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Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2798-2818页

作者： Peng Liu Caifang Gao Hongguo Chen Chi Teng Vong xu Wu xudong Tang Shengpeng Wang yitao Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Laboratory of Molecular Pharmacology Department of PharmacologySchool of PharmacySouthwest Medical UniversityLuzhou 646000China Department of Gastroenterology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

Inflammatory bowel disease(IBD)is a chronic intestinal disease with painful clinical manifestations and high risks of cancerization.With no curative therapy for IBD at present,the development of effective therapeutics is highly advocated.Drug delivery systems have been extensively studied to transmit therapeutics to inflamed colon sites through the enhanced permeability and retention(EPR)effect caused by the inflammation.However,the drug still could not achieve effective concentration value that merely utilized on EPR effect and display better therapeutic efficacy in the inflamed region because of nontargeted drug release.Substantial researches have shown that some specific receptors and cell adhesion molecules highly expresses on the surface of colonic endothelial and/or immune cells when IBD occurs,ligandmodified drug delivery systems targeting such receptors and cell adhesion molecules can specifically deliver drug into inflamed sites and obtain great curative effects.This review introduces the overexpressed receptors and cell adhesion molecules in inflamed colon sites and retrospects the drug delivery systems functionalized by related ligands.Finally,challenges and future directions in this field are presented to advance the development of the receptor-mediated targeted drug delivery systems for the therapy of IBD.

关键词： Receptor-mediated target Inflammatory bowel disease Crohn’s disease Ulcerative colitis Drug delivery Cell adhesion molecule Active target Targeted therapy

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Photoreduction of CO_2 to methanol over Bi_2S_3/CdS photocatalyst under visible light irradiation

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Journal of Natural Gas Chemistry 2011年第4期20卷 413-417页

作者： Xin Li Juntao Chen Huiling Li Jingtian Li Yitao Xu Yingju Liu Jiarong Zhou The Guangdong Provincial Laboratory of Green Chemical Technology School of Chemistry and Chemical EngineeringSouth China University of Technology Guangzhou 510641 Guangdong China Institute of Biomaterial College of ScienceSouth China Agricultural University Guangzhou 510642 Guangdong China

The Bi 2 S 3 , CdS and Bi 2 S 3 /CdS photocatalysts were prepared by direct reactions between their corresponding salt and thiourea in a hydrothermal autoclave. The photocatalytic activities of these photocatalysts for reducing CO 2 to CH 3 OH under visible light irradiation have been investigated. The results show that the photocatalytic activity and visible light response of Bi 2 S 3 are higher than those of CdS. The Bi 2 S 3 modification can enhance the photocatalytic activity and visible light response of CdS. The photocatalytic activity of Bi 2 S 3 /CdS hetero-junction photocatalyst was the highest and the highest yields of methanol was 613 μmol/g when the weight proportion of Bi 2 S 3 to CdS was 15%, which was about three times as large as that of CdS or two times of that of Bi 2 S 3 .

关键词： photocatalytic reduction carbon dioxide heterogeneous catalysts CdS Bi2S3 CO2 reduction

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宋金时期“下卷昂”的形制演变与时空流布研究

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文物 2017年第2期 89-96+1页

作者：徐怡涛北京大学考古文博学院

按《营造法式》定义,昂分为上昂、下昂两类,下昂又可分为琴面、批竹两种亚型。本文从北方地区现存的建筑史料中,选取了一种不同于批竹昂、琴面昂的"下卷昂",以建筑考古类型学的方法,对这一非主流下昂形制的时空问题进行了初步探讨,认为... 详细信息

按《营造法式》定义,昂分为上昂、下昂两类,下昂又可分为琴面、批竹两种亚型。本文从北方地区现存的建筑史料中,选取了一种不同于批竹昂、琴面昂的"下卷昂",以建筑考古类型学的方法,对这一非主流下昂形制的时空问题进行了初步探讨,认为下卷昂最大可能首现于中晚唐前后的今陕西西安地区,继而沿交通线向周边地区扩散,但其流传仅以两京和陕西周边地区为主,未能影响到河北、山东、山西北部等地。下卷昂形制在宋金两朝形制的变化主要体现在华头子、昂嘴及其与其他斗拱构件的共存关系上,其中,晋西南地区是目前已知宋金时期下卷昂形制变化最显著的地区。

关键词：下昂万荣稷王庙大殿木构建筑宋金时期

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Energy saving and environment-friendly element-transfer reactions with industrial application potential

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Chinese Chemical Letters 2020年第5期31卷 1078-1082页

作者： Chao Chen yitao Cao Xixi Wu Yuanli Cai Jian Liu Lin xu Kehong Ding Lei Yu School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Tianzhu Hongfu Lithium Industry Technology Development Company Limited Wuwei 733200China Department of Applied Chemistry Faculty of EngineeringKyushu Institute of TechnologyKitakyushu 804-8550Japan Jiangsu Yangnong Chemical Group Company Limited Yangzhou 225009China

Herein we wish to propose the concept of"element-transfer reaction",which may afford the access to elemental compounds by transferring certain elements from easily available resources efficiently,concisely and precisely.A good element-transfer reaction with industrial application potential shall not generate waste and is performed under energy-saving and environment-friendly conditions.During the past decade,we have developed a series of methods for the synthesis of fluorine-and seleniumcontaining compounds via the fluorine-and selenium-transfer reactions,while the redox reactions we re considered to be the oxygen-and hydrogen-transfer reactions as well and were also widely studied by our group for producing the high-value-added fine chemicals.Some of these technologies have been successfully industrialized.This review summarizes our staged research results on fluorine-,oxygen-,hydrogen-and selenium-transfer reactions and makes a prospect on the developing trend in the field.

关键词： Element-transfer reaction Fluorine Redox Selenium Green chemistry Photocatalysis

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辽代建筑营造“大尺”与尺度构成研究——以独乐寺、奉国寺、开善寺辽构为例

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故宫博物院院刊 2023年第12期 24-47,150页

作者：王一臻徐怡涛东京大学工学系研究科建筑史研究室北京大学考古文博学院

由于辽尺史料匮乏,致使辽尺尺度存在较大的不确定性,因而影响了辽代建筑营造尺的推算和尺度研究。本文收集三处四座辽构实测数据,在木构建筑设计的整数尺法前提下,通过标准差计算法推测营造尺长,并结合控制性数据加以验证,提出辽代存在... 详细信息

由于辽尺史料匮乏,致使辽尺尺度存在较大的不确定性,因而影响了辽代建筑营造尺的推算和尺度研究。本文收集三处四座辽构实测数据,在木构建筑设计的整数尺法前提下,通过标准差计算法推测营造尺长,并结合控制性数据加以验证,提出辽代存在长于唐尺、宋尺的“大尺”制度。在此基础上归纳出辽代建筑具有总体规整尺数控制、细部灵活调整的尺度设计特点。

关键词：辽代营造尺整尺法标准差材分制

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Photocatalytic degradation of amoxicillin by carbon quantum dots modified K2Ti6O13 nanotubes:Effect of light wavelength

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Chinese Chemical Letters 2019年第6期30卷 1214-1218页

作者： Qiankun Chen Long Chen Juanjuan Qi Yingqian Tong yitao Lv Chaokai xu Jinren Ni Wen Liu The Key Laboratory of Water and Sediment Sciences Ministry of Education College of Environmental Sciences and Engineering Peking University Beijing 100871 China The Beijing Innovation Center for Engineering Science and Advanced Technology (BIC-ESAT) Peking University Beijing 100871 China

A novel carbon quantum dots modified potassium titanate nanotubes(CQDs/K2 Ti6 O13)composite photocatalyst was synthesized by hydrothermal treatment combined with calcination.X-ray diffraction(XRD)pattern and transmission electron microscopy(TEM)indicated formation of potassium titanate nanotubes and successful deposition of CQDs onto K2 Ti6 O13.The photocatalytic performance of CQDs/K2 Ti6 O13 composite was evaluated by degradation of amoxicillin(AMX)under the irradiation of visible light and lights with the wavelengths of 365,385,420,450,485,520,595 and 630 nm.The results showed that the photocatalytic activity of CQDs/K2 Ti6 O13 hybrid material was greatly enhanced compared with the neat K2 Ti6 O13 calcined at 300 ℃.The narrowed band gap energy(Eg)and transfer of photo-excited electron by CQDs inhibited the immediate combination of electron-hole pairs,thus promoting photocatalytic activity.Moreover,CQ,Ds/K2 Ti6 O13 exhibited a broad spectrum of photocatalytic ability and it was interesting that the photocatalytic activity decreased with the increase of the irradiation wavelength.Reactive oxygen species(ROS)quenching tests suggested the hole(h^+)and hydroxyl radical(^·OH)played the primary roles in photocatalytic degradation of AMX.Moreover,CQ.Ds/K2 Ti6 O13 showed good reusability for AMX photocatalytic degradation after five successive runs.This study proposed an available method for titanate nanomaterials modification,and the developed novel CQDs/K2 Ti6 O13hyb rid material is p ro mising fo r potential application on antibiotics removal fro m water and wastewater.

关键词： Potassium titanate nanotubes Carbon quantum dots Photocatalysis Antibiotics Photo energy

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Remarkable mechanochromism and force-induced thermally activated delayed fluorescence enhancement from white-light-emitting organic luminogens with aggregation-induced emission

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Chinese Chemical Letters 2022年第10期33卷 4536-4540页

作者： yitao Zheng Lingqi Zuo Letian Zhang Zihao Huang Shufeng Li Zhan Yang Zhu Mao Suilian Luo Cong Liu Fengqiang Sun Guang Shi Zhenguo Chi Bingjia xu Key Laboratory of Theoretical Chemistry of Environment Ministry of Education/School of ChemistrySouth China Normal UniversityGuangzhou 510006China State Key Laboratory of Optoelectronic Materials and Technologies(Sun Yat-sen University) Guangzhou 510275China School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China Shenzhen Institute of Advanced Electronic Materials Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

The development of organic materials with white-light emission and thermally activated delayed fluorescence(TADF)properties in the solid state remain a challenge.Herein,a series of white-light-emitting organic luminogens have been developed and are found to show aggregation-induced delayed fluorescence(AIDF)characteristics.The AIDF emitters present dual-emission consisted of prompt fluorescence and TADF in the crystalline state.Their white-light emissions can be easily tuned by altering the chemical structure and connecting position of the heterocyclic aromatic substituent.Under the stimuli of mechanical force and solvent vapor,the compounds exhibit remarkable and reversible mechanochromism,in which their emission colors are switchable between white and yellow.Upon grinding,they also display linearly tunable luminescence colors,as well as force-induced TADF enhancement,which may be associated with the more compact molecular packing and the restriction of intramolecular motions.The results from time-resolved emission scanning and theoretical calculation suggest that the dual-emission of the AIDF luminogens likely results from the twisted intramolecular charge transfer transitions of the molecules,and the reversible mechanochromism properties probably stem from the interconversion of the quasi-axial and the quasi-equatorial conformations.

关键词： White-light emission Thermally activated delayed fluorescence Aggregation-induced delayed fluorescence mechanochromism Force-induced emission enhancement

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c-MYC-mediated TRIB3/P62^(+) aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1240-1253页

作者： Min-Xia Su Yu-Lian xu Xiao-Ming Jiang Mu-Yang Huang Le-Le Zhang Luo-Wei Yuan Xiao-Huang xu Qi Zhu Jian-Li Gao Jia-Hong Lu Xiuping Chen Ming-Qing Huang yitao Wang Jin-Jian Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310000China College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350000China Mo E Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China

The mammalian target of rapamycin(m TOR) pathway is abnormally activated in lung cancer.However, the anti-lung cancer effect of m TOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an active component of Panax ginseng C. A. Mey., enhanced the anti-cancer effect of the m TOR inhibitor everolimus both in vitro and in vivo. Moreover, ginsenoside Rh2 alleviated the hepatic fat accumulation caused by everolimus in xenograft nude mice models. The combination of everolimus and ginsenoside Rh2(labeled Eve-Rh2) induced caspase-independent cell death and cytoplasmic vacuolation in lung cancer cells, indicating that Eve-Rh2 prevented tumor progression by triggering paraptosis. EveRh2 up-regulated the expression of c-MYC in cancer cells as well as tumor tissues. The increased cMYC mediated the accumulation of tribbles homolog 3(TRIB3)/P62+ aggresomes and consequently triggered paraptosis, bypassing the classical c-MYC/MAX pathway. Our study offers a potential effective and safe strategy for the treatment of lung cancer. Moreover, we have identified a new mechanism of TRIB3/P62+ aggresomes-triggered paraptosis and revealed a unique function of c-MYC.

关键词： Everolimus Ginsenoside Rh2 Paraptosis Aggresomes P62 TRIB3 c-MYC Lung cancer

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国外私立基础教育的发展及其启示

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中国教育学刊 2022年第5期 43-48页

作者：王一涛侯琮刘绪苏州大学教育学院江苏苏州215123 南方科技大学高等教育研究中心广东深圳518055

私立基础教育是许多国家基础教育的重要组成部分。各国基础教育阶段中私立教育占比差距大,经济发展水平、社会福利制度、文化多样性和教育制度等因素影响着不同国家基础教育阶段私立教育的比例。私立教育承担着为国家培养人才、促进社... 详细信息

私立基础教育是许多国家基础教育的重要组成部分。各国基础教育阶段中私立教育占比差距大,经济发展水平、社会福利制度、文化多样性和教育制度等因素影响着不同国家基础教育阶段私立教育的比例。私立教育承担着为国家培养人才、促进社会公平、增强社会凝聚力的重要职责,各国普遍重视对私立学校的扶持和监管。由此带给我们的重要启示在于:一要形成对我国民办教育规模和占比的科学认识;二要对不同类型民办学校区别施策、精准发力;三要加强对我国民办教育政策的正面解读和宣传引导,探索中国特色的民办教育治理经验。

关键词：基础教育私立教育民办教育国际比较

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“双一流”背景下大学教师师德建设:范式转型、价值定位与实践路径

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现代教育管理 2018年第10期 75-79页

作者：刘奕涛彭旭嘉应学院广东梅州514015

高素质的教师是"双一流"建设的基石,而师德建设是高素质教师形成的核心。"双一流"建设对大学教师队伍成长与发展提出更高的要求,在"双一流"建设背景下大学教师师德发展面临转型要求,应进一步明确大学教师师德建设的价值定位,通过教师主... 详细信息

高素质的教师是"双一流"建设的基石,而师德建设是高素质教师形成的核心。"双一流"建设对大学教师队伍成长与发展提出更高的要求,在"双一流"建设背景下大学教师师德发展面临转型要求,应进一步明确大学教师师德建设的价值定位,通过教师主体师德自觉发展、制度完善和共同体建构的路径造就一流教师师德。

关键词：双一流大学教师师德

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