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Photoisomerization,assembling and fluorescence photoswitching behaviors of a water-soluble stiff-stilbene with cucurbit[7]uril

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中国化学快报:英文版 2023年第8期34卷 184-188页

作者： liangru Yang yixin li Haifan Zhang Changming Tian Qiaohong Cao Yongmei Xiao libo Yuan Guoxing liu College of Chemistry and Chemical Engineering Henan University of TechnologyZhengzhou 450001China College of Science Henan Agricultural UniversityZhengzhou 450002China

Photoresponsive supramolecular systems have merited extensive attention for their applications in materials science and life ***,we synthesized a water-soluble stiff-stilbene molecular photoswitch,exhibiting outstanding photoisomerization reaction between its(E)-and(Z)-configurations upon irradiation at distinct *** photoswitch can assemble with cucurbit[7]uril(CB[7])to form a superior fluorescent supramolecular complex(compared to the only guest)with excellent water solubility,which manifested dramatic photoluminescence enhancement caused by restriction of intramolecular rotation and remained good photochromic ***,introduction of CB[7]influence photoreaction quantum yield(Φ)of the stiff-stilbene,leading to reduction ofΦ_(E→Z) and increase ofΦ_(Z→E) of the ***,the photoadjustable supramolecular assembly can act as a fluorescence switch,and the phototunable guest further selectively modulate G-quadruplex structure of Tel22 upon light irradiation or with addition of CB[7].The study provides a new simple way for accurately regulating photochromic properties of molecular switches and developing smart materials with potential applications in controlled modulation of G-quadruplex,targeted biological imaging and so on.

关键词： Supramolecular assemble Photoreponse Stiff-stilbene Cucurbituril Fluorescence photoswitch Host-guest complexation

孕期运动减轻青春期雄性后代小鼠的焦虑和抑郁样行为及相关机制研究

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神经损伤与功能重建 2024年第8期19卷 435-440,469页

作者：李奕欣周麟肖玲王惠玲王高华武汉大学人民医院精神科武汉430060 湖北省神经精神病研究所武汉430060

目的:探究孕期运动对青春期雄性后代小鼠焦虑与抑郁样行为影响以及相关机制研究。方法:母鼠怀孕第2天开始受人为控制进行跑轮运动(1 h/d),一直到生产日结束。分娩后每周评估母鼠的母性行为。青春期雄性后代(产后4周)接受为期2周,每天3... 详细信息

目的:探究孕期运动对青春期雄性后代小鼠焦虑与抑郁样行为影响以及相关机制研究。方法:母鼠怀孕第2天开始受人为控制进行跑轮运动(1 h/d),一直到生产日结束。分娩后每周评估母鼠的母性行为。青春期雄性后代(产后4周)接受为期2周,每天3小时的慢性束缚应激后进行行为学测试,取海马组织检测神经炎症和神经凋亡水平。结果:来自孕期运动增加母鼠母性行为,同时减少青春期后代雄鼠慢性应激后焦虑与抑郁样行为,并抑制海马中的细胞凋亡和NLRP3相关的神经炎症激活。结论:母鼠在怀孕期间进行跑轮运动后,哺乳期间对后代的母性行为增加,减少了青春期雄性后代慢性应激后焦虑和抑郁样行为,其机制可能与抑制了海马神经元凋亡以及NLRP3炎症小体相关的神经炎症激活有关。

关键词：孕期运动怀孕焦虑抑郁 NLRP3 细胞凋亡青春期

Modeling of Rectangular Microchannel Heat Sink with Non-Uniform Channels and Multi-Objective Optimization

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Journal of Thermal Science 2024年第5期33卷 1701-1711页

作者： SHANG Xueshuo WANG yixin li Qingwen WANG Rui CUI Zheng SHAO Wei Institute of Advanced Technology Shandong UniversityJi'nan 250014China Institute of Thermal Science and Technology Shandong UniversityJi'nan 250014China Shandong Institute of Advanced Technology Ji'nan 250100China

Rectangular microchannel heat sinks(MCHS)are widely used to cool high-heat-flux electronic ***,previous studies focused mainly on MCHS with uniform channels(UCs).This study considers a microchannel heat sink with non-uniform channels(NUCs).A mathematical model is developed based on energy equations and the Darcy flow *** expressions for total thermal resistance and coolant pressure drop are derived using the thermoelectric *** and numerical simulations are performed to verify the mathematical *** non-uniformity increases,total coolant pressure drop decreases but at the cost of higher thermal *** overall performance of NUCs is better than that of UCs because of their lower ratio of pumping power to cooling *** transfer performance of NUCs changes little for more than 120 channels and depends mainly on channel arrangement.A multi-objective optimization is conducted to minimize the thermal resistance and pumping power of an *** optimal NUC saves 64%pumping power compared with a conventional UC for the total thermal resistance of 0.1℃/W,indicating that the use of non-uniform channels could be very helpful to reduce the flow resistance of MCHS.

关键词： microchannel heat sink non-uniform channel mathematical model multi-objective optimization

含抽水蓄能电站与分布式能源的输电网联合规划多阶段模型

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电工技术 2024年第4期 39-44页

作者：吴伟杰李逸欣林勇张伊宁陈逸鹏广东电网有限责任公司电网规划研究中心广东广州510000 中国能源建设集团广东省电力设计研究院有限公司广东广州510663

虽然能源消耗量仍在增加,但由于电力系统的管制放松、需求响应方案的应用、微电网和智能电网的实施等,系统峰值负荷正在下降,作为公共实体的输电系统运营商必须加强输电系统以保持电力系统的可靠性。为此,提出了一种含抽水蓄能电站与分... 详细信息

虽然能源消耗量仍在增加,但由于电力系统的管制放松、需求响应方案的应用、微电网和智能电网的实施等,系统峰值负荷正在下降,作为公共实体的输电系统运营商必须加强输电系统以保持电力系统的可靠性。为此,提出了一种含抽水蓄能电站与分布式能源的输电网联合规划双层模型。其中,上层从输电系统运营商的角度出发,最大限度地降低线路投资成本和从传统发电机和配电系统购买能源的成本,同时确保分布式能源投资的给定回报率;下层模拟市场清算以找到节点价格,用于计算配电商的利润和购买能源的成本。通过强对偶技术、big-M方法和互补松弛条件,将所提出的模型转化为一个单层混合整数线性规划问题,并在IEEE RTS-24母线测试系统中验证了其有效性。

关键词：输电系统分布式能源双层模型混合整数线性规划

液态深层发酵松杉灵芝提取麦角硫因的技术研究

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现代食品 2024年第7期30卷 78-80,86页

作者：康梦媛任芮瑶刘月含李意心李芯悦杨萍吉林农业科技学院食品科学与营养工程学院吉林吉林132101

本文通过单因素以及正交试验确定液态深层发酵松杉灵芝提取麦角硫因的提取条件。结果表明,最佳提取条件为最大允许装液量的60%,转速200 r·min^(-1),发酵液pH=6,发酵温度30℃,发酵通气量0.6 L·min^(-1)。

关键词：松杉灵芝麦角硫因液态深层发酵

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短期大气颗粒物暴露和MTNR1B基因多态性对甘油三酯-葡萄糖指数影响的家系研究

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北京大学学报（医学版） 2024年第3期56卷 375-383页

作者：郭煌达彭和香王斯悦侯天姣李奕昕章涵宇王梦莹武轶群秦雪英唐迅李劲陈大方胡永华吴涛北京大学公共卫生学院流行病与卫生统计学系北京100191 北京大学公共卫生学院营养与食品卫生学系北京100191 重大疾病流行病学教育部重点实验室(北京大学) 北京100191

目的:利用北京房山家系队列研究资料,探索短期大气颗粒物(particulate matter,PM)暴露和褪黑素受体1B(melatonin receptor 1B,MTNR1B)基因多态性对甘油三酯-葡萄糖(triglyceride-glucose,TyG)指数的影响。方法:纳入来自北京市房山区9个... 详细信息

目的:利用北京房山家系队列研究资料,探索短期大气颗粒物(particulate matter,PM)暴露和褪黑素受体1B(melatonin receptor 1B,MTNR1B)基因多态性对甘油三酯-葡萄糖(triglyceride-glucose,TyG)指数的影响。方法:纳入来自北京市房山区9个乡镇的先证者及其亲属作为研究对象,使用混合线性模型评估短期PM暴露和MTNR1B基因rs10830963位点多态性与TyG指数的关联,进一步利用最大似然法进行基因-环境交互作用分析,探索rs10830963位点多态性在PM与TyG指数关联中的效应修饰作用。结果:共纳入来自2084个家系的4395名参与者,研究对象平均年龄(58.98±8.68)岁,女性占比53.90%。关联分析结果显示,PM 2.5浓度每升高10μg/m 3,TyG指数升高0.017(95%CI:0.007~0.027),而PM 10每升高10μg/m 3,TyG指数升高0.010(95%CI:0.003~0.017),且关联均存在滞后效应。此外,rs10830963位点与TyG指数存在阳性关联。每增加一个风险等位基因G,TyG指数升高0.040(95%CI:0.004~0.076)。与CC基因型携带者相比,GG基因型携带者的TyG指数高0.079(95%CI:0.005~0.152)。未发现该位点多态性与PM暴露的交互作用具有统计学意义。结论:PM 2.5和PM 10短期暴露与较高的TyG指数相关,MTNR1B基因的rs10830963位点G等位基因与TyG指数升高相关联。

关键词：颗粒物吸入暴露甘油三酯-葡萄糖指数 MTNR1B基因家系研究

Predesigned covalent organic framework with sulfur coordination: Anchoring Au nanoparticles for sensitive colorimetric detection of Hg(Ⅱ)

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Chinese Chemical Letters 2024年第5期35卷 392-396页

作者： Guorong li Yijing Wu Chao Zhong yixin Yang Zian lin Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyCollege of ChemistryFuzhou UniversityFuzhou 350108China

Targeted construction of new covalent organic frameworks(COFs)with specific purposes and rationalities to build colorimetric assay platform for environmental pollutant monitoring have attracted increasing ***,it is still challenging due to lack of available coordination sites inside COFs pores and only a slight bonding ability for anchoring *** this work,a two-dimensional(2D)COFs(termed as Tz-COF)with high crystallinity,excellent chemical stability,and abundant sulfur coordination in its skeletons was synthesized and used for the confined growth of Au *** was found that the Au NPs showed significant dispersibility for the support of *** proposed Tz-COF@Au NPs possessed outstanding Hg^(2+)-activated peroxidase-like activity benefited from physicochemical properties of gold amalgam and synergistic effect between COFs and Au NPs to oxidize chromogenic *** on highly efficient activity and distinctive color evolution,the strategy for detecting Hg^(2+)was developed and successfully applied to determine the content of Hg^(2+)in real environmental *** work manifests that a potential strategy to establish a colorimetric assay platform for environmental pollutant monitoring based on the targeted manufacturing of novel COFs with specific functions.

关键词： Covalent organic frameworks Thiazole Sulfur coordination Au nanoparticles Hg^(2+)-activated peroxidase-like activity

含抽水蓄能电站的输电线路扩展规划启发式算法

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电工技术 2024年第3期 12-15页

作者：李逸欣吴伟杰左郑敏郑敏嘉陈逸鹏广东电网有限责任公司电网规划研究中心广东广州510000 中国能源建设集团广东省电力设计研究院有限公司广东广州510663

针对含抽水蓄能电站的输电线路规划中存在的非线性和非凸问题,提出了一种基于MILP的输电线路扩展规划启发式算法。首先将混合整数线性问题(MILP)传输扩展规划(TEP)模型的精确解与元启发式算法的随机解相结合;然后引入了基于MILP的启发(M... 详细信息

针对含抽水蓄能电站的输电线路规划中存在的非线性和非凸问题,提出了一种基于MILP的输电线路扩展规划启发式算法。首先将混合整数线性问题(MILP)传输扩展规划(TEP)模型的精确解与元启发式算法的随机解相结合;然后引入了基于MILP的启发(MBH)算法来解决线性近似和元启发式过程中出现的问题;最后在IEEE RTS-24节点测试系统的单阶段TEP验证了所提出算法的有效性。

关键词：输电扩展规划元启发式混合整数线性问题线性近似

Effects of antioxidant‑rich Lactiplantibacillus plantarum inoculated alfalfa silage on rumen fermentation, antioxidant and immunity status, and mammary gland gene expression in dairy goats

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1227-1240页

作者： yixin Zhang Samaila Usman Qiang li Fuhou li Xia Zhang Luiz Gustavo Nussio Xusheng Guo State Key Laboratory of Grassland Agro‑ecosystems School of Life SciencesLanzhou UniversityLanzhou 730000PR China Probiotics and life Health Institute Lanzhou UniversityLanzhou 730000PR China Probiotics and Biological Feed Research Centre Lanzhou UniversityLanzhou 730000PR China Department of Animal Science Luiz de Queiroz College of AgricultureUniversity of Sao PauloPiracicaba 13418‑900Brazil

Background Milk synthesis in lactating animals demands high energy metabolism,which results in an increased production of reactive oxygen metabolites(ROM)causing an imbalance between oxidants and antioxidants thereby inducing oxidative stress(OS)on the *** mitigate OS and postpartum disorders in dairy goats and gain insight into the impact of dietary choices on redox status during lactation,a feeding trial was conducted using alfalfa silage inoculated with a high-antioxidant strain of Lactiplantibacillus *** Twenty-four Guanzhong dairy goats(38.1±1.20 kg)were randomly assigned to two dietary treatments:one containing silage inoculated with *** MTD/1(RSMTD-1),and the other containing silage inoculated with high antioxidant activity *** 24-7(ES24-7).Results ES24-7-inoculated silage exhibited better fermentation quality and antioxidant activity compared to *** ES24-7 diet elevated the total antioxidant capacity(T-AOC),superoxide dismutase(SOD),glutathione peroxi-dase(GSH-Px),and catalase(CAT)activities in milk,serum,and feces of lactating goats(with the exception of T-AOC in milk).Additionally,the diet containing ES24-7 inoculated silage enhanced casein yield,milk free fatty acid(FFA)content,and vitamin A level in the goats’***,an increase of immunoglobulin(Ig)A,IgG,IgM,inter-leukin(IL)-4,and IL-10 concentrations were observed,coupled with a reduction in IL-1β,IL-2,IL-6,interferon(IFN)-γ,and tumor necrosis factor(TNF)-αconcentrations in the serum of lactating goats fed *** concentrations of total volatile fatty acid(VFA),acetate,and propionate were observed in the rumen fluid of dairy goats fed ES24-7 inoculated ***,the diet containing ES24-7 inoculated silage significantly upregulated the expression of nuclear factor erythroid 2 like 2(NFE2L2),beta-carotene oxygenase 1(BCO1),SOD1,SOD2,SOD3,GPX2,CAT,glu-tathione-disulfide reductase(GSR),and heme oxygenase 1(HMOX1)genes in the mammary gland,

关键词： Alfalfa silage Antioxidant activity Gene expression Goats Immunity Lactation