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Methodological challenges to human medical study

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Frontiers of Medicine 2014年第3期8卷 328-336页

作者： yixin zhong Baoyan Liu Hua Qu Qi Xie Beijing University of Posts and Telecommunications Beijing 100876 China China Academy of Traditional Chinese Medicine Beijing 100700 China

与现代药用的模式的转变，医药研究与方法学的挑战被面对。由分析在物理事系统和信息系统的学习存在的二方法论，文章指出那繁体中文药(TCM ) ，特别处理基于症候群区别，表达方法学的位置的信息概念，当西方的药代表方法学的位置的事... 详细信息

与现代药用的模式的转变，医药研究与方法学的挑战被面对。由分析在物理事系统和信息系统的学习存在的二方法论，文章指出那繁体中文药(TCM ) ，特别处理基于症候群区别，表达方法学的位置的信息概念，当西方的药代表方法学的位置的事概念时。它建议由 combinating 考虑 TCM 和西方的药的联合的一个新方法二种方法学的方法。

关键词：医学模式方法论信息系统物理系统传统医药辨证治疗位置信息 TCM

A conjecture on mechanism of information understanding

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Frontiers of Electrical and Electronic Engineering in China 2010年第4期5卷 411-418页

作者： yixin zhong Research Center for Intelligence Science and Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

All kinds of sensing organs in humans are able to reflect only the formal factors of objects,named formal information.It is believed,however,that not only the formal information but also the content information and value information of objects could play fundamental roles in the process of information understanding and decisionmaking in human thinking.Therefore,the questions of where and how the content information and the value information be produced from the formal information become critical in the theory of information understanding and decision-making.A conjectural theory that may reasonably answer the question is presented here in the paper.

关键词： formal information content information value information information conversion mechanism of information understanding and decision-making

LIFU-responsive nanomedicine enables acoustic droplet vaporization-induced apoptosis of macrophages for stabilizing vulnerable atherosclerotic plaques

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Bioactive Materials 2022年第10期7卷 120-133页

作者： Jingxin Hou Jun Zhou Meiqi Chang Guangcheng Bao Jie Xu Man Ye yixin zhong Shuling Liu Junrui Wang Wei Zhang Haitao Ran Zhigang Wang Yu Chen Dajing Guo Department of Radiology Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China Materdicine Lab School of Life SciencesShanghai UniversityShanghai200444PR China Chongqing Key Laboratory of Ultrasound Molecular Imaging&Department of Ultrasound Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Department of Radiology Children’s Hospital of Chongqing Medical UniversityChongqing400014PR China

Due to the high risk of tearing and rupture,vulnerable atherosclerotic plaques would induce serious cardiovascular and cerebrovascular diseases.Despite the available clinical methods can evaluate the vulnerability of plaques and specifically treat vulnerable plaques before a cardiovascular event,but the efficiency is still low and undesirable.Herein,we rationally design and engineer the low-intensity focused ultrasound(LIFU)-responsive FPD@CD nanomedicine for the highly efficient treatment of vulnerable plaques by facilely loading phase transition agent perfluorohexane(PFH)into biocompatible PLGA-PEG-PLGA nanoparticles(PPP NPs)and then attaching dextran sulphate(DS)onto the surface of PPP NPs for targeting delivery.DS,as a typical macrophages-targeted molecule,can achieve the precise vaporization of NPs and subsequently controllable apoptosis of RAW 264.7 macrophages as induced by acoustic droplet vaporization(ADV)effect.In addition,the introduction of DiR and Fe3O4 endows nanomedicine with near-infrared fluorescence(NIRF)and magnetic resonance(MR)imaging capabilities.The engineered FPD@CD nanomedicine that uses macrophages as therapeutic targets achieve the conspicuous therapeutic effect of shrinking vulnerable plaques based on in vivo and in vitro evaluation outcomes.A reduction of 49.4%of vascular stenosis degree in gross pathology specimens were achieved throughout the treatment period.This specific,efficient and biosafe treatment modality potentiates the biomedical application in patients with cardiovascular and cerebrovascular diseases based on the relief of the plaque rupture concerns.

关键词： Vulnerable plaques Acoustic droplet vaporization Macrophages Apoptosis Nanomedicine

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社交机器人对社会舆论的影响因素研究

智能系统学报 2024年第1期19卷 122-131页

作者：许灵毓钟义信陈志成英国布里斯托大学社会科学与法学院英国布里斯托北京邮电大学人工智能学院北京100876 北京邮电大学−格分维普惠人工智能联合实验室北京100876 北京格分维科技有限公司北京100070

近年来,社交机器人已经成为人工智能领域的一个最新的研究方向。由于新冠疫情、俄乌冲突、英国脱欧等一系列重大事件中,社交机器人对公众舆论产生了重要影响,学界对社交机器人的关注度日渐升高。本文提出了基于社交机器人的社会舆论形... 详细信息

近年来,社交机器人已经成为人工智能领域的一个最新的研究方向。由于新冠疫情、俄乌冲突、英国脱欧等一系列重大事件中,社交机器人对公众舆论产生了重要影响,学界对社交机器人的关注度日渐升高。本文提出了基于社交机器人的社会舆论形成过程模型,分为舆论出现、争夺影响力、舆论形成3个阶段,社交机器人可以在3个阶段介入和影响。研究了社交机器人的级联效应、工作原理、影响因素,指出媒体类型、事件模糊性和争议性、受众群体等均是影响社会舆论的主要因素。调查问卷实验与案例分析表明:社交机器人对信息传播速度、网民意见/倾向的形成等具有显著影响,实验数据对今后研究具有重要参考意义。

关键词：社交机器人社会舆论公众媒体舆论影响影响因素人工智能社交媒体舆论形成机制

IDEAS模式访视干预在结肠息肉内窥镜下黏膜切除术患者的应用效果

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中国临床研究 2024年第1期37卷 156-160页

作者：杨雯陈玥钟艺馨左罗成都医学院第二附属医院·核工业四一六医院消化内科四川成都610051

目的观察在结肠息肉内窥镜下黏膜切除术(EMR)患者中应用IDEAS模式访视干预的效果。方法选择成都医学院第二附属医院2021年1月至2022年12月收治的137例行EMR的结肠息肉患者为研究对象,依照随机化法将其分为对照组68例和观察组69例。对... 详细信息

目的观察在结肠息肉内窥镜下黏膜切除术(EMR)患者中应用IDEAS模式访视干预的效果。方法选择成都医学院第二附属医院2021年1月至2022年12月收治的137例行EMR的结肠息肉患者为研究对象,依照随机化法将其分为对照组68例和观察组69例。对照组实施常规护理干预,观察组则在常规护理干预基础上实施IDEAS模式访视干预。比较两组围术期基本情况(手术时间、住院时间、术后并发症发生率),对比干预前、干预后两组患者应对方式[简易应对方式问卷(SCSQ)]及生活质量[生存质量评定量表(SF-12)]评分。结果两组手术时间比较差异无统计学意义(P>0.05),观察组住院时间[(3.07±0.34)d vs(3.48±0.51)d,t=5.544,P<0.01]、术后并发症发生率[18.84%vs 35.29%,χ^(2)=4.703,P<0.05]低于对照组,差异有统计学意义。干预后观察组SCSQ量表积极应对维度评分、SF-12量表总评分较干预前均有显著升高(P<0.05),且干预后两种评分观察组均高于对照组[(19.25±4.13)分vs(16.60±3.72)分,(71.78±8.88)分vs(66.62±8.90)分,P<0.01]。观察组SCSQ量表消极应对维度评分较干预前均有降低(P<0.05),且观察组低于对照组[(10.83±4.08)分vs(12.94±4.32)分,P<0.01],差异均有统计学意义。结论 IDEAS模式访视干预能缩短结肠息肉EMR术患者住院时间,降低术后并发症发生率,同时还能增加患者的积极应对方式和提高生活质量,具有较好的临床应用价值。

关键词： IDEAS模式访视结肠息肉内窥镜下黏膜切除术应对方式生活质量简易应对方式问卷生存质量评定量表

I^2oT: Advanced Direction of the Internet of Things

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ZTE Communications 2015年第2期13卷 3-6页

作者： yixin zhong University of Posts and Telecommunications

The Internet of Things （IoT） is still in its infancy because of the limited capability of its embedded processor. In the meantime, re- search on artificial intelligence （AI） has made plenty of progress. The application of AI to loT will significantly increase the capa- bilities of IoT, and this will benefit both economic and social development. In this paper, the elementary concepts and key tech- nologies of AI are explained, and the model and principle of intelligent IoT, denoted I^2oT, resulting from the integration of AI and loT are discussed. I^2oT will be the most promising version of IoT. Finally, recommendations for further study and standardization of I2oT are made.

关键词： lnternet of Things artificial intelligence knowledge producing strategy formulation intelligent internet of things

中国西沙海域永兴岛—七连屿海域鱼体内有机污染物含量特征与来源解析及风险评价

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岩矿测试 2024年第1期43卷 152-165页

作者：姚慧敏陆天启钟奕昕寻看雨颜巧丽黄磊中国地质调查局广州海洋地质调查局三亚南海地质研究所海南三亚572025 中国地质调查局长沙自然资源综合调查中心湖南长沙410600

环境中的有机污染物对生态系统和人类健康产生严重威胁。有机污染物在全球海域鱼体内普遍检出,且长期食用会对人类造成一定的健康风险。为研究中国西沙海域鱼体内有机污染物污染情况、来源及生态风险,本文利用气相色谱-质谱法(GC-MS)分... 详细信息

环境中的有机污染物对生态系统和人类健康产生严重威胁。有机污染物在全球海域鱼体内普遍检出,且长期食用会对人类造成一定的健康风险。为研究中国西沙海域鱼体内有机污染物污染情况、来源及生态风险,本文利用气相色谱-质谱法(GC-MS)分析测定了永兴岛和七连屿鱼体内有机氯农药(OCPs)、多环芳烃(PAHs)和多氯联苯(PCBs)的含量,采集了包括蜂巢石斑鱼、红裸颊鲷、黑身蓝子鱼在内的17种鱼类共50条。结果表明:鱼体内OCPs、PAHs和PCBs的总含量均值范围分别为2.23~91.57ng/g ww、2.11~31.70ng/g ww和1.55~54.04ng/g ww,平均值分别为32.50ng/g ww、17.29ng/g ww和18.79ng/g ww,中位数分别为16.92ng/g ww、13.34ng/g ww和7.61ng/g ww。双对氯苯基三氯乙烷(DDTs)类农药在美欧沿海鱼体内的含量分别为0.65~107.6ng/g ww和763~5357ng/g lw,中国浙江沿海水域鱼体内PAHs含量为10.4~140ng/g ww,地中海、意大利沿海和美国查尔斯顿港口采集的鱼体内PCBs含量分别为1234~12327ng/g lw、56.8~4791ng/g lw和5.02~232.20ng/g ww,研究区DDTs和PAHs含量水平处于全球海域的低端,推测由于研究区远离污染源。利用DDTs/[双对氯苯基二氯乙烯(DDE)+双对氯苯基二氯乙烷(DDD)]比值来判断DDTs的来源,研究区50%鱼体内DDTs/(DDE+DDD)>1,表明中国西沙海域有部分新近输入的DDTs,研究区沉积物来源为陆源,推测中国西沙海域DDTs为陆源DDTs和永兴岛农业活动的综合作用。利用蒽(ANT)/[ANT+菲(PHE)]比值>0.1或该比值0.1,表明PAHs来源于化石燃料燃烧。风险评价结果显示,鱼体内OCPs和PCBs生态风险低。

关键词：中国西沙海域海鱼有机污染物气相色谱-质谱法含量特征来源解析生态评价

Predesigned covalent organic framework with sulfur coordination: Anchoring Au nanoparticles for sensitive colorimetric detection of Hg(Ⅱ)

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Chinese Chemical Letters 2024年第5期35卷 392-396页

作者： Guorong Li Yijing Wu Chao zhong yixin Yang Zian Lin Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyCollege of ChemistryFuzhou UniversityFuzhou 350108China

Targeted construction of new covalent organic frameworks(COFs)with specific purposes and rationalities to build colorimetric assay platform for environmental pollutant monitoring have attracted increasing interest.However,it is still challenging due to lack of available coordination sites inside COFs pores and only a slight bonding ability for anchoring metal.In this work,a two-dimensional(2D)COFs(termed as Tz-COF)with high crystallinity,excellent chemical stability,and abundant sulfur coordination in its skeletons was synthesized and used for the confined growth of Au NPs.It was found that the Au NPs showed significant dispersibility for the support of Tz-COF.The proposed Tz-COF@Au NPs possessed outstanding Hg^(2+)-activated peroxidase-like activity benefited from physicochemical properties of gold amalgam and synergistic effect between COFs and Au NPs to oxidize chromogenic substrate.Based on highly efficient activity and distinctive color evolution,the strategy for detecting Hg^(2+)was developed and successfully applied to determine the content of Hg^(2+)in real environmental samples.This work manifests that a potential strategy to establish a colorimetric assay platform for environmental pollutant monitoring based on the targeted manufacturing of novel COFs with specific functions.

关键词： Covalent organic frameworks Thiazole Sulfur coordination Au nanoparticles Hg^(2+)-activated peroxidase-like activity

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台州地区促成栽培葡萄采后管理技术

现代农业科技 2024年第10期 209-212页

作者：郑龙健李其明钟意欣徐继根张顺昌吴昊浙江省台州市农资股份有限公司浙江台州318000

葡萄是我国重要的水果作物种类之一,甘甜可口,具有很大的市场需求量。葡萄促成栽培技术是利用棚膜的增温保温作用,创造葡萄生长发育的适宜条件,使其比露地栽培提早生长、提早成熟。本文从采后揭膜、抗逆保叶、病虫害防治、控梢和冬剪、... 详细信息

葡萄是我国重要的水果作物种类之一,甘甜可口,具有很大的市场需求量。葡萄促成栽培技术是利用棚膜的增温保温作用,创造葡萄生长发育的适宜条件,使其比露地栽培提早生长、提早成熟。本文从采后揭膜、抗逆保叶、病虫害防治、控梢和冬剪、中耕松土、土壤水分管理、施肥管理、冬季清园等方面介绍了台州地区促成栽培葡萄的采后管理技术,以期为推广高效实用的栽培技术提供参考。

关键词：促成栽培葡萄采后管理浙江台州