检索结果-南通市图书馆

Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer(NECTAR):a multi-center phase 2 study

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1721-1729页

作者： Zhengyang Yang Jiale Gao Jianyong Zheng Jiagang Han Ang Li Gang liu Yi Sun Jie Zhang Guangyong Chen Rui Xu Xiao Zhang yishan liu Zhigang Bai Wei Deng Wei He Hongwei Yao Zhongtao Zhang Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityState Key Lab of Digestive HealthNational Clinical Research Center for Digestive DiseasesBeijingChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Air Force Medical UniversityXi'anChina Department of General Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of General Surgery Beijing Xuanwu HospitalCapital Medical UniversityBeijingChina Department of General Surgery Tianjin Medical University General HospitalTianjinChina Department of Anorectal Tianjin People's HospitalTianjinChina Department of Radiology Beijing Friendship Hospital Capital Medical UniversityBeijingChina Department of Pathology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Thoracic Surgery/Institute of Thoracic Oncology West China HospitalSichuan UniversityChengduChina

Adding PD-1 blockade in the neoadjuvant regimens for locally advanced rectal cancer(LARC)patients with microsatellite stable(MsS)/mismatch repair-proficient(pMMR)tumors is an attractive,but debatable *** phase 2,multicenter,prospective,single-arm study enrolled patients from 6 centers from June 2021 to November *** advanced rectal cancer(LARC,cT_(3-4a)N_(0)M_(0) and cT_(1-4a)N_(1-2)M_(0))patients aged≥18 years with the distance from distal border of tumor to anal verge≤10 cm(identified by Magnetic Resonance Imaging)were qualifed for *** patients received long-course radiotherapy(50 Gy/25 fractions,2 Gy/fraction,5 days/week)and three 21-day cycles capecitabine(850-1000 mg/m2,bid,po,day1-14)and three 21-day cycles tislelizumab(200 mg,***,day8)as *** mesorectal excision(TME)was 6-12 weeks after the end of radiotherapy to achieve radical resection.A total of 50 patients were enrolled in this *** pathological complete response rate was 40.0%[20/50,95%confidence interval(CI):27.61-53.82%],while 15(30.0%,95%CI:19.1-43.75%),9(18.0%,95%CI:9.77-30.8%),2(4.0%,95%CI:1.10-13.46%)patients respectively achieved grade 1,2,and 3 tumor ***-related adverse events(TRAEs)occurred in 28(56.0%)LARC patients,including 26(52.0%)with grade I-II and 2(4.0%)with grade II(1 with grade 3 immune-related colitis and 1 with grade 3 rash).PD-1 blockade plus long-course chemoradiotherapy(CRT)showed promising therapeutic effects according to pathological complete response rate and is well-tolerated in LARC patients.A larger randomized controlled study is desired to further validate the above findings.

关键词： rectal cancer phase

非物质文化遗产保护现状及文旅融合发展策略研究——以莲花山花儿为例

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丝绸之路 2024年第2期 107-114页

作者：刘奕杉兰州石化职业技术大学国际教育学院甘肃兰州730300

在乡村振兴战略推进过程中,产业发展和乡风文明建设是极为重要的两个部分。我国乡村非物质文化遗产根植于广大农村文化土壤,凝结着当地民俗文化的独特精神内涵,与村民的日常生活息息相关,具有广泛民众基础和天然亲和力。通过分析康乐县... 详细信息

在乡村振兴战略推进过程中,产业发展和乡风文明建设是极为重要的两个部分。我国乡村非物质文化遗产根植于广大农村文化土壤,凝结着当地民俗文化的独特精神内涵,与村民的日常生活息息相关,具有广泛民众基础和天然亲和力。通过分析康乐县非物质文化遗产莲花山花儿的起源、特点和传承现状,探究非物质文化遗产与乡村文旅融合的创新发展,提出如何在文旅融合发展模式中解决莲花山花儿传承与发展的困境并促进乡村的经济建设发展,可充实非物质文化遗产保护与传承的相关理论研究,拓宽乡村旅游研究领域,从而为非物质文化遗产与文旅融合创新发展提供理论支持与思路借鉴。

关键词：非物质文化遗产康乐县莲花山花儿文旅融合

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城市社区养老设施需求识别与空间配置模式——以天津市中心城区为例

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南方建筑 2024年第2期 94-104页

作者：刘奕杉刘丛红杨鸿玮程坦天津大学建筑学院

在完善城市公共服务设施背景下,标准化配置的社区养老设施往往忽略了供需的精准匹配。立足于供需视角,聚焦不同人群特征对需求进行差异化探讨,运用安德森模型和Kano模型展开调研,判断被测群体需求层次和需求程度,通过需求影响因素的相... 详细信息

在完善城市公共服务设施背景下,标准化配置的社区养老设施往往忽略了供需的精准匹配。立足于供需视角,聚焦不同人群特征对需求进行差异化探讨,运用安德森模型和Kano模型展开调研,判断被测群体需求层次和需求程度,通过需求影响因素的相关性分析和基于需求层次的聚类分析划分人群特征,提取典型群体,分析需求情况。结果表明,人群特征差异和功能空间差异均对需求有显著影响。基于此,分别建立了整体人群和典型人群功能空间配置模型,提出功能独立型社区养老设施配置模式,给出了一套可精准识别需求并合理配置功能空间的方法,为未来社区养老设施设计提供参考。

关键词：社区养老设施空间配置模式 Kano模型需求层次需求程度

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总体国家安全观的世界观和方法论意蕴

马克思主义哲学 2024年第3期 45-51页

作者：李家富刘一杉重庆理工大学马克思主义学院

总体国家安全观是习近平新时代中国特色社会主义思想的国家安全篇,凝结着中国共产党百余年来推进国家安全建设的理论原则和经验总结,贯穿其中的人民至上、自信自立、守正创新、问题导向、系统观念、胸怀天下的立场、观点和方法,充分展... 详细信息

总体国家安全观是习近平新时代中国特色社会主义思想的国家安全篇,凝结着中国共产党百余年来推进国家安全建设的理论原则和经验总结,贯穿其中的人民至上、自信自立、守正创新、问题导向、系统观念、胸怀天下的立场、观点和方法,充分展现了总体国家安全观深厚的马克思主义哲学基础,闪耀着马克思主义世界观和方法论的深邃光辉,为做好新时代国家安全工作提供了强大思想武器。必须坚持人民至上是总体国家安全观的价值导向,必须坚持自信自立是总体国家安全观的精神特质,必须坚持守正创新是总体国家安全观的发展路径,必须坚持问题导向是总体国家安全观的实践原则,必须坚持系统观念是总体国家安全观的思想方法,必须坚持胸怀天下是总体国家安全观的人类情怀。总体国家安全观是一个开放发展的思想体系,必将随着中国式现代化的国家安全建设而不断丰富和发展。

关键词：总体国家安全观世界观和方法论 “六个必须坚持”

松辽盆地古龙页岩纳米孔喉体系中页岩油组分及成熟度分异效应

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大庆石油地质与开发 2024年第4期43卷 105-115页

作者：张婧雅窦立荣朱如凯刘一杉曾花森中国石油勘探开发研究院北京100083 多资源协同陆相页岩油绿色开采全国重点实验室黑龙江大庆163712 中国石油大庆油田有限责任公司勘探开发研究院黑龙江大庆163712

陆相页岩油储层中石油的微运移效应会导致微观孔隙空间中赋存的页岩油性质发生分异,然而页岩储层孔隙半径较小,孔喉结构复杂,很难通过常规手段对其进行精细刻画,导致对页岩油的微观富集机理认识不清。通过对松辽盆地古龙凹陷青山口组页... 详细信息

陆相页岩油储层中石油的微运移效应会导致微观孔隙空间中赋存的页岩油性质发生分异,然而页岩储层孔隙半径较小,孔喉结构复杂,很难通过常规手段对其进行精细刻画,导致对页岩油的微观富集机理认识不清。通过对松辽盆地古龙凹陷青山口组页岩岩心样品进行分步-接力抽提、低温氮气吸附实验,并开展全烃气相色谱、族组分定量、饱和烃气相色谱质谱和金刚烷双质谱等地球化学分析,揭示出页岩储层纳米孔喉体系内的石油组分和成熟度分异效应。结果表明,古龙页岩孔隙以介孔为主,随着页岩样品粒径的逐级减小,更多初始连通性较差的孔隙会被释放出来,同时微观纳米孔喉中烃类的重质组分相对增加,极性更强,页岩油的成熟度也相对更高,这与不同连通性孔隙空间中页岩油的排烃和微运移效应具有一定的相关性。研究成果可为精细表征页岩油的微观赋存特征,阐明页岩油储层烃类微观差异富集机理提供有效的技术手段,同时也为页岩油的可动性评价和甜点优选提供可靠的理论依据。

关键词：古龙页岩分步-接力抽提纳米孔喉体系烃类差异富集机理组分分异效应成熟度分异效应

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妊娠期妇女和儿童丙型肝炎的管理

临床肝胆病杂志 2024年第4期40卷 654-658页

作者：刘奕杉张兰婷赵蕴玉纪泛扑曾庆磊西安交通大学第二附属医院感染科西安710004 郑州大学第一附属医院感染科郑州450052

HCV感染是全球性的公共卫生问题,直接抗病毒药物的出现为丙型肝炎患者的治疗带来了革命性的突破。尽管直接抗病毒药物在成人患者中的治疗效果显著,但对于孕妇、婴幼儿、青少年这一特殊人群的治疗仍存在诸多挑战。本文旨在探讨这些特殊... 详细信息

HCV感染是全球性的公共卫生问题,直接抗病毒药物的出现为丙型肝炎患者的治疗带来了革命性的突破。尽管直接抗病毒药物在成人患者中的治疗效果显著,但对于孕妇、婴幼儿、青少年这一特殊人群的治疗仍存在诸多挑战。本文旨在探讨这些特殊丙型肝炎人群在抗病毒治疗方面的现状及尚需解决的问题,以期为临床工作者提供参考与借鉴。

关键词：丙型肝炎儿童孕妇

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DSPP与BMP-2在牙髓干细胞修复再生牙髓牙本质复合体中的表达及意义

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健康研究 2024年第2期44卷 187-191,F0003页

作者：铁晓敏钟良军刘奕杉杭州师范大学附属医院口腔医学中心浙江杭州310015 新疆医科大学第一附属医院(附属口腔医院)儿牙预防保健科新疆乌鲁木齐830054

目的探讨牙本质涎磷蛋白(dentin sialophosphoprotein,DSPP)与骨形态发生蛋白-2(bone morphogenetic protein-2,BMP-2)在第三代同质异体牙髓干细胞(dental pulp stem cell,DPSCs)再生修复牙髓牙本质复合体后的表达和意义,为年轻恒牙牙髓根尖周疾病提供新的诊疗思路。方法 18只SD大鼠随机分为实验组和对照组,两组均在全麻下摘除大鼠上颌双侧第一磨牙冠髓,实验组同期髓腔定植体外培养的同质异体大鼠牙髓干细胞,对照组冠髓摘除后不进行任何处理,术后均使用玻璃离子充填封闭髓腔。两组动物均于术后2、4、6周处死,取其上颌骨进行免疫组织化学方法检测DSPP和BMP-2的表达。结果术后2、4、6周时,实验组牙髓牙本质复合体处的DSPP、BMP-2的表达水平均高于对照组,差异有统计学意义(P<0.05)。结论同质异体牙髓干细胞再植后会增加牙髓牙本质复合体处的DSPP和BMP-2的表达,有助于修复再生牙髓牙本质复合体。

关键词：牙髓干细胞牙本质涎磷蛋白骨形态发生蛋白-2

Phenotypical and gene co-expression network analyses of seed shattering in divergent sorghum(Sorghum spp.)

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The Crop Journal 2023年第2期11卷 478-489页

作者： Xin Xiao Mengjiao Zhu yishan liu Jingru Zheng Yiping Cui Candong Xiong Jiangjiang liu Jun Chen Hongwei Cai College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China College of Grassland Science and Technology China Agricultural UniversityBeijing 100193China Forage Crop Research Institute Japan Grassland Agricultural and Forage Seed Association388-5 HigashiakadaNasushiobaraTochigi 329-2742Japan

Sorghum[Sorghum bicolor(L.)Moench],a multipurpose C4 crop,is also a model species of the Poaceae family for plant *** the process of domestication,the modification of seed dispersal mode is considered a key event,as the loss of seed shattering caused a significant increase in *** order to understand the seed shattering process in sorghum,we further studied eight previously identified divergent sorghum germplasm with different shattering *** described their phenotypes in great detail,analyzed the histology of abscission zone,and conducted a gene co-expression *** observed that the abscission layer of the most strong-shattering varieties began to differentiate before the 5-10 cm panicles development stage and was completely formed at flag leaf *** protective cells on the pedicels were also fully lignified by *** the weighted gene correlation network analysis(WGCNA),we mined for candidate genes involved in the abscission process at the heading *** found that these genes were mainly associated with such biological processes as hormone signal transmission(SORBI_3003G361300,SORBI_3006G216500,SORBI_3009G027800,SORBI_3007G077200),cell wall modification and degradation(SORBI_3002G205500,SORBI_3004G013800,SORBI_3010G022400,SORBI_3003G251800,SORBI_3003G254700,SORBI_3003G410800,SORBI_3009G162700,SORBI_3001G406700,SORBI_3004G042700,SORBI_3004G244600,SORBI_3001G099100),and lignin synthesis(SORBI_3004G220700,SORBI_3004G062500,SORBI_3010G214900,SORBI_3009G181800).Our study has provided candidate genes required for shedding for further *** believe that function characterization of these genes may provide insight into our understanding of seed shattering process.

关键词： Divergent sorghum Seed shattering Abscission zone WGCNA

Key theoretical and technical issues and countermeasures for effective development of Gulong shale oil, Daqing Oilfield, NE China

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Petroleum Exploration and Development 2023年第3期50卷 638-650页

作者： YUAN Shiyi LEI Zhengdong LI Junshi YAO Zhongwen LI Binhui WANG Rui liu yishan WANG Qingzhen CNPC Advisory Center Beijing 100724China PetroChina Research Institute of Petroleum Exploration&Development Beijing 100083China PetroChina Daging Oilfield Co. Ltd.Daging 163002China

Aiming at the four issues of underground storage state,exploitation mechanism,crude oil flow and efficient recovery,the key theoretical and technical issues and countermeasures for effective development of Gulong shale oil are put *** key exploration and research on fluid occurrence,fluid phase change,exploitation mechanism,oil start-up mechanism,flow regime/pattern,exploitation mode and enhanced oil recovery(EOR)of shale reservoirs with different storage spaces,multi-scale occurrence states of shale oil and phase behavior of fluid in nano confined space were provided,the multi-phase,multi-scale flow mode and production mechanism with hydraulic fracture-shale bedding fracture-matrix infiltration as the core was clarified,and a multi-scale flow mathematical model and recoverable reserves evaluation method were preliminarily *** feasibility of development mode with early energy replenishment and recovery factor of 3o%was *** on these,the researches of key theories and technologies for effective development of Gulong shale oil are proposed to focus on:(1)in-situ sampling and non-destructive testing of core and fluid;(2)high-temperature,high-pressure,nano-scale laboratory simulation experiment;(3)fusion of multi-scale multi-flow regime numerical simulation technology and large-scale application software;(4)waterless(CO_(2))fracturing technique and the fracturing technique for increasing the vertical fracture height;(5)early energy replenishment to enhance oil recovery;(6)lifecycle technical and economic ***,a series of exploitation tests should be performed on site as soon as possible to verify the theoretical understanding,optimize the exploitation mode,form supporting technologies,and provide a generalizable development model,thereby supporting and guiding the effective development and production of Gulong shale oil.

关键词： Gulong shale oil continental shale oil nano confined space production mechanism flow mode early energy replenishment enhanced oil recovery