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Harnessing cytokine-induced killer cells to accelerate diabetic wound healing:an approach to regulating post-traumatic inflammation

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Regenerative Biomaterials 2024年第2期3卷 88-99页

作者： yixi yang Cheng Zhang Yuan Jiang Yijun He iawei Cai Lin Liang Zhaohuan Chen Sicheng Pan Chu Hua Keke Wu Le Wang Zhiyong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseDepartment of Orthopaedic SurgeryMedical Technology and Related Equipment Research for Spinal Injury TreatmentCity Key LaboratoryThe Third Affliated Hospital of Guangzhou Medical UniversitySchool of Biomedical EngineeringGuangzhou MedicalUniversityGuangzhouGuangdong510150P.R.China Department of Osteoarthropathy and Sports Medicine Panyu Central HospitalGuangzhou 511400P.R.China

Impaired immunohomeostasis in diabetic wounds prolongs infiammation and cytokine dysfunction,thus,delaying or pre-venting wound-surface *** clinical studies have been conducted on cytokine-induced killer(CIK)cells recently,as they can be easily proliferated using a straightforward,inex-pensive ***,the function of CIK cells in regulat-ing inflammatory environments has been drawing attention for clinical *** the current investigation,we discovered the regenerative capacity of these cells in the chal-lenging environment of wounds that heal poorly due to *** demonstrated that the intravenous injection of CIK cells can re-establish a proregenerative inflammatory *** *** accelerateskin healing in diabetic *** results indicated that CIK cell treatment affects macrophage polarization and restores the function regenerative cells under hyperglycemic *** novel cellular therapy offers a promising intervention for clinical applic tions through specific inflammatory regulation functions.

关键词： macrophage diabetic wound post-traumatic inflammation cytokine-induced killer cells vascularization

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改进遗传算法的电子会议汉语语音识别方法

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电子设计工程 2024年第18期32卷 132-135,140页

作者：杨艺西武志栋袁洲陈思平何宇泽国家电网有限公司信息通信分公司北京100000

语音识别普遍存在识别不准确、不全面的问题,影响电子会议汉语记录的质量。面对这种情况,为提高语音识别性能,提出一种改进遗传算法的电子会议汉语语音识别方法。该方法通过预加重、分帧加窗以及去噪,预处理语音信号。利用改进遗传算法... 详细信息

语音识别普遍存在识别不准确、不全面的问题,影响电子会议汉语记录的质量。面对这种情况,为提高语音识别性能,提出一种改进遗传算法的电子会议汉语语音识别方法。该方法通过预加重、分帧加窗以及去噪,预处理语音信号。利用改进遗传算法选取最优语音特征,语音特征包括梅尔频率倒谱系数、短时平均能量以及频谱均值。以三个特征对应数值的标准化数值为输入,利用构建的基于改进神经网络的识别模型将语音转换为对应的汉语文字,实现语音识别。结果表明,在基于改进遗传算法的识别方法应用下,误识率最高仅为2.122%,识全率最低为95.621%,由此说明所研究识别方法的识别更为准确和全面,识别效果更好。

关键词：改进遗传算法电子会议特征选取汉语语音识别

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基于图像识别的会场画面效果智能判别技术及应用

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电视技术 2024年第5期48卷 23-25页

作者：仇亚骏杨艺西苏童刘翰文何宇泽周倩国家电网有限公司信息通信分公司北京100053

随着科技的不断发展,图像识别技术已经逐渐成为人工智能领域的热点之一。会场画面效果的智能判别,是图像识别技术的一个重要应用方向。针对基于图像识别的会场画面效果智能判别技术进行深入研究,探讨其原理、方法和应用,提出一种基于深... 详细信息

随着科技的不断发展,图像识别技术已经逐渐成为人工智能领域的热点之一。会场画面效果的智能判别,是图像识别技术的一个重要应用方向。针对基于图像识别的会场画面效果智能判别技术进行深入研究,探讨其原理、方法和应用,提出一种基于深度学习的智能判别算法,并将其应用于实际会场场景。实验结果表明,所提方法在会场画面效果的判断上取得了良好的效果。

关键词：图像识别会场画面效果智能判别

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造口治疗师主导富血小板血浆联合湿性敷料治疗术后不愈合慢性伤口的效果观察

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中国实用护理杂志 2024年第23期40卷 1761-1767页

作者：夏振兰杨晓君周永林杨逸禧陈月玲陈丽萍刘泽炫广州医科大学附属第三医院创伤外科广州510150 广州医科大学附属第三医院3D打印再生医学转化研究中心广州510150 广州医科大学附属第三医院外科门诊广州510150 广州医科大学附属第三医院护理部广州510150

目的:探讨由造口治疗师(ET)主导的多学科协作模式下,综合运用富血小板血浆(PRP)联合湿性敷料治疗术后不愈合慢性伤口的应用效果,为提高慢性伤口患者的临床实践与管理水平提供参考和借鉴。方法:采用随机对照试验,便利抽样法选取2018年10... 详细信息

目的:探讨由造口治疗师(ET)主导的多学科协作模式下,综合运用富血小板血浆(PRP)联合湿性敷料治疗术后不愈合慢性伤口的应用效果,为提高慢性伤口患者的临床实践与管理水平提供参考和借鉴。方法:采用随机对照试验,便利抽样法选取2018年10月至2023年2月广州医科大学附属第三医院慢性伤口护理门诊就诊的术后不愈合慢性伤口患者88例,采用抛硬币法随机分组,对照组(41例)采用标准的湿性敷料治疗,试验组(47例)采用以PRP联合湿性敷料为核心的综合治疗方案,由ET采用三通头同步推注PRP和助凝混合液并覆盖超薄型泡沫敷料的创新护理技术。观察2组患者伤口压疮愈合计分量表(PUSH)评分、伤口面积愈合指数(WSHI)、换药过程中的疼痛程度、伤口愈合时间和治疗满意率。结果:88例患者中,对照组女25例,男16例,年龄为58.00(37.00,79.00)岁,试验组女31例,男16例,年龄为57.00(35.00,72.00)岁。试验组患者在伤口治疗后第7、14、21天的PUSH评分中位数分别是11.00、9.00、7.00分,优于对照组的13.00、11.00、9.00分,WSHI中位数分别是0.35、0.58、0.84,优于对照组的0.09、0.30、0.50,2组比较差异均有统计学意义(Z值为4.08~8.20,均P<0.01);试验组换药治疗第7天、第14天、第21天疼痛评分分别为3.00(2.00,3.00)、2.00(1.00,2.00)、0.00(0.00,1.00)分,低于对照组的3.00(3.00,3.00)、2.00(2.00,3.00)、2.00(1.00,2.00)分,差异有统计学意义(Z=2.16、3.38、6.14,均P<0.05);试验组伤口愈合时间为(37.04±25.33)d,短于对照组的(52.88±36.58)d,差异有统计学意义(t=5.53,P<0.05);试验组满意率为97.90%(46/47),高于对照组的87.80%(36/41),差异有统计学意义(χ^(2)=3.13,P<0.05)。结论:由ET主导的多学科协作模式下,以PRP联合湿性敷料为核心的综合治疗对术后不愈合慢性伤口具有明显的治疗效果,包括缩短伤口愈合时间、加快愈合速度、降低伤口疼痛程度以及提高患者满意度,具有较高的临床应用价值和社会效益。

关键词：富血小板血浆伤口愈合外科伤口治疗结果

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Rheology of continental lithosphere and seismic anisotropy

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Science China Earth Sciences 2024年第1期67卷 31-60页

作者： Shengsi SUN Yunpeng DONG yixi LI Yihai yang Chao CHENG Bo HUI Bin ZHANG Rutao ZANG State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China Shaanxi Earthquake Agency Xi’an 710068China

Rheology of rocks controls the deformation of the Earth at various space-time scales,which is crucial to understand the tectonic evolution of continental *** of rock rheology are mainly conducted via high-pressure and hightemperature rheological experiments and multi-scale observations and measurements of naturally deformed *** present,a large amount of data from such kinds of studies have been *** paper first provides an up-to-date comprehensive review of the rheological mechanisms,fabric types and seismic properties of the main rock-forming minerals at different depths of continental lithosphere,including olivine,orthopyroxene,clinopyroxene,amphibole,plagioclase,quartz and ***,progress in high-pressure and high-temperature experiments and natural deformation observations is introduced,mainly regarding the rheological strength and behavior,seismic velocity and anisotropy of lithospheric mantle peridotite,eclogite,mafic granulite,amphibolite and felsic ***,by taking the Tibetan Plateau as an example,the application of rock rheology for quantitative interpretation of seismic anisotropy data is *** combination of mineral deformation fabrics and seismic anisotropy is expected to make an important breakthrough in understanding the rheological properties and structure of continental lithosphere.

关键词： Lithosphere Mineral fabric Rheology Seismic velocity Anisotropy

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The Variation of Plankton Community Structure in Artificial Reef Area and Adjacent Waters in Haizhou Bay

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Journal of Ocean University of China 2024年第1期23卷 264-276页

作者： GAO Shike SHI yixi LU Yanan ZHANG Shuo College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China Joint Laboratory for Monitoring and Conservation of Aquatic Living Resources in the yangtze Estuary Shanghai 200000China

Plankton are an important component of marine protected areas(MPAs),and its communities would require much smaller interpatch distances to ensure connection among *** to the survey from MPAs dominated by artificial reefs and adjacent waters(estuary area(EA),aquaculture area(AA),artificial reef area(ARA),natural area(NA)and comprehensive effect area(CEA))in Haizhou Bay in spring and autumn,we analyzed phyto-zooplankton composition,abundance and biomass,and correlation with hydrologic variables to gain information about the forces that structure the *** results showed that the dominant zooplankton were copepods(spring,98.9%;autumn,94.2%),while the phytoplankton were mainly composed of Bacillariophyta(spring,61.8%;autumn,95.6%).The RDA results showed that temperature,salinity and depth highly associated with the distribution and composition of plankton species among the habitats than other factors in spring;temperature,Chla and DO had the strongest influence in *** zooplankton in the ARA and AA ecosystems basically contained the same species as those in other habitats,and each habitat also exhibited a relatively unique combination of plankton *** structures of the EA zooplankton in spring and the EA phytoplankton in both seasons were much different than other habitats,which may have been caused by factors such as currents and *** concluded that there exists similarity of the plankton community between artificial reef area and adjacent waters,whereas the EAs may be relatively independent ***,these interaction between plankton community should be considered when designing MPA networks,and ocean circulations should be considered more than the environmental factors.

关键词： zooplankton phytoplankton seasonal variation environmental factor artificial reef

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Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis

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Regenerative Biomaterials 2022年第1期9卷 202-218页

作者： yixi yang Le Wang Yonglin Zhou Yijun He Shaozhang Lin Yuwei Zeng Yunhe Zhou Wei Li Zaopeng He Qi Zhao Lihao Chen Zijie Li Wenhao Wang Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Medical Technology and Related Equipment Laboratory The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Hand and Foot Surgery&Plastic Surgery Affiliated Shunde Hospital of Guangzhou Medical UniversityShunde DistrictFoshanP.R.China

Successful wound healing depends on the reconstruction of proper tissue homeostasis,particularly in the posttraumatic inflammatory tissue *** jeopardizes tissues’immune homeostasis in cutaneous wounds,causing persistent chronic inflammation and cytokine ***,we developed an autologous regeneration factor(ARF)technology to extract the cytokine composite from autologous tissue to restore immune homeostasis and promote wound ***,treatment efficacy was significantly compromised in diabetic ***,we proposed that a combination of melatonin and ARF,which is beneficial for proper immune homeostasis reconstruction,could be an effective treatment for diabetic *** research showed that the utilization of melatonin-mediated ARF biogel(AM gel)promoted diabetic wound regeneration at a more rapid healing ***-Seq analysis showed that AM gel treatment could restore more favorable immune tissue homeostasis with unique inflammatory patterning as a result of the diminished intensity of acute and chronic ***,AM gel could be a novel and promising therapeutic strategy for diabetic wounds in clinical practice through favorable immune homeostatic reconstructions in the tissue microenvironment and proper posttraumatic inflammation patterning.

关键词： autologous regeneration factors wound healing homeostasis tissue microenvironment inflammation patterning

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A bHLH transcription factor,CsSPT,regulates high-temperature resistance in cucumber

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Horticultural Plant Journal 2024年第2期10卷 503-514页

作者： Yonggui Liang Chenyu yang Fangyan Ming Bingwei Yu Zhihua Cheng yixi Wang Zhengkun Qiu Xiaolan Zhang Bihao Cao Shuangshuang Yan Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(South China) Ministry of Agriculture and Rural AffairsGuangdong Vegetable Engineering and Technology Research CenterCollege of HorticultureSouth China Agricultural UniversityGuangzhouGuangdong 510642China State Key Laboratories of Agrobiotechnology Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable CropsMOE Joint Laboratory for International Cooperation in Crop Molecular BreedingChina Agricultural UniversityBeijing 100193China

High-temperature stress threatens the growth and yield of crops. Basic helix-loop-helix(bHLH) transcription factors(TFs) have been shown to play important roles in regulating high-temperature resistance in plants. However, the bHLH TFs responsible for high-temperature tolerance in cucumbers have not been identified. We used transcriptome profiling to screen the high temperature-responsive candidate bHLH TFs in cucumber. Here, we found that the expression of 75 CsbHLH genes was altered under high-temperature stress. The expression of the CsSPT gene was induced by high temperatures in TT(Thermotolerant) cucumber plants. However, the Csspt mutant plants obtained by the CRISPR-Cas9 system showed severe thermosensitive symptoms, including wilted leaves with brown margins and reduced root density and cell *** Csspt mutant plants also exhibited elevated H_(2)O_(2) levels and down-regulated photosystem-related genes under normal ***, there were high relative electrolytic leakage(REC), malondialdehyde(MDA), glutathione(GSH), and superoxide radical(O_(2)^(·-)) levels in the Csspt mutant plants, with decreased Proline content after the high-temperature treatment. Transcriptome analysis showed that the photosystem and chloroplast activities in Csspt mutant plants were extremely disrupted by the high-temperature stress compared with wildtype(WT) plants. Moreover, the plant hormone signal transduction, as well as MAPK and calcium signaling pathways were activated in Csspt mutant plants under high-temperature stress. The HSF and HSP family genes shared the same upregulated expression patterns in Csspt and WT plants under high-temperature conditions. However, most bHLH, NAC, and bZIP family genes were significantly down-regulated by heat in Csspt mutant plants. Thus, these results demonstrated that CsSPT regulated the high-temperature response by recruiting photosynthesis components, signaling pathway molecules, and transcription factors. Our results pro

关键词： Cucumber bHLH CsSPT Photosynthesis High temperature

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Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation

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Bioactive Materials 2022年第3期7卷 491-507页

作者： Yijun He Wenhao Wang Shaozhang Lin yixi yang Lizhi Song Yihan Jing Lihao Chen Zaopeng He Wei Li Ao Xiong Kelvin W.K.Yeung Qi Zhao Yuan Jiang Zijie Li Guoxian Pei Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Hand and Foot Surgery&Plastic Surgery Affiliated Shunde Hospital of Guangzhou Medical UniversityFoshan528315PR China Department of Bone&Joint Surgery Peking University Shenzhen HospitalShenzhen518036PR China National&Local Joint Engineering Research Center of Orthopaedic Biomaterials Peking University Shenzhen HospitalShenzhen518036PR China Department of Orthopaedics and Traumatology The University of Hong KongPokfulamHong Kong999077PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053PR China The Third Affiliated Hospital of Southern University of Science and Technology Southern University of Science and TechnologyShenzhen518055PR China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Medical Technology and Related Equipment Research for Spinal Injury Treatment City Key LaboratoryThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China

The potential translation of bio-inert polymer scaffolds as bone substitutes is limited by the lack of neovascularization upon implantation and subsequently diminished ingrowth of host bone,most likely resulted from the inability to replicate appropriate endogenous crosstalk between *** umbilical vein endothelial cell-derived decellularized extracellular matrix(HdECM),which contains a collection of angiocrine biomolecules,has recently been demonstrated to mediate endothelial cells(ECs)-osteoprogenitors(OPs)*** employed the HdECM to create a PCL(polycaprolactone)/fibrin/HdECM(PFE)hybrid *** hypothesized PFE scaffold could reconstitute a bio-instructive microenvironment that reintroduces the crosstalk,resulting in vascularized bone *** implantation in a rat femoral bone defect,the PFE scaffold demonstrated early vascular infiltration and enhanced bone regeneration by microangiography(μ-AG)and micro-computational tomography(μ-CT).Based on the immunofluorescence studies,PFE mediated the endogenous angiogenesis and osteogenesis with a substantial number of type H vessels and *** addition,superior osseointegration was observed by a direct host bone-PCL interface,which was likely attributed to the formation of type H *** bio-instructive microenvironment created by our innovative PFE scaffold made possible superior osseointegration and type H vessel-related bone *** could become an alternative solution of improving the osseointegration of bone substitutes with the help of induced type H vessels,which could compensate for the inherent biological inertness of synthetic polymers.

关键词： Cell-derived decellularized extracellular matrix Microenvironment Vascularized bone regeneration Type H vessels Osseointegration

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A graph neural network approach to the inverse design for thermal transparency with periodic interparticle system

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Chinese Physics B 2024年第8期33卷 295-303页

作者：刘斌王译浠 Department of Electronic Information and Artificial Intelligence LeShan Normal UniversityLeShan 614099China Department of Physics State Key Laboratory of Surface Physicsand Key Laboratory of Micro and Nano Photonic Structures(MOE)Fudan UniversityShanghai 200438China

Recent years have witnessed significant advances in utilizing machine learning-based techniques for thermal metamaterial-based structures and devices to attain favorable thermal transport *** the various thermal transport behaviors,achieving thermal transparency stands out as particularly desirable and *** earlier work demonstrated the use of a thermal metamaterial-based periodic interparticle system as the underlying structure for manipulating thermal transport behavior and achieving thermal *** this paper,we introduce an approach based on graph neural network to address the complex inverse design problem of determining the design parameters for a thermal metamaterial-based periodic interparticle system with the desired thermal transport *** work demonstrates that combining graph neural network modeling and inference is an effective approach for solving inverse design problems associated with attaining desirable thermal transport behaviors using thermal metamaterials.

关键词： thermal metamaterial thermal transparency inverse design machine learning graph neural net-work

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