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Chronic consumption of thermally processed palm oil or canola oil modified gut microflora of rats

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Food Science and Human Wellness 2021年第1期10卷 94-102页

作者： Mengcheng Ruan yiran bu Fangjie Wu Shijie Zhang Rulong Chen Na Li Zhiguo Liu Hualin Wan School of Biology and Pharmaceutical Engineering Wuhan Polytechnic UniversityWuhanHubei430023China Hubei Provincial Key Laboratory for Applied Toxicology Hubei Provincial Academy of Preventive MedicineWuhan 430079China Hubei Research Centre for Laboratory Animal Wuhan 430079China

Dietary oils have critical influences on human health,and thermally cooking or frying modify the components and nutritional functions of *** oil was the most widely used oil in food processing industry,but its health effects remain *** the current study,we aimed to compare the effects of thermally oxidized palm oil and canola oil on gut *** oil or canola oil were heated at 180°C for 10 h to prepare high-fat *** were fed high-fat diets for 3 months,and hematological properties,gut microflora composition and intestinal gene expression were *** results indicated that heated canola oil consumption elevated plasma total cholesterol and LDL-c levels compared with unheated canola oil,but heated palm oil do not had these effects;and consumption of heated palm oil significantly elevated the relative abundance of Lactobacillucs and Roseburia in gut,compared with non-heated palm oil or two canola oil ***,intestinal expression of IL-22 was increased in heated palm oil fed animal,though ZO-1 and GPR41 were *** conclusion,heating process may enhance the effects of palm oil on proliferation of probiotics Lactobacillucs,and weaken the effects of canola oil on cholesterol transport and metabolism.

关键词： Palm oil Canola oil Gut microbiota Short-chain fatty acids Thermally oxidized oils

Recent advances of metal vacancies in energy and environmental catalysis:Synthesis,characterization,and roles

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Green Energy & Environment 2025年第1期10卷 84-108页

作者： Long Sun Shunzheng Zhao Sirui Gao Ronghui Zhu yiran Tan Xiaolong Tang Honghong Yi School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants Beijing100083China

With the ongoing depletion of fossil fuels,energy and environmental issues have become increasingly critical,necessitating the search for effective ***,being one of the hallmarks of modern industry,offers a promising avenue for ***,the question of how to significantly enhance the performance of catalysts has gradually drawn the attention of *** engineering,a commonly employed and effective approach to improve catalyst activity,has become a significant research focus in the catalysis field in recent *** vacancies have received extensive attention due to their simple ***,exploration of metal vacancies has remained stagnant for a considerable period,resulting in a scarcity of comprehensive reviews on this ***,based on the latest research findings,this paper summarizes and consolidates the construction strategies for metal vacancies,characterization techniques,and their roles in typical energy and environmental catalytic ***,it outlines potential challenges in the future,aiming to provide valuable references for researchers interested in investigating metal vacancies.

关键词： Metal vacancies Catalysis Construction strategies Characterization techniques Roles

AQDS Enhances Degradation of BDE-47 by Promoting Shewanella oneidensis MR-1-mediated Fenton Reaction with Fe(III)-containing Minerals

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Journal of Earth Science 2025年

作者： Yongguang Jiang Siqi Zhu Zhou Jiang yiran Dong Liang Shi School of Environmental Studies， China University of Geosciences State Key Laboratory of Biogeology and Environmental Geology， China University of Geosciences Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science， China University of Geosciences State Environmental Protection Key Laboratory of Source Apportionment and Control of Aquatic Pollution， Ministry of Ecology and Environment， China University of Geosciences(Wuhan)

Electron shuttles are widespread in the environments and play important role in microbe-mineral interaction. This study investigated the effects of a model electron shuttle (i.e.， anthraquinone-2， 6-disulfonate， AQDS) on Shewanella oneidensis MR-1-mediated Fenton reaction and subsequent degradation of 2， 2′， 4， 4′-tetrabrominated diphenyl ether (BDE-47). Three Fe(III)-containing minerals， namely， ferrihydrite， goethite and nontronite， were used as electron acceptors and Fe(II) sources. With each mineral， additions of 0.01 – 1 mM AQDS in the reactions significantly enhanced Fe(III) reduction by S. oneidensis MR-1 and increased the amounts of Fe(II) produced in anoxic phase. As a result， the amounts of cumulative ·OH formed in oxic phase were increased by 10% – 287%. Regression analysis revealed that ·OH cumulation has significant linear correlation with sorbed Fe(II) but not aqueous and structural Fe(II). This finding may be ascribed to the higher reactivity of sorbed Fe(II) in oxygenation than the latter two types of Fe(II). With more ·OH， the degradation efficiency of BDE-47 was elevated by 31% – 173%. Collectively， AQDS enhances ·OH formation and BDE-47 degradation by promoting production of Fe(II)， particularly sorbed Fe(II) in S. oneidensis MR-1-mediated Fenton reaction with Fe(III)-containing minerals.

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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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虾青素对肝脂代谢与昼夜节律的调节作用

食品科学 2019年第3期40卷 165-172页

作者：左正宇邵洋刘杨卜怡然王华林李娜刘志国武汉轻工大学生物与制药工程学院湖北武汉430023

研究虾青素对非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的干预作用及与代谢相关的昼夜节律紊乱的缓解作用。采用高脂/高胆固醇饲喂建立NAFLD小鼠模型和添加虾青素的干预模型。动物实验选用SPF级C57BL/6小鼠,随机分... 详细信息

研究虾青素对非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的干预作用及与代谢相关的昼夜节律紊乱的缓解作用。采用高脂/高胆固醇饲喂建立NAFLD小鼠模型和添加虾青素的干预模型。动物实验选用SPF级C57BL/6小鼠,随机分成正常组、高脂模型组和高脂添加虾青素组。采用常规酶联免疫吸附测定法测定血清中甘油三酯、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)浓度及谷丙转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(aspartate transaminase,AST)活力等肝损伤指标,苏木精-伊红染色法观察肝组织形态学变化,荧光定量聚合酶链式反应(real-time quantitative polymerase chain reaction,qPCR)检测与肝脂代谢、胆固醇代谢、昼夜节律相关的基因表达及昼夜节律变化。结果显示:与正常组相比,高脂模型组小鼠体质量、肝脏指数、肥胖指数均高度显著增加(P<0.001),虾青素干预后肝脏指数、肥胖指数均极显著降低(P<0.01)。高脂饲喂导致小鼠血脂水平升高(HDL-C除外),尤其是LDL-C浓度升高明显,而虾青素干预可以有效降低TC和LDL-C浓度,并升高HDL-C浓度,改善脂质的代谢。高脂/高胆固醇饲喂会高度显著升高小鼠血清ALT、AST活力(P<0.001),造成肝损伤。与高脂模型组相比,虾青素干预可极显著降低小鼠ALT、AST活力(P<0.01),缓解肝脏损伤,并明显改善肝脏脂质代谢关键酶的基因表达,包括脂肪酸合成酶和胆固醇合成关键酶羟甲基戊二酸单酰辅酶A还原酶。同时,虾青素干预也增加了胆固醇7α-羟化酶的表达量,促进胆固醇氧化。虾青素调节上述基因的表达具有昼夜节律性,能够缓解或修正由高脂导致的生物钟节律相关因子时钟昼夜节律调节器及脑和肌肉芳香烃受体核转运体样蛋白1以及肝脏脂质代谢关键基因昼夜节律表达的紊乱。本研究表明虾青素具有改善高脂所致肝代谢紊乱的节律性调节作用。

关键词：虾青素非酒精性脂肪性肝病昼夜节律

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业务层智能管道的研究与实施

邮电设计技术 2013年第10期 5-9页

作者：梁鹏卜毅然蓝宇娜中国联合网络通信集团有限公司北京100140 北京中网华通设计咨询有限公司北京100070

分析了现网流量运营业务中建设智能管道的必要性;阐述了智能管道的定义和优先建设业务层智能管道的理由;提出了业务层智能管道的整体架构,并对该架构中的各个元素的要求进行了描述;对业务层智能管道的业务场景进行了预期。

关键词：移动互联网智能管道流量运营

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移动互联网用户标识管理技术的研究

邮电设计技术 2011年第12期 30-33页

作者：朱振祺卜毅然朱旭明中国联通广州分公司广东广州510655 北京中网华通设计咨询有限公司北京100070 中国联通广东分公司广东广州510627

详细分析了公网上的内容提供商因无法获得移动用户身份信息而导致的难以对其实现计费和应用管理的主要原因,提出了移动互联网用户标识管理技术研究背景及原理;详细论述了在运营商移动互联网结构中增加I-UIM系统解决方案及新移动互联网... 详细信息

详细分析了公网上的内容提供商因无法获得移动用户身份信息而导致的难以对其实现计费和应用管理的主要原因,提出了移动互联网用户标识管理技术研究背景及原理;详细论述了在运营商移动互联网结构中增加I-UIM系统解决方案及新移动互联网业务网络的结构和功能。

关键词：移动互联网用户标识管理 IP地址溯源

Microscopic and spectroscopic analysis of atmospheric iron-containing single particles in Lhasa,Tibet

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Journal of Environmental Sciences 2024年第7期141卷 40-50页

作者： Junyu Chen Daobin Zhang yiran Fu Jinhu Wang Xiaomei Cui Ci-ren Qu-zong Qiangying Zhang Chan Jin bu Duo School of Ecology and Environment Tibet UniversityLhasa 850000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China

The Tibetan Plateau,known as the“Third Pole”,is currently in a state of perturbation caused by intensified human *** this study,56 samples were obtained at the five sampling sites in typical area of Lhasa city and their physical and chemical properties were investigated by TEM/EDS,STXM,and NEXAFS *** careful examination of 3387single particles,the results showed that Fe should be one of the most frequent metal *** Fe-containing single particles in irregular shape and micrometer size was about7.8%and might be mainly from local ***,the Fe was located on the subsurface of single particles and might be existed in the form of iron ***,the core-shell structure of iron-containing particles were about 38.8%and might be present as single-,dual-or triple-core shell structure and multi-core shell structure with the Fe/Si ratios of 17.5,10.5,2.9 and 1.2,***,iron and manganese were found to coexist with identical distributions in the single particles,which might induce a synergistic effect between iron and manganese in catalytic ***,the solid spherical structure of Fe-containing particles without an external layer were about 53.4%.The elements of Fe and Mn were co-existed,and might be presented as iron oxide-manganese oxide-silica ***,the ferrous and ferric forms of iron might be *** information can be valuable in expanding our understanding of Fe-containing particles in the Tibetan Plateau atmosphere.

关键词： Fe-containing single particle Irregular shape Core-shell structure Solid spherical structure Transmission electron microscopy Synchrotron X-ray microscopy

A Dislocation-based Model for the Dynamics of Sliding Precursors

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Acta Mechanica Solida Sinica 2021年第5期34卷 624-631页

作者： yiran Li Ganyun Huang Department of Mechanics School of Mechanical EngineeringTianjin UniversityTianjin300350China

The onset of dynamic friction plays an important role in the study of sliding ***,the sliding precursors in the form of crack-like defects have been detected in experiments and their strain fields have been measured to be comparable to those of moving *** the present work,we considered the dynamics of sliding precursors by solving the elastic problem due to a moving dislocation in a half-plane and the transient emission of a dislocation at the *** has been found that both the strain field of a moving dislocation and the spatiotemporal evolution agree well with those of a sliding precursor detected in *** results may cast new light to the dynamics of sliding onset.

关键词： Sliding precursor Crack-like defects Moving dislocations Dislocation emission