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Journal of Energy Chemistry 2024年第10期97卷 371-378页

作者： Juntao si Xiaoying Li Yixuan Li Kuo Cao yiran Zhu Chunhua Chen CAS Key Laboratory of Precision and Intelligent Chemistry Department of Materials Science and Engineering University of Science and Technology of China

The lithium metal anode is hailed as the desired "holy grail" for the forthcoming generation of highenergy-density batteries,given its astounding theoretical capacity and low ***,the formation and growth of dendrites seriously compromise battery life and ***,an yttriastabilized bismuth oxide（YSB） layer is fabricated on the polypropylene（PP） separator,where YSB reacts with Li anode in-situ in the cell to form a multi-component composite interlayer consisting of Li3Bi,Li2O,and *** interlayer can function not only as a redistributor to regulate Li+distribution but also as an anion adsorber to increase the Li+transference number from 0.37 to 0.79 for suppressing dendrite nucleation and ***,compared with the cell with a baseline separator,those with modified separators exhibit prolonged lifespan in both Li/Li symmetrical cells and Li/Cu ***,the full cells coupled with ultrahigh-loading LiFePO4display an excellent cycling performance of 1700 cycles with a high capacity retention of ～80% at 1 C,exhibiting great potential for practical *** work provides a feasible and effective new strategy for separator modification towards building a much-anticipated dendrite-free Li anode and realizing long-lifespan lithium metal batteries.

关键词： Conversion-alloying reaction Dendrite-free Lithium metal battery Multifunctional interlayer Separator

Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer

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Cancer Biology & Medicine 2023年第2期20卷 155-168页

作者： Yimeng Chen Xue Wang Feng Du Jian Yue yiran si Xiaochen Zhao Lina Cui Bei Zhang Ting Bei Binghe Xu Peng Yuan Department of Medical Oncology and Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China The Medical Department 3D Medicines Inc.Shanghai 201114China

Objective:The choice of chemotherapeutic regimen for triple-negative breast cancer(TNBC)remains *** recombination deficiency(HRD)has attracted increasing attention in informing chemotherapy *** study was aimed at investigating the feasibility of HRD as a clinically actionable biomarker for platinum-containing and platinum-free ***:Chinese patients with TNBC who received chemotherapy between May 1,2008 and March 31,2020 were retrospectively analyzed with a customized 3D-HRD *** positivity was defined by an HRD score≥30 or deleterious BRCA1/2 mutation.A total of 386 chemotherapy-treated patients with TNBC were screened from a surgical cohort(NCT01150513)and a metastatic cohort,and 189 patients with available clinical and tumor sequencing data were ***:In the entire cohort,49.2%(93/189)of patients were identified as HRD positive(40 with deleterious BRCA1/2 mutations and 53 with BRCA1/2 intact with an HRD score of≥30).In the first-line metastatic setting,platinum therapy was associated with longer median progression-free survival(mPFS)than platinum-free therapy[9.1 vs.3.0 months;hazard ratio(HR),0.43;95%confidence interval 0.22–0.84;P=0.01].Among HRD-positive patients,the mPFS was significantly longer in those treated with platinum rather than platinum-free therapy(13.6 vs.2.0 months;HR,0.11;P=0.001).Among patients administered a platinum-free regimen,HRD-negative patients showed a PFS significantly superior to that of HRD-positive patients(P=0.02;treatment-biomarker P-interaction=0.001).similar results were observed in the BRCA1/2-intact *** the adjuvant setting,HRD-positive patients tended to benefit more from platinum chemotherapy than from platinum-free chemotherapy(P=0.05,P-interaction=0.02).Conclusions:HRD characterization may guide decision-making regarding the use of platinum treatment in patients with TNBC in both adjuvant and metastatic settings.

关键词： Homologous recombination deficiency triple-negative breast cancer platinum survival BRCA

Bioinformatics analysis of human kallikrein 5 (KLK5) expression in metaplastic triple‐negative breast cancer

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Cancer Innovation 2023年第5期2卷 376-390页

作者： Yue Song Guiying Bai Xiaoqing Li Liyan Zhou yiran si Xiaohui Liu Yilin Deng Yehui Shi Department of Phase I Clinical Trial Tianjin Medical University Cancer Institute and HospitalTianjinChina Medical Oncology Department of Breast Cancer Tianjin Medical University Cancer Institute and HospitalTianjinChina National Clinical Research Center for Cancer TianjinChina

Background:Metaplastic breast carcinoma(MBC)is a rare breast cancer subtype;most cases are triple‐negative breast cancers(TNBCs)and are poorly responsive to conventional systemic *** potential diagnostic and prognostic markers for distinguishing between metaplastic TNBC and nonmetaplastic TNBC have been *** performed bioinformatic analysis to explore the underlying mechanism by which metaplastic TNBC differs from nonmetaplastic TNBC and provides potential pathogenic genes of metaplastic ***:Differentially expressed genes(DEGs)in metaplastic tumors and nonmetaplastic tumors from TNBC patients were screened using *** GSE76275 data set and The Cancer Genome Atlas(TCGA)database were used to screen DEGs in TNBC and non‐*** and DAVID were used for the Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and Gene Ontology(GO)analysis of *** databases,including UALCAN,GEPIA,HPA,Breast Cancer Gene‐Expression Miner,and quantitative PCR and western blot,were used to examine KLK5 messenger RNA and protein expression in breast *** of KLK5‑associated genes was performed with TCGA data,and the LinkedOmics database was used to detect the genes co‐expressed with ***(Search Tool for the Retrieval of Interacting Genes)and Cytoscape were used to screen for hub ***‑Meier plotter was used for survival ***:KLK5 was identified among the DEGs in nonmetaplastic TNBC and metaplastic *** KLK5 gene was overexpressed in nonmetaplastic TNBC but downregulated in metaplastic *** and GO analyses revealed that epithelial‐to‐mesenchymal transition was a pathogenic mechanism in metaplastic TNBC and an important pathway by which KLK5 and its associated genes DSG1and DSG3 influence metaplastic TNBC progression. Prognosis analysis showedthat only low expression of KLK5 in metaplastic TNBC had clinical ***: Our research indicated that KLK5 may be a pivotal moleculewit

关键词： bioinformatics analysis differentially expressed genes EMT KLK5 metaplastic breast carcinoma

Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer

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Cancer Biology & Medicine 2021年第3期18卷 849-859页

作者： Nanlin Hu yiran si Jian Yue Tingting Sun Xue Wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao Jiayu Wang Yang Luo Fei Ma Binghe Xu Peng Yuan Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Nanjing Geneseeq Technology Inc. Nanjing 210032China Cancer Hospital of Huanxing Chaoyang District Beijing Beijing 100021China

Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking *** study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast ***:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were *** was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity ***,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment *** primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and ***:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)*** median follow-up time was 10.5 *** ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 *** changes in the detectable ct DNA variant allele frequency were consistent with the tumor *** most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast *** dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response.

关键词： Anlotinib angiogenesis HER2-negative breast cancer ct DNA

Regional climate response to global warming in the source region of the Yellow River and its impact on runoff

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Science China Earth Sciences 2024年第3期67卷 843-855页

作者： yiran ZHANG Degang ZHOU Xiaofeng GUO Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

The source region of the Yellow River has experienced obvious climate and discharge changes in recent decades due to global warming, which largely affects the water resources and ecological and environmental security in the Yellow River basin. This study analyzed the changes in runoff and several climate factors in the source region of the Yellow River based on the observed discharges at the Tangnag hydrological station, routine meteorological data from China Meteorological Administration(CMA) stations within and near this source region, and several evaporation datasets. The results indicate that the runoff in the source region was relatively abundant from 1960 to 1989 and then declined sharply afterward. It recovered slightly after 2005 but was still below normal—10% less than that during 1960–1989. similarly, the precipitation amounts in the source region were relatively low in the 1990s, but they increased significantly after 2003, with an average increase of 31.4 mm or 6% more when compared to that in 1960–1989. In addition, the temperatures in the source region continued to rise from 1960 to 2017, and the evaporation levels also showed an upward trend after 1990. The influences of the spatial and temporal variations in climatic factors on runoff in the source region were then further analyzed. The results indicate that the decreases in precipitation and the number of days of heavy rainfall in the source region from 1990 to 2002 were important reasons for the lower runoff during this period. After 2003, the precipitation in the southeastern part of the source region, which is a key area for runoff generation,increased only to a limited extent, but the evaporation in the entire source region generally increased with increasing temperature,which might have led to the low capacity for actual runoff production in each subbasin and persistent low runoff in the source region. Therefore, such a climate response to global warming in the source region might be unfavorabl

关键词： The source region of the Yellow River Climate response Runoff variation Evaporation Precipitation

Investigation on the Velocity-Dependent Adhesion Hysteresis via Molecular Dynamics simulation

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Acta Mechanica Solida sinica 2024年第3期37卷 423-429页

作者： Jinshan He yiran Li Zhaoyang Ma Ganyun Huang Department of Mechanics School of Mechanical EngineeringTianjin UniversityTianjin300350China

Adhesion plays an important role in miniaturized devices and technologies,which depends not only on indentation depth but also on the history of contact making and breaking,giving rise to adhesion *** the present work,adhesion hysteresis has been investigated via molecular dynamics simulations on approaching and retracting a rigid tip to and from a *** results show that hysteresis in the force-displacement curve that depends on approaching and retraction velocities arises under both elastic and plastic *** underlying mechanisms have been *** implications of the results in friction have been discussed briefly.

关键词： Adhesion hysteresis Molecular dynamics simulation Contact instability Plastic deformation

A robust vector tracking loop structure based on potential bias analysis

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Chinese Journal of Aeronautics 2024年第4期37卷 405-420页

作者： Qiongqiong JIA yiran LUO Bing XU Li-Ta HSU Renbiao WU Tianjin Key Lab for Advanced signal Processing Civil Aviation University of ChinaTianjin 300300China Interdisciplinary Division of Aeronautical and Aviation Engineering The Hong Kong Polytechnic University999077Hong KongChina Department of Geomatics Engineering University of CalgaryCalgary T2N1N4Canada

This paper proposes a robust vector tracking loop structure based on potential bias analysis. The influence of four kinds of biases on the existing two implementations of Vector Tracking Loops(VTLs) is illustrated by theoretical analysis and numerical simulations, and the following findings are obtained. Firstly, the initial user state bias leads to steady navigation solution bias in the relative VTL, while new measurements can eliminate it in the absolute VTL. Secondly, the initial code phase bias is transferred to the following navigation solutions in the relative VTL, while new measurements can eliminate it in the absolute VTL. Thirdly, the user state bias induced by erroneous navigation solution of VTLs can be eliminated by both of the two VTLs. Fourthly,the multipath/NLOS likely affects the two VTLs, and the induced tracking bias in the duration of the multipath/NLOS would decrease the performance of VTLs. Based on the above analysis,a robust VTL structure is proposed, where the absolute VTL is selected for its robustness to the two kinds of initialization biases;meanwhile, the instant bias detection and correction method is used to improve the performance of VTLs in the duration of the multipath/NLOS. Numerical simulations and experimental results verify the effectiveness of the proposed robust VTL structure.

关键词： Global Navigation Satellite System(GNSS) Vector Tracking Loop(VTL) Multipath Non-Line-of-sight(NLOS) Tracking bias propagation Least Absolute Shrinkage and Selection Operator(LASSO)

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糖尿病与结直肠癌患者预后相关的研究进展

肿瘤 2017年第4期37卷 427-432页

作者：司怡然邓婷巴一天津医科大学肿瘤医院国家肿瘤临床医学研究中心天津市"肿瘤防治"重点实验室天津市恶性肿瘤临床医学研究中心天津300060

近来研究发现,糖尿病与结直肠癌的发生具有密切相关性,即糖尿病是结直肠癌发生的独立危险因素。为了延长结直肠癌合并糖尿病患者的生存时间,提高患者的生存质量,近年来大量研究探讨了糖尿病对结直肠癌患者预后的影响。其中,一些研究结... 详细信息

近来研究发现,糖尿病与结直肠癌的发生具有密切相关性,即糖尿病是结直肠癌发生的独立危险因素。为了延长结直肠癌合并糖尿病患者的生存时间,提高患者的生存质量,近年来大量研究探讨了糖尿病对结直肠癌患者预后的影响。其中,一些研究结果证实,糖尿病与结直肠癌的预后具有相关性;而另一些研究则认为,糖尿病与结直肠癌的预后无关。因此,到目前为止,糖尿病是否对结直肠癌预后产生影响尚不明确,该问题已成为近年来肿瘤研究的热点之一。本文即对糖尿病与结直肠癌患者预后相关性的研究进展进行综述。

关键词：结直肠肿瘤糖尿病预后

Permeable and robust polymer-silica hybrid armor on cell catalyst for sustainable biomanufacturing

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颗粒学报（英文版） 2024年第9期92卷 106-112页

作者： yiran Cheng Zhenhua Wu Boyu Zhang Jiaxu Zhang Jiafu Shi Zhongyi Jiang School of Environmental Science and Engineering Tianjin UniversityTianjin300072China School of Environmental Science and Engineering Tianjin UniversityTianjin300072China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China

Inactivated cell catalysis is one of several central techniques in green biomanufacturing ***,the instability and leakage of enzymes in inactivated cell severely restrict the practical applications of inactivated cell *** armor on the surface of inactivated cells affords a feasible and effective strategy to enhance the stability of cells while commonly lowering the ***,polymer-silica hybrid armor(PSHA)is directly generated on the surface of enzyme-containing *** branched structure of PEI enables higher porosity of cell@PSHA,exhibiting 1.52-fold enhancement in substrate permeability by contrast with cell@silica armor(SA).The electrostatic interactions(NH3+with O-)and hydrogen bonding(N…H or O…H)interactions between structural units enables higher stability of cell@PSHA,showing 3.13-fold elevation in Young's modulus compared with cell@*** a result,the cell@PSHA can catalyze continuous conversion of starch to tagatose for 15 batches over 969 h,with an average yield of 77.76 g L-1.

关键词： Biomanufacturing Polymer-silica hybrid armor Starch conversion Tagatose production Whole cell catalysis

Topological Structure-Modulated Collagen Carbon as Two-in-One Energy Storage Configuration toward Ultrahigh Power and Energy Density

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Energy & Environmental Materials 2024年第2期7卷 22-33页

作者： Li Yuan Wenlong Cai Yunhong Wei yiran Pu Can Liu Yun Zhang Hao Wu College of Materials Science and Engineering Sichuan University Department of Applied Chemistry University of Science and Technology of China

Efficient energy storage devices with suitable electrode materials,that integrate high power and high energy,are the crucial requisites of the renewable power source,which have unwrapped new possibilities in the sustainable development of energy and the ***,a facile collagen microstructure modulation strategy is proposed to construct a nitrogen/oxygen dual-doped hierarchically porous carbon fiber with ultrahigh specific surface area(2788 m2g-1) and large pore volume(4.56 cm3g-1) via local microfibrous breakage/disassembly of natural structured *** operando spectroscopy and density functional theory unveil that the dual-heteroatom doping could effectively regulate the electronic structure of carbon atom framework with enhanced electric conductivity and electronegativity as well as decreased diffusion resistance in favor of rapid pseudocapacitive-dominated Li+-storage(353 mAh g-1at 10 A g-1).Theoretical calculations reveal that the tailored micro-/mesoporous structures favor the rapid charge transfer and ion storage,synergistically realizing high capacity and superior rate performance for NPCF-H cathode(75.0 mAh g-1at 30 A g-1).The assembled device with NPCF-H as both anode and cathode achieves extremely high energy density(200 Wh kg-1)with maximum power density(42 600 W kg-1) and ultralong lifespan（80%capacity retention over 10 000 cycles）.

关键词： collagen carbon energy storage device theoretical calculations topological structure modulation ultrahigh power and energy density