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NPR锚索对跨断层软岩大变形隧道控制技术研究

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隧道建设（中英文） 2024年第S1期44卷 113-123页

作者：陶志刚林伟军李勇孙滢滢熊弋文陈明亮中国矿业大学(北京)隧道工程灾变防控与智能建养全国重点实验室北京100083 中国矿业大学(北京)力学与土木工程学院北京100083 中国矿业大学(北京)地球科学与测绘工程学院北京100083 中国矿业大学(北京)煤炭资源与安全开采国家重点实验室北京100083

为探究NPR锚索对东马场跨断层软岩大变形隧道控制效果,首先对NPR锚索进行静力拉伸试验,验证其恒阻大变形的能力和具有良好的抵御外力的效果;随后开展NPR锚索对东马场隧道围岩变形控制的三维物理模型试验。试验现象和数据表明:在开挖过程... 详细信息

为探究NPR锚索对东马场跨断层软岩大变形隧道控制效果,首先对NPR锚索进行静力拉伸试验,验证其恒阻大变形的能力和具有良好的抵御外力的效果;随后开展NPR锚索对东马场隧道围岩变形控制的三维物理模型试验。试验现象和数据表明:在开挖过程中,隧道围岩也没有出现较大垮落和坍塌,NPR锚索对软岩隧道围岩有较好的支护效果。在加载完成后,NPR锚索对非断层处的隧道围岩最大位移约为14 mm,断层处的围岩最大位移约为21 mm,隧道区域所受应力分布的不规律性,导致隧道围岩出现挤压变形,位移曲线呈振荡状。在NPR锚索的支护下,围岩应力最大发生在左拱肩,围岩临空面3 cm处切应力最大(0.3 MPa),隧道未出现大规模的不对称破坏现象,隧道总体呈现出“小塌而不垮”,变形总体可控。

关键词：断层隧道软岩大变形 NPR锚索物理模型试验

Intuitive Human-Robot-Environment Interaction With EMG Signals:A Review

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1075-1091页

作者： Dezhen xiong Daohui Zhang Yaqi Chu yiwen Zhao Xingang Zhao State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016 Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang 110169 University of Chinese Academy of Sciences Beijing 100049China

A long history has passed since electromyography(EMG)signals have been explored in human-centered robots for intuitive ***,it still has a gap between scientific research and real-life *** studies mainly focused on EMG decoding algorithms,leaving a dynamic relationship between the human,robot,and uncertain environment in real-life scenarios seldomly *** fill this gap,this paper presents a comprehensive review of EMG-based techniques in human-robot-environment interaction(HREI)*** general processing framework is summarized,and three interaction paradigms,including direct control,sensory feedback,and partial autonomous control,are ***-based intention decoding is treated as a module of the proposed *** key issues involving precision,stability,user attention,compliance,and environmental awareness in this field are *** important directions,including EMG decomposition,robust algorithms,HREI dataset,proprioception feedback,reinforcement learning,and embodied intelligence,are proposed to pave the way for future *** the best of what we know,this is the first time that a review of EMG-based methods in the HREI system is *** provides a novel and broader perspective to improve the practicability of current myoelectric interaction systems,in which factors in human-robot interaction,robot-environment interaction,and state perception by human sensations are considered,which has never been done by previous studies.

关键词： robot summarized Robot

Hydroxysafflor yellow A induced ferroptosis of Osteosarcoma cancer cells by HIF-1α/HK2 and SLC7A11 pathway

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Oncology Research 2024年第5期32卷 899-910页

作者： yiwen ZHU LIU YANG YING YU YING xiong PING XIAO XIAO FU XIN LUO Department of Rehabilitation Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang330006China Department of General Practice The Second Affiliated Hospital of Nanchang UniversityNanchang330006China

Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal *** there is no permanent therapy for this condition,it is necessary to develop a ***,this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A(HYSA)in osteosarcoma cell lines(MG63).In this investigational study,MG63 cells were *** experiments,quantitative polymerase chain reaction(qPCR),immunofluorescent staining,extracellular acidification rate(ECAR),oxygen consumption rate(OCR),glucose consumption,lactate production,and ATP levels,proliferation assay,5-Ethynyl-2′-deoxyuridine(EDU)staining,and Western blot were *** MG63 cells,HYSA lowered cell proliferation and metastasis rates,suppressed EDU cell number,and enhanced caspase-3/9 activity *** reduced the Warburg effect and induced ferroptosis(FPT)in MG63 *** ferroptosis diminished HYSA’s anti-cancer activities in MG63 *** stimulation of the HIF-1α/SLC7A11 pathway decreased HYSA’s anti-cancer activities in MG63 ***-1αis one target spot for HYSA in a model of osteosarcoma cancer(OC).HYSA altered HIF-1α’s thermophoretic activity;following binding with HYSA,HIF-1α’s melting point increased from~55°C to~60°*** significantly enhanced the thermal stability of exogenous WT HIF-1αwhile not affecting Mut HIF-1α,suggesting that ARG-311,GLY-312,GLN-347,and GLN-387 may be involved in the interaction between HIF-1αand ***,our study revealed that HYSA induced FPT and reduced the Warburg effect of OC through mitochondrial damage by HIF-1α/HK2/SLC7A11 *** is a possible therapeutic option for OC or other cancers.

关键词： Hydroxysafflor yellow A Osteosarcoma HIF-1α FPT

A general climatology of categorized Martian ionospheric irregularities

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Science China Earth Sciences 2024年第10期67卷 3302-3325页

作者： Xin WAN Jiahao ZHONG Yongqiang HAO Chao xiong Hui WANG Yutian CAO Jun CUI yiwen LIU Qiaoling LI Jiawei KUAI Planetary Environmental and Astrobiological Research Laboratory(PEARL) School of Atmospheric SciencesSun Yat-sen UniversityZhuhai 519082China Key Laboratory of Tropical Atmosphere-Ocean System Ministry of EducationZhuhai 519082China Department of Space Physics College of Electronic InformationLuojia LaboratoryWuhan UniversityWuhan 430079China School of Physics and Electronic Information Shangrao Normal UniversityShangrao 334001China School of Petroleum China University of Petroleum-Beijing at KaramayKaramay 834000China College of Astronautics Nanjing University of Aeronautics and AstronauticsNanjing 210016China

A climatological survey of Martian ionospheric plasma density irregularities was conducted by exploring the in-situ measurements of the Mars Atmosphere and Volatile EvolutioN(MAVEN) spacecraft. The irregularities were first classified as enhancement, depletion, and oscillation. By checking the simultaneous magnetic field fluctuation, the irregularities have been classified into two types: with or without magnetic signatures. The classified irregularities exhibit diverse global occurrence patterns, as those with magnetic signatures tend to appear near the periphery of the crustal magnetic anomaly(MA), and those without magnetic signatures prefer to appear either inside of the MA or outside of the MA, depending on the type and solar zenith angle. Under most circumstances, the irregularities have a considerable occurrence rate at altitudes above the ionospheric dynamo height(above 200 km), and the magnetization state of the ions seems irrelevant to their occurrence. In addition, the irregularities do not show dependence on magnetic field geometry, except that the enhancement without magnetic signatures favors the vertical field line, implying its equivalence to the localized bulge. Other similarities and discrepancies exist in reference to previous studies. We believe this global survey complements previous research and provides crucial research clues for future efforts to clarify the nature of the Martian ionospheric irregularities.

关键词： Mars MAVEN Ionosphere Ionospheric irregularities Crustal magnetic anomaly Plasma

Toosendanin: upgrade of an old agent in cancer treatment

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Chinese Journal of Natural Medicines 2024年第10期22卷 887-899页

作者： LI Shuwei xiong Qingyi SHEN yiwen LIN Jiayi ZHANG Lijun WU Ye JIN Jinmei LUAN Xin Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital Shanghai University of Traditional Chinese Medicine

Toosendanin(TSN), a tetracyclic triterpenoid derived from Melia toosendan and M. azedarach, demonstrates broad application prospects in cancer treatment. Although previously employed as a pesticide, recent studies have revealed its potential therapeutic value in treating various types of cancer. TSN exerts an anticancer effect via mechanisms including proliferation inhibition, apoptosis induction, migration suppression, and angiogenesis inhibition. However, TSN's toxicity, particularly its hepatotoxicity, significantly limits its therapeutic application. This review explored the dual nature of TSN, evaluating both its anticancer potential and toxicological risks, emphasizing the importance of balancing these aspects in therapeutic applications. Furthermore, we investigated the incorporation of TSN into novel therapeutic strategies, such as Proteolysis-targeting chimeras(PROTAC) technology and nanotechnology-based drug delivery systems(DDS), which enhance treatment efficacy while mitigating toxicity in normal tissues.

关键词： Cancer therapy Hepatotoxicity Nano-delivery systems PROTAC Toosendanin

“自然极限”还是“自然创造”?--伯克特和本顿围绕马克思生态思想的争论

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理论月刊 2023年第5期 48-55页

作者：熊易文孙玉忠哈尔滨师范大学马克思主义学院

生态学马克思主义者泰德·本顿和保罗·伯克特关于马克思是否有“自然极限”的思想展开了激烈争论。本顿将马克思思想误判为以生产力为主导的工业主义意识形态,并认为马克思没有自然极限思想。伯克特则通过分析马克思对马尔萨斯的批判,... 详细信息

生态学马克思主义者泰德·本顿和保罗·伯克特关于马克思是否有“自然极限”的思想展开了激烈争论。本顿将马克思思想误判为以生产力为主导的工业主义意识形态,并认为马克思没有自然极限思想。伯克特则通过分析马克思对马尔萨斯的批判,区分马克思人类生产的自然条件,辨析马克思劳动过程的生态调节,指出本顿对马克思的理解出现了较大的偏差。在伯克特看来,马克思所认为的自然极限是在具体生产关系下劳动的边界,人们在这个边界内进行“自然创造”获取财富。而这种自然创造的思想无疑比本顿所理解的自然极限思想更为深刻。梳理反思伯克特与本顿的争论,有助于加深对马克思自然创造思想的理解,厘清生态学马克思主义领域的争论,为我国生态文明建设提供重要的理论资源。

关键词：自然极限自然创造本顿伯克特生态学马克思主义

从课程思政的角度谈“物联网工程导论”课程的教学设计

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科教文汇 2020年第36期 133-134页

作者：熊艺文桂林航天工业学院广西桂林541004

物联网工程是一门新兴技术学科,其整合了计算机、通信技术、传感器等技术,以感知为基础,通过部署多种类型的传感器采集数据,通过无线网络进行远距离传输,最后通过网关进行智能处理。“物联网工程导论”是物联网工程专业学生了解物联网... 详细信息

物联网工程是一门新兴技术学科,其整合了计算机、通信技术、传感器等技术,以感知为基础,通过部署多种类型的传感器采集数据,通过无线网络进行远距离传输,最后通过网关进行智能处理。“物联网工程导论”是物联网工程专业学生了解物联网技术的入门课程,该课程能使学生更快地了解物联网技术的基础知识及相关概念,为后续专业课程的学习打下坚实的基础。导论课结合时政,在教学过程中融入大学生思想政治教育,注重强化对学生的工程伦理教育,培养学生精益求精的工匠精神,激发学生科技报国的家国情怀和使命担当。

关键词：物联网工程导论课程思政教学设计

从中西数学思想体系看“中国古代有无科学”问题

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科教文汇 2019年第12期 48-49页

作者：熊易文哈尔滨师范大学马克思主义学院黑龙江哈尔滨150025

中西数学思想在其各自的文化领域中各成体系。中国古代数学思想体系是以《九章算术》为代表的机械化体系;西方数学思想体系是以《几何原本》为代表的公理化体系。中西数学思想体系的不同造成看待问题的视角不同。论文通过分析《九章算... 详细信息

中西数学思想在其各自的文化领域中各成体系。中国古代数学思想体系是以《九章算术》为代表的机械化体系;西方数学思想体系是以《几何原本》为代表的公理化体系。中西数学思想体系的不同造成看待问题的视角不同。论文通过分析《九章算术》和《几何原本》,表达中西数学思想体系的不同来进行"中国古代有无科学"问题的探究。

关键词：《九章算术》《几何原本》机械化公理化

“互联网+”背景下大学英语教师TPACK水平及影响因素研究

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山东外语教学 2018年第6期39卷 40-51页

作者：王雪梅熊奕雯上海外国语大学英语学院上海200083 南昌理工学院外国语学院江西南昌330044

为了解"互联网+"时代下大学英语教师TPACK水平及其影响因素,本文采用混合式研究方法,对141位大学英语教师进行问卷调查,并从中选取4位教师进行访谈。量化结果表明:大学英语教师TPACK水平较低,TK知识薄弱;男教师TPACK明显高于女教师;教... 详细信息

为了解"互联网+"时代下大学英语教师TPACK水平及其影响因素,本文采用混合式研究方法,对141位大学英语教师进行问卷调查,并从中选取4位教师进行访谈。量化结果表明:大学英语教师TPACK水平较低,TK知识薄弱;男教师TPACK明显高于女教师;教师教龄越长,CK、PK水平越高,TK水平越低;教师是否接受过师范教育对其CK、PK、PCK水平有一定影响;教师培训对TK等知识有一定的促进作用;教师信念、教师的学习与交流以及教学设施是影响大学英语教师TPACK的三个主要境脉因素。针对以上发现,文章提出了相关建议,以期为大学英语教师TPACK发展提供启示。

关键词： “互联网+" TPACK 大学英语教师影响因素