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现代养生 2024年第7期24卷 547-550页

作者：乔继琛张玲红陈艳丽倪艺轩崔令花江西中医药高等专科学校医学基础部蚌埠医科大学安徽省感染与免疫重点实验室

目的探讨约氏疟原虫红内期不同发育阶段虫体蛋白电泳差异情况。方法采用约氏疟原虫17XNL虫株感染6～8周龄昆明小鼠，制备疟疾小鼠模型；每天尾静脉采血计数小鼠红细胞疟原虫感染率。待疟疾小鼠红细胞感染率达到10%以上，将小鼠摘眼球... 详细信息

目的探讨约氏疟原虫红内期不同发育阶段虫体蛋白电泳差异情况。方法采用约氏疟原虫17XNL虫株感染6～8周龄昆明小鼠，制备疟疾小鼠模型；每天尾静脉采血计数小鼠红细胞疟原虫感染率。待疟疾小鼠红细胞感染率达到10%以上，将小鼠摘眼球取血滴入肝素管抗凝，后经过白细胞滤器滤除白细胞。将含虫红细胞分为混合阶段组（对照组）和不同发育阶段组，不同发育阶段组红细胞通过Percoll分离液分离为裂殖体组和滋养体（含大、小滋养体）组。分别裂解3组疟原虫虫体，获得虫体蛋白；测定蛋白浓度后每孔上样20μg总蛋白，进行十二烷基硫酸钠聚丙烯酰胺凝胶电泳（SDS-PAGE）电泳分析；并对差异蛋白条带进行灰度值检测。结果使用Percoll分离液可以分离出滋养体、裂殖体阶段疟原虫虫体，不同发育阶段可溶性虫体蛋白条带数量差异不明显；有7个蛋白条带差异肉眼可见。其中，3个蛋白混合阶段、滋养体阶段、裂殖体阶段蛋白表达量均由高逐渐减低；3个蛋白混合阶段、滋养体阶段、裂殖体阶段蛋白表达量均由低逐渐增高；1个蛋白滋养体阶段表达量最高，混合阶段次之，裂殖体阶段最低。结论使用Percoll分离液可以分离出不同发育阶段疟原虫，不同发育阶段可溶性蛋白在蛋白表达量上有一定差异，为后续不同发育阶段虫体蛋白研究奠定基础。

关键词：约氏疟原虫红内期不同发育阶段虫体蛋白电泳分析

Solid-state synthesis and ion transport characteristics of the β-KSbF_(4) for all-solid-state fluoride-ion batteries

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Journal of Energy Chemistry 2024年第7期94卷 758-767页

作者： Jiali Liu Huahui Zhao Jingcheng Xia Lingguang Yi Xiaoyi Chen Dongdu Li Shuhan ni Xinyi Su yixuan Chen Min Liu Xianyou Wang National Base for International Science&Technology Cooperation National Local Joint Engineering Laboratory for Key Materials of New Energy Storage BatteryHunan Province Key Laboratory of Electrochemical Energy Storage&ConversionSchool of ChemistryXiangtan UniversityXiangtan 411105HunanChina College of New Energy Ningbo University of TechnologyNingbo 315336ZhejiangChina

All-solid-state fluoride ion batteries(FIBs)have been recently considered as a post-lithium-ion battery system due to their high safety and high energy *** like all solid-state lithium batteries,the key to the development of FIBs lies in room-temperature electrolytes with high ionic conductivity.β-KSbF_(4) is a kind of promising solid-state electrolyte for FIBs owing to its rational ionic conductivity and relatively wide electrochemical stability window at room ***,the previous synthesis routes ofβ-KSbF_(4) required the use of highly toxic hydrofluoric acid and the ionic conductivity of as-prepared product needs to be further ***,the β-KSbF_(4) sample with an ionic conductivity of 1.04×10^(-4)s cm^(-1)(30°C)is synthesized through the simple solid-state *** order to account for the high ionic conductivity of the as-synthesizedβ-KSbF_(4),X-ray diffraction(XRD),scanning electron microscopy(SEM),and energy dispersive X-ray spectroscopy(EDS)are used to characterize the physic-ochemical *** results show that the as-synthesizedβ-KSbF_(4) exhibits higher carrier concentra-tion of 1.0×10^(-6)S cm-Hz^(-1)K and hopping frequency of 1.31×10^(6)Hz at 30°C due to the formation of the fluorine ***,the hopping frequency shows the same trend as the changes of ionic conductivity with the changes of temperature,while the carrier concentration is found to be almost *** two different trends indicate the hopping frequency is mainly responsible for the ionic conduc-tion behavior withinβ-KSbF_(4).Furthermore,the all-solid-state FIBs,in which Ag and Pb+PbF_(2) are adopted as cathode and anode,andβ-KSbF_(4) as fluoride ion conductor,are capable of reversible charge and *** assembled FIBs show a discharge capacity of 108.4 mA h g^(-1) at 1st cycle and 74.2 mA h g^(-1) at 50th *** on an examination of the capacity decay mechanism,it has been found that deterioration of the electrolyte/electrode int

关键词： Solid-state electrolyte Carrier concentration Hopping frequency β-KSbF_(4) All-solid-state fluoride ion batteries

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基于REC技术的激光器阵列传感系统设计

红外与激光工程 2017年第10期46卷 46-51页

作者：秦逸轩倪屹姚辉轩江南大学物联网工程学院江苏无锡214122 南京大学现代工程与应用科学学院江苏南京210093

分析并提出了基于重构等效啾啁(REC)技术激光器阵列的传感系统和解调算法。REC工艺满足激光器阵列的低成本大量生产,并具备小体积的优势,在未来传感领域中有较大的实用价值。提出了一种激光器扫描的高效算法用来测量光纤布拉格光栅(FBG... 详细信息

分析并提出了基于重构等效啾啁(REC)技术激光器阵列的传感系统和解调算法。REC工艺满足激光器阵列的低成本大量生产,并具备小体积的优势,在未来传感领域中有较大的实用价值。提出了一种激光器扫描的高效算法用来测量光纤布拉格光栅(FBG)因外界应力而产生的位移量。系统的独特性在于阵列激光器通道仅需调谐0.4 nm采样数据,取代了扫描FBG主功率峰,并且算法在FBG的任意谱段均适用,可以用于多通道波峰复用的FBG传感网络中。在单通道和四通道的实验中对FBG反射谱的位移进行精确定位,初步实验证明了该系统和算法的有效性和可行性。算法得出单通道中心波长与实际中心波长误差均在5 pm以下,四通道可以到达在2 pm以下,应力与算法结果中心波长呈现很好的线性度。对今后多通道激光阵列传感具有一定参考价值。

关键词：光纤传感器激光阵列传感器解调算法多通道波分复用

DDAH1 promotes neurogenesis and neural repair in cerebral ischemia

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2097-2118页

作者： Qiming Gao Pinfei ni Yilin Wang Peiyun Huo Xiaojie Zhang Sihan Wang Fuyao Xiao yixuan Li Wei Feng Juntao Yuan Teng Zhang Qiang Li Boyu Fan Yuhao Kan Zhirui Li Yimiao Qi Junfei Xing Zhenghong Yang Haixiao Cheng Xinran Gao Xiaoyan Feng Ming Xue Yang Liu Yumin Luo Zhongbing Lu Yuming Zhao Department of Pharmacology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Cerebrovascular Diseases Research Institute and Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of ChemistryChinese Academy of SciencesBeijing 100190China College of Life Science University of Chinese Academy of SciencesBeijing 100049China Department of Laboratory Animal School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Department of Physiology and Pathophysiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Choline acetyltransferase(ChAT)-positive neurons in neural stem cell(NSC)niches can evoke adult neurogenesis(AN)and restore impaired brain function after injury,such as acute ischemic stroke(AIS).However,the relevant mechanism by which ChAT+neurons develop in NSC niches is poorly *** RNA-seq analysis revealed that dimethylarginine dimethylaminohydrolase 1(DDAH1),a hydrolase for asymmetric NG,NG-dimethylarginine(ADMA),regulated genes responsible for the synthesis and transportation of acetylcholine(ACh)(Chat,Slc5a7 and Slc18a3)after stroke *** dual-luciferase reporter assay further suggested that DDAH1 controlled the activity of ChAT,possibly through hypoxia-inducible factor 1α(HIF-1α).KC7F2,an inhibitor of HIF-1α,abolished DDAH1-induced ChAT expression and suppressed *** expected,DDAH1 was clinically elevated in the blood of AIS patients and was positively correlated with AIS *** comparing the results among Ddah1 general knockout(KO)mice,transgenic(TG)mice and wild-type(WT)mice,we discovered that DDAH1 upregulated the proliferation and neural differentiation of NSCs in the subgranular zone(SGZ)under ischemic *** a result,DDAH1 may promote cognitive and motor function recovery against stroke impairment,while these neuroprotective effects are dramatically suppressed by NSC conditional knockout of Ddah1 in mice.

关键词： DDAH1 Neurogenesis Neural repair ChAT HIF-1α ACh Stroke ADMA

An organometallic salt as the electrolyte additive to regulate lithium polysulfide redox and stabilize lithium anodes for robust lithium-sulfur batteries

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Science China Materials 2024年第9期67卷 2880-2888页

作者： yixuan Meng Meifang Zhang Youliang Wang Chen Liu Ze Zhang Ji Yu Jianxin Cai Zhenyu Yang Key Laboratory of Jiangxi Province for Environment and Energy Catalysis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Institute of Carbon Neutral New Energy Research Yuzhang Normal UniversityNanchang330031China School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhou310023China

Lithium-sulfur(Li-S)batteries with high theoretical specific energy are considered to be one of the highly promising next-generation energy storage ***,the shuttle effect of lithium polysulfides(LiPSs)and the interfacial instability of Li anodes have seriously hindered the practical application of Li-S *** the electrolyte composition with additives can significantly improve the battery performance and has attracted great ***,we propose an organometallic salt,i.e.,nickel bromide dimethoxyethane(niBr_(2)DME),as an electrolyte additive,which serves as the dual function of regulating LiPSs redox and synchronously stabilizing Li *** reveal that niBr_(2)DME can interact with LiPSs via ni-S and Li-Br bonds,and accelerate the mutual transformation of LiPSs,thus reducing the accumulation of LiPSs in the *** addition,niBr_(2)DME can form a stable LiBr-containing interfacial layer on the Li metal surface,and promote the uniform electrodeposition of Li^(+)ions,and inhibit the formation of Li ***,Li-S batteries with a concentration of 0.5 mmol L^(-1)niBr_(2)DME show an initial capacity of 919.8 mAh g^(-1)at 0.2 C,and a high capacity retention of 89.3%after 100 *** at the 4 C rate,a high discharge capacity of 602.9 mAh g^(-1)is ***,the good cycling performance is maintained under poor electrolyte conditions with sulfur loading of 4.8 mg cm^(-2)and electrlyte/sulfur ratio of 5µL mg^(-1).This work provides a positive solution to achieve the suppression of shuttle effect,the regulation of LiPSs redox and the stabilization of Li anodes.

关键词： Li-S batteries electrolyte additive nickel bromide dimethoxyethane regulating LiPSs redox stabilizing Li anode

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贾占清“安神调肝脾”法在回乳中的应用

中国民族民间医药 2024年第11期33卷 64-67,72页

作者：仝珺代波马怡轩倪江涛甘肃中医药大学甘肃兰州730000 宁夏回族自治区中医医院暨中医研究院宁夏银川750021

回乳是哺乳后期女性都会经历的一段特殊生理时期,若回乳方式不当会为乳痈、乳发等疾病的产生埋下隐患。贾占清老先生是宁夏回族自治区名老中医,从事临床工作60余载,尤工女科,并且对女性各类乳房疾病的诊治方面有自己独到的见解和丰富的... 详细信息

回乳是哺乳后期女性都会经历的一段特殊生理时期,若回乳方式不当会为乳痈、乳发等疾病的产生埋下隐患。贾占清老先生是宁夏回族自治区名老中医,从事临床工作60余载,尤工女科,并且对女性各类乳房疾病的诊治方面有自己独到的见解和丰富的经验。文章总结贾占清以“安神调肝脾”诊治回乳的经验,并对乳汁分泌及调节的中医机理佐以探讨,以期为临床治疗回乳相关疾病提供新的诊疗思路。

关键词：乳汁分泌产后回乳贾占清安神调肝脾

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水稻种质资源萌发期耐旱性评价及耐旱种质筛选

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杂交水稻 2024年第4期39卷 27-35页

作者：黄一轩刘雪严圣杰黎妮张先文刘志王伟平湖南农业大学生物科学技术学院湖南长沙410128 湖南杂交水稻研究中心湖南长沙410125 杂交水稻全国重点实验室湖南长沙410125

为探索水稻早期耐旱性鉴定方法,筛选耐旱水稻种质资源,选择4份耐旱能力有差异的水稻材料,分析其种子萌发能力在不同浓度PEG-6000模拟干旱胁迫处理下的变化,确定最适处理浓度为20%;然后以该处理浓度对26份水稻材料进行萌发试验,采用主成... 详细信息

为探索水稻早期耐旱性鉴定方法,筛选耐旱水稻种质资源,选择4份耐旱能力有差异的水稻材料,分析其种子萌发能力在不同浓度PEG-6000模拟干旱胁迫处理下的变化,确定最适处理浓度为20%;然后以该处理浓度对26份水稻材料进行萌发试验,采用主成分分析方法,明确以相对发芽势、相对发芽率、相对苗高、相对根长、萌发耐旱指数及活力指数作为耐旱评价指标,并利用平均总隶属函数和系统聚类的方法综合评价耐旱能力,筛选出高抗旱材料20H022,抗旱材料20H100、20H152、20H263和非洲陆稻;进一步以鉴定的6份抗旱能力不同的材料(20H022、20H100、20H195、20H066、非洲陆稻、日本晴)在苗期进行干旱模拟胁迫,较好地验证了萌发期耐旱性分级结果。本研究有助于水稻种质耐旱性的早期快速鉴定,为耐旱育种提供材料和鉴定方法。

关键词：水稻耐旱性种子萌发期筛选方法

钎焊时间对TiH_(2)-65ni+TiB_(2)钎料钎焊连接TiAl合金接头的影响

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机械工程学报 2024年第8期60卷 176-185页

作者：李力王一轩罗芬张文涛赵巍李小强华东交通大学材料科学与工程学院南昌330013 华东交通大学轨道交通基础设施性能监测与保障国家重点实验室南昌330013 华南理工大学国家金属材料近净成形工程技术研究中心广州510641

基于Kissinger方程计算激活能对机械球磨法制备的(TiH_(2)-65ni)_(1−x)(TiB_(2))_(x)(x=0~17.70wt.%)复合粉末钎料进行成分优化,并采用TiB_(2)含量为8.16 wt.%的最优钎料在1230℃下钎焊连接Ti-47Al-2Nb-2Cr-0.15B(at.%)合金。系统研究TiAl钎焊接头界面组织和形成机理以及钎焊时间(0~20 min)对接头界面组织和抗剪强度的影响规律,并在详尽分析接头界面组织与抗剪强度关联性基础上揭示TiB晶须的强化机制。结果表明,TiAl钎焊接头界面组织为γ-TiAl/α_(2)-Ti_(3)Al+τ_(3)-Al_(3)niTi_(2)(层Ⅰ)/τ_(3)-Al_(3)niTi_(2)+α_(2)-Ti_(3)Al(层Ⅱ)/α_(2)-Ti_(3)Al+τ_(3)-Al_(3)niTi_(2)+TiB(层Ⅲ)/τ_(3)-Al_(3)niTi_(2)+α_(2)-Ti_(3)Al(层Ⅱ)/α_(2)-Ti_(3)Al+τ_(3)-Al_(3)niTi_(2)(层Ⅰ)/γ-TiAl。随着钎焊时间的增加,与钎缝基体热力学相容性较好的TiB晶须长径比先增大而后团聚堆积,钎缝中孔洞先消失而后又出现,时间过长时钎缝中还会存在裂纹和高的残余应力,导致接头抗剪强度先增加后急剧减小。钎焊时间10 min时,接头抗剪强度达到最大值332.87 MPa,以准解理断裂方式脆断于层Ⅱ中。通过改变钎焊时间来调控TiAl合金的溶解和扩散量以期生成较多大长径比的TiB晶须,促使接头组织细化、物相分布均匀,为TiAl合金的推广使用及其高质量钎焊连接提供技术支撑。

关键词：钛基粉末钎料钛铝合金钎焊时间界面显微组织抗剪强度

基于改进YOLOv5s的绝缘子定位检测及红外故障识别

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测控技术 2024年第8期43卷 7-14,22页

作者：任毅王鹏倪彬顾鹏汪易萱刘凯波国网新疆电力有限公司巴州供电公司新疆库尔勒841000 华北电力大学北京102206

在绝缘子定位检测和热故障识别中,由于绝缘子红外图像的背景干扰严重,导致平均识别准确率低,为了实现精确定位、检测绝缘子位置和提高识别其热故障的可靠性和准确性,提出了一种基于改进YOLOv5s的绝缘子定位检测和红外故障识别方法。首先... 详细信息

在绝缘子定位检测和热故障识别中,由于绝缘子红外图像的背景干扰严重,导致平均识别准确率低,为了实现精确定位、检测绝缘子位置和提高识别其热故障的可靠性和准确性,提出了一种基于改进YOLOv5s的绝缘子定位检测和红外故障识别方法。首先,将全局上下文注意力机制与YOLOv5s Backbone部分的C3结构进行融合,提出一种新的结构——C3GC,增强了模型提取特征的能力,并且减少了其计算量。其次,将损失函数替换为VariFocal Loss,提升了模型的召回率,解决了模型漏检的问题。最后,通过引入转置卷积,动态地学习需要补充的参数,减少了模型在上采样过程中特征的丢失,提升了检测效果。实验与测试结果表明,改进后的方法与原YOLOv5s相比,定位精度提升了1.3个百分点,针对故障点的检测精度提升了4个百分点,平均精度提升了2.8个百分点,并且其精确率和召回率均有提升。

关键词： YOLOv5s 红外图像定位检测故障检测热故障