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Polyp-Canal Reconstruction Reveals Evolution Toward Complexity in Corals

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Research 2024年第1期2023卷 417-428页

作者： yixin li Xin liao Xin Wang Yuanchao li Hongwei Zhao Yunpeng Zhao Junyuan Chen Chunpeng He Zuhong Lu State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Guangxi Key Lab of Mangrove Conservation and Utilization Guangxi Mangrove Research CenterGuangxi Academy of SciencesBeihai 536000China Hainan Academy of Ocean and Fishery Sciences Haikou 571126China State Key Laboratory of Marine Resources Utilization in South China Sea Hainan UniversityHaikou 570228China Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences39 East Beijing RoadNanjing 210008China

Modern scleractinian corals are classified into robust,complex,and basal clades through comparative molecular studies.However,only few morphological or biological criteria can systematically determine the evolutionary trajectories of these major scleractinian coral clades.Here,we obtained the structural information of 21 scleractinian coral species representing robust and complex clades:High-resolution micro-computed tomography was used to reconstruct the polyp-canal systems in their colonies and to visualize the dynamic polyp growth processes.We found that the emergence of mesh-like canals may distinguish representatives of complex and robust clades.The differences in polyp-canal connections suggest distinct evolutionary trajectories among coral species:The formation of the canal network promoted the development of more complex coral structures,and coral polyps within this network formed calices of very similar volume,following precise axial growth directions.The influence of individual polyps on the coral colony becomes less significant as coral structures become more complex,and coral species with more complicated polyp-canal systems occupied niches more efficiently.This work supplements current evolutionary studies on reef-building corals,providing insight for further studies on coral growth patterns.

关键词： Coral representing directions

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng yixin li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion injury.Autophagy occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains unclear.In this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion injury.We found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced autophagy.Furthermore,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating autophagy.Blocking autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion injury.Findings from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

N,N-dimethylformamide tailors solvent effect to boost Zn anode reversibility in aqueous electrolyte

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National Science Review 2022年第10期9卷 147-157页

作者： Yilin Ma Qiu Zhang Luojia liu yixin li Haixia li Zhenhua Yan Jun Chen Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Renewable Energy Conversion and Storage Center (RECAST) College of Chemistry Nankai University

Rechargeable aqueous Zn batteries are considered as promising energy-storage devices because of their high capacity,environmental friendliness and low cost.However,the hydrogen evolution reaction and growth of dendritic Zn in common aqueous electrolytes severely restrict the application of Zn batteries.Here,we develop a simple strategy to suppress side reactions and boost the reversibility of the Zn electrode.By introducing 30%（volume fractions） N,N-dimethylformamide（DMF） to the 2 M Zn（CF3SO3）2-H2O electrolyte（ZHD30）,the preferential hydrogen-bonding effect between DMF and H2O effectively reduces the water activity and hinders deprotonation of the electrolyte.The ZHD30 electrolyte improves the Zn plating/stripping coulombic efficiency from～95.3% to～99.4% and enhances the cycles from 65 to 300.The Zn-polyaniline full battery employing the ZHD30 ele ctrolyte can operate over a wide temperature range from-40℃ to+25℃ and deliver capacities of 161.6,127.4 and 65.8 mAh g-1at 25,-20 and-40℃,respectively.This work provides insights into the role of tuning solvent effects in designing low-cost and effective aqueous electrolytes.

关键词： aqueous electrolyte Zn reversibility hydrogen bond solvent effect rechargeable Zn battery

Application of transfer learning and ensemble learning in image-level classification for breast histopathology

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智慧医学(英文) 2023年第2期3卷 115-128页

作者： Yuchao Zheng Chen li Xiaomin Zhou Haoyuan Chen Hao Xu yixin li Haiqing Zhang Xiaoyan li Hongzan Sun Xinyu Huang Marcin Grzegorzek Microscopic Image and Medical Image Analysis Group College of Medicine and Biological Information EngineeringNortheastern UniversityShenyangLiaoning 110819 China China Medical University ShenyangLiaoning 110122 China Institute of Medical Informatics University of LuebeckLuebeckGermany

Background Breast cancer has the highest prevalence among all cancers in women globally.The classification of histopathological images in the diagnosis of breast cancers is an area of clinical concern.In computer-aided diagnosis,most traditional classification models use a single network to extract features,although this approach has significant limitations.Moreover,many networks are trained and optimized on patient-level datasets,ignoring lower-level data labels.Methods This paper proposed a deep ensemble model based on image-level labels for the binary classification of breast histopathological images of benign and malignant lesions.First,the BreaKHis dataset was randomly divided into training,validation,and test sets.Then,data augmentation techniques were used to balance the numbers of benign and malignant samples.Third,based on their transfer learning performance and the complementarity between networks,VGG16,Xception,ResNet50,and DenseNet201 were selected as base classifiers.Results In a ensemble network model with accuracy as the weight,the image-level binary classification achieved an accuracy of 98.90%.To verify the capabilities of our method,it was experimentally compared with the latest transformer and multilayer perception(MLP)models on the same dataset.Our ensemble model showed a 5%-20%advantage,emphasizing its far-reaching abilities in classification tasks.Conclusions This research focuses on improving the performance of a classification model with an ensemble algorithm.Transfer learning has an essential role in classification of small datasets,improving training speed and accuracy.Our model may outperform many existing approaches with respect to accuracy and has applications in the field of auxiliary medical diagnosis.

关键词： Convolutional neural network Transfer learning Ensemble learning Image classification Histopathological image Breast cancer

Timing of the formation of the Baiyinnuo'er skarn Zn–Pb deposit,NE China:evidence from sulfide Rb–Sr dating

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Acta Geochimica 2022年第2期41卷 185-196页

作者： yixin li Qihai Shu Xudong Niu Fan Yu Qingwen Zeng liangmin Wei Yang Xiao Xianglin Dai State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of GeosciencesBeijing 100083China Chifeng Hongling Nonferrous Mining Co.Ltd.(Shandong Gold Group) Chifeng 025420Inner MongoliaChina

The Baiyinnuo’er deposit in northern China is located in the south section of the Great Xing’an Range,and it is the largest skarn Zn–Pb deposit in the region.Skarn and Zn–Pb orebodies mainly occur between the different units of the Permian Huanggangliang Formation,or within the contact zone between the intrusive rocks and the marble.Although Baiyinnuo’er has been well investigated previously,the timing of the Zn–Pb mineralization is still controversial,largely due to the lack of appropriate ore or alteration minerals that could be directly used for isotopic dating.In this study,we report the results of Rb–Sr isotopic analysis for sphalerite and pyrite samples from the Baiyinnuo’er orebodies,which yielded two isochron ages of 137.4±3.4 and 140.0±7.8 Ma,respectively,constraining the Zn–Pb mineralization time of the deposit as the Early Cretaceous.The data are also consistent with the age of the granitoids in the mining area,indicating a potential genetic relationship between the Early Cretaceous magmatism and mineralization.Many other intrusion-related hydrothermal deposits(including the two typical skarns,Huanggang and Haobugao)in the southern Great Xing’an Range also share similar mineralization ages(i.e.,140–130 Ma).Together,these data suggest an Early Cretaceous mineralization event in this region,and this largescale mineralization could be related to the regional tectonic regime transition from compression to extension as a result of the rollback of the subducted Paleo-Pacific plate.The initial87 Sr/86 Sr ratios of the sphalerite and pyrite samples are 0.70569 and 0.70616,respectively,implying that the ore-forming material could have a significant contribution from the mantle components.The current study shows that sulfide Rb–Sr dating could be used in deciphering the timing of skarn deposit formation.

关键词： Rb-Sr dating Sphalerite and pyrite Skarn Zn-Pb deposit Baiyinnuo’er Southern Great Xing’an Range

Photoisomerization,assembling and fluorescence photoswitching behaviors of a water-soluble stiff-stilbene with cucurbit[7]uril

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中国化学快报:英文版 2023年第8期34卷 184-188页

作者： liangru Yang yixin li Haifan Zhang Changming Tian Qiaohong Cao Yongmei Xiao libo Yuan Guoxing liu College of Chemistry and Chemical Engineering Henan University of TechnologyZhengzhou 450001China College of Science Henan Agricultural UniversityZhengzhou 450002China

Photoresponsive supramolecular systems have merited extensive attention for their applications in materials science and life science.Here,we synthesized a water-soluble stiff-stilbene molecular photoswitch,exhibiting outstanding photoisomerization reaction between its(E)-and(Z)-configurations upon irradiation at distinct light.The photoswitch can assemble with cucurbit[7]uril(CB[7])to form a superior fluorescent supramolecular complex(compared to the only guest)with excellent water solubility,which manifested dramatic photoluminescence enhancement caused by restriction of intramolecular rotation and remained good photochromic characteristics.Furthermore,introduction of CB[7]influence photoreaction quantum yield(Φ)of the stiff-stilbene,leading to reduction ofΦ_(E→Z) and increase ofΦ_(Z→E) of the stiff-stilbene.Importantly,the photoadjustable supramolecular assembly can act as a fluorescence switch,and the phototunable guest further selectively modulate G-quadruplex structure of Tel22 upon light irradiation or with addition of CB[7].The study provides a new simple way for accurately regulating photochromic properties of molecular switches and developing smart materials with potential applications in controlled modulation of G-quadruplex,targeted biological imaging and so on.

关键词： Supramolecular assemble Photoreponse Stiff-stilbene Cucurbituril Fluorescence photoswitch Host-guest complexation

铁精矿内配某生物质高温高压热解及其还原行为研究

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中南大学学报（自然科学版） 2024年第3期55卷 860-870页

作者：黄柱成李屹鑫舒阳中南大学资源加工与生物工程学院湖南长沙410083

以生物质为还原剂,在温度为1 040℃、压力为30 kPa下对铁精矿内配生物质热解气化及其还原行为进行研究。研究结果表明:初期热解产生了酚类等大分子碳氢氧化合物液相,并与铁精矿形成了焦油包裹体,显著迟滞了生物质挥发分的释放;外配水和... 详细信息

以生物质为还原剂,在温度为1 040℃、压力为30 kPa下对铁精矿内配生物质热解气化及其还原行为进行研究。研究结果表明:初期热解产生了酚类等大分子碳氢氧化合物液相,并与铁精矿形成了焦油包裹体,显著迟滞了生物质挥发分的释放;外配水和铁精矿中的晶格氧促进了大分子碳氢氧化合物逐步氧化为酮类、酸类化合物,并最终转化为CO和H_(2)等还原性气体;铁精矿还原生成了铁晶须,部分形成了碳铁化合物,实现了铁氧化物的高效快速还原,入炉50 min时,金属化率达96.72%。

关键词：生物质高温高压热解直接还原

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A pair of G-type lectin receptor-like kinases modulates nlp20-mediated immune responses by coupling to the RLP23 receptor complex

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Journal of Integrative Plant Biology 2023年第5期65卷 1312-1327页

作者： Yazhou Bao yixin li Qin Chang Rubin Chen Weijie Wang Qian Zhang Shuxian Chen Guangyuan Xu Xiaodan Wang Fuhao Cui Daolong Dou Xiangxiu liang MOA Key Laboratory of Pest Monitoring and Green Management Department of Plant PathologyCollege of Plant ProtectionChina Agricultural UniversityBeijing100193China College of Plant Protection Nanjing Agricultural UniversityNanjing 210095China Collegeof lifeSciences SouthChinaAgricultural UniversityGuangzhou 510642China

Plant cells recognize microbial patterns with the plasma-membrane-localized pattern-recognition receptors consisting mainly of receptor kinases(RKs) and receptor-like proteins(RLPs). RKs, such as bacterial flagellin receptor FLS2, and their downstream signaling components have been studied extensively. However, newly discovered regulatory components of RLP-mediated immune signaling, such as the nlp20 receptor RLP23, await identification. Unlike RKs, RLPs lack a cytoplasmic kinase domain, instead recruiting the receptor-like kinases(RLKs) BAK1 and SOBIR1. SOBIR1 specifically works as an adapter for RLP-mediated immunity. To identify new regulators of RLP-mediated signaling, we looked for SOBIR1-binding proteins(SBPs) in Arabidopsis thaliana using protein immunoprecipitation and mass spectrometry,identifying two G-type lectin RLKs, SBP1 and SBP2, that physically interacted with SOBIR1.SBP1 and SBP2 showed high sequence similarity,were tandemly repeated on chromosome 4, and also interacted with both RLP23 and BAK1. sbp1 sbp2 double mutants obtained via CRISPR-Cas9 gene editing showed severely impaired nlp20-induced reactive oxygen species burst, mitogenactivated protein kinase(MAPK) activation, and defense gene expression, but normal flg22-induced immune responses. We showed that SBP1 regulated nlp20-induced immunity in a kinase activityindependent manner. Furthermore, the nlp20-induced the RLP23–BAK1 interaction, although not the flg22-induced FLS2–BAK1 interaction, was significantly reduced in sbp1 sbp2. This study identified SBPs as new regulatory components in RLP23 receptor complex that may specifically modulate RLP23-mediated immunity by positively regulating the interaction between the RLP23 receptor and the BAK1 co-receptor.

关键词： immune responses pattern-recognition receptors receptor-like proteins SBPs SOBIR1

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双向FDI技术溢出对区域创新的影响研究

科学学与科学技术管理 2024年第6期45卷 127-142页

作者：周霞李怡欣华南理工大学工商管理学院广州510630

外商直接投资的技术溢出和对外直接投资的逆向技术溢出是我国获取先进技术知识的重要路径,协调二者的发展水平以提升创新能力成为重要课题。以2007—2018年中国30个省级行政区为研究样本,考察了FDI技术溢出、OFDI逆向技术溢出和双向FDI... 详细信息

外商直接投资的技术溢出和对外直接投资的逆向技术溢出是我国获取先进技术知识的重要路径,协调二者的发展水平以提升创新能力成为重要课题。以2007—2018年中国30个省级行政区为研究样本,考察了FDI技术溢出、OFDI逆向技术溢出和双向FDI技术溢出协调度对区域创新能力的影响,探究了知识产权保护水平在技术溢出影响区域创新能力过程中的调节效应。结果表明:(1)FDI技术溢出、OFDI逆向技术溢出、双向FDI技术溢出协调水平显著促进了我国区域创新能力的提升,且双向FDI技术溢出协调水平对区域创新能力的正向影响较FDI技术溢出、OFDI逆向技术溢出更为突出。(2)在技术溢出影响区域创新的过程中,知识产权保护水平的调节效应体现了区域差异性,西部地区的知识产权保护水平显著增强了FDI技术溢出、OFDI逆向技术溢出和双向FDI技术溢出协调水平对区域创新能力的正向影响,而在东部和中部地区,知识产权保护水平的调节作用并不显著。这与东中西部地区的不同的创新基础、技术获取方式等方面有关。

关键词：区域创新技术溢出知识产权 FDI OFDI