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Transcriptomic profiling of tumor microenvironment reveals distinct immune subgroups of metastatic melanoma and its potential implications for immunotherapy

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Journal of Genetics and Genomics 2021年第5期48卷 426-428页

作者： yixuan huang Peng Zhang Division of Immunotherapy Institute of Human VirologyUniversity of Maryland School of MedicineBaltimoreMD 21201USA

Agents that induce an immune response against tumors by altering the immunologic microenvironment have shown remarkable efficacy in various solid cancers,such as metastatic melanoma(Johnson and Sosman,2015;Luke et al.,2017).However,despite the high rate of response in advanced melanoma compared with other cancer types,most patients still succumb to the disease(Sharma et al.,2017;O’Donnell et al.,2019).

关键词： melanoma al. metastatic

量子材料中基于空间自相位调制的激光诱导电子相干性

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光散射学报 2024年第1期36卷 52-62页

作者：黄逸轩赵继民中国科学院物理研究所北京凝聚态物理国家研究中心北京100190 中国科学院大学物理科学学院北京100049 松山湖材料实验室东莞523808

空间自相位调制是一种三阶非线性光学效应,又称光学克尔效应。空间自相位调制的物理机制为激光诱导的非局域电子相干性,是一种集体激发行为,非线性光学响应,演生现象。物质中电子在光场的驱动下以光学频率运动,获得由外场决定的相位,分... 详细信息

空间自相位调制是一种三阶非线性光学效应,又称光学克尔效应。空间自相位调制的物理机制为激光诱导的非局域电子相干性,是一种集体激发行为,非线性光学响应,演生现象。物质中电子在光场的驱动下以光学频率运动,获得由外场决定的相位,分离区域之间保持固定的由光场决定的相位差,从而演生出非局域电子相干性,其衍射光的平行光分量在远场形成一系列同心嵌套的圆锥形发射,在远场屏上形成干涉环,此即空间自相位调制。基于激光诱导在量子材料中产生电子相干性,可以实现全光开关,具有“以弱光控制强光”的特性,功能类似于光子学中的“三极管”。本文简要综述空间自相位调制的物理机理研究及其在全光开关领域的应用前景,重点梳理空间自相位调制在新阶段的发展以及微观物理机制。

关键词：自相位调制激光诱导电子相干性非线性光学全光开关

On Design of Conjugated Transmission Scheme for FBMC/OQAM Systems with Interference Cancellation

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China Communications 2017年第8期14卷 166-175页

作者： Chuanxue Jin Su Hu yixuan huang Fan Li Jing Zhang Shiyong Ma National Key Laboratory on Communications University of Electronic Science and Technology of ChinaChengdu 611731China

Compared to OFDM systems with cyclic prefi x, fi lterbank multicarrier with offset quadrature amplitude modulation(FBMC/OQAM) system is considered as an alternative technology for next generation wireless communication systems. However, FBMC systems suffer from intrinsic imaginary interference caused by the real-fi eld orthogonality destruction when passing through complex-valued fading channels. By analyzing the transmultiplexer's response of FBMC/OQAM systems, in this paper, a simple conjugated transmission scheme is proposed for FBMC/OQAM systems. Following the specific conjugation design, the intrinsic imaginary interference including the intrinsic inter-symbol and the inter-carrier interference can be eliminated at the receiver side through linear signal processing operation. Meanwhile, the proposed conjugated transmission scheme is able to obtain extra linear combination diversity gains for improving the systematic performance of FBMC/OQAM. Simulation results show that the proposed scheme is more efficient than conventional methods, especially in practical application scenarios with large Doppler spread caused by high-speed movement.

关键词： OQAM系统 OFDM系统干扰消除传动方案共轭设计正交幅度调制无线通信系统

政策性金融的逆周期与跨周期调节作用——基于中外比较视角

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海外投资与出口信贷 2024年第2期 27-30页

作者：黄亦炫陈旭中国财政科学研究院

国内外政策性金融均源自政府调控经济的客观需要,在平抑经济周期波动、促进可持续发展中具有重要作用。我国与发达国家政策性金融作用机制的差异性主要体现在投资领域、政策调控和目标导向等方面。为进一步发挥我国政策性金融的逆周期... 详细信息

国内外政策性金融均源自政府调控经济的客观需要,在平抑经济周期波动、促进可持续发展中具有重要作用。我国与发达国家政策性金融作用机制的差异性主要体现在投资领域、政策调控和目标导向等方面。为进一步发挥我国政策性金融的逆周期与跨周期调节作用,建议优化政策性金融机构体系,加强与国内外金融机构的合作;结合政策导向和市场需求,创新政策性金融产品和服务;完善风险管理与绩效评价机制,提升政策性金融持续运营能力;强化与财政政策和货币政策的协同,充分释放政策性金融调结构功能。

关键词：政策性金融逆周期调节跨周期调节中外比较

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长江经济带城市灾害风险与应对能力耦合分析

人民长江 2024年第5期55卷 7-14页

作者：张达石云李祖昊黄译萱防灾科技学院生态环境学院河北廊坊065201 湖南师范大学地理科学学院湖南长沙410006

长江经济带具有复杂多变的地理环境与水文条件,分析其主要城市的自然灾害风险以及评估综合应对能力的适应性具有现实紧迫性。建构了自然灾害风险和综合应对能力评价指标体系,评价分析了2014~2020年间重庆、武汉、上海3座中心城市的自然... 详细信息

长江经济带具有复杂多变的地理环境与水文条件,分析其主要城市的自然灾害风险以及评估综合应对能力的适应性具有现实紧迫性。建构了自然灾害风险和综合应对能力评价指标体系,评价分析了2014~2020年间重庆、武汉、上海3座中心城市的自然灾害风险与综合应对能力之间协调性程度的变化趋势及差异性,采用灰色关联度法分析探究其影响因素。研究表明:(1) 2014~2020年间长江经济带中心城市自然灾害风险系统与综合应对的协调程度存在差异。其中,重庆市的整体协调度相对优于武汉市和上海市。武汉市和上海市自然灾害风险和综合应对能力协调度呈波动起伏变化的特征。(2)自然地理环境、城市经济发展、产业结构、人口特征对不同城市的协调度表现出差异化的影响力。研究成果对提高长江经济带城市的抗风险能力和减少风险损失具有重要意义。

关键词：长江经济带自然灾害风险中心城市耦合协调度灰色关联分析

大坝安全巡检无人机最优图像采集工况试验研究

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水利水运工程学报 2024年第3期 158-165页

作者：魏海东徐世媚黄耀英方卫华黄译萱三峡大学水利与环境学院湖北宜昌443002 广东粤电南水发电有限责任公司广东韶关512600 水利部南京水利水文自动化研究所江苏南京210012 中南财经政法大学统计与数学学院湖北武汉430073

为提高大坝安全巡检无人机图像采集的有效性,针对拍摄距离、风速和光照条件三项重要影响因素,基于大疆Phantom 4 Pro无人机开展试验,分别结合图像自适应阈值二值化、无人机位移及深度学习方法对图像的信息提取效果进行评估,从而研究无... 详细信息

为提高大坝安全巡检无人机图像采集的有效性,针对拍摄距离、风速和光照条件三项重要影响因素,基于大疆Phantom 4 Pro无人机开展试验,分别结合图像自适应阈值二值化、无人机位移及深度学习方法对图像的信息提取效果进行评估,从而研究无人机大坝巡检最优的图形采集工况。研究结果表明,在拍摄距离为3 m、单向风速为2.5~4.0 m/s范围内、晴天背阳的光照条件下,无人机悬停能力较好,不会与被拍摄物体表面发生碰撞,且采集的图像质量最佳。优化了无人机图像采集方案,为基于无人机巡视大坝工作提供参考依据。未来可以进一步应用自动化巡检系统、传感器技术和智能飞行控制算法,实现无人机在大坝安全巡检中的全面应用。

关键词：大坝安全巡检无人机拍摄间距风速光照

Photonic synapses with ultralow energy consumption for artificial visual perception and brain storage

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Opto-Electronic Advances 2022年第9期5卷 1-13页

作者： Caihong Li Wen Du yixuan huang Jihua Zou Lingzhi Luo Song Sun Alexander OGovorov Jiang Wu Hongxing Xu Zhiming Wang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Microsystem and Terahertz Research Center China Academy of Engineering PhysicsChengdu 610200China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang 621999China Department of Physics and Astronomy Ohio UniversityAthensOhio 45701United States State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610065China School of Physics and Technology Wuhan UniversityWuhan 430072China

The human visual system,dependent on retinal cells,can be regarded as a complex combination of optical system and nervous system.Artificial retinal system could mimic the sensing and processing function of human eyes.Optically stimulated synaptic devices could serve as the building blocks for artificial retinas and subsequent information transmission system to brain.Herein,photonic synaptic transistors based on polycrystalline MoS_(2),which could simulate human visual perception and brain storage,are presented.Moreover,the photodetection range from visible light to near-infrared light of MoS_(2) multilayer could extend human eyes’vision limitation to near-infrared light.Additionally,the photonic synaptic transistor shows an ultrafast speed within 5μs and ultralow power consumption under optical stimuli about 40 aJ,several orders of magnitude lower than biological synapses(50 ms and 10 fJ).Furthermore,the backgate control could act as emotional modulation of the artificial brain to enhance or suppress memory function,i.***.the intensity of photoresponse.The proposed carrier trapping/detrapping as the main working mechanism is presented for the device.In addition,synaptic functionalities including short synaptic plasticity,long synaptic plasticity and paired-pulse facilitation could be successfully simulated based on the prepared device.Furthermore,the large difference between short synaptic plasticity and long synaptic plasticity reveals the better image pre-processing function of the prepared photonic synapses.The classical Pavlovian conditioning associated with the associative learning is successfully implemented as well.Therefore,the efficient and rich functionalities demonstrate the potential of the MoS_(2) synaptic device that integrates sensing-memory-preprocessing capabilities for realizing artificial neural networks with different emotions that mimic human retina and brain.

关键词： MoS_(2)synaptic transistors visual perception ultralow power consumption memory

组织工程治疗股骨头坏死软骨下分离的适用技术

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中国组织工程研究 2024年第21期28卷 3385-3392页

作者：黄艺轩陈浩薛鹏席洪钟何帅孙光权杜斌刘锌南京中医药大学附属医院江苏省南京市210029

背景:股骨头坏死出现新月征是病情进程的“分水岭”,修复和稳定骨-软骨界面对阻止病情继续进展和预防股骨头塌陷尤为重要。利用组织工程学同步修复、整合骨-软骨界面具有潜在优势。目的:综述探讨解决股骨头坏死软骨下分离的潜在适宜技... 详细信息

背景:股骨头坏死出现新月征是病情进程的“分水岭”,修复和稳定骨-软骨界面对阻止病情继续进展和预防股骨头塌陷尤为重要。利用组织工程学同步修复、整合骨-软骨界面具有潜在优势。目的:综述探讨解决股骨头坏死软骨下分离的潜在适宜技术。方法:检索1970年1月至2023年4月PubMed、Web of Science及中国知网、万方数据库中发表的相关文献,英文检索词:“Femoral head necrosis,Avascular necrosis of femoral head,Osteonecrosis of femoral head”等,中文检索词:“股骨头坏死,软骨下骨,软骨,软骨与软骨下骨整合”等,最终纳入114篇文献进行综述分析。结果与结论:①结构缺陷、缺血缺氧环境、炎症因素和应力集中可能造成股骨头坏死软骨下分离现象,软骨下骨分离会造成塌陷进展,并且可能与保髋手术失败相关,利用组织工程支架实现支架与骨-软骨界面的整合是治疗股骨头坏死软骨下分离的潜在方法之一。②目前的文献研究表明,多相、梯度支架和复合材料在促进骨、软骨细胞黏附与增殖,骨软骨基质的沉积方面均有提升,有助于支架与骨-软骨界面的整合,对治疗股骨头坏死软骨下分离有参考价值。③通过对支架表面进行修饰可以提高与界面整合的效率,但有各自不同的优缺点,提供不同环境的支架能够诱导同种间充质干细胞差异分化,有助于不同界面之间的整合。④未来有望应用于股骨头坏死软骨下分离的支架应为复合材料,具有梯度化和差异化的仿生结构,通过表面修饰和干细胞加载促进骨-软骨界面与支架的整合以实现治疗目的,但仍需进一步研究验证,而支架的降解速率与修复进度同步和不同界面之间的稳定性是未来需要解决的主要问题。

关键词：股骨头坏死新月征软骨下分离骨软骨界面骨软骨组织工程界面整合复合材料仿生支架表面修饰间充质干细胞

MXene-GaN van der Waals metal-semiconductor junctions for high performance multiple quantum well photodetectors

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Light(Science & Applications) 2021年第10期10卷 1829-1839页

作者： Lingzhi Luo yixuan huang Keming Cheng Abdullah Alhassan Mahdi Alqahtani Libin Tang Zhiming Wang Jiang Wu Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China610054 ChengduChina Materials Department University of CaliforniaSanta BarbaraCalifornia 93106USA King Abdulaziz City for Science and Technology(KACST) RiyadhSaudi Arabia Kunming Institute of Physics 650223 KunmingYunnanChina State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China610054 ChengduSichuanChina

A MXene-GaN-MXene based multiple quantum well photodetector was prepared on patterned sapphire substrate by facile drop casting.The use of MXene electrodes improves the responsivity and reduces dark current,compared with traditional Metal-Semiconductor-Metal(MSM)photodetectors using Cr/Au electrodes.Dark current of the device using MXene-GaN van der Waals junctions is reduced by three orders of magnitude and its noise spectral intensity shows distinct improvement compared with the traditional Cr/Au–GaN–Cr/Au MSM photodetector.The improved device performance is attributed to low-defect MXene-GaN van der Waals interfaces.Thanks to the high quality MXene-GaN interfaces,it is possible to verify that the patterned substrate can locally improve both light extraction and photocurrent collection.The measured responsivity and specific detectivity reach as high as 64.6 A/W and 1.93×1012 Jones,respectively,making it a potential candidate for underwater optical detection and communication.The simple fabrication of MXene-GaN-MXene photodetectors spearheaded the way to high performance photodetection by combining the advantages of emerging 2D MXene materials with the conventional III-V materials.

关键词： junctions sapphire performance