健康信息检索的行为特点、行为模式以及网络健康信息对老年人日常信息获取的影响。研究结果发现:老年人在检索过程中表现出明显的依赖性... 详细信息

采用用户检索实验的方法,从检索工具选择、检索式构造、检索结果浏览和选择4个阶段分析老年人网络健康信息检索的行为特点、行为模式以及网络健康信息对老年人日常信息获取的影响。研究结果发现:老年人在检索过程中表现出明显的依赖性和定势性。首页/重选网页模式、跟随链接模式、重构检索式模式是老年人的高频检索行为模式。健康状况、网络熟悉程度和网络健康信息的可信度是老年人日常利用网络获取健康信息时考虑的主要因素。

关键词：老年人网络健康信息信息检索行为

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面向可再生能源接入的综合能源系统熵态机理和分析方法

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电力系统自动化 2023年第9期47卷 47-58页

作者：李家熙王丹贾宏杰李宜哲智能电网教育部重点实验室(天津大学) 天津市300072 天津市智慧能源与信息技术重点实验室(天津大学) 天津市300072

综合能源系统(IES)中不同品质能量的转换和高比例可再生能源集成背景下源荷的不确定性均增加了系统能量的不可用性。为统一量化分析上述场景中的能量不可用性,基于IES的网络属性,提出了面向可再生能源集成的IES熵态机理与分析方法。基于... 详细信息

综合能源系统(IES)中不同品质能量的转换和高比例可再生能源集成背景下源荷的不确定性均增加了系统能量的不可用性。为统一量化分析上述场景中的能量不可用性,基于IES的网络属性,提出了面向可再生能源集成的IES熵态机理与分析方法。基于IES㶲流机理模型,建立了IES物理层面热力学熵增机理模型;基于广义信息功理论,引入IES信息学等效热力学熵增机理模型。结合IES的网络化特征,定义了熵态、熵增流、熵增流量、熵增源、节点熵增等IES熵态基本概念。在此基础上,提出了IES各个环节的熵态建模方法。最后,通过算例系统验证了所提模型可有效求解IES的熵态分布,并探讨了源荷预测差异性对系统熵态分布的影响。

关键词：综合能源系统能量退化不确定性熵态熵增流

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