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Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2-p65 pathway

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Frontiers of Medicine 2021年第5期15卷 750-766页

作者： Manling Liu Zhaoling Shi Yue Yin yishi wang Nan Mu Chen Li Heng Ma Qiong wang Department of Physiology and Pathophysiology Fourth Military Medical UniversityXi’an 710032China Department of Pediatrics Second Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712046China Department of Cardiovascular Medicine Xijing HospitalFourth Military Medical UniversityXi’an 710032China

Exposure to particulate matter 2.5(PM2.5)potentially triggers airway inflammation by activating nuclear factor-κB(NF-κB).Sirtuin 2(SIRT2)is a key modulator in ***,the function and specific mechanisms of SIRT2 in PM2.5-induced airway inflammation are largely ***,this work investigated the mechanisms of SIRT2 in regulating the phosphorylation and acetylation of p65 influenced by PM2.5-induced airway inflammation and bronchial *** revealed that PM2.5 exposure lowered the expression and activity of SIRT2 in bronchial ***,SIRT2 impairment promoted the phosphorylation and acetylation of p65 and activated the NF-κB signaling *** activation of p65 triggered airway inflammation,increment of mucus secretion by goblet cells,and acceleration of tracheal ***,p65 phosphorylation and acetylation,airway inflammation,and bronchial hyperresponsiveness were deteriorated in SIRT2 knockout mice exposed to ***(a specific p65 inhibitor)reversed p65 activation and ameliorated PM2.5-induced airway inflammation and bronchial *** findings provide novel insights into the molecular mechanisms underlying the toxicity of PM2.5 *** inhibition of p65 phosphorylation and acetylation could be an effective therapeutic approach in averting PM2.5-induced airway inflammation and bronchial hyperresponsiveness.

关键词： particulate matter 2.5 sirtuin 2 p65 airway inflammation bronchial hyperresponsiveness triptolide

Lipocalin-2-induced proliferative endoplasmic reticulum stress participates in Kawasaki disease-related pulmonary arterial abnormalities

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Science China(Life Sciences) 2021年第6期64卷 1000-1012页

作者： Zhaoling Shi Yue Yin Chen Li Hui Ding Nan Mu yishi wang Shanshan Jin Heng Ma Manling Liu Jie Zhou Department of Pediatrics Second Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000China Department of Physiology and Pathophysiology School of Basic Medical SciencesFourth Military Medical UniversityXi’an 710032China Department of Endocrinology Xijing HospitalFourth Military Medical UniversityXi’an 710032China

Clinical cases have reported pulmonary arterial structural and functional abnormalities in patients with Kawasaki disease(KD);however,the underlying mechanisms are *** this study,a KD rat model was established via the intraperitoneal injection of Lactobacillus casei cell wall extract(LCWE).The results showed that pulmonary arterial functional and structural abnormalities were observed in KD ***,proliferative endoplasmic reticulum stress(ER stress)was observed in the pulmonary arteries of KD ***,the level of lipocalin-2(Lcn 2),a trigger factor of inflammation,was remarkably elevated in the plasma and lung tissues of KD rats;increased Lcn 2 levels following LCWE stimulation may result from polymorphonuclear neutrophils(PMNs).Correspondingly,in cultured pulmonary artery smooth muscle cells(PASMCs),Lcn 2 markedly augmented the cleavage and nuclear localization of activating transcription factor-6(ATF6),upregulated the transcription of glucose regulated protein 78(GRP78)and neurite outgrowth inhibitor(NOGO),and promoted PASMCs ***,proapoptotic C/EBP homologous protein(CHOP)and caspase 12 levels were not *** with 4-phenyl butyric acid(4-PBA,a specific inhibitor of ER stress)inhibited PASMCs proliferation induced by Lcn 2 and attenuated pulmonary arterial abnormalities and right ventricular hypertrophy and reduced right ventricular systolic pressure in KD *** conclusion,Lcn 2 remarkably facilitates proliferative ER stress in PASMCs,which probably accounts for KD-related pulmonary arterial abnormalities.

关键词： Kawasaki disease lipocalin-2 endoplasmic reticulum stress pulmonary arterial structural and functional abnormalities

Melatonin attenuates chronic pain related myocardial ischemic susceptibility

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Melatonin attenuates chronic pain related myocardial ischemi...

河北地区中生代标准地层剖面侏罗系/白垩系界线——SHRIMP锆石U-Pb年龄标定

2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者： Zheng Yang Nan Mu Yue Yin yishi wang Lu Yu 马恒 Department of physiology and pathophysiology School of Basic Medicine Department of pathology Xijing HospitalFourth Military Medical University

Chronic pain is not in isolated pathophysiological condition, long-last pain leads body into a malignant stress state, which exerts pervasive influences on human *** pain often delineates the decline of physical fitness or the threat against organs health, which might incur derived diseases, abuse and side effect of analgesics and many other ***, for now,chronic pain influence towards other remote organs, such as the function of heart, remains *** studies have already shown clearly that, the morbidity of heart diseases increases in patients under chronic pain condition followed with a worse prognosis, nevertheless underlying pathophysiological mechanisms are not well *** data delineate that, chronic pain elevates the morbidity of myocardial ischemia patients which sheds light on the possibility of chronic pain contributing to the incidence of ischemia *** analgesics, such as non-steroid anti-inflammatory drugs, could increase the concurrence of heart diseases which constrict its ***, it is urgent to find out the outset and develop process of chronic pain-derived heart diseases and seek potential prevention and cure ***, this study aimed to discuss biological mechanisms of increased vulnerability against myocardial ischemia under chronic pain *** study was based on previous studies, emphasis on discuss: to verify the impact of chronic neuropathic pain on MI/R susceptibility;to analyze the role of myocardial Necroptosis in chronic pain related myocardial ischemic *** this study, chronic pain was induced by spared nerve injury model(SNI) for 4 *** showed decreased the ipsilateral hind paw withdrawal mechanical threshold(PWMT) in SNI *** dose melatonin treatment(60 mg/kg, i.p.) could reversed nociceptive threshold in SNI *** verify the effect of chronic pain on the cardiac tolerance to ischemic stress, mice were subjected to myocardi

关键词： chronic pain myocardial ischemia reperfusion myocardial necroptosis melatonin RIP 3

来源： cnki会议评论

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地质通报 2018年第7期37卷 1186-1192页

作者：高林志王屹石张恒中国地质科学院地质研究所北京100037 北京第八中学北京100033

在全国地层委员会组织的滦平盆地中生代地层野外考察中,采集了大北沟组凝灰岩样品,其锆石年龄测定结果引发对陆相侏罗系/白垩系界线的思考。冀北滦平地区陆相侏罗系—白垩系发育,各类陆相生物化石极丰富,地层产出大量火山凝灰岩层,是通... 详细信息

在全国地层委员会组织的滦平盆地中生代地层野外考察中,采集了大北沟组凝灰岩样品,其锆石年龄测定结果引发对陆相侏罗系/白垩系界线的思考。冀北滦平地区陆相侏罗系—白垩系发育,各类陆相生物化石极丰富,地层产出大量火山凝灰岩层,是通过岩石地层、生物地层、同位素测年和磁性年代地层综合研究侏罗系/白垩系界线的理想地区。根据生物地层研究,冀北滦平盆地侏罗系/白垩系界线附近的地层为大北沟组和大店子组。根据冀北—辽西地区同位素测年数据,侏罗系/白垩系界线年龄倾向于130Ma。获得榆树下标准剖面大北沟组顶部凝灰岩(斑脱岩)SHRIMP锆石U-Pb同位素年龄为129.9±1.1Ma。

关键词：侏罗系/白垩系陆相地层同位素测年冀北滦平地区

基于点云深度学习的对称结构空间目标相对位姿测量

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宇航学报 2023年第2期44卷 294-302页

作者：王艺诗徐田来张泽旭苏宇哈尔滨工业大学航天学院深空探测基础研究中心哈尔滨150080

针对对称结构空间目标相对位姿解算过程中点云误匹配带来的误差问题,提出一种基于点云深度学习的对称结构空间目标相对位姿测量方法。首先设计空间目标点云特征提取网络及关键点回归网络,将位姿测量问题转换为空间目标点云关键点回归问... 详细信息

针对对称结构空间目标相对位姿解算过程中点云误匹配带来的误差问题,提出一种基于点云深度学习的对称结构空间目标相对位姿测量方法。首先设计空间目标点云特征提取网络及关键点回归网络,将位姿测量问题转换为空间目标点云关键点回归问题,通过两个并行的回归网络分别输出空间目标平移向量和具有固定标签的目标点云三维边界框角点;其次利用具有连续稳定标签的角点求解目标姿态,可有效解决目标的对称结构导致的点云误配准问题;最后通过仿真数据集的实验表明,该方法相比于传统的点云配准方法有更高的准确率,能够精确求解具有对称结构的空间目标相对位姿。

关键词：空间目标点云特征提取网络回归网络三维边界框角点位姿测量

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古代文书档案影印出版中的问题与应对

济宁学院学报 2022年第6期43卷 102-107页

作者：王怡石人民出版社北京100706

古代文书档案影印出版不同于古籍影印出版,有自身形制上的特点。古代文书档案影印出版时需要重新划分页码,重新拼接。古代文书档案格式复杂,抬格、转行、满文部分等因素导致影印出版中产生一系列问题。应尽量采取措施减少透字,电子文件... 详细信息

古代文书档案影印出版不同于古籍影印出版,有自身形制上的特点。古代文书档案影印出版时需要重新划分页码,重新拼接。古代文书档案格式复杂,抬格、转行、满文部分等因素导致影印出版中产生一系列问题。应尽量采取措施减少透字,电子文件的拼接、缩放、裁切、核对都应符合科学的流程。档案辅文的撰写中繁体字和异体字需按照前人的经验处理得当。

关键词：古代文书档案影印出版问题应对

THE CONSERVATION LAW OF ENERGY MOMENTUM IN GENERAL RELATIVITY

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Science in China,Ser.A 1983年第9期 961-971页

作者：段一士王友堂 Lanzhoue University Shanghai Jiaotong University

From the standpoint that the conservation laws with the same physical meaning in general relativity and special relativity must be determined by one and the same Lie group, using the Nether theorem, we have proposed that the conservation law of energy-momentum in genera] relativity should be de（?）ived from the generalized translational transformationxμ’=xμ+λ?u b0where λa)u is the vierbein. By using the invarianec of this transformation, a satisfactory expression of energy-momentum tensor of gravitational field has been obtained. The reasonableness of this conservation law has been discussed according to the covariant property of the energy-momentum tensor, the total energy of static system and the gravitational radiation problems.

关键词： THE CONSERVATION LAW OF ENERGY MOMENTUM IN GENERAL RELATIVITY

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皖北城际铁路蒙城车站选址及布置方案研究

高速铁路技术 2017年第5期8卷 52-56页

作者：王艺诗中铁上海设计院集团有限公司上海200070

新建区域路网节点车站的站位和布置方案影响区域路网建设成本、运输组织效率和效益。规划设计中的皖北城际网含淮北至阜阳、亳州至蚌埠两条快速铁路,在蒙城地区交会,新建蒙城站是该城际路网的重要接轨站。文章通过分析区域路网客流特点... 详细信息

新建区域路网节点车站的站位和布置方案影响区域路网建设成本、运输组织效率和效益。规划设计中的皖北城际网含淮北至阜阳、亳州至蚌埠两条快速铁路,在蒙城地区交会,新建蒙城站是该城际路网的重要接轨站。文章通过分析区域路网客流特点,提出了东西向和南北向两个站位方案,通过定性比较分析,考虑客流适应性、区域路网建设代价和运营效益,推荐南北向设站方案。并结合区域路网客流走向,提出了3种站型布置方案,从建设成本、运输条件和开行方案适应性等方面对各站型详细比较分析,提出适应城际客流特点、技术经济合理的车站布置方案。

关键词：城际铁路接轨站选址站型

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基于热管改良的汽车电机散热效果研究

汽车实用技术 2019年第11期45卷 137-141页

作者：王宜时武汉理工大学汽车工程学院

文章利用热管对汽车电机的散热系统进行改良设计,使电机定子绕组的热量先通过热管直接传递到电机壳体,再由水套内的冷却液带走。根据电机的结构及工作原理,构建了电机内部传热模型,由此分析改良前后电机在不同冷却液流量下散热效果的差... 详细信息

文章利用热管对汽车电机的散热系统进行改良设计,使电机定子绕组的热量先通过热管直接传递到电机壳体,再由水套内的冷却液带走。根据电机的结构及工作原理,构建了电机内部传热模型,由此分析改良前后电机在不同冷却液流量下散热效果的差异。研究表明利用热管对汽车电机进行改良,可有效降低电机散热所需辅助能耗,研究可为汽车电机散热系统提供新的设计思路。

关键词：热管电机散热系统仿真