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CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury

Genes & Diseases 2024年第1期11卷 449-463页

作者： yixin ma Lili Huang Zheng Zhang Pengfei Yang Qingsong Chen Xujia Zeng Fangyan Tan Chunxia Wang Xiongzhong Ruan Xiaohui Liao Department of Nephrology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China Department of Cell Biology and Genetics Chongqing Medical UniversityChongqing 400016China Centre for Nephrology Royal Free and University College Medical SchoolUniversity College LondonRoyal Free CampusRowland Hill StreetLondon NW32PFUnited Kingdom Centre for Lipid Research Key Laboratory of Molecular Biology on Infectious DiseasesMinistry of EducationChongqing Medical UniversityChongqing 400016China Kuanren Laboratory of Translational Lipidology Centre for Lipid ResearchSecond Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Reactive oxidative species(ROos)production-driven ferroptosis plays a role in acute kidney injury(Akl).However,its exact molecular mechanism is poorly *** receptor CD36 has important roles in oxidizing lipids,lipid accumulation,metabolic syndrome,and insulin resistance in chronic kidney disease,but its roles remain unexplored in *** present study investigated the role and mechanism of CD36 in regulating proximal tubular cell ferroptosis and *** expression of CD36 was found to be significantly up-regulated in AKI renal tissues and correlated with renal function,which might serve as an independent biomarker for AKl ***,in adult mice subjected to AKl,deletion of CD36(CD36-/-)induced tubular cell Ros accumulation,ferroptosis activation,and renal ***,combining LC-MS/MS,co-IP,and ubiquitination analyses revealed that CD36 could specifically bind to ferroptosis suppressor protein 1(FSP1)and regulate its ubiquitination at sites K16 and K24,leading to FSP1 degradation and progression of ferroptosis in *** present results emphasize a novel mechanism of CD36 in cisplatin-induced *** discovery of the special CD36 roles in promoting ferroptosis and AKI development by regulating the ubiquitination of FSP1 in proximal tubular cells may be potential therapeutic targets for ***,CD36 may play a key role in the progression of ***,targeting CD36 may provide a promising treatment option for AKI.

关键词： Acute kidney injury CD36 Ferroptosis FSP1 Ubiquitin-dependent degradation

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铁掺杂铈基复合氧化物CO催化还原NO的性能研究

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中国稀土学报 2024年第1期42卷 40-46,I0002页

作者：徐亚欣杨劲萱马艺芯戚瑞龚志军内蒙古科技大学能源与环境学院内蒙古包头014010 内蒙古自治区高效洁净燃烧重点实验室内蒙古包头014010 白云鄂博共伴生矿资源高效综合利用省部共建协同创新中心内蒙古包头014010

采用浸渍法、水热法和微波加热法制备铁掺杂的铈基复合氧化物催化剂,研究温度、铈铁摩尔比、制备方法对铈基复合氧化物的催化还原性能的影响,并且使用BET,NO-TPD,H_(2)-TPR,XRD,Raman等对催化剂进行表征分析。结果表明:随着温度的升高,N... 详细信息

采用浸渍法、水热法和微波加热法制备铁掺杂的铈基复合氧化物催化剂,研究温度、铈铁摩尔比、制备方法对铈基复合氧化物的催化还原性能的影响,并且使用BET,NO-TPD,H_(2)-TPR,XRD,Raman等对催化剂进行表征分析。结果表明:随着温度的升高,NO转化率是一个先不断增加后趋于稳定的过程;无论是浸渍法、水热法还是微波加热法,最佳铈铁摩尔比均为10∶2;3种制备方法的催化活性顺序:微波加热法>水热法>浸渍法。微波加热法制备的铈基复合氧化物催化剂在500℃的脱硝率为76%,脱硝率在700℃达到99%。通过XRD和Raman表征说明Fe^(3+)取代Ce^(94+)进入到CeO_(2)晶格中,改变CeO_(2)的萤石结构,增加氧空位,造成晶格畸变。

关键词：铈基复合氧化物 NO转化 CO催化还原

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仿生竹纤维五系铝基复合结构强-韧性调控与界面显微组织研究(特邀)

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中国激光 2024年第10期51卷 187-195页

作者：杨光马一鑫赵朔钦兰云王向明沈阳航空航天大学机电工程学院辽宁沈阳110136 沈阳航空航天大学航空制造工艺数字化国防重点学科实验室辽宁沈阳110136 航空工业沈阳飞机设计研究所辽宁沈阳110035

为进一步提高铝基复合材料的强度与韧性,避免强韧性倒置关系,通过在铝基体中加入不同体积分数与尺寸的钛合金骨架结构,制备出强韧性可调控的仿竹纤维Al-Ti复合结构。研究发现:钛合金强化骨架与铝合金基体界面间发生了扩散反应,形成了致... 详细信息

为进一步提高铝基复合材料的强度与韧性,避免强韧性倒置关系,通过在铝基体中加入不同体积分数与尺寸的钛合金骨架结构,制备出强韧性可调控的仿竹纤维Al-Ti复合结构。研究发现:钛合金强化骨架与铝合金基体界面间发生了扩散反应,形成了致密的冶金结合,界面内析出相为钛铝金属间化合物。与传统铝基复材相比,复合结构铝基复合材料抗压强度高达380~1085 MPa,形成一体化微/宏观“高强-高韧”纤维状复合结构。对微观变形机制进行研究:高强度化合物的析出有效阻止了异质界面内裂纹萌生、扩展。同时高分辨下观察发现,界面内析出的Ti3Al相变形后在晶粒内部形成了有效的变形孪晶,提升了界面内高、低模量析出相间协调变形能力,是复合结构增强-增韧的主要机制。

关键词：激光技术增材制造仿生结构 Al-Ti复合结构材料微/宏观强韧性调控

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Separation of isopropyl alcohol+isopropyl acetate azeotropic mixture:Selection of ionic liquids as entrainers and vapor-liquid equilibrium validation

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Chinese Journal of Chemical Engineering 2022年第10期50卷 326-334页

作者： Lianzheng Zhang Jie Wang Lin Yang Dongmei Xu yixin ma Jun Gao Yinglong Wang College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao 266590China College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China

Based on the COSMO-SAC model,1-ethyl-3-methylimidazolium acetate and 1-ethyl-3-methylimidazolium p-toluenesulfonate were selected from 30 ILs as entrainers to investigate the separation of the isopropyl alcohol+isopropyl acetate *** screening indicators,σ-profile and infinite dilution selectivity(S^(∞)),were adopted as the *** iso baric vapor-liquid equilibrium experiments for isopropyl alcohol+isopropyl acetate binary system and isopropyl alcohol+isopropyl acetate+confirmed ILs ternary systems were performed at the pressure of atmospheric *** experimental measurement demonstrated that the adopt ILs enhanced the relative volatility of the above alcohol-ester azeotrope,leading to the elimination of the azeotropic point with a certain amount ***,the thermodynamic correlation for two systems containing ILs was explored with the NRTL model,which also reflects the extensive applicability of that by comparing the deviation between experimental and calculated *** its binary interaction parameters were regressed,which can provide a basis for its simulation process.

关键词： Vapor-liquid equilibrium Ionic liquids NRTL Alcohol-ester azeotrope COSMO-SAC model

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一种FC交换式网络节点机信任管理方法

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信息技术与信息化 2024年第3期 184-187页

作者：张奕然曹月步京蓬马艺新航空工业计算所陕西西安710068 中航西安飞机工业集团股份有限公司陕西西安710089

伴随着计算机系统对高速数据大量传输的需求,美国国家标准委员会提出具有高带宽、低延迟、灵活的FC(光纤通道协议),但光纤存储网络可以存储大量数据的同时,也存在着数据信息安全隐患问题。当网络中的节点机被外部或内部攻击节点攻击后,... 详细信息

伴随着计算机系统对高速数据大量传输的需求,美国国家标准委员会提出具有高带宽、低延迟、灵活的FC(光纤通道协议),但光纤存储网络可以存储大量数据的同时,也存在着数据信息安全隐患问题。当网络中的节点机被外部或内部攻击节点攻击后,便会造成整个网络中的安全隐私数据存在泄露的风险。针对上述问题,提出一种FC交换式网络信任模型,并将其应用于节点机的信任管理模块中。实验测试结果表明,所提出的模型可以将综合信任值小于信任阈值的恶意节点机从FC网络中剔除,提高FC网络的安全性。

关键词： FC网络信任模型网络安全信任管理恶意节点剔除

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Economy, environmental assessment and energy conservation for separation of isopropanol/diisopropyl ether/water multi-azeotropes via extractive distillation coupled pervaporation process

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Chinese Journal of Chemical Engineering 2023年第2期54卷 353-363页

作者： Qinggang Xu Yasen Dai Qing Zhao Zhengrun Chen Peizhe Cui Zhaoyou Zhu Yinglong Wang Jun Gao yixin ma College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China College of Chemical and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China

This wok proposed the extraction distillation coupled pervaporation(ED+PV) technology process using two different solvents to separate isopropanol(IPA) and diisopropyl ether(DIPE) from DIPE/IPA/H_(2)O ternary heterogeneous azeotropes in industrial wastewater from the synthesis of isopropanol in this *** on strict design specifications, simulation and sequential iteration methods are used for process design and optimization. Compared to the ethylene glycol(EG)-EG+H_(2)O process and the 1,3-propanediol(PDO)-IPA+H_(2)O process, the total annual cost(TAC) of the EG-IPA+H_(2)O process decreased by 20.76% and 7.86%(PDO). Compared to the EG-EG+H_(2)O process, the TAC of the PDO-IPA+H_(2)O process reduced 14%, but the global warming potential(GWP) and human toxicity of the PDO-IPA+H_(2)O process increased 11.3% and 4.07% respectively. Compared to the PDO-IPA+H_(2)O process, the EG-IPA+H_(2)O process saves 7.86%(TAC), 9.78%(GWP) and 9.85%(human toxicity). The ED+PV process with EG is superior to PDO in factors of TAC, energy consumption, human toxicity and environment. The EG-IPA+H_(2)O process changed the separation order of the products of the multi-azeotropic system, reduced the cost and energy conservation of the system, and enhanced the environmental protection evaluation of the process, is the best process through life cycle assessment for analyzing the economy, energy conservation, environmental assessment and human toxicity, designing cleaner products, controlling waste discharge, and promoting the chemical purification industry. This work provides a new process design and optimized separation ideas, will have a good guiding significance for the research and application separation of multi-azeotropic mixture with mixed solvents in organic wastewater from the cleaner chemical production, has been up to standard wastewater discharge process, and realized the development goal of carbon peak and carbon neutrality in the sustainable development of chemical clean i

关键词： Life cycle assessment Extractive distillation coupled pervaporation Isopropanol/diisopropyl ether/water azeotropes Thermodynamic efficiency Human toxicity

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黔南苗族传统纹样的演变及其美学特征

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浙江理工大学学报（社会科学版） 2024年第2期52卷 223-230页

作者：曲艺张红霞祝成炎马一心王宇轩谢雯浙江理工大学纺织纤维材料与加工技术国家地方联合工程实验室杭州310018

黔南苗族传统纹样是黔南苗族人民生活方式、精神信仰与审美风格的集中体现,是研究其历史文化的重要窗口。文章以黔南苗族传统纹样作为研究对象,采用调查研究法与比较互证法,从黔南苗族传统纹样的基本形态入手,探究其成型及演化过程,进... 详细信息

黔南苗族传统纹样是黔南苗族人民生活方式、精神信仰与审美风格的集中体现,是研究其历史文化的重要窗口。文章以黔南苗族传统纹样作为研究对象,采用调查研究法与比较互证法,从黔南苗族传统纹样的基本形态入手,探究其成型及演化过程,进而从纹样造型方式、构成形式、色彩风格与美学内涵四个方面分析黔南苗族传统纹样的美学特征。研究发现:黔南苗族传统纹样源自其历史文化生活与宗教精神信仰,并随着族群的迁徙融合形成传承、再创与发展的良性循环,在此过程中形成了纹样特殊的美学表达形式,蕴含着黔南苗族“万物有灵”的美学内涵。该研究可为后续的苗族纹样创新设计提供借鉴,促进现代艺术风格融入新的设计语言。

关键词：黔南苗族传统纹样起源演变美学特征

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QSPR modeling of azeotropic temperatures and compositions for binary azeotropes containing lower alcohols using a genetic function approximation

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Chinese Journal of Chemical Engineering 2019年第4期27卷 835-844页

作者： yixin ma Kang ma Huixin Wang Xueli Geng Jun Gao Zhaoyou Zhu Yinglong Wang College of Chemical and Environmental Engineering Shandong University of Science and Technology Qingdao 266590 China College of Chemical Engineering Qingdao University of Science and Technology Qingdao 266042 China National Registration Center for Chemicals SINOPEC Research Institute of Safety Engineering Qingdao 266071 China

Binary azeotropes, which contain two chemicals with a relative volatility of 1, are very common in the chemical industry. Understanding azeotropes is essential for effectively separating binary azeotropes containing lower alcohols. Experimental techniques and ab initio approaches can produce accurate results;however, these two processes are time consuming and labor intensive. Although thermodynamic equations such as UNIFAC are widely used, experimental values are required, and it is difficult to choose the best groups to represent a complex system. Because of their high efficiency and fast calculation speed, quantitative structure–property relationship(QSPR) tools were used in this work to predict the azeotropic temperatures and compositions of binary azeotropes containing lower alcohols. The QSPR models for 64 binary azeotropes based on centroid approximation and weighted-contribution-factor approximation were established using the genetic function approximation(GFA) procedure in materials Studio software, and a leave-one-out cross-validation procedure was *** tests of an additional 16 azeotropes were also investigated, and high determination coefficient values were obtained. The best QSPR models were explained in terms of the molecular structure of the azeotropes,and good predictive ability was obtained within acceptable prediction error levels.

关键词： QSPR Azeotropic temperature Azeotropic composition Genetic function approximation Binary azeotropes

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A review of extractive distillation from an azeotropic phenomenon for dynamic control

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1510-1522页

作者： yixin ma Peizhe Cui Yongkun Wang Zhaoyou Zhu Yinglong Wang Jun Gao College of Chemical and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China

Extractive distillation is an effective method for separating azeotropic or close boiling point mixtures by adding a third *** technologies for performing the extractive distillation process have been explored to protect the environment and save *** paper focuses on the improvement of these advanced technologies in recent *** distillation is retrieved and analyzed from the view of phase equilibrium,selection of solvent in extractive distillation,process design,energy conservation,and dynamic *** quantitative structure–property relationship used in extractive distillation is discussed,and the future development of extractive distillation is proposed to determine how the solvent affects the relative volatility of the separated *** the steady state design,the relationship between the curvature of the residue curve and parameters of the optimal steady state is also highlighted as another field worthy of further study to simplify the distillation process.

关键词： Thermodynamic Quantitative Structure-property relationship Solvent selection Process design Energy conservation Dynamic control

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DLX3(Q178R)mutation delays osteogenic differentiation via H19/miR-29c-3p/KDM5B axis in TDO-iPSCs-derived MSCs

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Genes & Diseases 2024年第4期11卷 49-52页

作者： Liying Dong Na Zhao Dongmei Wang Meng Wang yixin Zhang Liangjie Sun Chong Ding Yixiang Wang Zeyun ma Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China Department of Oral and maxillofacial Surgery Peking University School and Hospital of StomatologyBeijing 100081China National Engineering Laboratory for Digital and material Technology of Stomatology Peking University School and Hospital of StomatologyBeijing 100081China Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of StomatologyBeijing 100081China The Second Clinical Division Peking University School and Hospital of StomatologyBeijing 100081China Department of VIP Service Peking University School and Hospital of StomatologyBeijing 100081China Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental MedicineBostonMA 02115USA Department of Prosthodontics Fudan UniversityShanghai 200001China Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological HospitalFudan UniversityShanghai 200001China

Tricho-dento-osseous(TDO)syndrome is a rare autosomal dominant disease resulting from distal-less homeobox 3(DLX3)mutation.1,2 Accumulative bone density in alveolar bone is a clinically favorable phenotype for TDO ***... 详细信息

关键词： patients clinically alveolar

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