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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.spicer Jianqi Yang Daniel Fu Alison N.DeVore Marisol Lauffer Nilufer s.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGs6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGs6fl/fl;APP_(sWE) mice and used retroviral approaches to examine the impact of RGs6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(sWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGs6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(sWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGs6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGs6-expressing ***,RGs6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(sWE) mice,identifying RGs6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGs6)

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.G.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

A review:synthesis,modification and photocatalytic applications of ZnIn_(2)s_(4)

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Journal of Materials science & Technology 2021年第19期78卷 1-19页

作者： Jie Wang sijia sun Run Zhou Yangzi Li Zetian He Hao Ding Daimei Chen Weihua ao Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of GeosciencesXueyuan RoadHaidian DistrictBeijing100083China

solar energy is an ideal energy source for solving energy shortages and serious environmental *** the past few decades,photocatalytic technology which uses solar energy to deal with the above problems has caused great ***_(2)s_(4),as a layered ternary metal chalcogenide compound,has a series of advantages such as the wide light absorption range and adjustable *** has been applied in the different fields of photocatalysis in recent *** review introduced the crystal structures and growth mechanism of ZnIn_(2)s_(4)and summarized the preparation methods of ZnIn_(2)s_(4).Also,the promoted strategies of ZnIn_(2)s_(4)based photocatalytic system and their applications in the pollutant removal,hydrogen evolution,reduction of CO_(2),nitrogen fixation,and chemical synthesis was ***,the challenges and development directions of the current ZnIn_(2)s_(4)based photocatalytic system were *** is hoped that this review will help researchers design a better ZnIn_(2)s_(4)based photocatalytic system.

关键词： Crystal modify Band structure Charges transport Interfacial interaction Heterostructure

Na-doping-induced modification of the Cu_(2)Znsn(s,se)_(4)/Cds heterojunction towards efficient solar cells

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Journal of Energy Chemistry 2021年第6期30卷 618-626,I0015页

作者： Yali sun Hongling Guo Pengfei Qiu shengli Zhang siyu Wang Li Wu Jianping ao Yi Zhang Institute of Photoelectronic Thin Film Devices and Technology and Tianjin Key Laboratory of Thin Film Devices and Technology Nankai UniversityTianjin 300350China College of Physics science and Technology Hebei UniversityBaoding 071002HebeiChina The MOE Key Laboratory of Weak-Light Nonlinear Photonics School of PhysicsNankai UniversityTianjin 300071China

It is very important to understand why a small amount of alkali metal doping in Cu_(2)Znsn(s,se)_(4)(CZTsse)solar cells can improve the conversion *** this work,Na-doped CZTsse is prepared by a simple solution method,and then the effects on the surface properties of the absorber layer,the buffer layer growth,and the modifications of the solar cell performance induced by the Na doping are *** surface of the absorber layer is more Cu-depletion and less roughness due to the Na *** addition,the contact angle of the surface increases because of Na *** a consequence,the thickness of the Cds buffer layer is significantly reduced and the optical losses in the Cds buffer layer are *** difference of quasi-Fermi levels(EFn-EFp) increases with a small amount of Na doping in the CZTsse solar cell,so that open circuit voltage(VOC) increased *** work offers new insights into the effects of Na doping on CZTsse via a solution-based approach and provides a deeper understanding of the origin of the efficiency improvement of Na-doped CZTsse thin film solar cells.

关键词： Cu_(2)Znsn(s,se)_(4)solar cells Na doping Heterojunction Contact angles simulation analysis

Positron emission tomography/computerized tomography in the evaluation of primary non-Hodgkin's lymphoma of prostate

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World Journal of Gastroenterology 2013年第39期19卷 6699-6702页

作者： Bo Pan Jian-Kui Han shi-Cun Wang ao Xu PET/CT Center Qilu Hospitalthe First Affiliated Hospital of Shandong University PET/CT Center Affiliated Anhui Provincial Hospital of Anhui Medical University Department of Pathology Affiliated Anhui Provincial Hospital of Anhui Medical University

Primary malignant lymphoma of the prostate is exceedingly *** we report a case of a 65-year-old man who presented with increased urinary frequency,urinary urgency,and urinary incontinence for two *** prostatic hypertrophy was suspected at primary *** revealed a hypoechoic lesion of the *** total serum prostate-specific antigen was within normal *** emission tomography/computerized tomography(PET/CT)showed a hypermetabolic prostatic *** biopsy was consistent with a non-germinal center diffuse large B cell *** was complete remission of the prostatic lesion following six cycles of chemotherapy as shown on the second PET/CT imaging.18F-fluoro-deoxy glucose PET/CT is not only a complement to conventional imaging,but also plays a significant role in the diagnosis and evaluation of treatment response of prostatic lymphoma.

关键词： Fluoro-Deoxy-Glucose Positron emission tomography/computerized tomography Non-Hodgkin’s lymphoma Prostatic lymphoma Evaluation

Defect engineering on carbon black for accelerated Li-s chemistry

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Nano Research 2020年第12期13卷 3315-3320页

作者： Wenlong Cai Yingze song Yuting Fang Weiwei Wang songlin Yu Huaisheng ao Yongchun Zhu Yitai Qian Hefei National Laboratory for Physical sciences at Microscale and Department of Chemistry University of Science and Technology of ChinaHefei230026China state Key Laboratory of Environment-Friendly Energy Materials School of Materials Science and EngineeringSouthwest University of Science and TechnologyMianyang621010China

Rationally designing sulfur hosts with the functions of confining lithium polysulfides(LiPss)and promoting sulfur reaction kinetics is critically important to the real implementation of lithium-sulfur(Li-s)***,the defect-rich carbon black(CB)as sulfur host was successfully constructed through a rationally regulated defect ***-obtained defect-rich CB can act as an active electrocatalyst to enable the sulfur redox reaction kinetics,which could be regarded as effective inhibitor to alleviate the LiPs *** expected,the cathode consisting of sulfur and defect-rich CB presents a high rate capacity of 783.8 mA·h·g^−1 at 4 C and a low capacity decay of only 0.07% per cycle at 2 C over 500 cycles,showing favorable electrochemical *** strategy in this investigation paves a promising way to the design of active electrocatalysts for realizing commercially viable Li-s batteries.

关键词： Li-s chemistry defect engineering carbon black sulfur reaction kinetics

ADVANCE sELLING IN THE PREsENCE OF PRODUCT DIFFUsION EFFECT

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Journal of systems science and systems Engineering 2017年第1期26卷 77-99页

作者： Xiaoyan Xu Xuemei Li yiwen Bian Yanhong sun school of Management University of Science & Technology of China Hefei 230026 China school of Management Zhejiang University Hangzhou 310058 China sHU-UTs sILC Business school Shanghai University Shanghai 201899 China

Product diffusion refers to the phenomenon that the later demand is dependent on the early sales. To investigate how a firm＇s advance selling strategy is affected by the effect of product diffusion, we consider a monopolist seller who sells a fashionable product in a market that comprises of myopic and strategic consumers over two periods （i.e., the advance selling season and the regular selling season）. For a linear product diffusion effect we fred that, when the effect of product diffusion is positive, the seller may set an extremely high advance selling price to induce the strategic consumers to purchase in the regular selling season, which is counter-intuitive. Moreover, the optimal procurement quantity for the seller may increase in the negative effect of product diffusion and decrease in the amount of strategic consumers. When we extend our model to consider a concave quadratic product diffusion effect, however, the optimal procurement quantity is concave in the amount of strategic consumers. Numerical studies are further presented to discuss the managerial insights.

关键词： Advance selling product diffusion strategic consumer behavior interface on marketing andoperations management

Advancing sustainable agriculture: Enhancing crop nutrition with next-generation nanotech-based fertilizers

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Nano Research 2023年第12期16卷 13205-13225页

作者： yiwen Liao Dawei Xu Yuhong Cao Yong-Guan Zhu state Key Laboratory of Urban and Regional Ecology Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of sciences Beijing 100049China CAs Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

The pressing need to enhance nutrient use efficiency(NUE)in fertilizers has become increasingly urgent in light of food insecurity and climate-related *** offers promising prospects for the development of effective and environmentally friendly alternatives in the field of *** review focuses on the impact of nanotechnology on conventional fertilizers,encompassing inorganic,organic,and microbial *** emphasize the superior attributes of nano-fertilizers compared with their conventional counterparts and explore their potential and versatility in boosting crop productivity,reducing fertilizer expenses,and mitigating detrimental environmental *** conclusion,given the significant challenges posed by food insecurity and climate change,the application of nano-fertilizers demonstrates immense potential for advancing sustainable and intelligent agricultural practices.

关键词： nanobiotechnology nano-fertilizers(NFs) nutrient use efficiency(NUE) slow release sustainable agriculture