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目的论扩张的再思考

商丘师范学院学报 2024年第5期40卷 84-89页

作者：郑易通澳门科技大学法学院中国澳门逃仔999078

目的论扩张概念的问题表现为逻辑有效性、适用前提和表现形式等方面存在瑕疵,而可能的辩护未能全面深入地展开。以卡纳里斯的法律漏洞理论为起点,可以发现目的论扩张的适用对象为禁止拒绝裁判漏洞中的规范漏洞,这表明了适用目的论扩张... 详细信息

目的论扩张概念的问题表现为逻辑有效性、适用前提和表现形式等方面存在瑕疵,而可能的辩护未能全面深入地展开。以卡纳里斯的法律漏洞理论为起点,可以发现目的论扩张的适用对象为禁止拒绝裁判漏洞中的规范漏洞,这表明了适用目的论扩张的必要性和类推适用的局限性。在分析规范漏洞特征的基础上,发现适用目的论扩张的关键在于规范缺乏相应的构成要件要素,或者是法律后果不够清晰准确,并非简单的法律文义狭隘。这也是目的论扩张应有的恰当理解,也表明目的论扩张不是类推的特殊形式。

关键词：禁止拒绝裁判漏洞目的论扩张类推

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切角凹槽矩形截面桥塔的气动特性试验研究

石家庄铁道大学学报（自然科学版） 2024年第1期37卷 9-15,23页

作者：韩笑高创郑怡彤刘小兵石家庄铁道大学土木工程学院河北石家庄050043 郑州市政集团有限公司河南郑州450000 河北省风工程和风能利用工程技术创新中心河北石家庄050043

基于刚性模型测压风洞试验方法,研究了不同切角率和凹槽率的矩形截面桥塔气动特性随风向角的变化规律.结果表明,切角凹槽矩形截面桥塔气动特性随风向角的变化会出现2个临界风向角αcr1和α_(cr2),临界风向角附近气动特性出现突变.当0°... 详细信息

基于刚性模型测压风洞试验方法,研究了不同切角率和凹槽率的矩形截面桥塔气动特性随风向角的变化规律.结果表明,切角凹槽矩形截面桥塔气动特性随风向角的变化会出现2个临界风向角αcr1和α_(cr2),临界风向角附近气动特性出现突变.当0°≤α<α_(cr1)和α_(cr2)<α≤90°时,随风向角增大,平均阻力系数和脉动升力系数先减小后增大,斯托罗哈数先增大后减小;当αcr1<α<α_(cr2)时,平均阻力系数和脉动升力系数变化不大,斯托罗哈数消失.2个临界风向角间的范围随切角率的增大而减小,随凹槽率的增大而增大.同一风向角下,气动特性受凹槽率影响较小;随切角率的增大,平均阻力系数减小,斯托罗哈数增大,脉动升力系数变化较小.

关键词：桥塔切角凹槽风洞试验气动特性

靶向EGFRvⅢ的CAR-NK细胞对胶质瘤细胞杀伤作用的体外实验研究

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中华神经外科杂志 2024年第8期40卷 841-847页

作者：陈举林依日扎提·艾力秦虎吉文玉郑伊桐汪永新新疆医科大学第一附属医院神经外科乌鲁木齐830000 神经肿瘤精准诊断与临床转化重点实验室乌鲁木齐830000

目的探索靶向表皮生长因子受体Ⅲ型突变体(EGFRvⅢ)的嵌合抗原受体(CAR)修饰的人外周血来源自然杀伤(NK)细胞在脑胶质瘤细胞中的杀伤作用。方法通过Ficoll密度梯度离心法获得人外周血来源的NK细胞并进行体外扩增培养,并通过慢病毒感染... 详细信息

目的探索靶向表皮生长因子受体Ⅲ型突变体(EGFRvⅢ)的嵌合抗原受体(CAR)修饰的人外周血来源自然杀伤(NK)细胞在脑胶质瘤细胞中的杀伤作用。方法通过Ficoll密度梯度离心法获得人外周血来源的NK细胞并进行体外扩增培养,并通过慢病毒感染构建靶向EGFRvⅢ的CAR-NK细胞及U87-EGFRvⅢ稳转细胞株。根据不同效应细胞作用于不同靶细胞而将实验组分为NK+U87组、NK+U87-EGFRvⅢ组、CAR-NK+U87组、CAR-NK+U87-EGFRvⅢ组,通过实时无标记细胞分析(RTCA)及乳酸脱氢酶(LDH)释放实验评价CAR-NK细胞对胶质瘤细胞的杀伤作用,同时使用酶联免疫吸附实验(ELISA)检测肿瘤坏死因子α(TNF-α)、γ干扰素(IFN-γ)、颗粒酶B(GzmB)以及穿孔蛋白1(PRF1)在细胞培养上清中的分泌情况。结果流式细胞分析显示分离、培养得到的人外周血来源NK细胞的纯度为97.6%,存活率为98.2%;成功构建第二代靶向EGFRvⅢ的CAR分子,并成功构建靶向EGFRvⅢ的CAR-NK细胞,流式分析显示阳性细胞率为69.6%。RTCA结果显示靶细胞的生长曲线随时间呈上升趋势,过表达EGFRvⅢ的U87细胞增殖速率要高于U87细胞;在加入效应细胞后,细胞指数呈现下降趋势,在相同效靶比(E∶T)下,CAR-NK+U87-EGFRvⅢ组的细胞指数下降趋势快于NK+U87-EGFRvⅢ组,且快于CAR-NK+U87组。LDH释放实验进一步证明随着效靶比的增加,靶细胞的裂解率逐渐升高(F_(NK+U87)=700.61、F_(CAR-NK+U87)=2063.97、F_(NK+U87)-EGFRvⅢ=5707.00、F_(CAR-NK+U87)-EGFRvⅢ=28858.57,均P0.05);CAR-NK+U87-EGFRvⅢ组分别与NK+U87-EGFRvⅢ组、CAR-NK+U87组相比,TNF-α、IFN-γ、GzmB、PRF1的分泌量均增高(均P<0.05)。结论靶向EGFRvⅢ的CAR-NK细胞对EGFRvⅢ表达阳性的胶质瘤细胞具有较强的杀伤作用,其抗肿瘤能力优于NK细胞。

关键词：神经胶质瘤受体,表皮生长因子杀伤细胞,天然体外研究

Liquid metal in prohibiting polysulfides shuttling in metal sulfides anode for sodium-ion batteries

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Journal of Energy Chemistry 2024年第9期96卷 559-567页

作者： Xiaobo zheng Xinwei Guan Xuan Cheng Xiaoning Li Yang Fu yitong Li Zhi zheng Weikong Pang Xun Xu Peng Li Tianyi Ma Institute for Superconducting&Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongWollongongNSW 2522Australia School of Science RMIT UniversityMelbourneVIC 3000Australia CSIRO Manufacturing ClaytonVIC 3168Australia

Metal sulfides are a class of promising anode materials for sodium-ion batteries(SIBs)owing to their high theoretical specific ***,the reactant products(polysulfides)could dissolve into electrolyte,shuttle across separator,and react with sodium anode,leading to severe capacity loss and safety ***,for the first time,gallium(Ga)-based liquid metal(LM)alloy is incorporated with MoS_(2)nanosheets to work as an anode in *** electron-rich,ultrahigh electrical conductivity,and self-healing properties of LM endow the heterostructured MoS_(2)-LM with highly improved conductivity and electrode ***,LM is demonstrated to have excellent capability for the adsorption of polysulfides(e.g.,Na_(2)S,Na_(2)S_(6),and S_(8))and subsequent catalytic conversion of Na_(2)***,the MoS_(2)-LM electrode exhibits superior ion diffusion kinetics and long cycling performance in SIBs and even in lithium/potassium-ion battery(LIB/PIB)systems,far better than those electrodes with conventional binders(polyvinylidene difluoride(PVDF)and sodium carboxymethyl cellulose(CMC)).This work provides a unique material design concept based on Ga-based liquid metal alloy for metal sulfide anodes in rechargeable battery systems and beyond.

关键词： GalnSn liquid metal alloy MoS_(2) Polysulfides shuttle effects Catalytic conversion Sodium-ion batteries

Gender and Race Differences in Mental Health and Well-Being Among Older Americans During the COVID-19 Pandemic

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International Journal of Disaster Risk Science 2024年第2期15卷 239-250页

作者： Dongjuan Xu Nasreen Lalani yitong Wang School of Nursing Purdue UniversityWest LafayetteIN 47907USA Center on Aging and the Life Course Purdue UniversityWest LafayetteIN 47907USA

The objectives of this study were to investigate(1) gender and race differences in mental health and psychological wellbeing among older adults during the COVID-19 pandemic and(2) whether there were significant interaction effects between gender and race. This study used the National Health and Aging Trends Study(NHATS) and COVID-19 public use data files. It focused on mental health and psychological well-being, including loneliness, no time to yourself, poor sleep quality, anxiety, depression, and post-traumatic stress disorder(PTSD). The sample consisted of 2465 older adults, and multivariate logistic and linear regression models were adopted for the analysis. The results show that approximately two out of five older people(43%) experienced poor sleep, followed by loneliness(35%), anxiety(30%), depression(23%), and no time to themselves(11%). The average PTSD score was 11. Mental health and psychological well-being varied by gender and race. There were significant interaction effects on anxiety and depression between females and Black older adults. Black females reported lower levels of anxiety and depressive symptoms than Black males, although the differences were not statistically significant. Black older adults were more likely to experience PTSD but less likely to feel lonely and have poorer sleep than their White counterparts. Female older adults reported poorer mental health and psychological well-being than males, except for Black females. Black females had the lowest levels of anxiety, depression, loneliness, and highest quality of sleep among all females of different ethnic and racial origins.

关键词： COVID-19 Gender Mental health Older adults Psychological well-being Race and ethnicity United States

Memristive oscillator to memristive map,energy characteristic

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Science China(Technological Sciences) 2024年第5期67卷 1567-1578页

作者： GUO yitong MA Jun ZHANG XiaoFeng HU XiKui College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhou730050China Department of Physics Lanzhou University of TechnologyLanzhou730050China School of Science Chongqing University of Posts and TelecommunicationsChongqing400065China

Most of nonlinear oscillators composed of capacitive and inductive variables can obtain the Hamilton energy by using the Helmholtz theorem when the models are rewritten in equivalent vector *** energy functions for biophysical neurons can be obtained by applying scale transformation on the physical field energy in their equivalent neural *** dynamical systems often have exact energy functions,while some mathematical models just suggest generic Lyapunov functions,and the energy function is effective to predict mode *** this paper,a memristive oscillator is approached by two kinds of memristor-based nonlinear circuits,and the energy functions are defined to predict the dependence of oscillatory modes on energy *** absence of capacitive variable for capacitor,the physical time t and charge q are converted into dimensionless variables by using combination of resistance and inductance(L,R),e.g.,τ=t×R/*** energy function for each memristive map is proposed by applying the similar weights as energy function for the memristive *** example,energy function for the map is obtained by replacing the variables and parameters of the memristive oscillator with corresponding variables and parameters for the memristive *** memristive map prefers to keep lower average energy than the memristive oscillator,and chaos is generated in a discrete system with two *** scheme is helpful for energy definition in maps,and it provides possible guidance for verifying the reliability of maps by considering the energy characteristic.

关键词： Hamilton energy memristor Helmholtz theorem scale transformation memristive circuit

Modular Soft Robotic Crawlers Based on Fluidic Prestressed Composite Actuators

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Journal of Bionic Engineering 2024年第2期21卷 694-706页

作者： Zefeng Xu Linkai Hu Longya Xiao Hongjie Jiang yitong Zhou Shien-Ming Wu School of Intelligent Engineering South China University of TechnologyGuangzhou511442China School of Mechanical and Electrical Engineering Guangzhou UniversityGuangzhou510006China

Soft robotic crawlers have limited payload capacity and crawling *** study proposes a high-performance inchworm-like modular robotic crawler based on fluidic prestressed composite(FPC)*** FPC actuator is precurved and a pneumatic source is used to flatten it,requiring no energy cost to maintain the equilibrium curved *** and depressurizing the actuators generate alternating stretching and bending motions of the actuators,achieving the crawling motion of the robotic ***-modal locomotion(crawling,turning,and pipe climbing)is achieved by modular reconfiguration and gait *** analytical kinematic model is proposed to characterize the quasi-static curvature and step size of a single-module *** configurations of robotic crawlers are fabricated to demonstrate the crawling ability of the proposed design.A set of systematic experiments are set up and conducted to understand how crawler responses vary as a function of FPC prestrains,input pressures,and actuation *** per the experiments,the maximum carrying load ratio(carrying load divided by robot weight)is found to be 22.32,and the highest crawling velocity is 3.02 body length(BL)per second(392 mm/s).Multi-modal capabilities are demonstrated by reconfiguring three soft crawlers,including a matrix crawler robot crawling in amphibious environments,and an inching crawler turning at an angular velocity of 2/s,as well as earthworm-like crawling robots climbing a 20 inclination slope and pipe.

关键词： Soft robot Soft crawler Fluidic prestressed composite Kinematic model Enhanced loading Multi-modal capability

Insight into the adsorption behavior and mechanism of trace impurities from H_(2)O_(2) solution on functionalized zirconia by tuning the structure of amino groups

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 83-94页

作者： Yu Meng yitong Wang Guozhu Li Guozhu Liu Li Wang Key Laboratory for Green Chemical Technology of Ministry Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Primary,secondary and tertiary amino-functionalized zirconia(ZrO_(2)-NH_(2),ZrO_(2)-NH and ZrO_(2)-N)was synthesized by the postgrafting method for the adsorption removal of typical metallic ions,phosphate and total oxidizable carbon from a real H_(2)O_(2) ***_(2)-NH_(2),ZrO_(2)-NH and ZrO_(2)-N exhibited similar pore sizes and sequentially increased zeta *** adsorption results of single and binary simulated solutions showed that the removal efficiency increased in the order of Fe^(3+)>Al^(3+)>Ca^(2+)>Na^(+).There is competitive adsorption between metallic ions,and Fe^(3+) has an advantage over the other metals,with a removal efficiency of 90.7%.The coexisting phosphate could promote the adsorption of metallic ions,while total oxidizable carbon had no effect on *** adsorption results of the real H_(2)O_(2)solution showed that ZrO_(2)-NH_(2) exhibited the best adsorption affinity for metallic ions,as did phosphate and total oxidizable carbon,with a total adsorption capacity of 120.9 mg·g_(-1).Density functional theory calculations revealed that the adsorption process of metallic ions involves electron transfer from N atoms to metals and the formation of N-metal bonds.

关键词： adsorption metallic ion phosphate total oxidizable carbon zirconia H_(2)O_(2)

信用修复机制选择的困境与破局——以工具理性和价值理性平衡为方法

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华东政法大学学报 2022年第5期25卷 133-142页

作者：郑依彤华东理工大学法学院

《信用修复管理办法(试行)(征求意见稿)》将我国信用修复机制建设推向了新的起点。但由于上层制度供给不足,信用修复机制设计过程中未整体性嵌入信用体系的价值理念,导致信用修复机制选择陷入“激励价值逆向化、条件限制模糊化、方式选... 详细信息

《信用修复管理办法(试行)(征求意见稿)》将我国信用修复机制建设推向了新的起点。但由于上层制度供给不足,信用修复机制设计过程中未整体性嵌入信用体系的价值理念,导致信用修复机制选择陷入“激励价值逆向化、条件限制模糊化、方式选择偏离化、结果效力无力化”等困境,亟待制度破局和重构。本文以工具理性和价值理性相平衡为方法,剖析了信用修复机制的内在价值约束,同时以比例原则和成本收益分析原则为工具,度量信用修复机制重构的效益性与合理性,以求在双重理性判断下破除信用修复机制选择之迷雾。

关键词：信用修复价值约束工具理性成本收益分析原则比例原则