检索结果-南通市图书馆

The improvement of data selection method in data-driven model predictive control of uncertain systems

在线全文

学校读者我要写书评

暂无评论

The improvement of data selection method in data-driven mode...

不同氮磷浓度下2种无毒微藻的生长特性和脱氮除磷效能

第35届中国过程控制会议

作者： yixuan Ni Aoyun Ma Dewei Li The Department of Automation Shanghai Jiao Tong University

Data quality is pivotal for the performance of data-driven model predictive control systems. While traditional data processing methods, such as cleaning and enrichment, are necessary, they do not always improve the controller *** address this issue, this paper proposes a novel data selection method specifically designed for data-driven model predictive control. It includes a controller performance evaluation approach that assesses the quality of the current data, empowering the controller to select a set of informative data elements that enhance its performance. Additionally, a sliding window mechanism is implemented to compare current data against historical data, preventing the loss of significant patterns or trends. A simulation example illustrates the effectiveness of the proposed data selection method.

关键词： Data selection controller performance evaluation data-driven model predictive control

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

环境工程学报 2015年第2期9卷 559-566页

作者：章斐陈秀荣江子建王璐何怡萱鲍征华东理工大学资源与环境工程学院上海200237

根据城市二级出水水质特性,选择4种不同氮磷水平的二级出水作为培养基,研究纯培养与共培养下,椭圆小球藻(Chlorella ellipsoidea)和斜生栅藻(Scenedesmus obliquus)在不同初始氮磷浓度下的生长状况及脱氮除磷的能力。结果表明,纯培养条... 详细信息

根据城市二级出水水质特性,选择4种不同氮磷水平的二级出水作为培养基,研究纯培养与共培养下,椭圆小球藻(Chlorella ellipsoidea)和斜生栅藻(Scenedesmus obliquus)在不同初始氮磷浓度下的生长状况及脱氮除磷的能力。结果表明,纯培养条件下,椭圆小球藻在2#(TN=15.00 mg/L,TP=1.00 mg/L)实验组中生物量最高,斜生栅藻在4#(TN=10.00 mg/L,TP=0.20 mg/L)实验组中收获最大生物量,椭圆小球藻与斜生栅藻对TP均具有70%以上去除率。共培养下,3#(TN=15.00 mg/L,TP=0.50 mg/L)实验组收获最高生物量,斜生栅藻生物量均高于椭圆小球藻,表明斜生栅藻在共培养条件下更具有生长优势,培养基中TN、TP含量分别降至5.00 mg/L和0.05 mg/L以下。2种培养模式均可达到对二级出水的深度脱氮除磷。

关键词：椭圆小球藻斜生栅藻二级出水脱氮除磷

Ultraclean transfer of graphene by mechanically exfoliating polymer with modified crosslink density

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 6795-6802页

作者： Qi Lu Jiawei Yang Chaofan Zhou Zhaoning Hu Saiyu Bu Bingbing Guo yixuan Zhao Junhao Liao Mingpeng Shang Ge Chen Kaicheng Jia Jianbo Yin Qiang Zeng Li Lin Zhongfan Liu College of Science China University of Petroleum(Beijing)Beijing 102249China School of Materials Science and Engineering Peking UniversityBeijing 100871China Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular ScienceCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute Beijing 100095China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Department of Electronics Peking UniversityBeijing 100871China Second Clinical Division National Engineering Laboratory for Digital and Material Technology of StomatologyPeking University School and Hospital of StomatologyBeijing 100081China

The transfer of graphene from metallic substrates onto application-specific substrates is usually inevitable for the applications of high-quality graphene films derived from chemical vapour deposition(CVD)*** used to support the graphene films during the transfer,the coating of the polymer would produce the surface contaminations and hinder the industrially compatible *** this work,through the thermal imidization of polyamide acid(PAA)to polyimide(PI)and tuning of the concentration of dangling chains,we achieved the ultraclean and crack-free transfer of graphene wafers with high electronic *** resulting contamination-free and hydrophilic surface also enabled the observed improved cell viability in a biomedical *** avoiding aqueous etching or the usage of strong bases,our proposed transfer method is industrially compatible for batch transfer of graphene films towards the real applications.

关键词： chemical vapour deposition(CVD)graphene films graphene transfer ultraclean transfer transfer medium crosslink density cell viability assay

Phosphorylated protein chip combined with artificial intelligence tools for precise drug screening

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biomedical Research 2024年第3期38卷 195-205页

作者： Katsuhisa Horimoto Yuki Suyama Tadamasa Sasaki Kazuhiko Fukui Lili Feng Meiling Sun Yamin Tang yixuan Zhang Dongyin Chen Feng Han SOCIUM Inc. Tokyo 1350064Japan International Medical Center Saitama Medical UniversitySaitama 350-1298Japan Artificial Intelligence Research Center National Institute of Advanced Industrial Science and TechnologyTokyo 1350064Japan Department of Informatics and Data Science Sanyo-Onoda City UniversityYamaguchi 7560884Japan International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversitySuzhouJiangsu 215001China National Vaccine Innovation Platform Nanjing Medical UniversityNanjingJiangsu 211166China

We have developed a protein array system,named"Phospho-Totum",which reproduces the phosphorylation state of a sample on the *** protein array contains 1471 proteins from 273 known signaling *** to the activation degrees of tyrosine kinases in the sample,the corresponding groups of substrate proteins on the array are phosphorylated under the same *** addition to measuring the phosphorylation levels of the 1471 substrates,we have developed and performed the artificial intelligence-assisted tools to further characterize the phosphorylation state and estimate pathway activation,tyrosine kinase activation,and a list of kinase inhibitors that produce phosphorylation states similar to that of the *** Phospho-Totum system,which seamlessly links and interrogates the measurements and analyses,has the potential to not only elucidate pathophysiological mechanisms in diseases by reproducing the phosphorylation state of samples,but also be useful for drug discovery,particularly for screening targeted kinases for potential drug kinase inhibitors.

关键词： Phospho-Totum protein array signal transduction pathways artificial intelligence tools drug screening

Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第3期14卷 1150-1165页

作者： Yuzhen Qian yixuan Sun Peishang Shi Xiuman Zhou Qiongqiong Zhang Qingyu Dong Shengzhe Jin Lu Qiu Xiaoshuang Niu Xiaowen Zhou Wenshan Zhao Yahong Wu Wenjie Zhai Yanfeng Gao School of Life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China International Joint Laboratory for Protein and Peptide Drugs of henan Province Zhengzhou UniversityZhengzhou 450001China

Aside from antibodies,peptides show great potential as immune checkpoint inhibitors(ICIs)due to several advantages,such as better tumor penetration and lower ***-activation gene 3(LAG-3)is an immune checkpoint which can induce T cell dysfunction through interaction with its soluble ligand fibrinogen like protein-1(FGL1).here,we found that LAG-3 expression was higher than programmed cell death protein 1(PD-1)in multiple human cancers by TCGA databases,and successfully identified a LAG-3 binding peptide LFP-6 by phage display bio-panning,which specifically blocks the interaction of LAG-3/FGL1 but not LAG-3/***,D-amino acids were introduced to substitute the N-and C-terminus of LFP-6 to obtain the proteolysis-resistant peptide LFP-D1,which restores T cell function in vitro and inhibits tumor growth in ***,a bispecific peptide LFOP targeting both PD-1/PD-L1 and LAG-3/FGL1 was designed by conjugating LFP-D1 with PD-1/PD-L1blocking peptide OPBP-1(8-12),which activates T cell with enhanced proliferation and IFN-γ *** importantly,LFOP combined with radiotherapy significantly improve the T cell infiltration in tumor and elevate systemic antitumor immune *** conclusion,we developed a novel peptide blocking LAG-3/FGL1 which can restore T cell function,and the bispecific peptide synergizes with radiotherapy to further enhance the antitumor immune response.

关键词： LAG-3 FGL1 PD-1 PD-L1 Peptide Immune checkpoint Radiotherapy Cancer immunotherapy

儿童异基因造血干细胞移植相关性血栓性微血管病9例病例分析并文献复习

在线全文

学校读者我要写书评

暂无评论

中华实用儿科临床杂志 2018年第18期33卷 1419-1422页

作者：贺艺璇国家儿童医学中心、首都医科大学附属北京儿童医院血液肿瘤中心、儿童血液病与肿瘤分子分型北京市重点实验室、儿科学国家重点学科、儿科重大疾病研究教育部重点实验室北京100045

目的总结分析儿童异基因造血干细胞移植（allo－HSCT）相关血栓性微血管病（TA－TMA）的临床特征、疗效及转归。方法回顾性分析2008年1月至2017年11月于首都医科大学附属北京儿童医院血液肿瘤中心接受allo－HSCT后发生TA－TMA的9例患儿... 详细信息

目的总结分析儿童异基因造血干细胞移植（allo－HSCT）相关血栓性微血管病（TA－TMA）的临床特征、疗效及转归。方法回顾性分析2008年1月至2017年11月于首都医科大学附属北京儿童医院血液肿瘤中心接受allo－HSCT后发生TA－TMA的9例患儿临床资料、治疗及预后特点。结果纳入研究的283例行allo－HSCT患儿，9例（3.2%）发生TA－TMA。9例患儿中，男5例，女4例，中位年龄94个月（39-129个月），中位发病时间为移植后63 d（6-342 d），血小板中位数为44×10^9/L[（7-75）×10^9/L]，血红蛋白中位数为76 g/L（40-105 g/L），乳酸脱氢酶（LDH）中位水平为594 U/L（445-1 386 U/L）。所有患儿中5例出现神经系统症状，4例出现肾脏受累，6例出现胃肠道受累表现。TA－TMA确诊后的主要治疗措施为减停钙调磷酸酶体抑制剂，血浆置换，利妥昔单抗及去纤苷。4例经治疗后病情得到控制，治疗有效，5例患儿治疗无效死亡。结论TA－TMA是allo－HSCT后的致死性并发症，可导致全身多器官、系统功能损害，累及〉2个系统提示预后不良，联合治疗效果优于单药治疗，选择个体化的治疗方案对减缓TA－TMA病情进展及改善预后至关重要。

关键词：移植相关血栓性微血管病造血干细胞移植儿童治疗

A lightweight and efficient raw data collection scheme for IoT systems

在线全文

学校读者我要写书评

暂无评论

Journal of Information and Intelligence 2024年第3期2卷 209-223页

作者： yixuan Huang Yining Liu Jingcheng Song Weizhi Meng School of Computer and Information Security Guilin University of Electronic TechnologyGuilin 541004China School of Data Science and Artificial Intelligence Wenzhou University of TechnologyWenzhou 325027China School of Computer Science&Engineering LinYi UniversityLinyi 276000China Department of Aplied Mathematics and Computer Science Technical University of DenmarkKongens Lyngby 2800Denmark

With the prevalence of Internet of Things(loT)devices,data collection has the potential to improve people's lives and create a significant ***,it also exposes sensitive information,which leads to privacy *** approach called N-source anonymity has been used for privacy preservation in raw data collection,but most of the existing schemes do not have a balanced efficiency and *** this work,a lightweight and efficient raw data collection scheme is *** proposed scheme can not only collect data from the original users but also protect their ***,the proposed scheme can resist user poisoning attacks,and the use of the reward method can motivate users to actively provide *** and simulation indicate that the proposed scheme is safe against poison ***,the proposed scheme has better performance in terms of computation and communication overhead compared to existing *** efficiency and appropriate incentive mechanisms indicate that the scheme is practical for IoT systems.

关键词： Data privacy Raw data collection loT systems Unlinkability

高温及不同冷却方式对混掺纤维RPC强度的影响及红外检测

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

混凝土 2022年第3期 171-174页

作者：郭银河杜红秀贺一轩太原理工大学土木工程学院建筑材料与防灾减灾所山西太原030024

为探究不同冷却方式对高温后混掺纤维RPC物理力学性能的影响,对混掺聚丙烯纤维和玄武岩纤维的RPC试件进行模拟火灾试验,通过自然冷却和喷水冷却两种方式将高温后试件冷却至常温,测试RPC试件质量、抗压强度、抗折强度、红外热像温升及其... 详细信息

为探究不同冷却方式对高温后混掺纤维RPC物理力学性能的影响,对混掺聚丙烯纤维和玄武岩纤维的RPC试件进行模拟火灾试验,通过自然冷却和喷水冷却两种方式将高温后试件冷却至常温,测试RPC试件质量、抗压强度、抗折强度、红外热像温升及其随受火温度的变化情况。结果表明:两种冷却条件下,随受火温度的升高,RPC的抗压强度及抗折强度总体均呈下降趋势,其红外平均温升均呈升高趋势;受火温度相同情况下,自然冷却的RPC抗压强度、抗折强度高于喷水冷却的抗压强度、抗折强度;不超过300℃时,自然冷却的RPC抗压强度较常温略有增加,200℃时喷水冷却的RPC抗折强度骤降;相较于自然冷却,喷水冷却的RPC试件红外热像温升更高;红外热像温升与抗压强度、抗折强度相关性均较好。

关键词：混掺纤维RPC 高温冷却方式力学性能红外热像

Lactobacillus rhamnosus RL-H3-005 ameliorates allergic airway inflammation by modulating the gut microbiota in asthmatic mice

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Shugang Li Mingxin Li Guopeng Li Huanhuan Liu Wenxiu Zhu Donglin Sui yixuan Li Xiaomeng Ren Collaborative Innovation Center of Seafood Deep Processing， National Engineering Research Center of Seafood， School of Food Science and Technology， Dalian Polytechnic University Dalian Jinshiwan Laboratory

The symptoms of allergic airway disease are impacted by the interplay of gut microbiota， which may be modulated by probiotics. This study aimed to investigate the potential anti-inflammatory effects of three lactic acid bacteria (LAB) on allergic asthma through modulation of the gut microbiota. Ovalbumin (OVA)-induced asthmatic mice were treated with three LAB strains， and their gut microbiota profiles were analyzed using 16S rRNA sequencing. Fecal microbiota transplantation (FMT) from mice fed with Lactobacillus rhamnosus RL-H3-005 was administered to OVA-induced asthmatic mice. The results demonstrated that RL-H3-005 effectively reduced inflammatory infiltrates in the lung and colon， as well as suppressed cytokine levels associated with allergic asthma compared to other strains. In addition， the supplementation of RL-H3-005 modulated the composition of gut microbiota in mice with allergic asthma. FMT results further supported the notion that modulating the gut microbiota with RL-H3-005 plays a crucial role in attenuating airway inflammatory symptoms in allergic asthma.

关键词：