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高龄患者对侧隐匿性腹股沟疝的外科治疗

中华疝和腹壁外科杂志（电子版） 2014年第1期8卷 19-20页

作者：黄耿文李宜雄肖广发中南大学湘雅医院普外科长沙410008

目的探讨高龄患者对侧隐匿性疝（concealed hernia，COH）的临床特点和外科治疗。方法回顾性分析2009年5月至2013年4月，中南大学湘雅医院收治高龄腹股沟疝患者96例，行经腹腹前疝修补术（TAPP）治疗的临床资料。分析其中20例高龄患者CO... 详细信息

目的探讨高龄患者对侧隐匿性疝（concealed hernia，COH）的临床特点和外科治疗。方法回顾性分析2009年5月至2013年4月，中南大学湘雅医院收治高龄腹股沟疝患者96例，行经腹腹前疝修补术（TAPP）治疗的临床资料。分析其中20例高龄患者COH的临床特点和治疗结果。结果96例患者均顺利完成手术。术后出现并发症13例，主要包括血清肿和皮下气肿。全组平均手术时间（105±27）min，单侧疝手术时间（100±15）min，双侧疝手术时间（140±30）min，单侧疝合并COH手术时间（130±25）min。双侧疝、单侧疝合并COH与单侧疝组手术时间比较，差异有统计学意义（t=-2．36、2．12，P=0．03、0．04）。合并COH术后并发症发生率15．0％（3／20），单侧疝术后并发症发生率11．6％（8／60），差异无统计学意义（X2=3．34，P=0．12）。随访2～48个月，中位随访时间30个月，无复发。结论行TAPP时同时修补高龄患者对侧隐匿性疝是安全可行的，是腹腔镜腹股沟疝修补术相对于开放式腹股沟疝修补术的重要优势之一。

关键词：疝腹股沟隐匿疝疝修补术腹腔镜老年人

Single-cell RNA-seq of Lotus japonicus provide insights into identification and function of root cell types of legume

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Journal of Integrative Plant Biology 2023年第5期65卷 1147-1152页

作者： Zhanmin Sun Sanjie Jiang Dan Wang linxia li Boxin liu Qifan Ran lizhen Hu Junbo Xiong yixiong Tang Xiaofeng Gu Yanmin Wu Zhe liang Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China BGl Genomics Shenzhen 518083China Key Laboratory of Southwest China Wildlife Resources Conservation China West Normal UniversityNanchong 637002China Chongqing Academy of Animal Sciences Chongqing 402460China Institute of Animal and Veterinary Science Jiangxi Academy of Agricultural SciencesNanchang 330200China Hubei Key Laboratory of Animal Embryo and Molecular Breeding Institute of Animal and Veterinary ScienceHubei Academy of Agricultural ScienceWuhan 430072China

The roots of legume plant play a crucial role in nitrogen fixation. However, the transcriptomes of different cell types of legume root and their functions remain largely unknown. Here, we performed single-cell RNA sequencing and profiled more than 22,000 single cells from root tips of Lotus japonicus, a model species of *** identified seven clusters corresponding to seven major cell types, which were validated by in situ hybridization. Further analysis revealed regulatory programs including phytohormone and nodulation associated with specific cell types, and revealed conserved and diverged features for the cell types. Our results represent the first single-cell resolution transcriptome for legume root tips and a valuable resource for studying the developmental and physiological functions of various cell types in legumes.

关键词： genome legume Lotus japonicus single-cell RNA-seq

Effect of Precipitation on the Microhardness Distribution of Diode Laser Epitaxially Deposited IN718 Alloy Coating

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Journal of Materials Science & Technology 2013年第4期29卷 349-352页

作者： Yaocheng Zhang Zhuguo li Pulin Nie yixiong Wu Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghai Jiao Tong University State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong University

The microhardness distribution of the diode laser epitaxially deposited IN718 alloy coating was investigated. The Laves concentration in different regions of the coating was measured by binarization processing. The strengthening phase of the coating was characterized by transmission electron microscopy （TEM）. The results showed that the microhardness increased along the depth of the coating. Part of Laves dissolved into austenitic matrix during the successive laser deposition, A little amount of strengthening phase was precipitated in the bottom region of the coating. It was attributed to the heat effect from the thermal cycle of successive deposition on the microstructure in the bottom region of the epitaxially deposited coating.

关键词： IN718 alloy Laser epitaxial deposition Microhardness distribution Precipitation

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无功能胰岛细胞瘤的临床特点及诊治分析

中国普通外科杂志 2009年第8期18卷 843-846页

作者：胡国潢吕新生胡显桥王宪伟汤恢焕李宜雄中南大学湘雅医院普通外科湖南长沙410008

目的探讨无功能胰岛细胞瘤的临床特点和诊断治疗方法。方法回顾性分析23例无功能胰岛细胞瘤的临床资料。结果以腹部肿块(65.2%),腹痛腹胀(47.8%),梗阻性黄疸(26.1%)等为主要临床表现;经B超,CT,MRI等影像学检查均诊断为胰腺肿瘤,肿瘤平... 详细信息

目的探讨无功能胰岛细胞瘤的临床特点和诊断治疗方法。方法回顾性分析23例无功能胰岛细胞瘤的临床资料。结果以腹部肿块(65.2%),腹痛腹胀(47.8%),梗阻性黄疸(26.1%)等为主要临床表现;经B超,CT,MRI等影像学检查均诊断为胰腺肿瘤,肿瘤平均直径为9.5cm。行胰十二指肠切除11例(47.8%),胰体尾切除+脾切除术5例(21.7%),其他7例(30.4%)。术后病理证实20例为良性(87.0%),3例为恶性(13.0%)。胰瘘(3例,13.0%)是主要的术后并发症,均经非手术方法治愈。随访恶性者3例中1例术后1年内死亡,另2例现已无瘤生存29个月和8个月;随访17例良性者,已分别生存1～7年。结论无功能胰岛细胞瘤的诊断应根据临床表现、实验室和影像学检查并结合术中的探查、术后病理综合确定,手术治疗预后良好。

关键词：胰腺肿瘤/外科学无功能性胰岛细胞瘤/诊断无功能性胰岛细胞瘤/治疗

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胆石性肠梗阻的诊断与治疗:附302例分析

中国普通外科杂志 2014年第8期23卷 1093-1096页

作者：邹文茂黄耿文李宜雄孙维佳何群肖广发汤恢焕中南大学湘雅医院普外胰胆外科湖南长沙410008

目的：分析胆石性肠梗阻（BI）的临床特点和诊治现状。方法：回顾1995年1月—2014年12月间中南大学湘雅医院收治的18例BI患者资料,并汇总近20年22篇中文文献中284例患者资料,分析并总结BI发病特点与诊治现状。结果：302例BI患者中男86例... 详细信息

目的：分析胆石性肠梗阻（BI）的临床特点和诊治现状。方法：回顾1995年1月—2014年12月间中南大学湘雅医院收治的18例BI患者资料,并汇总近20年22篇中文文献中284例患者资料,分析并总结BI发病特点与诊治现状。结果：302例BI患者中男86例（28.2%）,女216例（71.8%）;年龄36～89岁,平均63.4岁;术前确诊率为24.2%（73/302）;294例（97.4%）行小肠切开取石术,8例（2.6%）行肠切除肠吻合术;结石嵌塞于十二指肠27例（8.9%）,空肠71例（23.5%）,回肠末端201例（66.6%）,结肠3例（1.0%）;一期行胆囊切除术94例（31.1%）,胆管切开取石术4例（1.3%）;术后并发症发生率为27.2%（82/302）,术后病死率为0.7%（2/302）。结论：BI多见于老年女性患者,常伴有较低的术前确诊率和较高的术后并发症率。

关键词：胆结石并发症肠梗阻诊断

捏脊疗法治疗轻中度脾虚型儿童特应性皮炎的临床观察

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中国民间疗法 2022年第24期30卷 104-107页

作者：张蕾李一雄朱虹位黄莺川北医学院附属医院四川南充637000 成都医学院第一附属医院四川成都610500 四川省攀枝花中心医院四川攀枝花617067 成都中医药大学附属医院四川成都610075

目的:观察捏脊疗法治疗轻中度脾虚型儿童特应性皮炎(AD)的临床疗效。方法:选择AD患儿72例,随机将其分为对照组和观察组,每组36例。对照组采用外擦润肤剂联合地奈德乳膏治疗,观察组在对照组基础上加用捏脊疗法治疗,均治疗8周。在治疗前... 详细信息

目的:观察捏脊疗法治疗轻中度脾虚型儿童特应性皮炎(AD)的临床疗效。方法:选择AD患儿72例,随机将其分为对照组和观察组,每组36例。对照组采用外擦润肤剂联合地奈德乳膏治疗,观察组在对照组基础上加用捏脊疗法治疗,均治疗8周。在治疗前及治疗2、4、8周记录特应性皮炎评分(SCORAD评分,包括皮肤病变范围、皮损严重程度及瘙痒、睡眠)以评估疗效,并记录不良反应发生情况。治疗后3个月随访,评估复发情况。结果:对照组两例患儿治疗过程中出现其他疾病退出,两例患儿因依从性差退出。观察组两例患儿因捏脊疗法施术疼痛不能接受退出,1例患儿因依从性差退出。治疗2、4、8周后,两组患儿SCORAD评分、皮肤病变范围评分、皮损严重程度评分、瘙痒评分、睡眠评分均低于治疗前(P0.05)。结论:在西药外用的基础上采用捏脊疗法治疗轻中度脾虚型AD患儿可以协同增效,改善睡眠质量,远期疗效较佳,且安全易操作。

关键词：儿童特应性皮炎四弯风脾虚型捏脊疗法

Optimization and control of a reactive distillation process for the synthesis of dimethyl carbonate

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Chinese Journal of Chemical Engineering 2017年第8期25卷 1079-1090页

作者： Zhixian Huang yixiong lin Xiaoda Wang Changshen Ye ling li School of Chemical Engineering Fuzhou University

Dimethyl carbonate is an environmentally benign and biodegradable *** on integration of reactive distillation and pressure-swing distillation technologies,a novel process for synthesis of dimethyl carbonate through transesterification with propylene carbonate and methanol has been developed by Huang et *** this work,the optimization of this process was performed by minimizing the total *** results show that the optimal design flowsheet can save energy consumption by 18.6% with the propylene carbonate conversion of 99.9%.Then,an effective plant-wide control structure for the process was *** simulation results demonstrate that the temperature/flow rate cascade control plus with simple temperature control can keep not only product purity but also the conversion of the reactant at their desired values in the face of the disturbance in reactant feed flow rate and feed composition.

关键词：碳酸二甲酯反应精馏法控制结构优化合成碳酸丙烯酯进料流量温度控制

STK_(11)基因突变在中国人Peutz-Jeghers综合征中的特征

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中华医学遗传学杂志 2001年第1期18卷 4-7页

作者：李宜雄吕新生夏家辉汤熙翔夏昆何云贵张桂英湖南医科大学附属湘雅医院普外科长沙410078 中国医学遗传学国家重点实验室中国医学遗传学消化内科

目的　明确 STK1 1 基因在中国人 Peutz- Jeghers(PJ)综合征的突变特征 ,为建立基因诊断奠定基础。方法　用 DNA直接测序方法 ,对 18个家系的 PJ综合征患者 STK1 1 基因 9个外显子进行研究。结果　在 6个家系中发现 6个使基因产物发生... 详细信息

目的　明确 STK1 1 基因在中国人 Peutz- Jeghers(PJ)综合征的突变特征 ,为建立基因诊断奠定基础。方法　用 DNA直接测序方法 ,对 18个家系的 PJ综合征患者 STK1 1 基因 9个外显子进行研究。结果　在 6个家系中发现 6个使基因产物发生改变的突变 ,推测最终导致产生截短型蛋白。结论　在中国人PJ综合征患者中 STK1 1 基因突变的检出率为 6 /18。突变位点比较广泛 ,2 /3集中在第 1外显子。两代以上发病的家系突变率为 6 6 .7% ,散发病例突变率为 16 .

关键词： Pruyz-Jeghers综合征 STK11基因基因突变 DNA测序

Preparation and shaping of solid acid SO_4^(2-)/TiO_2 and its application for esterification of propylene glycol monomethyl ether and acetic acid

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Chinese Journal of Chemical Engineering 2017年第9期25卷 1207-1216页

作者： Zhixian Huang yixiong lin ling li Changshen Ye Ting Qiu School of Chemical Engineering Fuzhou University

The solid acid SO_4^(2-)/TiO_2 was prepared by immersion method and applied for synthesis of propylene glycol methyl ether acetate(PMA) through esterification reaction of propylene glycol monomethyl ether(PM)and acetic acid(HAc). The optimal catalyst preparation condition was determined by orthogonal analysis of parameters in a five-factor and four-level test. The obtained solid acid catalysts were characterized in detail by means of X-ray powder diffraction, thermogravimetry, pyridine adsorbed IR analysis, scanning electron microscopy, and BET surface area method. Synthesis of PMA was studied in this paper through experimental investigation of reaction conditions such as temperature, molar ratio of reactants, catalyst dosage and agitation speed. Based on its possible reaction mechanism, a pseudo-homogeneous kinetic model was established and its activation energies E_a^+ and E_a^-,65.68 × 10~3J·mol^(-1) and 57.78 × 10~3J·mol^(-1), were estimated. To prepare shaped solid acid catalyst SO_4^(2-)/TiO_2, the shaping method of impregnation–shaping–impregnation was applied. The optimal molding formulation of solid acid catalyst, obtained from the orthogonal test, was found to be binder 7 wt%, reinforcing agent 20 wt%, pore forming material 2.5 wt%, and lubricant 4 wt%.The results of performance test of catalyst demonstrated that the shaped solid acid catalyst exhibited high activity and stability.

关键词： Propylene glycol methyl ether acetate Solid acid Shaping Kinetic modeling