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Response of Vegetation Cover Change to Drought at Different Time-scales in the Beijing-Tianjin Sandstorm Source Region,China

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Chinese Geographical Science 2021年第3期31卷 491-505页

作者： cao Bo KONG Xiaole WANG yixuan LIU Hang PEI Hongwei SHEN Yan-Jun Key Laboratory of Agricultural Water Resources Hebei Laboratory of Agricultural Water-SavingThe Innovative Academy of Seed Design(INASEED)Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050022China University of Chinese Academy of Sciences Beijing 100049China Hebei University of Architecture Zhangjiakou 075000China

Dominated by an arid and semiarid continental climate,the Beijing-Tianjin Sandstorm Source Region(BTSSR)is a typical ecologically fragile region with frequently occurring *** provide information for regional vegetation protection and drought prevention,we assessed the relations between vegetation cover change(measured by the Normalized Difference Vegetation Index,NDVI)and the Standardized Precipitation Evapotranspiration Index(SPEI)at different time-scales,in different growth stages,in different subregions and for different vegetation types based on the Pearson's correlation coefficient in the BTSSR from 2000 to *** showed that 88.19%of the vegetated areas experienced increased NDVI in the growing season;48.3%of the vegetated areas experi-enced significantly increased NDVI(P<0.05)and were mainly in the south of the *** the growing season,a wetter climate contributed to the increased vegetation cover from 2000 to 2017,and NDVI anomalies were closely related to *** maximum correlation coefficient in the growing season(Rmax)was significantly positive(P<0.05)in 97.84%of the total vegetated *** the vegetated areas with significantly positive Rmax,pixels with short time-scales(1-3 mon)accounted for the largest proportion(33.9%).The sensitivity of vegetation to the impact of drought rose first and then decreased in the growing season,with a peak in *** with two subregions in the south,subregions in the north of the BTSSR were more sensitive to the impacts of drought variations,especially in the Xilingol Plateau and Wuzhumuqin *** four major vegetation types were sensitive to the effects of drought variations,especially *** time-scales of the most impacting droughts varied with growth stages,regions,and vegetation *** results can help us understand the relations between vegetation and droughts,which are important for ecological restoration and drought prevention.

关键词： vegetation cover change standardized precipitation evapotranspiration index(SPEI) ecological restoration drought prevention Beijing-Tianjin Sandstorm Source Region(BTSSR)Citation:cao Bo,KONG Xiaole,WANG yixuan,LIU Hang

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Oddi括约肌功能障碍动物模型的研究进展

中华肝胆外科杂志 2024年第6期30卷 476-480页

作者：林豪男梁易璇赵王強曹君葳王天麒梁卓睿王长淼大连医科大学附属第一医院普外三科大连116000 大连医科大学中西医结合学院大连116000

Oddi括约肌功能障碍(SOD)是指Oddi括约肌生理功能异常,可引发胆道、胰腺和肝脏等的一系列疾病。目前SOD的相关研究正成为热点,但是其发病机制并不明确,本文将综述国内外关于SOD的文献,分析不同实验动物模型的优劣势,并对药物和手术造模... 详细信息

Oddi括约肌功能障碍(SOD)是指Oddi括约肌生理功能异常,可引发胆道、胰腺和肝脏等的一系列疾病。目前SOD的相关研究正成为热点,但是其发病机制并不明确,本文将综述国内外关于SOD的文献,分析不同实验动物模型的优劣势,并对药物和手术造模特点进行分析,为今后相关模型建立提供参考。

关键词：奥狄括约肌功能障碍动物模型综述

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关于镍钢中的“逆转变奥氏体”

材料热处理学报 1980年第2期 26-32页

作者：陈继勤程饴萱卜万龙曹云娣林兴法浙江大学材料系

以9%Ni钢为材料研究了镍钢中'逆转变奥氏体'的形成问题。实验表明;'逆转变奥氏体'（γ′）于540℃开始形成,渗碳体（θ）在540℃以前析出。θ及γ′相与基体（α）之间分别存在Bagaryatskii和Kurdjmov-Sachs取向关系。延长回火时间,γ... 详细信息

以9%Ni钢为材料研究了镍钢中'逆转变奥氏体'的形成问题。实验表明;'逆转变奥氏体'（γ′）于540℃开始形成,渗碳体（θ）在540℃以前析出。θ及γ′相与基体（α）之间分别存在Bagaryatskii和Kurdjmov-Sachs取向关系。延长回火时间,γ′相粒子数量增多并长大。提出了γ′相形成的可能机制。讨论了γ′相在较低的回火温度下形成的原因,认为是由于回火过程中合金元素镍在局部地区偏聚引起的。

关键词：奥氏体钢中 γ固溶体金相相组成渗碳体逆转变合金元素马氏体转变金属转变膨胀曲线板条马氏体取向关系

黄芪桂枝五物汤联合依帕司他片治疗糖尿病周围神经病变临床观察

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中国中医药现代远程教育 2023年第20期21卷 135-138页

作者：边媛媛孙永志曹轶轩王艳辉孙少品保定市中医院内科河北保定071000

目的探究黄芪桂枝五物汤加味联合依帕司他片治疗糖尿病周围神经病变(DPN)的效果及对炎性因子的影响。方法选取保定市中医院2020年9月—2020年12月收治的84例DPN患者作为研究对象,按随机数字表法分为对照组和研究组,各42例;在给予常规降... 详细信息

目的探究黄芪桂枝五物汤加味联合依帕司他片治疗糖尿病周围神经病变(DPN)的效果及对炎性因子的影响。方法选取保定市中医院2020年9月—2020年12月收治的84例DPN患者作为研究对象,按随机数字表法分为对照组和研究组,各42例;在给予常规降糖治疗的基础上,对照组行依帕司他片治疗,研究组行黄芪桂枝五物汤加味联合依帕司他片治疗,比较2组患者的临床疗效及治疗前后的神经传导速度、血清炎性因子和超氧化物歧化酶(SOD)水平变化情况。结果4个疗程后,研究组的治疗总有效率为90.48%(38/42),高于对照组的73.81%(31/42),差异有统计学意义(P<0.05)。治疗后,2组神经传导速度均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);研究组炎性因子水平低于对照组,SOD水平高于对照组,差异有统计学意义(P<0.05)。结论DPN患者在应用依帕司他片的基础上辅以黄芪桂枝五物汤加味治疗,有利于减轻炎症状态,起到抗氧化的作用,可提升临床效果。

关键词：痹证痿证糖尿病周围神经病变黄芪桂枝五物汤依帕司他片中西医结合疗法

急性胰腺炎继发脾大的影响因素分析及列线图预测模型构建

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中华消化外科杂志 2024年第5期23卷 712-719页

作者：黄铂涵曹锋丁乙轩李昂罗涛王晓辉高崇崇王喆张超李非首都医科大学宣武医院普通外科、首都医科大学急性胰腺炎临床诊疗与研究中心北京100053

目的探讨急性胰腺炎(AP)继发脾大的影响因素及列线图预测模型构建。方法采用回顾性病例对照研究方法。收集2017年12月至2021年12月首都医科大学宣武医院收治的180例AP患者的临床病理资料;男124例,女56例;年龄为(49±15)岁。180例患者中... 详细信息

目的探讨急性胰腺炎(AP)继发脾大的影响因素及列线图预测模型构建。方法采用回顾性病例对照研究方法。收集2017年12月至2021年12月首都医科大学宣武医院收治的180例AP患者的临床病理资料;男124例,女56例;年龄为(49±15)岁。180例患者中,60例AP继发脾大患者设为病例组;男48例,女12例;年龄为(47±13)岁。120例AP未继发脾大患者设为对照组;男76例,女44例;年龄为(50±16)岁。观察指标:(1)AP继发脾大的发生情况和临床特征。(2)AP继发脾大的影响因素分析。(3)AP继发脾大列线图预测模型的构建及评价。正态分布的计量资料以x±s表示,组间比较采用t检验;偏态分布的计量资料以M(Q1,Q3)表示,组间比较采用秩和检验。计数资料以绝对数表示,组间比较采用χ^(2)检验或Fisher确切概率法。单因素分析根据资料类型选择对应的统计学方法。采用受试者工作特征曲线判断最佳截断值。多因素分析采用Logistic向前逐步回归模型。根据多因素分析结果构建列线图预测模型,绘制受试者工作特征曲线,以曲线下面积评价列线图预测模型的区分度。以校准曲线评价列线图预测模型的一致性,以决策曲线评价其临床获益度。结果(1)AP继发脾大的发生情况及临床特征。60例AP患者继发脾大的首次发现时间为AP发病后60(30,120)d。60例AP继发脾大患者持续呼吸功能障碍,多器官功能衰竭,疾病严重程度(轻症、中度重症及重症),胰腺和(或)胰周感染、手术治疗分别为19例,17例,4、56例,37例,32例;120例AP未继发脾大患者上述指标分别为16例,19例,43、77例,39例,29例;两组患者上述指标比较,差异均有统计学意义(χ^(2)=8.58,3.91,17.64,13.95,15.19,P7、有局部并发症是影响AP继发脾大的独立危险因素(优势比=3.85,2.86,6.40,95%可信区间为1.68∼8.85,1.18∼6.95,1.56∼26.35,P7、有局部并发症是影响AP继发脾大的独立危险因素,其列线图预测模型可预测AP继发脾大发生概率。

关键词：急性胰腺炎脾大危险因素列线图预测模型

Three-dimensional delineation of soil pollutants at contaminated sites: Progress and prospects

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Journal of Geographical Sciences 2022年第8期32卷 1615-1634页

作者： TAO Huan LIAO Xiaoyong cao Hongying ZHAO Dan HOU yixuan Institute of Geographic Sciences and Natural Resources Research CASBeijing 100101China Chinese Academy of Environmental Planning Beijing 100012China University of Chinese Academy of Sciences Beijing 100049China

The precision remediation and redevelopment of contaminated sites are crucial issues for improving the human settlement and constructing a beautiful China. Three-dimensional delineation of soil pollutants at contaminated sites is a prerequisite for precision remediation and redevelopment. However, a contaminated site is a three-dimensional complex system coupling multiple spatial elements above-and under-ground. The complexity incurs high uncertainties about the three-dimensional delineation of soil pollutants based on sparse borehole and spatial statistics and inference models. This paper first systematically reviewed the objectives of fine three-dimensional delineation of soil pollutants, the sampling strategies for soil boring, the commonly used models for delineating soil pollutants, and the relevant cases of applying these models at contaminated sites. We then summarized the effects of borehole data and three-dimensional models on soil pollutants' delineation results from biased characteristics and nonstationary conditions. The present research status and related issues on correcting the biased characteristics and nonstationary conditions were analyzed. Finally, based on the problems and challenges, we suggested the three-dimensional delineation of soil pollutants in the underground “black box” for future research from the following six priority areas: multi-scenarios, nonstationary, non-linearity, multi-source data fusion, multiple model coupling, and the delineation of co-contaminated sites.

关键词： contaminated sites soil pollution three-dimensional delineation model sparse and biased nonstationarity

Tailoring the selective adsorption sites of NiMoO by Ni particles for biomass upgrading assisted hydrogen production

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Journal of Energy Chemistry 2023年第11期86卷 480-489,I0010页

作者： Jia Wu Zhixiang Zhai Tianqi Yu Xizi Wu Shuaiqin Huang Wenqing cao yixuan Jiang Jinge Pei Shibin Yin Guangxi Key Laboratory of Electrochemical Energy Materials School of Chemistry and Chemical EngineeringSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004GuangxiChina

5-Hydroxymethylfurfural electrooxidation reaction(HMFOR)is a promising route to produce valueadded chemicals from *** it involves HMF adsorption and C-H/O-H cleavage,understanding the adsorption behavior and catalytic process of organic molecules on catalysts is ***,the selective adsorption sites of NiMoO are tuned by Ni particles for HMFOR-assisted *** and theoretical calculation results indicate that the synergistic interaction between Ni and NiMoO optimizes the adsorption/desorption of HMF/intermediates/2,5-furandicarboxylic acid(FDCA)and promotes the C-H/O-H bond cleavage,thereby improving the HMFOR kinetics(kNiMoO-Ni/kNiMoO=1.97)and FDCA selectivity(99.3%).When coupled as a two-electrode system,it can drive efficient HMF conversion(FDCA yield:98.5%)and H2production(Faradaic efficiency:99.1%)at 1.45 *** work thus offers a strategy to tune the adsorption sites of catalyst for efficient HMFOR-assisted H2production.

关键词： 5-Hydroxymethylfurfural electrooxidation Hydrogen evolution reaction Kinetics Nanowires Catalyst

200例成骨不全症高风险胎儿的产前基因诊断

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中华医学杂志 2019年第42期99卷 3328-3334页

作者：赵秀丽高劲松李璐璐李闪汪涵肖继芳张静米欢杨玉姣赵飞跃管鑫曹一璇吴易阳卢超霞杨涛张学中国医学科学院基础医学研究所北京协和医学院基础学院医学遗传学系北京100005 中国医学科学院北京协和医院妇产科北京100730

目的在完成大样本成骨不全症(OI)家系致病基因突变鉴定的基础上,为OI高风险胎儿提供遗传咨询和产前诊断.方法采用酚/氯仿法提取先证者与胎儿父母外周血及胎儿绒毛、羊水细胞或脐带血基因组DNA;联合应用聚合酶链反应(PCR)-Sanger测序方... 详细信息

目的在完成大样本成骨不全症(OI)家系致病基因突变鉴定的基础上,为OI高风险胎儿提供遗传咨询和产前诊断.方法采用酚/氯仿法提取先证者与胎儿父母外周血及胎儿绒毛、羊水细胞或脐带血基因组DNA;联合应用聚合酶链反应(PCR)-Sanger测序方法对来自158个OI家系的200例高风险胎儿和他们的父母进行相应位点的基因型鉴定;当胎儿与其母均为患病基因型时,应用微卫星标记等位基因分析的方法排除因胎儿基因组样本的母源DNA污染造成的假阳性.结果在200例OI高风险胎儿中检出OI患者83例(41.5%),隐性遗传携带者12例(6.0%).83例OI胎儿中包含COL1A1突变杂合子45例,COL1A2突变杂合子32例,IFITM5突变杂合子1例,FKBP10复合杂合突变2例,WNT1纯合突变1例,SEC24D复合杂合突变1例和CRTAP突变复合杂合子1例;12例隐性遗传携带者中包含WNT1杂合子7例、SERPINF1杂合子4例和SERPINH1杂合子1例;当母亲和胎儿同为OI致病基因型时,胎儿基因组DNA样本未见母源DNA污染,排除了胎儿假阳性可能.结论本研究建立了较完善的OI产前基因诊断体系,为200例OI高风险胎儿提供了产前基因诊断和精准遗传咨询.

关键词：成骨不全症 Ⅰ型胶原高风险胎儿产前基因诊断

Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis

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Acta Pharmaceutica Sinica B 2021年第2期11卷 505-519页

作者： Kaiyue Yu Xiuming Yu Sisi cao yixuan Wang Yuanhao Zhai Fengdie Yang Xiaoyuan Yang Yi Lu Chuanbin Wu Yuehong Xu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

Psoriatic arthritis(PsA)is a complicated psoriasis comorbidity with manifestations of psoriatic skin and arthritic joints,and tailoring specific treatment strategies for simultaneously delivering different drugs to different action sites in PsA remains *** developed a need-based layered dissolving microneedle(MN)system loading immunosuppressant tacrolimus(TAC)and antiinflammatory diclofenac(DIC)in different layers of MNs,i.e.,TD-MN,which aims to specifically deliver TAC and DIC to skin and articular cavity,achieving simultaneous alleviation of psoriatic skin and arthritic joint lesions in *** vitro and in vivo skin permeation demonstrated that the inter-layer retained TAC within the skin of~100μm,while the tip-layer delivered DIC up to~300μm into the articular ***-MN not only efficiently decreased the psoriasis area and severity index scores and recovered the thickened epidermis of imiquimod-induced psoriasis but also alleviated carrageenan/kaolin-induced arthritis even better than DIC injection through reducing joint swelling,muscle atrophy,and cartilage ***,TD-MN significantly inhibited the serum TNF-αand IL-17 A in psoriatic and arthritic *** results support that this approach represents a promising alternative to multi-administration of different drugs for comorbidity,providing a convenient and effective strategy for meeting the requirements of PsA treatment.

关键词： Layered microneedles Need-based drug delivery Tacrolimus Diclofenac sodium Psoriasis Psoriatic arthritis