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Dehydrogenation Based Asymmetric Epoxidation of Arylalkanes to Chiral Epoxides

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Chinese Journal of Chemistry 2022年第19期40卷 2263-2268页

作者： yiting Su feng Yu Guixia Liu Zheng Huang Chang-Kung Chuang Institute East China Normal UniversityShanghai200062 China State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai200032 China School of Chemistry and Material Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhouZhejiang310024 China

We report herein a formal asymmetric epoxidation of arylalkanes enabled by a one-pot dual-catalysts system comprising a pincer Ir catalyst for alkane dehydrogenation-alkene isomerization(AD-ISO)and a chiral ketone catalyst for asymmetric alkene epoxidation.This protocol provides a catalytic method for the synthesis of aryl epoxides in useful yields with high regio-and stereoselectivity directly from readily available alkyl arenes.Stereospecific derivatizations of the epoxidation product allow access to various enantioenriched compounds.

关键词： Alkanes Asymmetric epoxidation Dehydrogenation Dual-catalysts Iridium

Genetic and molecular exploration of maize environmental stress resilience:Toward sustainable agriculture

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Molecular Plant 2023年第10期16卷 1496-1517页

作者： Zhirui Yang Yibo Cao yiting Shi feng Qin Caifu Jiang Shuhua Yang State Key Laboratory of Plant Environmental Resilience Frontiers Science Center for Molecular Design BreedingCollege of Biological SciencesChina Agricultural UniversityBeijing 100193China

Global climate change exacerbates the effects of environmental stressors,such as drought,flooding,extreme temperatures,salinity,and alkalinity,on crop growth and grain yield,threatening the sustainability of the food supply.Maize(Zea mays)is one of the most widely cultivated crops and the most abundant grain crop in production worldwide.However,the stability of maize yield is highly dependent on environmental conditions.Recently,great progress has been made in understanding the molecular mechanisms underlying maize responses to environmental stresses and in developing stress-resilient varieties due to advances in high-throughput sequencing technologies,multi-omics analysis platforms,and automated phenotyping facilities.In this review,we summarize recent advances in dissecting the genetic factors and networks that contribute to maize abiotic stress tolerance through diverse strategies.We also discuss future challenges and opportunities for the development of climate-resilient maize varieties.

关键词： maize abiotic stress drought extreme temperatures salinity resistance

Targeting macrophagic 17β-HSD7 by fenretinide for the treatment of nonalcoholic fatty liver disease

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Acta Pharmaceutica Sinica B 2023年第1期13卷 142-156页

作者： Xiaoyu Dong Yiting Feng Dongqin Xu Mengya Zhang Xiao Wen Wenhao Zhao Qintong Hu Qinyong Zhang Hui Fu Jie Ping Department of Pharmacology School of Basic Medical SciencesWuhan UniversityWuhan 430071China Department of Anatomy School of Basic Medical SciencesWuhan UniversityWuhan 430071China

Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide and macrophage polarization plays an important role in its pathogenesis.However,which molecule regulates macrophage polarization in NAFLD remains unclear.Herein,we showed NAFLD mice exhibited increased 17β-hydroxysteroid dehydrogenase type 7(17β-HSD7)expression in hepatic macrophages concomitantly with elevated M1 polarization.Single-cell RNA sequencing on hepatic non-parenchymal cells isolated from wild-type littermates and macrophage-17β-HSD7 knockout mice fed with high fat diet(HFD)for 6 weeks revealed that lipid metabolism pathways were notably changed.Furthermore,17β-HSD7 deficiency in macrophages attenuated HFD-induced hepatic steatosis,insulin resistance and liver injury.Mechanistically,17β-HSD7 triggered NLRP3 inflammasome activation by increasing free cholesterol content,thereby promoting M1 polarization of macrophages and the secretion of pro-inflammatory cytokines.In addition,to help demonstrate that 17β-HSD7 is a potential drug target for NAFLD,fenretinide was screened out from an FDA-approved drug library based on its 17β-HSD7 dehydrogenase inhibitory activity.Fenretinide dose-dependently abrogated macrophage polarization and pro-inflammatory cytokines production,and subsequently inhibited fat deposition in hepatocytes co-cultured with macrophages.In conclusion,our findings suggest that blockade of 17β-HSD7 signaling by fenretinide would be a drug repurposing strategy for NAFLD treatment.

关键词： Nonalcoholic fatty liver disease 17β-HSD7 Macrophage Cholesterol Insulin resistance Fenretinide

Identification and validation of cardiac nonconserved human-specific enhancers

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Genes & Diseases 2023年第1期10卷 55-57页

作者： Yawen Zhang yiting Gui Xudong Chen feng Wang Fang Wu Youhua Wang Xu Wang Yonghao Gui Qiang Li Translational Medical Center for Development and Disease Shanghai Key Laboratory of Birth DefectInstitute of PediatricsChildren's Hospital of Fudan UniversityNational Children's Medical CenterShanghai 201102China Cardiovascular Center NHC Key Laboratory of Neonatal Diseases(Fudan University)Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai 201102China Department of Cardiology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cancer Institute Fudan University Shanghai Cancer CenterShanghai200032China

Congenital heart disease(CHD)is one of the most common causes of neonatal mortality.The worldwide morbidity of CHD is 9.410%o,while the proportion of CHD patients who are reported to carry mutations in coding regions is<50%.Enhancers play an important role in the spatio-temporal expression of target genes,and a lot of related variations are associated with CHD.There are conserved and nonconserved enhancers.

关键词： mortality conserved neonatal

Aquaporin 9 is involved in CRC metastasis through DVL2-dependent Wnt/β-catenin signaling activation

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Gastroenterology Report 2023年第1期11卷 350-364页

作者： yiting Liu Qianling Gao Xingzhi feng Guanxing Chen Xuefei Jiang Daici Chen Zihuan Yang Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangzhouGuangdongP.R.China Department of General Surgery(Colorectal Surgery) The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Artificial Intelligence Medical Research Center School of Intelligent Systems EngineeringSun Yat-sen UniversityShenzhenGuangdongP.R.China Department of Clinical Laboratory The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Aquaporin 9(AQP9)is permeable to water or other small molecules,and plays an important role in various cancers.We previously found that AQP9 was related to the efficacy of chemotherapy in patients with colorectal cancer(CRC).This study aimed to identify the role and regulatory mechanism of AQP9 in CRC metastasis.Methods:The clinical significance of AQP9 was analysed by using bioinformatics and tissue microarray.Transcriptome sequencing,Dual-Luciferase Reporter Assay,Biacore,and co-immunoprecipitation were employed to demonstrate the regulatory mechanism of AQP9 in CRC.The relationship between AQP9 and CRC metastasis was verified in vitro and in vivo by using real-time cell analysis assay,high content screening,and liver metastasis models of nude mice.Results:We found that AQP9 was highly expressed in metastatic CRC.AQP9 overexpression reduced cell roundness and enhanced cell motility in CRC.We further showed that AQP9 interacted with Dishevelled 2(DVL2)via the C-terminal SVIM motif,resulting in DVL2 stabilization and the Wnt/b-catenin pathway activation.Additionally,we identified the E3 ligase neural precursor cell expressed developmentally downregulated 4-like(NEDD4L)as a modulator regulating the ubiquitination and degradation of AQP9.Conclusions:Collectively,our study revealed the important role of AQP9 in regulating DVL2 stabilization and Wnt/β-catenin signaling to promote CRC metastasis.Targeting the NEDD4L–AQP9–DVL2 axis might have therapeutic usefulness in metastatic CRC treatment.

关键词： aquaporin 9 colorectal cancer metastasis Dishevelled 2 Wnt/b-catenin signaling

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基于儿童绘画的师幼关系评价研究

中国考试 2024年第3期 46-56页

作者：杨镒汀冯婉桢深圳市坪山区联馨幼儿园深圳518118 北京师范大学北京100875

师幼关系是评价学前教育过程质量的核心指标。师幼关系评价需要儿童视角的加入,以有效获知幼儿对师幼关系的体验。本研究采用开放性儿童绘画的方法,建立三个维度17项指标来分析师幼关系主题绘画《我和老师在一起》。研究结果证明了基于... 详细信息

师幼关系是评价学前教育过程质量的核心指标。师幼关系评价需要儿童视角的加入,以有效获知幼儿对师幼关系的体验。本研究采用开放性儿童绘画的方法,建立三个维度17项指标来分析师幼关系主题绘画《我和老师在一起》。研究结果证明了基于儿童绘画评价师幼关系方法的有效性,不同师幼关系水平下儿童绘画作品在画面构图、人物情感与互动、画面特点三个维度上存在明显差异。幼儿园中、大班的师幼关系质量整体状况良好;儿童知觉到的师幼关系表现出明显的年龄差异和性别差异。本研究为从儿童视角开展学前教育评价以及采用量化与质性相结合研究方法获取评价信息提供了借鉴。广大学前教师应更加重视儿童视角下的师幼关系评价,全面评价、定期诊断并及时改进幼儿与教师的关系。

关键词：儿童绘画儿童视角幼儿园学前教育评价师幼关系评价

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基于力电响应的压电悬臂梁疲劳寿命预测

振动与冲击 2023年第17期42卷 314-322页

作者：冯逸亭刘文光吴兴意南昌航空大学航空制造工程学院南昌330063

针对压电振动能量收集器的疲劳问题,旨在研究基于力电响应的压电悬臂梁振动疲劳寿命预测方法。结合压电悬臂梁振动疲劳试验测得的试验结果,以剩余刚度理论和“两段式”疲劳寿命分析模型为基础提出一种基于谐振频率的压电悬臂梁疲劳寿命... 详细信息

针对压电振动能量收集器的疲劳问题,旨在研究基于力电响应的压电悬臂梁振动疲劳寿命预测方法。结合压电悬臂梁振动疲劳试验测得的试验结果,以剩余刚度理论和“两段式”疲劳寿命分析模型为基础提出一种基于谐振频率的压电悬臂梁疲劳寿命预测方法;进一步分析振动疲劳过程中谐振频率变化与负载功率变化的关系模型,提出一种基于负载功率的压电悬臂梁疲劳寿命预测方法。结果表明:基于谐振频率的压电悬臂梁疲劳寿命预测方法的平均误差在10%~20%之间,其误差范围控制在1.5倍误差线以内;而基于负载功率的压电悬臂梁疲劳寿命预测方法的平均误差集中于25%左右,误差范围均控制在2倍误差线以内且属于偏安全的预测效果。

关键词：压电悬臂梁振动疲劳力电响应寿命预测

Mo5+ doping induced interface polarization for improving performance of planar perovskite solar cells

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Journal of Semiconductors 2020年第5期41卷 78-85,105-106页

作者： Yurong Jiang Yue Yang yiting Liu Shan Yan Yanxing feng Congxin Xia School of Physics Henan Key Laboratory of Photovoltaic MaterialsHenan Normal UniversityXinxiang 453007China

In this paper,we investigate how interface-induced polarization affects the photovoltaic performance of hybrid perovskite solar cell(PSC)devices.The polarization of the hole transport layer(HTL)is regulated through incorporating metalliclike Mo Ox into PEDOT:PSS.The common Mo O3 doped into PEDOT:PSS is used as a reference,and the device that used PEDOT:PSS-Mo Ox as the HTL shows an enhanced Jsc and FF compared to the reference device.The open-circuit photovoltage decay and impedance spectroscopy measurements indicate that trap-assisted recombination is effectively suppressed at the interface between the hybrid perovskite and the PEDOT:PSS-Mo Ox HTL,while severe trap assisted recombination takes place at the perovskite/PEDOT:PSS and perovskite/PEDOT:PSS-Mo O3 interface.We attribute these experimental findings to the fact that the incorporation of metallic-like Mo5+into PEDOT:PSS enhances the conductivity of HTL and the interface polarization between PEDTOT:PSS layer and perovskite,which helps to induce an interface polarization electric field to facilitate separation of charges and screen the recombination between the traps and free charges.

关键词： conductivity hole-transporting layer dielectric constant polarization

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地震破裂模型约束的中国阿里地震三维形变场

武汉大学学报（信息科学版） 2018年第9期43卷 1369-1375页

作者：温扬茂冯怡婷武汉大学测绘学院湖北武汉430079 地球空间信息技术协同创新中心湖北武汉430079 武汉大学地球空间环境与大地测量教育部重点实验室湖北武汉430079

利用环境卫星（Environmental Satellite,Envisat）的升、降轨数据在地震破裂模型约束下获取2007年阿里地震的高质量同震地表三维形变场。首先,对合成孔径雷达（synthetic aperture radar,SAR）影像进行差分干涉处理,得到地震造成的视... 详细信息

利用环境卫星（Environmental Satellite,Envisat）的升、降轨数据在地震破裂模型约束下获取2007年阿里地震的高质量同震地表三维形变场。首先,对合成孔径雷达（synthetic aperture radar,SAR）影像进行差分干涉处理,得到地震造成的视线向同震地表形变场;然后,以地震破裂模型为约束条件,采用赫尔默特方差分量估计法来解算阿里地震的高质量地表三维同震形变场。结果表明,震中区域最大下沉达约4.7cm,东西向位移较小,南北向呈挤压趋势。总体上,三维形变的特征表明阿里地震是一个以正倾滑为主兼少量右旋走滑运动的地震事件。

关键词：阿里地震 InSAR 地震破裂模型三维地表形变方差分量估计