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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui Ma Yue Zhang Jinfeng Li Xiaojuan Hou yixin yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

Deep learning-based software engineering: progress,challenges, and opportunities

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Science China(Information Sciences) 2025年第1期68卷 57-144页

作者： Xiangping CHEN Xing HU Yuan HUANG He JIANG Weixing JI Yanjie JIANG Yanyan JIANG Bo LIU Hui LIU Xiaochen LI Xiaoli LIAN Guozhu MENG Xin PENG Hailong SUN Lin SHI Bo WANG Chong WANG Jiayi WANG Tiantian WANG Jifeng XUAN Xin XIA Yibiao yang yixin yang Li ZHANG Yuming ZHOU Lu ZHANG School of Journalism and Communication Sun Yat-sen University School of Software Technology Zhejiang University School of Software Engineering Sun Yat-sen University School of Software Dalian University of Technology School of Computer Science and Technology Beijing Institute of Technology Key Laboratory of High Confidence Software Technologies (Peking University) Ministry of EducationSchool of Computer Science Peking University State Key Laboratory for Novel Software Technology Nanjing University School of Computer Science and Engineering Beihang University Institute of Information Engineering Chinese Academy of Sciences School of Computer Science Fudan University State Key Laboratory of Complex & Critical Software Environment (CCSE) School of Software Beihang University School of Computer and Information Technology Beijing Jiaotong University School of Computer Science and Technology Harbin Institute of Technology School of Computer Science Wuhan University Huawei Technologies

Researchers have recently achieved significant advances in deep learning techniques, which in turn has substantially advanced other research disciplines, such as natural language processing, image processing, speech recognition, and software engineering. Various deep learning techniques have been successfully employed to facilitate software engineering tasks, including code generation, software refactoring, and fault localization. Many studies have also been presented in top conferences and journals, demonstrating the applications of deep learning techniques in resolving various software engineering tasks. However,although several surveys have provided overall pictures of the application of deep learning techniques in software engineering,they focus more on learning techniques, that is, what kind of deep learning techniques are employed and how deep models are trained or fine-tuned for software engineering tasks. We still lack surveys explaining the advances of subareas in software engineering driven by deep learning techniques, as well as challenges and opportunities in each subarea. To this end, in this study, we present the first task-oriented survey on deep learning-based software engineering. It covers twelve major software engineering subareas significantly impacted by deep learning techniques. Such subareas spread out through the whole lifecycle of software development and maintenance, including requirements engineering, software development, testing, maintenance, and developer collaboration. As we believe that deep learning may provide an opportunity to revolutionize the whole discipline of software engineering, providing one survey covering as many subareas as possible in software engineering can help future research push forward the frontier of deep learning-based software engineering more systematically. For each of the selected subareas,we highlight the major advances achieved by applying deep learning techniques with pointers to the available datasets i

关键词： deep learning software engineering software benchmark software artifact representation survey

Range estimation of few-shot underwater sound source in shallow water based on transfer learning and residual CNN

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Journal of Systems Engineering and Electronics 2023年第4期34卷 839-850页

作者： YAO Qihai WANG Yong yang yixin School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of Underwater Information Technology Xi’an 710072China

Taking the real part and the imaginary part of complex sound pressure of the sound field as features,a transfer learning model is *** on the pre-training of a large amount of underwater acoustic data in the preselected sea area using the convolutional neural network(CNN),the few-shot underwater acoustic data in the test sea area are retrained to study the underwater sound source ranging *** S5 voyage data of SWellEX-96 experiment is used to verify the proposed method,realize the range estimation for the shallow source in the experiment,and compare the range estimation performance of the underwater target sound source of four methods:matched field processing(MFP),generalized regression neural network(GRNN),traditional CNN,and transfer *** data processing results show that the transfer learning model based on residual CNN can effectively realize range estimation in few-shot scenes,and the estimation performance is remarkably better than that of other methods.

关键词： transfer learning residual convolutional neural network(CNN) few shot vertical array range estimation

Comprehensive Study of Inversion Methods for Sound Speed Profiles in the South China Sea

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Journal of Ocean University of China 2022年第6期21卷 1487-1494页

作者： LI Jiemeihui SHI yang yang yixin CHEN Cheng School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710000China Shaanxi Key Laboratory of Underwater Information Technology Northwestern Polytechnical UniversityXi’an 710000China

Traditional acquisition method of sound speed profiles using hydro-acoustic instruments is accurate but time-consuming and *** overcome this problem,some inversion methods have been developed over the last few *** this study,a comprehensive comparison of two inversion methods–the acoustic inversion method(AIM)and the satellite observation reconstruction method(SOR)–is *** AIM,the sound speed profile is first parameterized by the empirical orthogonal function(EOF)and the optimal parameters are searched by simulated annealing algorithm with respect to the cross-correlation function of the receiving signal and the simulation *** SOR,remotely sensed data are used to construct sound speed *** experiment was conducted in the northeast of the South China Sea to verify the two *** methods can obtain sound speed profiles quickly and *** with the sound speed profiles obtained by a conductivity-temperature-depth(CTD)instrument,the root-meansquare-error(RMSE)of AIM is 0.55 m s^(−1) and that of SOR is 1.71 m s^(−1).It is clear that AIM provides better inversion performance than *** primary benefit of AIM is that this method has no limitation to the inversion *** simulation results of sound propagation in regard to the inversed sound speed profiles show that the transmission losses of AIM and CTD are consistent and that of SOR is adversely affected by the inversion error of the sound speed and the inversion *** SOR has particular advantages in the inversion ***,all of these advantages make the AIM particularly valuable in practice.

关键词： sound speed profile inversion EOF cross-correlation remote sensing South China Sea

Compensating for intensity loss in a large-aperture MIMO sonar imaging system

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Journal of Systems Engineering and Electronics 2016年第1期27卷 63-71页

作者： Xionghou Liu Chao Sun yixin yang Jie Zhuo School of Marine Science and Technology Northwestern Polytechnical University State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of Sciences

To reduce the computation burden of a large-aperture multiple-input multiple-output（MIMO） sonar imaging system,the phase-shift beamformer（PSBF） is used at the cost of bringing the intensity loss（IL）.The cause of the IL is analyzed in detail and a variable termed as IL factor is defined to quantify the loss *** compensate for the IL,two methods termed as intensity compensation for the PSBF（IC-PSBF） and the hybrid beamforming（HBF）,respectively,are *** IC-PSBF uses previously estimated IL factors to compensate for output intensities of all PSBFs;and the HBF applies the IC-PSBF to the center beam region and the shifted-sideband beamformer（SSBF） to the side beam region,*** simulations demonstrate the effectiveness of the two proposed methods.

关键词： multiple input multiple output(MIMO)sonar phase-shift beamformer sector-scan sonar shifted-sideband beamformer sonar imaging

Kink-like breathers in Bose–Einstein condensates with helicoidal spin–orbit coupling

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Frontiers of physics 2022年第3期17卷 155-163页

作者： yixin yang Peng Gao Li-Chen Zhao Zhan-Ying yang School of Physics Northwest UniversityXi'an 710127China Shaanxi Key Laboratory for Theoretical Physics Frontiers Xi'an 710127China Peng Huanwu Center for Fundamental Theory Xi'an 710127China

We report a kind of kink-like breathers in one-dimensional Bose–Einstein condensates (BECs) with helicoidal spin–orbit coupling (SOC), on whose two sides the background densities manifest obvious difference (called kink amplitude). The kink amplitude and shape of breather can be adjusted by the strength and period of helicoidal SOC, and its atomic number in two components exchanges periodically with time. The SOC has similar influence on the kink amplitude and the exchanged atomic number, especially when the background wave number is fixed. It indicates that the oscillating intensity of breather can be controlled by adjusting initial kink amplitude. Our work showcases the great potential of realizing novel types of breathers through SOC, and deepens our understanding on the formation mechanisms of breathers in BECs.

关键词： Bose–Einstein condensates spin–orbit coupling breather

Removal of Phenanthrene from Contaminated Soil by Ozonation Process

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China Petroleum Processing & Petrochemical Technology 2020年第3期22卷 73-79页

作者： yang yixin Gao Wenfang yang Jingchao Cao Hongbin Beijing Key Laboratory of Fuels Cleaning and Advanced Catalytic Emission Reduction Technology College of Chemical EngineeringBeijing Institute of Petrochemical TechnologyBeijing 102617 Beijing Engineering Research Centre of Process Pollution Control and Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190 College of Environmental and Energy Engineering Beijing University of TechnologyBeijing 100124

In order to improve the ozonation efficiency for the remediation of PAHs contaminated soil,the performance experiments were carried out with quartz sand artificially contaminated with *** byproducts of phenanthrene were detected by GC-MS and the toxicity was evaluated by seed germination *** influence of the particle size and moisture content of quartz sand on the ozonation efficiency was *** addition,two kinds of real soil was used to compare with the quartz *** was revealed that the phenanthrene removal rate reached 96%after 600 minutes by using the ozonation *** byproducts of phenanthrene,including 9,10-phenanthrenedione,(1,1’-biphenyl)-2,2’-dicarboxaldehyde,and(1,1’-biphenyl)-2,2’-dicarboxylic acid,were *** proven by seed germination tests,the toxicity of the byproducts was lower than *** phenanthrene was removed more effectively by ozonation in the quartz sand with finer particle *** ozonation efficiency was significantly improved by increasing the moisture content,which is assumed to be related to the alkalinity of quartz sand.

关键词： ozonation phenanthrene quartz sand soil remediation

Bifurcation analysis of dual-sidestay landing gear locking performance considering joint clearance

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Chinese Journal of Aeronautics 2022年第7期35卷 209-226页

作者： Kui XU Yin YIN yixin yang Hong NIE Xiaohui WEI State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Fundamental Science for National Defense-Advanced Design Technology of Flight Vehicle Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Sidestay lock mechanism is an important part of landing gear system,and the locking performance can be analyzed based on changes in its ***,during numerical continuation analysis of fully-rigid dual-sidestay landing gear without clearance,it has been found that the appearance of bifurcation points does not necessarily imply that both sidestay links can be locked *** problem reveals the limitations of fully-rigid model with ideally-articulated in solving dual-sidestay mechanisms with extremely high motion ***,this study proposes a bifurcation analysis method for synchronous locking of dual-sidestay landing gears,which takes into consideration the joint *** in-depth analysis of this problem,we initially build kinematic and mechanical models of a landing gear mechanism that consider joint ***,the models are solved based on *** fundamental causes of synchronous locking are discussed in detail,and the number of bifurcation points is found to be closely related to whether the landing gear is completely ***,the effects of structural parameters on the synchronous locking are analyzed,and the feasible region of parameters satisfying synchronous locking condition is given,which agrees well with the test results.

关键词： Bifurcation Clearance Dual-sidestay landing gear Numerical continuation Synchronous locking

Reverberation nulling and echo enhancement at low frequency using waveguide invariance

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Chinese Science Bulletin 2011年第2期56卷 142-150页

作者： GUO GuoQiang yang yixin SUN Chao Institute of Acoustic Engineering Northwestern Polytechnical University Xi' an 710072 China

Based on the fact that the transfer function vector between a source receiver array and the dominant scatterer of boundary reverberation at a range can be obtained from the corresponding reverberations scattered from this range cell,a reverberation nulling concept using time reversal processing has been ***,current reverberation nulling methods have certain limitations when applied into practice,which would null boundary reverberation and target echo *** a solution,a passive reverberation nulling and echo enhancement method at low frequency using waveguide invariance is proposed in this *** this method,the reverberation subspace for the target range cell is not obtained directly from the return signals scattered by the target range cell but from the return signals scattered by a range cell located before the target using waveguide invariance,so as to suppress the reverberation embodied in the target echo by passive reverberation ***,a range-dependent optimal weighting vector rather than conventional projector matrix is deduced to null the reverberation component meanwhile maximizing the target echo,thereby enhancing the echo-to-reverberation ratio *** simulations in typical range-independent shallow water environment demonstrate the efficacy and the improved performance of the proposed method for echo-to-reverberation enhancement.

关键词：低频率混响调零变性波导目标回波回声距离单元