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Incidence and mortality of laryngeal cancer in China,2008–2012

Chinese Journal of Cancer Research 2018年第3期30卷 299-306页

作者： Yuqin Liu Qin Zhao Gaoheng Ding yitong zhu Wenying Li Wanqing Chen Central Cancer Registry of Gansu Gansu Cancer Hospital National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective：To analyze the incidence and mortality rates of laryngeal cancer in China from 2008 to ***：Incident and death cases of laryngeal cancer were retrieved from the National Central Cancer Registry（NCCR）database collecting from 135 cancer registries in China during 2008–*** crude incidence and mortality rates of laryngeal cancer were calculated by area（urban/rural）,region（eastern,middle,western）,gender and age group（0,1–4,5–9,…,85＋）.China census in 2000 and Segi’s world population were applied for age standardized *** Point（Version 4.***.0.1）model was used for time trend ***：The crude incidence rate of laryngeal cancer was 1.86/100,000 ranked the 21st in overall *** age-standardized incidence rates by China population（ASIRC）and by World population（ASIRW）were1.22/100,000 and 1.23/100,000,*** crude mortality of laryngeal cancer in China was 1.01/100,000and it was the 21st cause of cancer-related death in overall *** the age-standardized mortality rates by Chinese standard population（ASMRC）and by world standard population（ASMRW）were 0.63/100,*** and mortality rates of laryngeal cancer were higher in males than in females and higher in urban areas than in rural *** areas had the highest incidence and mortality rates followed by eastern and western *** and mortality rates of laryngeal cancer retained low level before age of 40 years old but increased greatly after and peaked in age group of *** showed significant down trends in recent 10 years by 1.27%annually[95%confidence interval（95%CI）：–2.2%,–0.3%].Mortality declined in females sharply by 5.18%per year although stable in males and both sexes ***：Appropriate targeted prevention,early detection and treatment programs should be carried out to control the local burden of laryngeal cancer.

关键词： Laryngeal cancer incidence mortality China

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The Internet as a Forget-Cue: The Effect of Assumptions About Future Accessibility of Information from the Internet on Memory

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校园英语 2019年第18期 251-252页

作者： yitong zhu University of Minnesota

There is a previous study motivate us: The effects of technology on individuals. This research investigates in how does transactive memory will be influenced by technology. This study attempted to answer the question: While people are given a forgetting cue(prior to the list of information) which suggests that they will have access through internet later, how will people perform in both condition: with or without forgetting cue? We have tested people in two trails of tests, and used Qualtrics Survey software to construct memory recall test. SPSS 20.0 was used to analysis our data. The result shows that there is significant difference between with or without internet as forget-cue and number recalled items from memory recall test. Our research shows when people believe internet as a reliable external memory storage, people will not attend to the information when receive internet as forgetting cue. which suggests that people need to be more aware, since the decision to use technology as an external memory storage happens mostly when people are not aware of it.

关键词： Forget-Cue Assumptions Future Accessibility

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Spinal cord conduits for spinal cord injury regeneration

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Engineered Regeneration 2023年第1期4卷 68-80页

作者： Yanyu Ma Quanchi Chen Wenhan Li Haiwen Su Song Li yitong zhu Jie Zhou Zhenhua Feng Zhen Liu Saihu Mao Yong Qiu Huan Wang Zezhang zhu Division of Spine Surgery Department of Orthopedic SurgeryAffiliated Drum Tower HospitalMedical SchoolNanjing UniversityNanjing210008China Division of Spine Surgery Department of Orthopedic SurgeryAffiliated Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjing210008China Department of Nephrology Affiliated Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjing210008China Division of Spine Surgery Department of Orthopedic SurgeryNanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing210008China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen518033China

Spinal cord injury(SCI),which causes irreversible damage in both sensory and motor function,is considered an insurmountable challenge in the field of *** previous researchers have developed many kinds of biomaterials for SCI,and spinal cord conduits(SCCs)are an important classification for bridging spinal cord tissues while performing their corresponding *** this review,we first describe the original sources of the different polymers that determine the properties of the different ***,we focus on the different types of crosslinking methods used for preparing ***,various practical applications and therapeutic effects of SCCs are summarized and ***,we conclude the existing limitations of current *** hope that this paper will serve as a further inspiration for the development of SCCs in future.

关键词： Spinal cord injury Neuron regeneration Hydrogel Spinal cord conduit Tissue engineering

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Development of plant cytosine base editors with the Cas12a system

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The Crop Journal 2023年第5期11卷 1451-1457页

作者： Huanhuan Wang Jing Liang Like Chen Bufang Deng Dongfang Gu Xiaoshuang Liu Shan Jin Rongfang Xu Ruiying Qin yitong zhu Liangxia Zhao Dourong Kou Yanjun Chen Yingli Jiang Juan Li Pengcheng Wei College of Agronomy Anhui Agricultural UniversityHefei 230036AnhuiChina Key Laboratory of Rice Genetic Breeding of Anhui Province Rice Research InstituteAnhui Academy of Agricultural SciencesHefei 230031AnhuiChina

Base editors of the Cas9 system have been widely used for precise nucleotide substitution in crops. In this study, Cas12a was applied to construct plant cytosine base editors(CBEs). The main elements of Cas12aCBEs were engineered and their efficiency was evaluated in stably transformed rice cells. An optimized ttCas12a-hyA3Bctd editor, consisting of a LbCas12a variant carrying catalytic inactive D832A and temperature-tolerance D156R double mutations, a truncated human APOBEC3B deaminase, a human RAD51 single-stranded DNA-binding domain, and double copies of UGI, outperformed other Cas12aCBEs in base editing efficiency. In T0transgenic rice plants, ttCas12a-hyA3Bctd edited an average of42.01% and a maximum of 68.75% of lines at six genomic targets. A-to-G conversions were generated in rice by an adenine base editor with a similar architecture to the optimized CBE. Our results provide preliminary evidence for the feasibility of robust and efficient plant Cas12a base editing systems, which could be useful for precise crop breeding.

关键词： Cas12a Base editing Rice ABE CBE

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Expression of synaptic plasticity associated proteins in hyperglycemia state and its relationship with cognitive function

Expression of synaptic plasticity associated proteins in hyp...

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2015年老年医学学术年会

作者： Miao Ya zhu yitong Zhong Yuan He Ting Li Wei Department of Geriatrics Shanghai Jiaotong University Affiliated Sixth People’s Hospital

Objective Increasing evidence from experimental and clinical researches suggested that hyperglycemia played a key role in the diabetes associated cognitive decline(DACD). Here the molecular changes of BDNF, Arc, CREB and p CREB in the hippocampus, associated with synaptic plasticity,were investigated in cell and animal models *** Primary hippocampal neurons were exposed to 75mmoml/L glucose for 72h. High-fat diet andlow-dose streptozocin were adopted to induce diabetes in SD rats. Cognitive impairmentwas evaluated with the Morris water maze test. We alsoassessed the expression of BDNF, Arc, CREB and p CREB by Western-Blotting. The cell and animal models were both divided into two groups, the control and the high glucose groups. Results Both in the cell and animal models, the expression of BDNF, Arc, CREB and p CREB in hyperglycemia group were decreased significantly compared with the control group. In the meantime, the performance of diabetic rats in Morris water navigation task were not as good as rats in control group. Conclusion This present study suggests that high glucose decreases cognitivefunction and damages synaptic plasticity by reducing the expression of BDNF, Arc, CREB and p CREB.

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Neuroprotective effect of brain-derived neurotrophic factor on hippocampal neurons through the regulation of synaptic plasticity associated proteins

Neuroprotective effect of brain-derived neurotrophic factor ...

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2015年老年医学学术年会

作者： Zhong Yuan zhu yitong Miao Ya He Ting Li Wei Department of Geriatrics Shanghai Jiaotong University Affiliated Sixth People’s Hospital

Objective Accumulating evidence from experimental and clinical suggested that hyperglycemia played a key role in hippocampus dysfunction in patients with diabetes mellitus. Hippocampus is the most vulnerable target of hyperglycemia attacking. The purpose of this research was to evaluate whether high glucose, which mimic the condition of hyperglycemia in vivo,induce significant changes in cell viability as well as some proteins in primary cultured hippocampal neurons. Furthermore, we tested the protective effect of BDNF on the hippocampal neurons under the condition of *** Hippocampal neurons were exposed to different concentrations of glucose (25, 50, 75, 100m M) for 24, 48, 72, 96h. Then CCK8 was used to detect the survival rate of neurons to identify the most suitable glucose concentrations and time in order to build the hyperglycemia model of primary hippocampal neurons. Put 50ng/m L BDNF on hyperglycemia hippocampal neurons for 96h. After that, cellular apoptosis of neurons in control group, high glucose group and high glucose+BDNF group were tested by FCM. Western Blotting was used to detect the expression levels of CREB, phosphor-CREB (p CREB), Arc and synaptophysin protein of three groups (control group, high glucose group, high glucose +BDNF group). Results OD value of the 75mmol/L glucose group decreased significantly at 72h compared with the control group (P < 0.01). The apoptosis rate of the control group, hyperglycemia group and hyperglycemia +BDNF group was 2.80%, 38.86% and 11.49% respectively. Compared with the control group, protein expressions of synaptophysin, CREB, and Arc all decreased significantly (all p < 0.05);Compared with the high glucose group, protein expressions of synaptophysin, CREB and Arc levels were significantly increased in the high glucose +BDNF group (p < 0.05). Conclusion High glucose can induce apoptosis of hippocampal neurons. Exogenous BDNF can conserve the apoptosis of hyperglycemia hippocampal neurons and

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本科生数字素养与创业胜任力的关系:创业学习的中介作用和领悟社会支持的调节作用

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中国健康心理学杂志 2023年第6期31卷 919-925页

作者：朱奕潼杨强江西师范大学教育学院南昌330022

目的:探讨本科生数字素养与创业胜任力的关系,并探究创业学习和领悟社会支持在其中的作用。方法:采用大学生数字素养量表、创业胜任力量表、创业学习量表、领悟社会支持量表对华东地区509名本科生进行问卷调查。结果:数字素养正向预测... 详细信息

目的:探讨本科生数字素养与创业胜任力的关系,并探究创业学习和领悟社会支持在其中的作用。方法:采用大学生数字素养量表、创业胜任力量表、创业学习量表、领悟社会支持量表对华东地区509名本科生进行问卷调查。结果:数字素养正向预测创业学习(β=0.61,t=14.19,P<0.001),创业学习正向预测创业胜任力(β=0.49,t=10.25,P<0.001),数字素养正向预测创业胜任力(β=0.30,t=6.29,P<0.001)。创业学习是数字素养与创业胜任力关系间的中介变量(β=0.30,SE=0.05,95%CI=[0.21,0.40]),中介效果量为0.50。领悟社会支持调节了创业学习与大学生创业胜任力之间的关系(β=0.10,t=4.68,P<0.001)。结论:本科生数字素养通过创业学习对创业胜任力产生影响,且领悟社会支持在其中发挥调节作用。

关键词：数字素养创业胜任力创业学习领悟社会支持

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阿尔茨海默病的蛋白质组学研究进展

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中华老年医学杂志 2015年第1期34卷 106-108页

作者：朱奕潼苗雅钟远上海交通大学附属第六人民医院老年科 200233

近年来,蛋白质组学研究和应用的蓬勃发展为阿尔茨海默病（Alzheimer＇s disease,AD）的深入研究打开了一扇窗.科学家们利用蛋白质组学技术寻找用于临床诊断的生物标记物以及发现药物的治疗位点,以期促进AD的早期诊断和治疗.

关键词：阿尔茨海默病蛋白质组学

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墨西哥Burgos盆地Perdido构造带深浅双层盐分布特征及南北差异构造形变

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中国海上油气 2021年第6期33卷 62-70页

作者：朱钇同李爱山陈亮蔺频中国海洋石油国际有限公司北京100028

墨西哥湾油气资源丰富、资源潜力巨大,复杂的盐构造变形是油气成藏的重要影响因素。为了研究复杂盐构造的变形规律,本文利用区域地质、重力和地震资料,对Burgos盆地Perdido构造带的双层盐构造开展研究,探讨了深浅双层盐的特征,从盐岩变... 详细信息

墨西哥湾油气资源丰富、资源潜力巨大,复杂的盐构造变形是油气成藏的重要影响因素。为了研究复杂盐构造的变形规律,本文利用区域地质、重力和地震资料,对Burgos盆地Perdido构造带的双层盐构造开展研究,探讨了深浅双层盐的特征,从盐岩变形机制的角度说明盐构造样式的不同。研究表明,深层母盐受控于基底古构造格局,边缘隆起带控制了母盐底辟的分布;浅层盐蓬受控于母盐的重力滑脱再变形,母盐的剪切撕裂作用控制了浅层盐蓬的分布。深浅两套盐不同的空间配置关系最终决定了Perdido带南北不同的盐构造变形机制与构造样式。北段深浅双层盐构造整体变形,形成以盐底辟和冲断背斜为主的构样式;而南段深浅双层盐构造分层变形,形成了以盐核背斜和盐前滑脱逆冲为主的构造样式。

关键词： Perdido构造带双层盐分布特征差异构造形变构造样式

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防火封堵在地铁站工程中的应用

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铁道建筑技术 2018年第11期 98-100,105页

作者：朱贻彤中铁建电气化局集团南方工程有限公司湖北武汉430017

地铁站工程中的防火封堵是整个地铁站消防安全中非常重要的环节。提高防火封堵施工质量,要重点抓防火封堵部位和选用的材料及施工工艺三个方面。地铁站的防火封堵主要是对站内过墙洞口、竖井洞口、各种接口缝隙以及配电箱、柜等七大类... 详细信息

地铁站工程中的防火封堵是整个地铁站消防安全中非常重要的环节。提高防火封堵施工质量,要重点抓防火封堵部位和选用的材料及施工工艺三个方面。地铁站的防火封堵主要是对站内过墙洞口、竖井洞口、各种接口缝隙以及配电箱、柜等七大类施工部位进行封堵;这些部位的孔洞因大小、形态不同,适宜采用的防火封堵材料也不同,主要包括阻火包和防火包、板材、防火圈和阻火带、防火涂料四大类;这些部位因孔洞和封堵材料的不同,具体的施工工艺也不同,科学合理的施工才能达到预期的防火封堵效果。

关键词：机电安装防火封堵孔洞管道穿越

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