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Timely renal replacement therapy linked to better outcome in patients with sepsis-associated acute kidney injury

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Journal of Intensive Medicine 2022年第3期2卷 173-182页

作者： yiwen fan Liang Chen Shaowei Jiang Yingying Huang Yuxin Leng Chengjin Gao Department of Emergency Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pathology and Medical Biology University of GroningenUniversity Medical Center GroningenGronigen 9713GZthe Netherlands Department of Intensive Care Unit Peking University Third HospitalBeijing 100191China

Background:Recent studies suggest that acute kidney injury(AKI)can be treated with renal replacement therapy(RRT).However,its benefits to patients with sepsis-associated AKI(SA-AKI),which is linked to high mortality and morbidity rates,remain under debate.The aim of this study was to compare the outcomes of different RRT strategies for patients with SA-AKI.Methods:This retrospective study evaluated patients who were admitted to the hospital with sepsis and devel-oped SA-AKI during hospitalization from 1st January 2014 to 31st January 2019.Mortality,renal recovery,and systemic organ function at 90 days following admission were compared between the RRT group(RG)and non-RRT group(NRG),as well as the early-RRT group(EG)and delayed-RRT group(DG).The groups were defined according to the time from admission to RRT initiation(criterion 1,EG1 and DG1)and Kidney Disease Improving Global Outcomes(KDIGO)classification(criterion 2,EG2 and DG2).Categorical and continuous variables were compared using the chi-squared test or Fisher’s exact test and Student’s t-test or Wilcoxon test.Kaplan-Meier curves were constructed to determine the unadjusted survival rates for the different subgroups.Results:A total of 116 patients were included in this study;of those,38 received RRT and 46 expired within 90 days.Among different strategies of RRT,there were no significant differences found in 90-day mortality(RG vs.NRG:𝜒2=0.610,P=0.435;EG1 vs.DG1:𝜒2=0.835,P=0.360;EG2 vs.DG2:𝜒2=0.022,P=0.899)and renal recovery.However,the values of change in sequential organ failure assessment(ΔSOFA)max-min of patients in the EG and RG were significantly higher than those recorded in the NRG(ΔSOFA RG=7.0,ΔSOFA NRG=3.60,ΔSOFA EG1=9.00,ΔSOFA EG2=6.30;P<0.050).Also,the 90-day renal recovery in the EG was better than that noted in the DG with criterion 1(87.5%vs.38.5%,respectively,𝜒2=10.425,P=0.032),suggesting that RRT(especially timely RRT)may be beneficial to the restoration of systemic organ function in patients with SA-AKI.Conclusion:RRT did not reduce the 9

关键词： Dialysis Sepsis Renal failure Kidney injury Creatinine Shock

PAI-1 genetic polymorphisms influence septic patients’outcomes by regulating neutrophil activity

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Chinese Medical Journal 2023年第16期136卷 1959-1966页

作者： Shaowei Jiang Yang Wang Liang Chen Honghua Mu Connor Meaney yiwen fan Janesh Pillay Hairong Wang Jincheng Zhang Shuming Pan Chengjin Gao Department of Emergency Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Division of Rheumatology Department of Internal MedicineUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Pathology Medicine Biology University Medical Center GroningenThe Netherlands Department of Critical Care University Medical Center GroningenThe Netherlands Department of Critical Care Medicine Zhongshan HospitalFudan UniversityShanghai 200032China

Background:Plasminogen activator inhibitor-1(PAI-1)plays an important role in the pathophysiology of sepsis,but the exact mechanism remains debatable.In this study,we investigated the associations among the serum levels of PAI-1,the incidence of 4G/5G promoter PAI-1 gene polymorphisms,immunological indicators,and clinical outcomes in septic patients.Methods:A total of 181 patients aged 18-80 years with sepsis between November 2016 and August 2018 in the intensive care unit in the Xinhua Hospital were recruited in this retrospective study,with 28-day mortality as the primary outcome.The initial serum level of PAI-1 and the presence of rs1799768 single nucleotide polymorphisms(SNPs)were examined.Univariate logistic regression and multivariate analyses were performed to determine the factors associated with different genotypes of PAI-1,serum level of PAI-1,and 28-day mortality.Results:The logistic analysis suggested that a high serum level of PAI-1 was associated with the rs1799768 SNP of PAI-1(4G/4G and 4G/5G)(Odds ratio[OR]:2.49;95%confidence interval[CI]:1.09,5.68).Furthermore,a high serum level of PAI-1 strongly influenced 28-day mortality(OR 3.36;95%CI 1.51,7.49).The expression and activation of neutrophils(OR 0.96;95%CI 0.93,0.99),as well as the changes in the expression patterns of cytokines and chemokine-associated neutrophils(OR:1.00;95%CI:1.00,1.00),were both regulated by the genotype of PAI-1.Conclusions:Genetic polymorphisms of PAI-1 can influence the serum levels of PAI-1,which might contribute to mortality by affecting neutrophil activity.Thus,patients with severe sepsis might clinically benefit from enhanced neutrophil clearance and the resolution of inflammation via the regulation of PAI-1 expression and activity.

关键词： Gene polymorphism Neutrophil Plasminogen activator inhibitor-1 PAI-1 Sepsis Single nucleotide polymorphism

多尺度决策系统中测试代价敏感的属性与尺度同步选择

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模式识别与人工智能 2024年第4期37卷 368-382页

作者：廖淑娇吴迪卢亚倩范译文闽南师范大学数学与统计学院漳州363000 闽南师范大学福建省粒计算及其应用重点实验室漳州363000 闽南师范大学数字福建气象大数据研究所漳州363000 闽南师范大学数据科学与统计重点实验室漳州363000

属性与尺度同步选择方法可有效解决涉及代价因素的多尺度决策系统的知识约简问题,然而在现有研究中,少有基于代价进行属性与尺度的同步选择,并且大多数算法只针对协调的多尺度决策系统或不协调的多尺度决策系统.为了解决这一问题,文中... 详细信息

属性与尺度同步选择方法可有效解决涉及代价因素的多尺度决策系统的知识约简问题,然而在现有研究中,少有基于代价进行属性与尺度的同步选择,并且大多数算法只针对协调的多尺度决策系统或不协调的多尺度决策系统.为了解决这一问题,文中以最小化数据处理的总测试代价为目标,提出测试代价敏感的属性与尺度同步选择算法,同时适用于协调的多尺度决策系统和不协调的多尺度决策系统.首先,构造基于粗糙集的理论模型,模型中的概念及性质同时考虑属性因素和尺度因素.其次,基于粗糙集的理论模型,设计启发式算法,能基于测试代价对多尺度决策系统同时进行属性约简与尺度选择,并且不同的属性可选择不同的尺度.最后,在12个数据集上的实验验证文中算法的有效性、实用性及优越性.

关键词：属性与尺度选择代价敏感学习多尺度决策系统粗糙集单调性

Key technologies for medium and low voltage DC distribution system

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Global Energy Interconnection 2021年第1期4卷 91-103页

作者： yiwen fan Yongning Chi Yan Li Zhibing Wang Hongzhi Liu Wei Liu Xiangyu Li China Electric Power Research Institute Beijing 100192P.R.China College of Electrical and Electronic Engineering North China Electric Power UniversityBeijing 102206P.R.China School of Engineering Cardiff UniversityCF243AAUK

Development of the medium and low voltage DC distribution system is of great significance to a regional transmission of electric energy,increasing a penetration rate of new energy,and enhancing a safety of the operation of the AC/DC interconnected grid.This paper first summarizes the medium and low voltage DC distribution system schemes and plans put forward by many countries,and then elaborate status of under-construction medium and low voltage DC distribution system project cases in China.Based on these project cases,this paper analyzes key issues involved in the medium and low voltage DC distribution system topologies,equipment,operation control technologies and DC fault protections,in order to provide theoretical and technical reference for future medium and low voltage DC distribution system-related projects.Finally,this paper combines a current China research status to summarize and give a prediction about the future research direction of medium and low voltage DC distribution system,which can provide reference for the research of medium and low voltage DC distribution system.

关键词： Medium and low voltage DC distribution system System topology Key equipment DC fault protection Operation control technology

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见“书”如画读聂崇正《谐谑丹青》

紫禁城 2024年第4期351卷 157-159页

作者：樊祎雯中国国家博物馆

聂崇正先生的新书《谐谑丹青》已于近日出版,承蒙聂先生信任,邀我为其写评书,作为晚生后学,自然诚惶诚恐,与其说书评,不如说是对聂先生最新研究成果的学习心得与体会更恰当。

关键词：崇正谐谑最新研究成果心得与体会丹青

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四川泡菜母水的微生物群落与理化特性分析

中国食品学报 2024年第2期24卷 281-291页

作者：胡此海杨絮郭全友郑尧李保国范逸文上海理工大学健康科学与工程学院上海200093 中国水产科学研究院东海水产研究所上海200090

为明确泡菜母水中的优势微生物与理化特性的相关性,采用高通量测序技术分析母水中的微生物群落结构,并进行相关性分析。结果表明:泡菜母水的总酸含量为3.00~18.90 g/kg,pH值为3.27~4.71,盐含量为11.00~15.50 g/100 g,检出草酸、苹果酸... 详细信息

为明确泡菜母水中的优势微生物与理化特性的相关性,采用高通量测序技术分析母水中的微生物群落结构,并进行相关性分析。结果表明:泡菜母水的总酸含量为3.00~18.90 g/kg,pH值为3.27~4.71,盐含量为11.00~15.50 g/100 g,检出草酸、苹果酸、琥珀酸和乳酸等7种有机酸。微生物主要群落包括厚壁菌门和子囊菌门2个门,占比均超过99.00%。优势细菌是乳杆菌属、片球菌属,优势真菌是毕赤酵母属、哈克斯坦酵母属、德巴利酵母属。相关性分析表明,乳酸杆菌属与乳酸呈显著正相关关系(P<0.05),与乙酸呈极显著正相关关系(P<0.01)。片球菌属与苹果酸呈极显著正相关关系(P<0.01)。结论:乳酸杆菌和片球菌是泡菜母水的优势微生物,研究结果为泡菜母水高效发酵菌株的选育和泡菜工业化生产提供试验参考。

关键词：泡菜母水高通量测序微生物多样性理化特性相关性

基于动态神经网络NARX时间序列的双排桩基坑变形预测

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广西大学学报（自然科学版） 2024年第1期49卷 49-59页

作者：侯福昌曾家俊江杰李结全范懿文广西瑞宇建筑科技有限公司广西南宁530004 桂林理工大学土木与建筑工程学院广西桂林541004 广西大学土木建筑工程学院广西南宁530004 工程防灾与结构安全教育部重点实验室广西南宁530004 广西建设职业技术学院土木工程学院广西南宁530004

针对目前基于含基本假设或经验公式的传统土力学计算方法,不能有效地反映具有多因素交叉性以及时空性的基坑变形规律,而监测数据时间序列能够真实地表现基坑土体变形的演变,以南宁市亭洪路72号河南水厂住宅小区危旧房改造项目双排桩基... 详细信息

针对目前基于含基本假设或经验公式的传统土力学计算方法,不能有效地反映具有多因素交叉性以及时空性的基坑变形规律,而监测数据时间序列能够真实地表现基坑土体变形的演变,以南宁市亭洪路72号河南水厂住宅小区危旧房改造项目双排桩基坑工程为依托,考虑开挖深度和土体暴露时间这2个因素对监测时间序列的影响,提出一种带有外部输入的非线性自回归(NARX)动态神经网络时间序列模型,多方位预测关键断面重要测点的竖向位移和水平位移。结果表明:预测值和实际监测数据的变化趋势具有较好的一致性,且竖向位移预测值与实际监测值的预测残差小于1.0 mm,水平位移预测残差小于0.3 mm。该模型预测效果良好,同时验证了此模型应用于双排桩基坑变形动态分析的可行性。

关键词：动态神经网络时间序列预测模型双排桩基坑变形

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构网型变流器:物理本质与特征

高电压技术 2024年第2期50卷 590-604页

作者：迟永宁江炳蔚胡家兵林伟芳刘宏志范译文马士聪姚骏中国电力科学研究院有限公司北京100192 华中科技大学电气与电子工程学院武汉430074 输变电装备技术全国重点实验室(重庆大学) 重庆400044

全球能源产业变革促进了电力系统电力电子化转型,以新能源为主体的电力电子化电力系统中同步机占比低,系统呈现低惯量、弱阻尼特征,引发了一系列运行问题。构网型变流器本质为电压源,能够主动构建电压频率,为系统提供惯量支撑,有利于改... 详细信息

全球能源产业变革促进了电力系统电力电子化转型,以新能源为主体的电力电子化电力系统中同步机占比低,系统呈现低惯量、弱阻尼特征,引发了一系列运行问题。构网型变流器本质为电压源,能够主动构建电压频率,为系统提供惯量支撑,有利于改善系统稳定性,是提高新能源主动支撑能力的有效手段,近年来成为研究热点。该文从电力电子化电力系统的运行问题出发,梳理了下垂控制、虚拟同步机控制等典型构网型控制策略的实现原理及内在联系,建立构网型控制策略的统一数学模型;通过类比稳态条件下同步机与构网型变流器的电压频率构建原理,揭示了构网型变流器的物理本质,从电压频率构建、惯量阻尼支撑、同步机制等角度解释了构网型变流器的内涵与特性,可为构网型变流器的稳定与控制提供理论参考。

关键词：构网型控制新能源并网变流器物理本质电压频率构建稳定控制电力电子化电力系统

Cu-substituted nickel hexacyanoferrate with tunable reaction potentials for superior ammonium ion storage

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Journal of Materials Science & Technology 2024年第2期169卷 19-27页

作者： Leiyu fan Guangchang Shu yiwen Liu Haoxiang Yu Lei Yan Liyuan Zhang Jie Shu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China

In this work,a variety of Cu_(x)Ni_(2-x)Fe(CN)_(6)(x=0,0.4,0.8,1.2,1.6,2)cathodes for ammonium ion batteries are prepared and their electrochemical performances are investigated.During the introduction of copper in nickel hexacyanoferrate,the electrochemical performance varies without changing the structure of nickel hexacyanoferrate.The increase of Cu content in nickel hexacyanoferrate leads to the enhancement of reaction potential and capacity.Electrochemical results suggest that the substitution of Cu for Ni has a positive effect on improving the cycling stability and rate capacity of nickel hexacyanoferrate when x in Cu_(x)Ni_(2-x)Fe(CN)_(6)is less than 0.4.Therefore,Cu_(0.4)Ni_(1.6)Fe(CN)_(6)exhibits the best cycling per-formance(capacity retention of 97.54%at 0.3 C)and the highest rate capacity(41.4 mAh g^(-1)at 10 C)in Cu_(x)Ni_(2-x)Fe(CN)_(6).Additionally,the X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)tests also reveal that the structural evolution of Cu_(0.4)Ni_(1.6)Fe(CN)_(6)is highly reversible upon NH_(4)^(+)storage.Therefore,this work proposes a candidate material for ammoniumion batteries and offers a novel avenue for adjusting the operating potential of the material.

关键词： Nickel hexacyanoferrate Copper hexacyanoferrate NH_(4)^(+)storage Ammonium ion batteries Aqueous batteries