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儿童非典型性畸胎样/横纹肌样瘤放疗疗效及预后分析

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中华放射肿瘤学杂志 2024年第6期33卷 511-517页

作者：唐文芳范文琦李毅媛周仁华陆冬青周晴蒋马伟上海交通大学医学院附属新华医院肿瘤科上海200092

目的:分析非典型性畸胎样/横纹肌样瘤(AT/RT)患儿综合治疗的疗效及预后影响因素。方法:回顾性分析2012年11月至2022年9月于上海交通大学医学院附属新华医院肿瘤科行初次放疗的病理确诊为AT/RT儿童的临床资料。采用Pearson卡方检验或连... 详细信息

目的:分析非典型性畸胎样/横纹肌样瘤(AT/RT)患儿综合治疗的疗效及预后影响因素。方法:回顾性分析2012年11月至2022年9月于上海交通大学医学院附属新华医院肿瘤科行初次放疗的病理确诊为AT/RT儿童的临床资料。采用Pearson卡方检验或连续性校正卡方检验或Fisher确切概率法进行分类变量组间比较,采用独立样本 t检验或Wilcoxon秩和检验进行连续变量的组间比较;采用Kaplan-Meier法计算1、2年总生存(OS)率及无进展生存(PFS)率。采用单因素和多因素Cox回归分析来确定相关预后因素。结果:共纳入45名患儿,其中诊断年龄≥3岁者27名,男女比例为1.65∶1。所有患儿均行手术及放疗,39例行化疗,41例行全中枢放疗(CSI),4例行全脑或局部瘤床放疗。中位随访时间为28(13.5,49)个月。综合治疗后共14例死亡。患儿1年OS率为80.0%,PFS率为71.1%。2年OS率为75.5%,PFS率为65.7%。生存预后分析提示放疗后无影像肿瘤残存( HR=0.087,95% CI为0.011~0.697, P=0.022)是PFS的有利因素。肿瘤原发灶<4.8 cm( HR=0.221,95% CI为0.052~0.935, P=0.040)及行CSI( HR=0.085,95% CI为0.011~0.651, P=0.018)是OS的有利因素。在亚组分析中,CSI也有利于提高≥3岁患儿OS期( HR=0.014,95% CI为0~0.470, P=0.017),但PFS无明显获益。在无脑脊液播散的患儿中,放疗后无影像肿瘤残存( HR=0.066,95% CI为0.009~0.481, P=0.007;HR=0.076,95% CI为0.008~0.695, P=0.024)及行CSI( HR=0.105,95% CI为0.012~0.937, P=0.044;HR=0.054,95% CI为0.005~0.629, P=0.020)是患儿PFS及OS的有利因素,肿瘤原发灶<4.8 cm也提示更长的OS期( HR=0.094,95% CI为0.013~0.690, P=0.020)。结论:包括放疗在内的综合治疗模式提升了AT/RT患儿预后。放疗后无影像肿瘤残存与PFS改善相关;肿瘤原发灶<4.8 cm及行CSI是OS的有利因素;CSI也是≥3岁患儿及无脑脊液播散患儿的显著正面预后因素。

关键词：中枢神经系统肿瘤非典型性畸胎样/横纹肌样瘤放射疗法颅脊柱照射无进展生存总生存

COVID-19 vaccines and beyond

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Cellular & Molecular Immunology 2024年第3期21卷 207-209页

作者： yiyuan liu Danying li Jiahuai Han State Key Laboratory of Cellular Stress Biology Innovation Center for Cell BiologySchool of Life SciencesXiamen UniversityXiamenFujianChina Laboratory Animal Center Xiamen UniversityXiamenFujianChina Research Unit of Cellular Stress of CAMS Cancer Research Center of Xiamen UniversityXiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenFujianChina

Hundreds of vaccines have been developed worldwide for Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the cause of Coronavirus disease 2019(COVID-19),since the beginning of the *** vaccines have saved innumerable lives and contributed to partial control of the COVID-19 *** of the vaccines approved for clinical use exhibit satisfactory initial protection rates against corresponding ***,vaccine protection declines over time,with almost all vaccines falling below 50%protection after 6 months[1].In the case of natural infections,protection lasts longer,but the incidence of reinfection is also quite high.

关键词： vaccines acute beyond

Quantitative analysis and prediction of the sound field convergence zone in mesoscale eddy environment based on data mining methods

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Acta Oceanologica Sinica 2024年第5期43卷 110-120页

作者： Ming li Yuhang liu yiyuan Sun Kefeng liu College of Advanced Interdisciplinary Studies National University of Defense TechnologyNanjing 211101China Jiangsu Ocean University Lianyungang 222061China College of Horticulture Forestry Sciences Huazhong Agricultural UniversityWuhan 430070China

The mesoscale eddy(ME)has a significant influence on the convergence effect in deep-sea acoustic *** paper use statistical approaches to express quantitative relationships between the ME conditions and convergence zone(CZ)*** on the Gaussian vortex model,we construct various sound propagation scenarios under different eddy conditions,and carry out sound propagation experiments to obtain simulation *** a large number of samples,we first adopt the unified regression to set up analytic relationships between eddy conditions and CZ *** sensitivity of eddy indicators to the CZ is quantitatively ***,we adopt the machine learning(ML)algorithms to establish prediction models of CZ parameters by exploring the nonlinear relationships between multiple ME indicators and CZ *** the research,we can express the influence of ME on the CZ quantitatively,and achieve the rapid prediction of CZ parameters in ocean *** prediction accuracy(R)of the CZ distance(mean R:0.9815)is obviously better than that of the CZ width(mean R:0.8728).Among the three ML algorithms,Gradient Boosting Decision Tree has the best prediction ability(root mean square error(RMSE):0.136),followed by Random Forest(RMSE:0.441)and Extreme Learning Machine(RMSE:0.518).

关键词： convergence zone mesoscale eddy statistic analysis quantitative prediction machine learning

Temporoparietal Fascia Flaps for Surgical Treatment of Cartilage Exposure After the First-Stage Microtia Reconstruction

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第2期3卷 76-78页

作者： Zhicheng XU Ruhong ZHANG Qun ZHANG Feng XU Datao li yiyuan li Xia CHEN Department of Plastic and Reconstructive Surgery Shanghai Jiao Tong University School of MedicineHuangpu DistrictShanghai 200011China

Significant improvements have been achieved in microtia reconstruction using an autogenous costal cartilage ***,complications such as skin necrosis and cartilage exposure often destroy the final contour of the reconstructed *** fascia flaps are commonly used in salvage surgery because of their reliability and satisfactory ***,we report the case of a 26-year-old woman with multiple skin necroses and cartilage exposure on day 21 after the first-stage microtia *** exposure area was covered by a temporoparietal fascia flap as a single-stage *** most essential subunits survived,and the esthetic concours were harmonious and natural at 12 months *** fascia flaps are recommended as the surgical treatment for multiple skin necroses and cartilage exposure in microtia *** axial-pattern temporoparietal fascia flap is reliable for salvage auricular reconstruction and ensures satisfactory results at long-term follow-up.

关键词： Microtia Cartilage exposure Temporoparietal fascia flaps

Serious Adverse Reactions from Anti-tuberculosis Drugs among 599 Children Hospitalized for Tuberculosis

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Serious Adverse Reactions from Anti-tuberculosis Drugs among...

CAS FGOALS-g3 Model Datasets for the CMIP6 Scenario Model Intercomparison Project(ScenarioMIP)

中华医学会结核病学分会2019年全国结核病学术大会

作者： yiyuan li the second hospital of sichuan university

Backgrounds:To summarize clinical characteristics of serious adverse reactions (AR) related to antituberculosis (TB) drugs in children hospitalized for tuberculosis and to improve their ***:Inpatients diagnosed with tuberculosis during 2008 to 2013 were enrolled *** of the participants such as demographics,diagnosis,adverse reactions was recorded and ***:Of the total 599 inpatients 3.51%(21 cases) developed serious adverse reactions due to antituberculosis *** was the most common one (1.84%,11 cases).The incidence of rash with or

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Advances in Atmospheric Sciences 2020年第10期37卷 1081-1092页

作者： Ye PU Hongbo liU Ruojing YAN Hao YANG Kun XIA yiyuan li li DONG lijuan li He WANG Yan NIE Mirong SONG Jinbo XIE Shuwen ZHAO Kangjun CHEN Bin WANG Jianghao li and ling ZUO State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Atmospheric Sciences Yunnan UniversityKunming 650504China

This paper describes the datasets from the Scenario Model Intercomparison Project(ScenarioMIP)simulation experiments run with the Chinese Academy of Sciences Flexible Global Ocean–Atmosphere–Land System Model,GridPoint version 3(CAS FGOALS-g3).FGOALS-g3 is driven by eight shared socioeconomic pathways(SSPs)with different sets of future emission,concentration,and land-use *** Tier 1 and 2 experiments were carried out and were initialized using historical runs.A branch run method was used for the ensemble *** outputs were three-hourly,six-hourly,daily,and/or monthly mean values for the primary variables of the four component *** evaluation and analysis of the simulations is also *** present results are expected to aid research into future climate change and socio-economic development.

关键词： ScenarioMIP CMIP6 CAS FGOALS-g3

A multi-terminal ion-controlled transistor with multifunctionality and wide temporal dynamics for reservoir computing

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Nano Research 2024年第5期17卷 4444-4453页

作者： Kekang liu Jie li Fangzhou li yiyuan lin Hongrui liu linzi liang Zhiyuan Luo Wei liu Mengye Wang Feichi Zhou Yanghui liu School of Materials Sun Yat-Sen UniversityShenzhen 518107China School of Microelectronics Southern University of Science and TechnologyShenzhen 518055China School of Software East China Jiaotong UniversityNanchang 330013China

Reservoir computing(RC)is an energy-efficient computational framework with low training cost and high efficiency in processing spatiotemporal *** state-of-the-art fully memristor-based hardware RC system suffers from bottlenecks in the computation efficiencies and accuracy due to the limited temporal tunability in the volatile memristor for the reservoir layer and the nonlinearity in the nonvolatile memristor for the readout ***,integrating different types of memristors brings fabrication and integration *** overcome the challenges,a multifunctional multi-terminal electrolyte-gated transistor(MTEGT)that combines both electrostatic and electrochemical doping mechanisms is proposed in this work,integrating both widely tunable volatile dynamics with high temporal tunable range of 10^(2) and nonvolatile memory properties with high long-term potentiation/long-term depression(LTP/LTD)linearity into a single *** ion-controlled physical RC system fully implemented with only one type of MTEGT is constructed for image recognition using the volatile dynamics for the reservoir and nonvolatility for the readout ***,an ultralow normalized mean square error of 0.002 is achieved in a time series prediction *** is believed that the MTEGT would underlie next-generation neuromorphic computing systems with low hardware costs and high computational performance.

关键词： reservoir computing multi-terminal electrolyte-gated transistor ionic controlling rich dynamics nonlinear dynamical prediction

湖南澧县彭头山遗址燧石石制品的技术、功能与相关问题

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江汉考古 2017年第6期 42-51页

作者：李意愿湖南省文物考古研究所湖南长沙410008

对彭头山遗址中出土的燧石石制品的技术类型学分析,表明石器技术属典型的简单石核—石片技术传统,与北方的小石片石器工业特征相近。微痕分析显示石制品使用率较高,运动方式以切割和刮为主,加工对象以动物软性物质居多,推测其主要用于... 详细信息

对彭头山遗址中出土的燧石石制品的技术类型学分析,表明石器技术属典型的简单石核—石片技术传统,与北方的小石片石器工业特征相近。微痕分析显示石制品使用率较高,运动方式以切割和刮为主,加工对象以动物软性物质居多,推测其主要用于食物资源的处理。"细小石器"个体形态普遍较小的特点主要是受石料性能影响的结果,也反映了这一区域先民在原料开发利用策略上的变化。它作为一个文化因素共存于澧阳平原地区旧、新石器时代的遗址中应是打制石器传统的延续,这种现象也见于华南、华北的很多同时期文化遗存中,因此以往过分强调"细小石器"作为文化纽带的认识可能有必要重新思考。

关键词：彭头山遗址细小石器技术类型学微痕分析

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华南旧石器时代中期文化初步探讨

南方文物 2021年第1期 98-104页

作者：李意愿湖南省文物考古研究所

对澧水流域及华南地区晚更新世早中期遗址的分析,认为这一阶段旧石器文化有了新的发展,表现出明显的进步性特征。华南北部地区表现最为明显,新出现的文化因素已能表明这一时期的旧石器文化进入了承前启后、持续发展的新阶段,具有一定的... 详细信息

对澧水流域及华南地区晚更新世早中期遗址的分析,认为这一阶段旧石器文化有了新的发展,表现出明显的进步性特征。华南北部地区表现最为明显,新出现的文化因素已能表明这一时期的旧石器文化进入了承前启后、持续发展的新阶段,具有一定的区域文化和技术阶段性发展的内涵。这些新的文化特点在一定程度上也可以划分成为一个考古学文化时期,反映了华南地区特别是长江中下游古人类文化发展的一段特殊历程。同时,华南北部和南部地区的文化面貌具有的多样性,又可能与更新世晚期这一区域演化人群的复杂性有关。

关键词：华南澧水流域旧石器中期文化砾石石器工业石片石器工业