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ZIKV viral proteins and their roles in virus-host interactions

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Science China(Life Sciences) 2021年第5期64卷 709-719页

作者： Moujian Guo Lixia Hui yiwen nie Boris Tefsen Ying Wu State Key Laboratory of Virology School of Basic Medical SciencesWuhan UniversityWuhan 430071China Department of Biological Sciences Xi'an Jiaotong-Liverpool UniversitySuzhou 215123China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

The re-emergence of Zika virus(ZIKV) and its associated neonatal microcephaly and Guillain-Barré syndrome have led the World Health Organization to declare a global health emergency. Until today, many related studies have successively reported the role of various viral proteins of ZIKVin the process of ZIKVinfection and pathogenicity. These studies have provided significant insights for the treatment and prevention of ZIKV infection. Here we review the current research advances in the functional characterization of the interactions between each ZIKV viral protein and its host factors.

关键词： ZIKV viral protein host-virus interactions immune response pathogenicity

Secure and Efficient Computing Resource Management in Blockchain-Based Vehicular Fog Computing

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China Communications 2021年第4期18卷 115-125页

作者： Ming Kong Junhui Zhao Xiaoke Sun yiwen nie School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School of Information Engineering East China Jiaotong UniversityNanchang 330013China

In vehicular fog computing(VFC),the resource transactions in the Internet of Vehicles(IoV)have become a novel resource management scheme that can improve system resource utilization and the quality of vehicle services.In this paper,in order to improve the security and fairness of resource transactions,we design a blockchain-based resource management scheme for VFC.First,we propose the concept of resource coin(RC)and develop a blockchain-based secure computing reource trading mechanism in terms of RC.As a node of the blockchain network,the roadside unit(RSU)participates in verifying the legitimacy of transactions and the creation of new blocks.Next,we propose a resource management scheme based on contract theory,encouraging parked vehicles to contribute computing resource so that RSU could complete proof of work(PoW)quickly,improve the success probability of block creation and get RC rewards.We use the gradient descent method to solve the computing resource utilization that can maximize the RC revenue of RSUs and vehicles during the block creation.Finally,the performance of this model is validated in simulation result and analysis.

关键词： blockchain vehicular fog computing resource management contract theory

Energy-Efficient UAV Trajectory Design for Backscatter Communication: A Deep Reinforcement Learning Approach

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China Communications 2020年第10期17卷 129-141页

作者： yiwen nie Junhui Zhao Jun Liu Jing Jiang Ruijin Ding School of Electronic and Information Engineering Beijing Jioatong UniversityBeijing 100044China School of Information Engineering East China Jiaotong UniversityNanchang 330013China Institute of Network Sciences and Cyberspace Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology(BNRist) Beijing 100084China Shaanxi Key Laboratory of Information Communication Network and Security Xi’an University of Posts and TelecommunicationsXi’an 710121China Institute for Artificial Intelligence Tsinghua University(THUAI)Beijing 100084China State Key Laboratory of Intelligent Technologies and Systems Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology(BNRist) Department of AutomationTsinghua UniversityBeijing 100084China

Recently,backscatter communication(BC)has been introduced as a green paradigm for Internet of Things(IoT).Meanwhile,unmanned aerial vehicles(UAVs)can serve as aerial base stations(BSs)to enhance the performance of BC system thanks to their high mobility and flexibility.In this paper,we investigate the problem of energy efficiency(EE)for an energy-limited backscatter communication(BC)network,where backscatter devices(BDs)on the ground harvest energy from the wireless signal of a flying rotary-wing quadrotor.Specifically,we first reformulate the EE optimization problem as a Markov decision process(MDP)and then propose a deep reinforcement learning(DRL)algorithm to design the UAV trajectory with the constraints of the BD scheduling,the power reflection coefficients,the transmission power,and the fairness among BDs.Simulation results show the proposed DRL algorithm achieves close-to-optimal performance and significant EE gains compared to the benchmark schemes.

关键词： unmanned aerial vehicle(UAV) trajectory design backscatter communication deep reinforcement learning energy-efficient

Rearrangement of Actin Cytoskeleton by Zika Virus Infection Facilitates Blood–Testis Barrier Hyperpermeability

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Virologica Sinica 2021年第4期36卷 692-705页

作者： yiwen nie Lixia Hui Moujian Guo Wei Yang Rui Huang Junsen Chen Xinyue Wen Meng Zhao Ying Wu State Key Laboratory of Virology School of Basic Medical SciencesWuhan UniversityWuhan 430072China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

In recent years,various serious diseases caused by Zika virus(ZIKV)have made it impossible to be ignored.Confirmed existence of ZIKV in semen and sexually transmission of ZIKV suggested that it can break the blood–testis barrier(BTB),or Sertoli cell barrier(SCB).However,little is known about the underlying mechanism.In this study,interaction between actin,an important component of the SCB,and ZIKV envelope(E)protein domainⅢ(EDⅢ)was inferred from coimmunoprecipitation(Co-IP)liquid chromatography–tandem mass spectrometry(LC–MS/MS)analysis.Confocal microscopy confirmed the role of actin filaments(F-actin)in ZIKV infection,during which part of the stress fibers,the bundles that constituted by paralleled actin filaments,were disrupted and presented in the cell periphery.Colocalization of E and reorganized actin filaments in the cell periphery of transfected Sertoli cells suggests a participation of ZIKV E protein in ZIKV-induced F-actin rearrangement.Perturbation of F-actin by cytochalasin D(CytoD)or Jasplakinolide(Jas)enhanced the infection of ZIKV.More importantly,the transepithelial electrical resistance(TEER)of an in vitro mouse SCB(mSCB)model declined with the progression of ZIKV infection or overexpression of E protein.Co-IP and confocal microscopy analyses revealed that the interaction between F-actin and tight junction protein ZO-1 was reduced after ZIKV infection or E protein overexpression,highlighting the role of E protein in ZIKV-induced disruption of the BTB.We conclude that the interaction between ZIKV E and F-actin leads to the reorganization of F-actin network,thereby compromising BTB integrity.

关键词： Zika virus(ZIKV) Envelope protein Actin filaments Sertoli cell barrier(SCB) Blood-testis barrier(BTB)

3种超声方式对蓝莓蜡质层和细胞结构及真空冷冻干燥特性的影响

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食品科学技术学报 2024年第3期42卷 159-170页

作者：肖亚冬杨慧珍李大婧聂梅梅杨亦雯王迪刘春菊牛丽影杨润强南京农业大学食品科技学院江苏南京210095 江苏省农业科学院农产品加工研究所江苏南京210014 南京市产品质量监督检验院江苏南京210019

蓝莓表皮蜡质成分严重阻碍其真空冷冻干燥过程中的水分扩散。以新鲜蓝莓为原料,分析3种超声方式对蓝莓蜡质层和内部细胞结构的影响,结合蓝莓脆品质特性和干燥特性,探究适宜蓝莓真空冷冻干燥的超声预处理方式。气相色谱-质谱联用结果表明... 详细信息

蓝莓表皮蜡质成分严重阻碍其真空冷冻干燥过程中的水分扩散。以新鲜蓝莓为原料,分析3种超声方式对蓝莓蜡质层和内部细胞结构的影响,结合蓝莓脆品质特性和干燥特性,探究适宜蓝莓真空冷冻干燥的超声预处理方式。气相色谱-质谱联用结果表明:不同超声处理对蓝莓表皮蜡质组成和含量影响不同,其中间歇式超声处理后蓝莓表皮蜡质组成和总相对含量变化最大,与对照组相比总相对含量减少了35%。微观结构分析结果表明:探头式和间歇式超声处理后蓝莓表皮的蜡质分布疏松,表皮裸露;连续式超声处理后蓝莓表皮蜡质晶体结构由管状变为片状。探头式和间歇式超声处理对蓝莓内部细胞结构破坏较大,使其形成大尺寸微通道,并且探头式超声处理后,蓝莓细胞膜渗透率显著高于其他处理方式(P<0.05)。不同超声处理后蓝莓的T 2弛豫曲线均整体向左移动,峰面积和信号幅值减小;3种超声处理方式明显改善了真空冷冻干燥蓝莓干燥速率,连续式和探头式超声处理显著改善了真空冷冻干燥蓝莓的脆性,分别提高了38.25%、40.09%。连续式超声处理获得的真空冷冻干燥蓝莓维生素C和花青素保留率显著提高,分别为86.17%±0.18%和71.30%±1.88%。综合比较,连续式超声处理是较优的蓝莓真空冷冻干燥预处理方式。

关键词：蓝莓超声蜡质真空冷冻干燥细胞膜渗透率质构

超声预处理蓝莓真空冷冻干燥工艺优化及对品质的影响

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南京农业大学学报 2024年第3期47卷 551-563页

作者：聂梅梅杨慧珍李大婧肖亚冬杨亦雯于蕊刘春菊牛丽影金鹏南京农业大学食品科学技术学院江苏南京210095 江苏省农业科学院农产品加工研究所江苏南京210014

[目的]本文旨在更好提高蓝莓真空冷冻干燥速率与产品品质。[方法]利用超声处理作为预处理方式,研究超声温度(45、55、65和75℃)、频率(45、80和100 kHz)、功率(600、700、800、900和1000 W)和时间(25、30、35和40 min)对蓝莓真空冷冻干... 详细信息

[目的]本文旨在更好提高蓝莓真空冷冻干燥速率与产品品质。[方法]利用超声处理作为预处理方式,研究超声温度(45、55、65和75℃)、频率(45、80和100 kHz)、功率(600、700、800、900和1000 W)和时间(25、30、35和40 min)对蓝莓真空冷冻干燥特性、质构、色泽、营养物质保留率及抗氧化活性的影响,并以干燥速率、花青素含量、色泽和脆性为指标进行四因素三水平响应面优化试验,筛选出最佳超声预处理工艺及参数。[结果]超声温度对蓝莓花青素含量的影响极显著(P0.05)。最终获得蓝莓超声预处理的优化工艺条件:超声温度55℃,频率80 kHz,功率700 W,时间30 min,此条件下蓝莓的干燥速率为1.69 g·g^(-1)·h^(-1),花青素含量0.55 mg·g^(-1),脆性2770.00 g,ΔE值6.16。[结论]超声预处理可改善蓝莓真空冷冻干燥品质,该结果为蓝莓真空冷冻干燥研究及产品开发提供基础。

关键词：蓝莓真空冷冻干燥超声干燥速率响应面

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见“书”如画读聂崇正《谐谑丹青》

紫禁城 2024年第4期351卷 157-159页

作者：樊祎雯中国国家博物馆

聂崇正先生的新书《谐谑丹青》已于近日出版,承蒙聂先生信任,邀我为其写评书,作为晚生后学,自然诚惶诚恐,与其说书评,不如说是对聂先生最新研究成果的学习心得与体会更恰当。

关键词：崇正谐谑最新研究成果心得与体会丹青

Decision Intelligence Empowered Resource Management for 6G Vehicle-to-Everything Communications

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Chinese Journal of Electronics 2023年

作者： ZHAO Junhui nie yiwen ZHANG Huan WANG Dongming East China Jiaotong University Lenovo Research Beijing Jiaotong University Southeast University

To meet more requirements for the future communications, the sixth generation(6G) wireless communication networks are expected to provide the better coverage, spectra/energy efficiency, intelligence, and security than the fifth generation(5G) networks. With the recent advances in artificial intelligence(AI), the 6G vehicle-to-everything(V2X) focus on the further AI applications for intelligent transportation systems(ITS), especially for extending decision intelligence(DI) of resource management. Specifically, a new V2X framework integrated 6G techniques and AI approaches is proposed in this article. We introduce some typical 6G techniques to assist the vehicular intelligence as alternative schemes.Moreover, we provide the intelligent resource managements based on edge intelligence, integrated intelligence,distributed intelligence, and secure intelligence to overcome challenges of efficiency, delay, mobility, and privacy,respectively. We also propose a federated reinforcement learning(FRL) based algorithm to validate the privacyaware secure intelligence with effective resource management. Simulation results show that the proposed algorithm significantly outperforms the non-AI baseline schemes in the novel network structure. To enlighten future topics for 6G vehicular resource management, we discuss some potential scenarios with the promising AIbased solutions.

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Room-temperature hydrogenation of halogenated nitrobenzenes over metal-organic-framework-derived ultra-dispersed Ni stabilized by N-doped carbon nanoneedles

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Frontiers of Chemical Science and Engineering 2022年第12期16卷 1782-1792页

作者： Yuemin Lin Yuanyuan Zhang Renfeng nie Kai Zhou Yao Ma Mingjie Liu Dan Lu Zongbi Bao Qiwei Yang yiwen Yang Qilong Ren Zhiguo Zhang Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China School of Chemical Engineering Henan Center for Outstanding Overseas ScientistsZhengzhou UniversityZhengzhou 450001China Institute of Zhejiang University—Quzhou Quzhou 324000China

Ultra-dispersed Ni nanoparticles(7.5 nm)on nitrogen-doped carbon nanoneedles(Ni@NCNs)were prepared by simple pyrolysis of Ni-based metal–organic-framework for selective hydrogenation of halogenated nitrobenzenes to corresponding anilines.Two different crystallization methods(stirring and static)were compared and the optimal pyrolysis temperature was explored.Ni@NCNs were systematically characterized by wide analytical techniques.In the hydrogenation of p-chloronitrobenzene,Ni@NCNs-600(pyrolyzed at 600°C)exhibited extraordinarily high performance with 77.9 h^(–1)catalytic productivity and>99%p-chloroaniline selectivity at full p-chloronitrobenzene conversion under mild conditions(90°C,1.5 MPa H2),showing obvious superiority compared with reported Ni-based catalysts.Notably,the reaction smoothly proceeded at room temperature with full conversion and>99%selectivity.Moreover,Ni@NCNs-600 afforded good tolerance to various nitroarenes substituted by sensitive groups(halogen,nitrile,keto,carboxylic,etc.),and could be easily recycled by magnetic separation and reused for 5 times without deactivation.The adsorption tests showed that the preferential adsorption of–NO2 on the catalyst can restrain the dehalogenation of p-chloronitrobenzene,thus achieving high p-chloroaniline selectivity.While the high activity can be attributed to high Ni dispersion,special morphology,and rich pore structure of the catalyst.

关键词： halogenated nitrobenzenes room-temperature hydrogenation Ni nanoparticles nitrogen-doped carbon nanoneedles metal–organic-framework