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Journal of Pharmaceutical Analysis 2015年第4期5卷 239-248页

作者： Hao Zhu Yijun Chen Changshun Huang Yangyang Han yiwei Zhang Shucan xie Xiaohong Chen Micong Jin Department of Anesthesia the First Hospital of Ningbo City Zhejiang Provincial Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals Ningbo Municipal Center for Disease Control and Prevention Ningbo Key Laboratory of Poison Research and Control Ningbo Municipal Center for Disease Control and Prevention

A rapid and sensitive method based on ultrafast liquid chromatography-tandem mass spectrometry was developed and validated for simultaneous determination of Sudan I, Sudan II, Sudan 111, and Sudan IV levels in rat whole blood. Cleanert C18 mixed-mode polymeric sorbent was used for effective solid-phase extraction cleanup. Separation was carried out on a reversed-phase C18 column （100 mm x 2.1 mm, 1.8 pro） using 0.1% （v/v） formic acid in water/0.] % （v/v） formic acid in acetonitrile as the mobile phase in gradient elution. Quantification was performed by an electrospray ionization source in the positive multiple reaction monitoring mode using Ds-Sudan I as the internal standard. Calibration curves showed good linearity between 0.2 and 20.0 μg/L, with correlation coefficients higher than 0.9990. The average recovery rates were between 93.05% and 114.98%. The intra- and inter-day relative standard deviations were within 6.2%. The lower limit of quantification was 0.2 μg/L. All the analytes were found to be stable in a series of stability studies. The proposed method was successfully applied to a pharmacokinetic study of four Sudan dyes after oral administration to rats.

关键词： Multiple reaction monitoringPbarmacokineticsRat whole bloodSudan dyeUFLC-MS/MS

Low-temperature sintered(Na_(1/2)Bi_(1/2))TiO_(3)-based incipient piezoceramics for co-fired multilayer actuator application

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Journal of Materiomics 2019年第3期5卷 480-488页

作者： Pengyuan Fan Yangyang Zhang Shan-Tao Zhang Bing xie yiwei Zhu Mohsin Ali Marwat Weigang Ma Kai Liu Liang Shu Haibo Zhang School of Materials Science andEngineering State Key Laboratory of Material ProcessingDie&Mould TechnologyHuazhong University of Science and TechnologyWuhan430074China Information Engineering Institute Huanghe Science and Technology CollegeZhengzhou450000China National Laboratory of Solid State Microstructures Department of Materials Science and EngineeringCollege of Engineering and Applied ScienceCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China Research Centre for Functional Ceramics Ministry of EducationHuazhong University of Science and TechnologyWuhan430074China

Low-temperature sintered(Na_(1/2)Bi_(1/2))_(0.935)Ba_(0.065)Ti_(0.975)(Fe_(1/2)Nb_(1/2))_(0.025)O_(3)(NBT-BT-0.025FN)lead-free incipient piezoceramics were investigated using high-purity Li_(2)CO_(3) as sintering *** the ≤0.5 wt%Li_(2)CO_(3) addition,the introduced Li^(+) cations precede to enter the A-sites of the perovskite lattice to compensate for the A-site *** the addition exceeds 0.5 wt%,the excess Lit cations will occupy B-sites and give rise to the generation of oxygen vacancies,which accelerate the mass transport and thus lower the sintering temperature effectively from 1100℃ down to 925℃.It was also found that a small amount of Lit addition has little effect on the phase structure and electromechanical properties of the system,but overweight seriously disturbs these characteristics because of the large lattice *** sintered NBT-BT-0.025FN incipient piezoceramics with 1.25 wt%Li_(2)CO_(3) addition at 925℃ provides a large strain of 0.33% and a corresponding large signal piezoelectric coefficient d_(33)^(*) of 550 pm/V at 60 kV/cm,indicating this system is a very promising candidate for lead-free co-fired multilayer actuator application.

关键词： Lead-free piezoceramics (Na_(1/2)Bi_(1/2))TiO_(3) Low-temperature sintering Electric-field-induced strain

Bipolar plasma vaporization of the prostate with button electrode:a new choice for patients with post-brachytherapy retention

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Bipolar plasma vaporization of the prostate with button elec...

2015年浙江省泌尿外科学男科学学术年会

作者： yiwei Lin Ben Liu Liping xie Department of Urology The First Affiliated HospitalSchool of MedicineZhejiang University

Urinary retention is a common urinary complication following brachytherapy for prostate *** conservative therapy has failed,surgical intervention such as transurethral resection of prostate(TURP)would be *** our current case report,we found that conventional bipolar TURP was an improper procedure during which the electrical loop could be easily ruptured and discharge sparks when encountering the seeds ***,bipolar plasma vaporization of the prostate with button electrode was a much safer ***"buttontype"electrode with a larger contacting surface was firm enough to tolerate the transient high-energy generated by short circuit and safely finish the procedure.

关键词： brachytherapy prostate cancer bipolar plasma vaporization of the prostate

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组态王软件在冲压行业中的应用

锻压装备与制造技术 2020年第5期55卷 89-91页

作者：徐凯谢一伟胡鹏沈盛阳江苏扬力坚城锻压机床有限公司江苏扬州225000

在工厂智能化越来越先进的今天,越来越多的企业需要对生产车间各种设备的工作状态进行远程监控,并希望对这些设备进行简单的控制。此时开发出一套具备生产现场监控及生产过程控制的系统就显得尤为重要。本文介绍通过组态王软件与欧姆龙C... 详细信息

在工厂智能化越来越先进的今天,越来越多的企业需要对生产车间各种设备的工作状态进行远程监控,并希望对这些设备进行简单的控制。此时开发出一套具备生产现场监控及生产过程控制的系统就显得尤为重要。本文介绍通过组态王软件与欧姆龙CJ2M-CPU33型PLC的通讯,实现对冲压车间冲床产量的实时监控以及对冲床的远程启停控制等功能。通过硬件及软件的测试验证了系统的可行性。

关键词：组态王冲压欧姆龙PLC Ethernet

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基于Modbus总线的变频器控制方法

锻压装备与制造技术 2020年第4期55卷 80-82页

作者：沈盛阳谢一伟曹祖鸣扬力集团股份有限公司江苏扬州225000

本文着重介绍了Modbus总线与汇川变频器的工作原理,并详细研究了通过Modbus总线实现欧姆龙CJ2M可编程控制器控制并读取汇川变频器各项参数的控制方法。

关键词： Modbus总线 CJ2M 汇川变频器

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m6A相关蛋白抑制剂的研究进展

药学研究 2024年第8期43卷 798-805页

作者：刘千姿全怡舟范一苇朱宇谢小娜赵承光赵海洋温州大学生命与环境科学学院浙江省生物医药协同创新中心浙江温州325035 北京中医药大学中药学院北京100102 温州医科大学药学院浙江温州325035 温州医科大学附属第一医院浙江温州325035

N6-甲基腺苷(N6-methyladenosine,m6A)是广泛存在于生物体内部的转录修饰,主要由甲基转移酶、去甲基化酶和阅读蛋白所调控,在RNA的加工、转运、翻译及稳定性方面发挥重要作用。近年来在肿瘤中发现m6A相关蛋白表达异常,并可通过改变靶基... 详细信息

N6-甲基腺苷(N6-methyladenosine,m6A)是广泛存在于生物体内部的转录修饰,主要由甲基转移酶、去甲基化酶和阅读蛋白所调控,在RNA的加工、转运、翻译及稳定性方面发挥重要作用。近年来在肿瘤中发现m6A相关蛋白表达异常,并可通过改变靶基因的m6A修饰水平来调控肿瘤的进展,因此针对m6A修饰的治疗具有广阔的前景。m6A相关蛋白抑制剂是一类能够抑制m6A甲基化修饰的化合物,可用于研究m6A修饰在基因表达调控中的作用机制。该文论述了m6A的3种关键分子及其与疾病的关系,并总结了这些m6A相关蛋白小分子抑制剂的最新研究进展。

关键词： N6-甲基腺苷甲基转移酶去甲基化酶肿瘤抑制剂

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“金花”菌的分离鉴定及其对紫娟红茶发酵品质的影响

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食品研究与开发 2024年第5期45卷 44-52页

作者：周祎炜燕飞曲东李新生谢侗闫瑞瑞习林杰陈小华赵璇陕西理工大学生物科学与工程学院陕西汉中723000 陕西省资源生物重点实验室陕西汉中723000 陕南秦巴山区生物资源综合开发协同创新中心陕西汉中723000 陕西省“四主体一联合”茶产业校企联合研究中心陕西汉中723000

为探究泾阳散装茯砖茶中“金花”菌的种类及其对紫娟红茶品质的影响,从泾阳散装茯砖茶中分离得到谢瓦曲霉(Aspergillus chevalieri),并用其对紫娟红茶进行固态发酵。结果表明,紫娟红茶经发酵后,“金花”菌数量极显著增加,茶汤色泽由亮... 详细信息

为探究泾阳散装茯砖茶中“金花”菌的种类及其对紫娟红茶品质的影响,从泾阳散装茯砖茶中分离得到谢瓦曲霉(Aspergillus chevalieri),并用其对紫娟红茶进行固态发酵。结果表明,紫娟红茶经发酵后,“金花”菌数量极显著增加,茶汤色泽由亮黄色变为橙红色;同时茶多酚、儿茶素、水浸出物、游离氨基酸、茶黄素和茶红素均整体出现不同程度的下降,而花青素、总黄酮含量整体呈升高的变化趋势。经谢瓦曲霉发酵后的紫娟红茶不仅能有效改善其茶汤色泽滋味,还可以促进紫娟红茶发酵过程中抗氧化物质的释放。

关键词：紫娟红茶谢瓦曲霉散茶发花茶叶品质抗氧化活性

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深度学习模型用于自动分类超声心动图切面

Measurement of the neutron total cross section of^(9)Be at the Back-n white neutron source of CSNS

中国医学影像技术 2024年第8期40卷 1124-1129页

作者：陈雯雯朱业张易薇吴纯李玉曼章子铭孙振兴谢明星张丽华中科技大学同济医学院附属协和医院超声医学科湖北武汉 430022 湖北省影像医学临床医学研究中心湖北省影像医学临床医学研究中心湖北武汉 430022 分子影像湖北省重点实验室分子影像湖北省重点实验室湖北武汉 430022

目的观察深度学习(DL)模型用于自动分类超声心动图切面的价值。方法回顾性分析100例心脏移植术后患者,按7:2:1比例将其分为训练集、验证集及测试集;基于2D心尖二腔、心尖三腔、心尖四腔、剑突下、胸骨旁左心室长轴、大动脉短轴、心尖水... 详细信息

目的观察深度学习(DL)模型用于自动分类超声心动图切面的价值。方法回顾性分析100例心脏移植术后患者,按7:2:1比例将其分为训练集、验证集及测试集;基于2D心尖二腔、心尖三腔、心尖四腔、剑突下、胸骨旁左心室长轴、大动脉短轴、心尖水平左心室短轴、乳头肌水平左心室短轴、二尖瓣水平左心室短轴、3D及CDFI切面超声心动图分别构建ResNet18、ResNet34、Swin Transformer及Swin Transformer V2模型;以准确率、精确率、召回率、F1分数及混淆矩阵评估各模型自动分类超声心动图切面的效能;以Qt Designer软件设计交互式界面并部署于桌面端。结果各模型自动分类测试集超声心动图切面效能均良好,分类左心室短轴切面效能有待提升,分类3D及CDFI切面效能优越。其中Swin Transformer V2为最优模型,其准确率、精确率、召回率及F1分数均较高(分别为92.56%、89.01 %、89.97%及89.31%),在混淆矩阵中对角线值最大,且t-SNE图显示各切面分类效果最好。结论基于DL模型自动分类超声心动图切面效能良好,尤以Swin Transformer V2模型效能最佳;交互式分类界面可进一步提高预测结果的可解释性。

关键词：心脏移植超声心动描记术深度学习

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Chinese Physics C 2024年第8期48卷 140-152页

作者： Jiangbo Bai Jingyu Tang Liqun Shi Yonghao Chen Han Yi Jie Bao Yu Bao Ping Cao Haolei Chen Zhen Chen Zengqi Cui Ruirui Fan Changqing Feng Keqing Gao Xiaolong Gao MinHao Gu Changcai Han Guozhu He Yongcheng He Yang Hong yiwei Hu Hanxiong Huang Xiru Huang Haoyu Jiang Wei Jiang Zhijie Jiang Hantao Jing Ling Kang Bo Li Chao Li Jiawen Li Qiang Li Xiao Li Yang Li Jie Liu Shubin Liu Ze Long Guangyuan Luan Changjun Ning Mengchen Niu Binbin Qi Jie Ren Xichao Ruan Zhaohui Song Kang Sun Zhijia Sun Zhixin Tan Xinyi Tang Binbin Tian Lijiao Wang Pengcheng Wang Zhaohui Wang Xiaoguang Wu Xuan Wu Likun xie Xiaoyun Yang Li Yu Tao Yu Yongji Yu Guohui Zhang Linhao Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Luping Zhou Zhihao Zhou Kejun Zhu Institute of Modern Physics Fudan UniversityShanghai 200433China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Sate Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

The neutron total cross section data of^(9)Be are essential in the nuclear structure model research of light nuclei and nuclear power *** neutron total cross section of^(9)Be in the 0.3 eV−120 MeV energy region has been measured using time-of-flight and transmission methods with the Neutron Total Cross Sectional Spectrometer(NTOX)based on the multi-cell fast fission chamber at the China Spallation Neutron Source(CSNS)-Back-n white neutron source(Back-n).The fission count-neutron energy distributions of ^(235)U and ^(238)U without samples and with Be samples with three thicknesses were measured in the double-bunch operation mode for a beam power of 100 *** Bayesian method was used to eliminate the influence of the double-bunch problem on neutron measurement in the energy region above 10 *** neutron total cross section of^(9)Be results was consistent with ENDF/B-VIII.0 evaluation library data in the 0.3 eV−20 MeV energy *** the energy ranges of 0.3 eV to 10 keV and 0.01 to 20 MeV,the deviations between our results and the evaluation results of ENDF/B-VIII.0 were within 2.5%and 15%,*** the resonance energy region,the measured resonance energies in our experiment were 0.63,0.82,and 2.8 MeV,*** results showed that the total cross section uncertainties of three Be samples were within 2.2%in the energy region below 1 *** total cross section uncertainty of 30 mm Be from ^(235)U was the smallest and less than 5%in the energy region of 0.3 eV−120 *** results of this experiment can provide technical support for further data analysis and related nuclear data evaluation.

关键词： ^(9)Be neutron total cross section CSNS Back-n time-of-flight method transmission method multi-cell fast fission chamber

Faster Inhibition Enables Earlier Maturation of Temporal processing in Layer 5 of Rat Primary Auditory Cortex

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Faster Inhibition Enables Earlier Maturation of Temporal pro...