检索结果-南通市图书馆

Genetic pathways in cerebral palsy:a review of the implications for precision diagnosis and understanding disease mechanisms

引用

Neural Regeneration Research 2024年第7期19卷 1499-1508页

作者： yiran Xu Yifei Li Seidu A.Richard Yanyan Sun Changlian Zhu Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina National Health Council(NHC)Key Laboratory of Birth Defects Prevention Henan Key Laboratory of Population Defects PreventionZhengzhouHenan ProvinceChina Department of Human Anatomy School of Basic Medicine and Institute of NeuroscienceZhengzhou UniversityZhengzhouHenan ProvinceChina Center for Brain Repair and Rehabilitation Institute of Neuroscience and PhysiologyUniversity of GothenburgGothenburgSweden

Ce rebral palsy is a diagnostic term utilized to describe a group of permanent disorders affecting movement and *** with cerebral palsy are often only capable of limited activity,resulting from non-progressive disturbances in the fetal or neonatal *** disturbances severely impact the child’s daily life and impose a substantial economic burden on the *** cerebral palsy encompasses various brain injuries leading to similar clinical outcomes,the unde rstanding of its etiological pathways remains incomplete owing to its complexity and *** review aims to summarize the current knowledge on the genetic factors influencing cerebral palsy *** is now widely acknowledged that genetic mutations and alterations play a pivotal role in cerebral palsy development,which can be further influenced by environmental fa *** pite continuous research endeavors,the underlying fa ctors contributing to cerebral palsy remain are still ***,significant progress has been made in genetic research that has markedly enhanced our comprehension of the genetic factors underlying cerebral palsy *** r,these genetic factors have been categorized based on the identified gene mutations in patients through clinical genotyping,including thrombosis,angiogenesis,mitochondrial and oxidative phosphorylation function,neuronal migration,and cellular ***,exploring targeted genotypes holds potential for precision *** conclusion,advancements in genetic research have substantially improved our understanding of the genetic causes underlying cerebral *** breakthroughs have the potential to pave the way for new treatments and therapies,consequently shaping the future of cerebral palsy research and its clinical *** investigation of cerebral palsy genetics holds the potential to significantly advance treatments and management *** elucidating the underlying cellular mechanisms,w

关键词： cerebral palsy environmental factors etiology genetic factors genetic mutation movement disorder spastic diplegia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Monochromatic cycles in 2-edge-colored bipartite graphs

引用

Acta Mathematica sinica,English Series 2024年

作者： yiran Zhang Yuejian Peng School of Mathematics Hunan University

DeBiasio and Krueger showed the following result:For all 0≤δ≤1 and?>0,there exists n0such that if G is a balanced bipartite graph on 2n≥2n0vertices with δ（G）=δn,then in every 2-coloring of G,there exists a monochromatic cycle of order at least (f （δ）-?)n,where f（δ）={δ,0≤δ≤2/3,4δ-2,2/3＜δ≤3/4，1,3/4＜δ＜*** and Peng （2023） extended the above result to off-diagonal cases when δ>3/*** this paper,we relax the condition δ>3/4 to δ>2/*** show the following result:For every η>0,there exists a positive integer N0such that for every integer N>N0the following *** 2/3＜δ≤3/4,and let a1≥（δa2） /（3δ-2） such that α1+α2=*** G[X,Y]be a balanced bipartite graph on 2N vertices with δ（G）=（δ+3η）*** for each red-blue-edge-coloring of G,either there exist red even cycles of each length in{4,6,8,...,2（2δ-1）(2-3η2)α1N},or there exist blue even cycles of each length in{4,6,8,...,2（2δ-1）(2-3η2)α2N}.There are constructions of colorings showing that the length of a longest monochromatic cycle is asymptotically tight and the condition a1≥（δa2） /（3δ-2） cannot be removed.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Strong metal-support interaction between AuPd nanoparticles and oxygen-rich defect ZrO_(2) for enhanced catalytic 5-hydroxymethylfurfural oxidation

引用

Chinese Chemical Letters 2024年第2期35卷 507-511页

作者： Yunlei Zhang yiran Liu Wen Guan Mengxue Cao Yao Chen Pengwei Huo Institute of Green Chemistry and Chemical Technology School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China School of the Environment and Safety Jiangsu UniversityZhenjiang 212013China

The unique properties of metal oxide surfaces,crystal surfaces and defects play vital roles in biomass upgrading *** this work,hierarchical porous bowl-shaped ZrO_(2)(HB-ZrO_(2))with mixed crystal phase was designed and employed as the support for loading AuPd bimetal with different proportions to synthesize AuPd/HB-ZrO_(2) *** effects of surface chemistry,oxygen defects,bimetal interaction and metal-support interaction of AuPd/HB-ZrO_(2) on catalytic performance for the selective oxidation of 5-hydroxymethylfurfural(HMF)to 2,5-furandicarboxylic acid(FDCA)were systematically *** Au 2 Pd1/HB-ZrO_(2) catalyst afforded a satisfactory FDCA yield of 99.9%from HMF oxidation using O_(2) as the oxidant in water,accompanied with an excellent FDCA productivity at 97.6 mmol g^(−1) h^(−1).This work offers fresh insights into rationally designing efficient catalysts with oxygen-rich defects for the catalytic upgrading of biomass platform chemicals.

关键词： 5-Hydroxymethylfurfural oxidation 2,5-Furandicarboxylic acid Oxygen-rich defect ZrO_(2) AuPd bimetal Bowl-shaped structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Using Longitudinal Fins to Improve the Melting Performance of Stearic Acid in Thermal Energy Storage Devices

引用

Journal of Thermal Science 2024年第5期33卷 1672-1687页

作者： YAN Suying LIU yiran AO Ci ZHAO Xiaoyan ZHANG Na ZHANG Ruiying AHMADI Mohammad Hossein School of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot 010051China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China School of Materials Science and Engineering Inner Mongolia University of TechnologyHohhot 010051China Faculty of Mechanical Engineering Shahrood University of TechnologyShahroodIran

The heat transfer efficiency of a thermal energy storage unit(TESU)can be improved by the addition of novel longitudinal fins.A series of TESUs are analyzed using the finite volume method(FVM)to determine the effect of fin angle on the heat transfer *** the fin angle increases,the TES rate first increases,then decreases,reaching a maximum rate at 60°,where the melting time is less by 30.9%,28.58%,21.99%,9.02%,and 18.1%than at 0°,15°,30°,45°,and 80°,*** addition,it is found that the melting time of the phase change material is significantly greater at the bottom of the *** time percentage of this stage decreases as the fin angle increases through these percentages by 7%,14%,23%,33%,and 20%,***,the response surface methodology(RSM)is applied to optimize the longitudinal fin by minimizing the total melting *** analysis concludes that a fin angle of 58.68°reduces the complete melting time of the stearic acid by 44%below the time at 0°.These findings fill a gap in knowledge of the effect on melting performance of the design angle of longitudinal fins and provide a reference for the design of horizontally placed longitudinal finned thermal energy storage units.

关键词： thermal energy storage melting rate enhancement longitudinal fins fin angle phase change materials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A wave-shaped electrode flexible sensor capable of sensitively responding to wrinkle excitation for a multifunctional human-computer interaction system

引用

Nano Research 2024年第5期17卷 4454-4461页

作者： Yongyang Chen Zhiyi Wu Chengcheng Han Zhi Cao yiran Hu Ping Zhao Yuanyu Wang College of Materials and Metallurgy Guizhou UniversityGuizhou 550025China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China Geological Brigade 105 Bureau of Geology and Mineral Exploration and Development of Guizhou ProvinceGuiyang 550018China

Human-machine interactions(HMIs)have advanced rapidly in recent decades in the fields of healthcare,work,and ***,people with disabilities and other mobility problems do not have corresponding high-tech aids for them to enjoy the convenience of *** this paper,we propose a sensor with a wave-shaped(corrugated)electrode embedded in a friction layer,which exhibits high sensitivity to skin fold excitation and enormous potential in *** to the wave-shaped electrode design,it has no built-in cavities,and its small size allows it to flexibly cope with folds at different *** specifying the carbon nanotube hybrid silicone film as the electrode layer material and silicone film as the friction layer,good electrical output performance,tensile properties,and biocompatibility can be ***,the sensor is tested on various joints and skin folds of the human body,the output signals of which can be distinguished between normal physiological behavior and test *** on this sensor,we designed a medical alarm system,a robotic arm assistive system,and a cell phone application control system for the disabled to help them in the fields of healthcare,work,and *** conclusion,our research presents a feasible technology to enhance HMIs and makes a valuable contribution to the development of high-tech aids for the disabled.

关键词： flexible sensors multifunctionality wrinkle excitation triboelectric nanogenerator human-machine interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dendrimer-induced synthesis of porous organosilica capsules for enzyme encapsulation

引用

Frontiers of Chemical Science and Engineering 2024年第4期18卷 41-48页

作者： Ziyi Chu Boyu Zhang Zhenhua Wu Jiaxu Zhang yiran Cheng Xueying Wang Jiafu Shi Zhongyi Jiang School of Environmental Science&Engineering Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Organic matter-induced mineralization is a green and versatile method for synthesizing hybrid nanostructured materials,where the material properties are mainly influenced by the species of natural biomolecules,linear synthetic polymer,or small molecules,limiting their ***,we adopted dendrimer poly(amidoamine)(PAMAM)as the inducer to synthesize organosilica-PAMAM network(OSPN)capsules for mannose isomerase(MIase)encapsulation based on a hard-templating *** structure of OSPN capsules can be precisely regulated by adjusting the molecular weight and concentration of PAMAM,thereby demonstrating a substantial impact on the kinetic behavior of the MIase@OSPN *** MIase@OSPN system was used for catalytic production of mannose from Dfructose.A mannose yield of 22.24% was obtained,which is higher than that of MIase in organosilica network capsules and similar to that of the free *** overall catalytic efficiency(kcat/Km)of the MIase@OSPN system for the substrate D-fructose was up to 0.556 s^(-1)·mmol^(-1)·***,the MIase@OSPN system showed excellent stability and recyclability,maintaining more than 50% of the yield even after 12 cycles.

关键词： enzyme immobilization enzyme catalysis organosilica networks capsules sugar biosynthesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemotherapy induces breast cancer stem cell enrichment through repression of glutathione S-transferase Mu

引用

Genes & Diseases 2024年第2期11卷 528-531页

作者： Jing He yiran Yu Yilin He Jie He Guangyu Ji Haiquan Lu The Second Hospital and Advanced Medical Research Institute Cheeloo College of MedicineShandong UniversityJinanShandong 250012China Department of Nursing The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250014China School of Medicine Xinjiang Medical UniversityUrumqiXinjiang 830054China School of Medicine Binzhou Medical UniversityYantaiShandong 264003China Oncology Department Jinan Zhangqiu District People's HospitalJinanShandong 250200China Key Laboratory for Experimental Teratology of the Ministry of Education Cheeloo College of MedicineShandong UniversityJinanShandong 250012China Center for Reproductive Medicine Shandong UniversityJinanShandong 250012China

Triple-negative breast cancer(TNBC)has aggressive characteristics as exemplified by the high risk of recurrence,metastasis,and patient mortality.1 Cytotoxic chemotherapy may reduce tumor burden initially,but leave behind chemo-resistant breast cancer stem cells(BCSCs)that lead to tumor recurrence and metastasis.2 Chemotherapy induces BCsC enrichment through the activation of glutathione biosynthesis pathways,which increases intracellular glutathione levels and specifies the BCSC phenotype through complicated downstream signaling pathways.3 Glutathione S-transferases(GSTs),a superfamily(which contains seven cytosolic classes:Alpha,Kappa,Mu,Omega,Pi,Theta,and Zeta,and one microsomal class MGSTs)of phase Il enzymes that catalyze the conjugation of glutathione with electrophilic compounds,play a critical role in detoxification and chemotherapy resistance of cancer ***,the role of GSTs in the regulation of BCSCs is largely elusive.

关键词： chemotherapy breast metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermofluidic investigations of oil natural transformer:Closed-loop modelling and experimental validation

引用

High Voltage 2024年第1期9卷 230-240页

作者： Yuan Li yiran Gao Chen Wang Chao Zhu Ying Li Yuankai Wang Guanjun Zhang State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anChina Electric Power Research Institute of State Grid Shaanxi Electric Power Co. Ltd.Xi'anChina TBEA Hengyang Transformer Co. Ltd.HengyangChina

Excessively high temperatures inside a power transformer can accelerate the ageing rate and even cause unplanned *** estimating the hot-spot temperature(HST)of a power transformer is important for regulating the load and ensuring long-term *** this study,a closed-loop model of a 110-kV product transformer with an oil natural/air forced(ONAF)cooling mode is built to predict HST,in which the compression ratio of windings,equivalent heat source and radiator geometry are *** to the flow field of the winding,the‘dead oil zone’and reverse oil flow are observed in the horizontal oil *** accuracy of the proposed model is experimentally validated by temperature-rise *** results show that the absolute errors between the measured results and simulation are below 5°C,and the average error is~2°***,the arrangements of windings and radiators are studied to enhance the oil *** adding 5 washers to the high-voltage winding,the average temperature can be decreased by 6°C compared with the case without a *** the radiator can also mitigate the characteristic temperatures,and the optimal height difference between the radiator and winding centre is suggested to be 0.66 m.

关键词： winding arrangement adding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mg-Al-hydrotalcite with alkaline sites protects Ni/KIT-6 from formation of amorphous coke in glycerol steam reforming via tailoring reaction intermediates

引用

Frontiers of Chemical Science and Engineering 2024年第4期18卷 25-39页

作者： Yunyu Guo yiran Wang Yuewen Shao Shu Zhang Yi Wang Song Hu Jun Xiang Xun Hu School of Material Science and Engineering University of JinanJinan 250022China Joint International Research Laboratory of Biomass Energy and Materials College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China State Key Laboratory of Coal Combustion Huazhong University of Science and TechnologyWuhan 430074China

During steam reforming,the performance of a catalyst and amount/property of coke are closely related to reaction intermediates reaching surface of a ***,modification of reaction intermediates by placing Mg-Al-hydrotalcite above Ni/KIT-6 catalyst in steam reforming of glycerol was conducted at 300 to 600°*** results revealed that the catalytic activity of Ni/KIT-6 in the lower bed was enhanced with either Mg1-Al5-hydrotalcite(containing more acidic sites)or Mg5-Al1-hydrotalcite(containing more alkaline sites)as upper-layer *** in situ infrared characterization of steam reforming demonstrated that Mg-Al-hydrotalcite catalyzed the deoxygenation of glycerol,facilitating the reforming of the partially deoxygenated intermediates over Ni/***-Al-hydrotalcite as protective catalyst,however,did not protect the Ni/KIT-6 from formation of more ***,this did not lead to further deactivation of Ni/KIT-6 while Mg5-Al1-hydrotalcite even substantially enhanced the catalytic stability,even though the coke was much more significant than that in the use of single Ni/KIT-6(52.7%vs.28.6%).The reason beneath this was change of the property of coke from more aliphatic to more ***5-Al1-hydrotalcite catalyzed dehydration of glycerol,producing dominantly reaction intermediates bearing C=C,which formed the catalytic coke of with carbon nanotube as the main form with smooth outer walls as well as higher aromaticity,C/H ratio,crystallinity,crystal carbon size,thermal stability,and resistivity toward oxidation on Ni/KIT-6 in the lower *** comparison,the abundance of acidic sites on Mg1-Al5-hydrotalcite catalyzed the formation of more oxygen-containing species,leading to the formation of carbon nanotubes of rough surface on Ni/KIT-6.

关键词： steam reforming of glycerol Mg-Alhydrotalcite sacrificial catalyst reaction intermediates property of coke

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Steam reforming of acetic acid over Ni/biochar of low metal-loading:Involvement of biochar in tailoring reaction intermediates renders superior catalytic performance

引用

Chinese Journal of Chemical Engineering 2024年第4期68卷 241-252页

作者： Yunyu Guo yiran Wang Shu Zhang Yi Wang Song Hu Jun Xiang Walid Nabgan Xun Hu School of Material Science and Engineering University of JinanJinan 250022China Joint International Research Laboratory of Biomass Energy and Materials College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China State Key Laboratory of Coal Combustion Huazhong University of Science and TechnologyWuhan 430074China Departament d'Enginyeria Química Universitat Rovira i VirgiliTarragona 43007Spain

Biochar is a reactive carrier as it may be partially gasified with steam in steam reforming,which could influence the formation of reaction intermediates and modify catalytic ***,the Ni/biochar as well as two comparative catalysts,Ni/Al_(2)O_(3) and Ni/siO_(2),with low nickel loading(2%(mass))was conducted to probe involvement of the varied carriers in the steam *** results indicated that the Ni/biochar performed excellent catalytic activity than Ni/siO_(2) and Ni/Al_(2)O_(3),as the biochar carrier facilitated quick conversion of the -OH from dissociation of steam to gasify the oxygen-rich carbonaceous intermediates like C=O and C-O-C,resulting in low coverage while high exposure of nickel species for maintaining the superior catalytic *** converse,strong adsorption of aliphatic intermediates over Ni/Al_(2)O_(3) and Ni/siO_(2) induced serious coking with polymeric coke as the main type(21.5%and 32.1%,respectively),which was significantly higher than that over Ni/biochar(3.9%).The coke over Ni/biochar was mainly aromatic or catalytic type with nanotube morphology and high *** high resistivity of Ni/biochar towards coking was due to the balance between formation of coke and gasification of coke and partially biochar with steam,which created developed mesopores in spent Ni/biochar while the coke blocked pores in Ni/Al_(2)O_(3) and Ni/siO_(2) catalysts.

关键词： Steam reforming Acetic acid Ni/biochar catalyst Property of coke Reaction intermediates

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：