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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui Ma Yue Zhang Jinfeng Li Xiaojuan Hou yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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AnimeNet: A Deep Learning Approach for Detecting Violence and Eroticism in Animated Content

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Computers, Materials & Continua 2023年第10期77卷 867-891页

作者： yixin Tang Department of Cooperative Course of Performance Film&AnimationSejong UniversitySeoul05006Korea

Cartoons serve as significant sources of entertainment for children and ***,numerous animated videos contain unsuitable content,such as violence,eroticism,abuse,and vehicular *** content detection methods rely on manual inspection,which is resource-intensive,time-consuming,and not always ***,more efficient detection methods are necessary to safeguard young *** paper addresses this significant problem by proposing a novel deep learning-based system,AnimeNet,designed to detect varying degrees of violent and erotic content in *** utilizes a novel Convolutional Neural Network(CNN)model to extract image features effectively,classifying violent and erotic scenes in videos and *** novelty of the work lies in the introduction of a novel channel-spatial attention module,enhancing the feature extraction performance of the CNN model,an advancement over previous efforts in the *** validate the approach,I compared AnimeNet with state-of-the-art classification methods,including ResNet,RegNet,ConvNext,ViT,and *** were used to identify violent and erotic scenes within specific video *** results showed that AnimeNet outperformed these models,proving it to be well-suited for real-time applications in videos or *** work presents a significant leap forward in automatic content detection in animation,offering a high-accuracy solution that is less resource-intensive and more reliable than current *** proposed approach enables it possible to better protect young audiences from exposure to unsuitable content,underlining its importance and potential for broad social impact.

关键词： Computer vision animation deep learning classification attention mechanism

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Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第1期 209-216页

作者： yixin Yang Wanlei Zhao Ruoxuan Zheng Hongqiang Li Wei Chen Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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ECGAN:Translate Real World to Cartoon Style Using Enhanced Cartoon Generative Adversarial Network

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Computers, Materials & Continua 2023年第7期76卷 1195-1212页

作者： yixin Tang Department of Cooperative Course of Performance Film&AnimationSejong UniversitySeoul05006Korea

Visual illustration transformation from real-world to cartoon images is one of the famous and challenging tasks in computer ***-to-image translation from real-world to cartoon domains poses issues such as a lack of paired training samples,lack of good image translation,low feature extraction from the previous domain images,and lack of high-quality image translation from the traditional generator *** solve the above-mentioned issues,paired independent model,high-quality dataset,Bayesian-based feature extractor,and an improved generator must be *** this study,we propose a high-quality dataset to reduce the effect of paired training samples on the model’s *** use a Bayesian Very Deep Convolutional Network(VGG)-based feature extractor to improve the performance of the standard feature extractor because Bayesian inference regu-larizes weights *** generator from the Cartoon Generative Adversarial Network(GAN)is modified by introducing a depthwise convolution layer and channel attention mechanism to improve the performance of the original *** have used the Fréchet inception distance(FID)score and user preference score to evaluate the performance of the *** FID scores obtained for the generated cartoon and real-world images are 107 and 76 for the TCC style,and 137 and 57 for the Hayao style,*** preference score is also calculated to evaluate the quality of generated images and our proposed model acquired a high preference score compared to other *** achieved stunning results in producing high-quality cartoon images,demonstrating the proposed model’s effectiveness in transferring style between authentic images and cartoon images.

关键词： GAN cartoon style transfer deep learning Bayesian neural network

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A Theory of Semantic Information(Invited Paper)

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China Communications 2017年第1期14卷 1-17页

作者： yixin Zhong Beijing University of Posts and Telecommunications Haidian District Beijing 100876 China

The information really useful to humans must be the trinity of its three components: the form termed syntactic information, the meaning termed semantic information, and the utility termed pragmatic information. But the theory of information set up by Shannon in 1948 is a statistical theory of syntactic information. Thus, the trinity of information theories needs to be established as urgently as possible. Such a theory of semantic information will be presented in the paper and it will also be proved that it is the semantic information that is the unique representative of the trinity. This is why the title of the paper is set to "a theory of semantic information" without mentioning the pragmatic information.

关键词： semantic information information ecology knowledge intelligence information-knowledge-intelligence conversion

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A calculation method for a power user's CIC under specific conditions in smart distribution grid

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Science China(Technological Sciences) 2015年第7期58卷 1162-1172页

作者： SUN Bing YU yixin Key Laboratory of Smart Grid of Ministry of Education Tianjin University

This paper presents a practical method for calculating a power user’s customer interruption costs(CIC)under specific *** novel method has been developed,based on the CIC results predicted by Lawrence Berkeley National Laboratory(LBNL),so that the key factors,such as customer type,customer size,interruption occurrence time and interruption duration can be *** compared to the LBNL method,the method proposed here is easy to understand and easy to execute with an acceptable *** lays a solid foundation for further investigation of distributed generators and demand response in assessing reliability value of smart distribution grid(SDG).The effectiveness of the proposed method is confirmed through the assessment of RBTS-Bus2.

关键词： smart distribution grid reliability value customer interruption costs customer type customer size interruption oc-currence time interruption duration

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Photonic band structure of one-dimensional metal/dielectric structures calculated by the plane-wave expansion method

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Science China(Physics,Mechanics & Astronomy) 2015年第7期58卷 84-89页

作者： ZONG yixin XIA JianBai The State Key Laboratory of Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences

The plane-wave expansion(PWE) method is employed to calculate the photonic band structures of metal/dielectric(M/D) periodic systems. We consider a one-dimensional(1D) M/D superlattice with a metal layer characterized by a frequency-dependent dielectric function. To calculate the photonic band of such a system, we propose a new method and thus avoid solving the nonlinear eigenvalue equations. We obtained the frequency dispersions and the energy distributions of eigen-modes of 1D superlattices. This general method is applicable to calculate the photonic band of a broad class of physical systems, e.g. 2D and 3D M/D photonic crystals. For comparison, we present a simple introduction of the finite-difference(FD) method to calculate the same system, and the agreement turns out to be good. But the FD method cannot be applied to the TM modes of the M/D superlattice.

关键词： photonic crystal PWE method frequency dispersion energy distribution

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“一带一路”倡议下实用新型制度的国际协调

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科技与法律（中英文） 2025年第1期 91-102页

作者：管荣齐赵旖鑫天津大学法学院天津300110

“一带一路”倡议提出以来已逾十载,我国在这一过程中逐渐具备了规则创新的能力与契机,该种创新可由缺乏国际协调的实用新型制度先行。“一带一路”共建国家以及沿线区域性知识产权组织存在实用新型制度本土化的立法基础、改革经验及协... 详细信息

“一带一路”倡议提出以来已逾十载,我国在这一过程中逐渐具备了规则创新的能力与契机,该种创新可由缺乏国际协调的实用新型制度先行。“一带一路”共建国家以及沿线区域性知识产权组织存在实用新型制度本土化的立法基础、改革经验及协调实践,考虑实用新型制度在保护渐进式创新、维护共建发展中国家利益、提升知识产权国际博弈话语权等方面所发挥的作用,我国应当推行从软法到硬法的实用新型国际协调行动。包括但非限于借助“一带一路”国际合作高峰论坛发起协调倡议、倡导由世界知识产权组织出台《实用新型示范法》、借鉴欧盟的开放协调机制进行规则协商等,并将实用新型制度引入更多双边、多边贸易协定谈判场景。

关键词： “一带一路” 实用新型渐进式创新国际协调发展中国家

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Janus(BNNS/ANF)-(AgNWs/ANF)thermal conductivity composite films with superior electromagnetic interference shielding and Joule heating performances

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Nano Research 2022年第5期15卷 4747-4755页

作者： yixin Han Kunpeng Ruan Junwei Gu Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

Highly thermal conductivity materials with excellent electromagnetic interference shielding and Joule heating performances are ideal for thermal management in the next generation of communication industry,artificial intelligence and wearable *** this work,silver nanowires(AgNWs)are prepared using silver nitrate as the silver source and ethylene glycol as the solvent and reducing agent,and boron nitride(BN)is performed to prepare BN nanosheets(BNNS)with the help of isopropyl alcohol and ultrasonication-assisted peeling method,which are compounded with aramid nanofibers(ANF)prepared by chemical dissociation,respectively,and the(BNNS/ANF)-(AgNWs/ANF)thermal conductivity and electromagnetic interference shielding composite films with Janus structures are prepared by the"vacuum-assisted filtration and hot-pressing"***(BNNS/ANF)-(AgNWs/ANF)composite films exhibit"one side insulating,one side conducting"performance,the surface resistivity of the BNNS/ANF surface is 4.7×10^(13) Ω,while the conductivity of the AgNWs/ANF surface is 5,275 S/*** Janus(BNNS/ANF)-(AgNWs/ANF)composite film with thickness of 95 pm has a high in-plane thermal conductivity coefficient of 8.12 W/(m·K)and superior electromagnetic interference shielding effectiveness of 70 *** obtained composite film also has excellent tensile strength of 122.9 MPa and tensile modulus and 2.7 *** also has good temperature-voltage response characteristics(high Joule heating temperature at low supply voltage(5 V,215.0℃),fast response time(10 s)),excellent electrical stability and reliability(stable and constant real-time relative resistance under up to 300 cycles and 1,500 s of tensile-bending fatigue work tests).

关键词： thermal conductivity composite film Janus structure aramid nanofibers electromagnetic interference shielding performance Joule heating

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