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Frontiers of Environmental Science & Engineering 2023年第4期17卷 109-126页

作者： yiqun cao Qingxin Ma Biwu Chu Hong He State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China

Nitrate is an important component of atmospheric particulate matter and affects air quality,climate,human health,and the *** was previously considered a permanent sink for nitrogen oxides(NO_(x)).However,this viewpoint has been challenged in recent years because growing research evidence has shown the transformation of nitrate into NO_(x)(i.e.,renoxification).The photolysis of nitrate/HNO3,especially in the particulate phase or adsorbed on particles,can be a significant renoxification process in the *** formation and photolysis of nitrate in aerosol not only change the diurnal variation of NO_(x),but also provide long-distance transport of NO_(x)in the form of nitrate,which affects local and regional atmospheric chemistry and air *** review summarizes recent advances in the fundamental understanding of the photolysis of nitrate/HNO3 under various atmospheric conditions,with a focus on mechanisms and key factors affecting the *** atmospheric implications are discussed and future research is recommended.

关键词： Nitrate Photolysis Renoxification Aerosol

Regulation of Cytokinesis by Exocyst Subunit SEC6 and KEULE in Arabidopsis thaliana

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Molecular Plant 2013年第6期6卷 1863-1876页

作者： Jiandong Wu Xiaoyun Tan ChengyunWu Kun cao yiqun Bao College of Life Sciences Nanjing Agricultural University Nanjing 210095 People's Republic of China

Proper vesicle tethering and membrane fusion at the cell plate are essential for cytokinesis. Both the vesicle tethering complex exocyst and membrane fusion regulator KEULE were shown to function in cell plate formation, but the exact mechanisms still remain to be explored. In this study, using yeast two-hybrid （Y-2-H） assay, we found that SEC6 interacted with KEULE, and that a small portion of C-terminal region of KEULE was required for the interaction. The direct SEC6-KEULE interaction was supported by further studies using in vitro pull-down assay, immunoprecipitation, and in vivo bimolecular florescence complementation （BIFC） microscopy, sec6 mutants were male gametophytic lethal as reported; however, pollen-rescued sec6 mutants （PRsec6） displayed cytokinesis defects in the embryonic cells and later in the leaf pavement cells and the guard cells. SEC6 and KEULE proteins were co-localized to the cell plate during cytokine- sis in transgenic Arabidopsis. Furthermore, only SEC6 but not other exocyst subunits located in the cell plate interacted with KEULE in vitro. These results demonstrated that, like KEULE, SEC6 plays a physiological role in cytokinesis, and the SEC6-KEULE interaction may serve as a novel molecular linkage between arriving vesicles and membrane fusion machin- ery or directly regulate membrane fusion during cell plate formation in plants.

关键词： SEC6 KEULE cytokinesis vesicle tethering membrane fusion embryogenesis plant development.

Deep brain stimulation of the subthalamic nucleus treats Parkinson's disease through enhancing metabolic activity of the corpus striatum Verification by single photon emission computed tomography and positron emission tomography

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Neural Regeneration Research 2010年第6期5卷 405-410页

作者： yiqun cao Xiaoping Zhou Zhifeng Zhang Xiaowu Hu Xiufeng Jiang Department of Neurosurgery Changhai Hospital Second Military Medical University of Chinese PLA Shanghai 200433 China Department of Nuclear Medicine Changhai HospitalSecond Military Medical University of Chinese PLA Shanghai 200433 China

BACKGROUND： Subthalamic nucleus deep brain stimulation （STN DBS） for Parkinson＇s disease （PD） has achieved good effects, but to date the mechanism of STN DBS remains poorly understood STN DBS may increase dopamine levels or metabolic activity of the corpus striatum. OBJECTIVE： To validate the effects of STN DBS on dopamine metabolism and glucose metabolism in the corpus striatum of hemiparkinsonian monkeys using single photon emission computed tomography （SPECT） and position emission tomography （PET）. DESIGN, TIME AND SET＇rING： A controlled animal study was performed at the Neurosurgery Laboratory, Changhai Hospital of the Second Military Medical University of Chinese PLA between January 2004 and December 2007. METHODS： Hemiparkinsonism was induced in adult Rhesus Macaque monkeys, which exhibit similar characteristics of PD in humans, through unilateral internal carotid artery infusion of 1-methy-4-phenyl-1, 2, 3, 6-tetrahydropyrindine. Following model establishment, stimulation electrodes were implanted in the right STN, and chronic high-frequency stimulation （60 μs pulse width, 130 Hz frequency, and 1.5-2.0 V pressure） was performed. MAIN OUTCOME MEASURES： The changes in dopamine transporter （DAT）, D2 receptor （D2R）, and glucose metabolism in the corpus striatum following STN DBS were observed using SPECT and PET. RESULTS： SPECT examination showed that DAT specific binding in the right corpus striatum was increased at 3 months after DBS compared with prior to stimulation, and D2R specific binding in the right corpus striatum gradually decreased near levels on the left （non-electrode-implanted） side within 3 months after DBS. PET examination showed that the glucose metabolism in the right corpus striatum was markedly increased at 3 months after effective DBS. Hemiparkinsonism monkeys showed improved left limb rigidity, increased activities, and stable gait under chronic high-frequency stimulation. CONCLUSION： STN DBS increased striatal DAT, decreased D2R, and enhan

关键词： subthalamic nucleus deep brain stimulation Parkinson's disease monkey single photon emission computed tomography positron emission tomography neural regeneration

Chronic deep brain stimulation of the subthalamic nucleus in a monkey model of hemiparkinsonian Dynamic alterations of extracellular fluid dopamine levels in corpus striatum

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Neural Regeneration Research 2009年第12期4卷 1037-1042页

作者： yiqun cao Hanhua Liu Xudong Zhao Xiaoping Zhou Jianmin Liu Dongmei Li Department of Neurosurgery Changhai Hospital Second Military Medical University of Chinese PLA Shanghai 200433 China

BACKGROUND： Although experimental studies have utilized high-frequency stimulation in animal models, few reports have focused on long-term subthalamic nucleus deep brain stimulation （STN DBS） in Parkinson＇s disease （PD） animal models. OBJECTIVE： The present study simulated long-term DBS system and utilized microdialysis technology to study the influence of STN DBS on levels of extracellular dopamine （DA） and its metabolites, homovanillic acid （HVA） and dihydroxy phenyl acetic acid, in the corpus striatum of a hemiparkinsonian monkey model. DESIGN, TIME AND SETTING： A controlled animal study was performed at the Neurosurgery Laboratory, Changhai Hospital of the Second Military Medical University of Chinese PLA between January 2004 and December 2007. MATERIALS： 1-methy-4-phenyl-1, 2, 3, 6-tetrahydropyrindinewas （MPTP） purchased from Sigma, USA. Type-3389 DBS electrode and type-7246 pulse generator were provided by Medtronic, USA. METHODS： Hemiparkinsonism was induced in 2 male, adult Rhesus Macaque monkeys through unilateral internal carotid artery infusion of MPTP. Following model establishment, stimulation electrodes were implanted in the right STN, and chronic high-frequency stimulation （60 μs pulse width, 130 Hz frequency, and 1.5 2.0 V pressure） was performed. MAIN OUTCOME MEASURES： Prior to, and 2 hours, 8 hours, 1 week, 1 month, and 2 months after DBS, samples were collected from the caudate nucleus and putamen using microdialysis technology Extracellular levels of DA and its metabolites were measured using high-performance liquid chromatography and electrochemical detection （HPLC-ECD） methods. RESULTS： At 8 hours, 1 week, 1 month, and 2 months after DBS, DA levels in the putamen and caudate nucleus were increased on the electrode-implanted side by 39%, 91%, 111%, and 114% and 31%, 91%, 106%, and 102%, respectively. The DA turnover rate （HVA/DA） was increased in the putamen and caudate nucleus by 186% and 91%, respectively, at 8 hours after DBS, while there was

关键词： subthalamic nucleus deep brain stimulation Parkinson's disease microdialysis dopamine

Five-year follow-up of 23 asymmetrical Parkinson's disease patients treated with unilateral subthalamic nucleus stimulation

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Neural Regeneration Research 2012年第18期7卷 1428-1435页

作者： Jinchuan Liang Xiaowu Hu Xiaoping Zhou Xiufeng Jiang yiqun cao Laixing Wang Aiguo Jin Jianmin Liu Department of Neurosurgery Changhai Hospital of the Second Military Medical University of Chinese PLA Shanghai 200433 China Department of Radiology Changhai Hospital of the Second Military Medical University of Chinese PLA Shanghai 200433 China

In this study, 23 asymmetrical Parkinson＇s disease patients were treated with unilateral deep brain stimulation of the subthalamic nucleus and followed up for 5 years. At 5 years after stimulation treatment, Unified Parkinson＇s Disease Rating Scale II, III and axial symptom scores in the off-drug condition were significantly increased compared those at baseline. However, total Unified Parkinson＇s Disease Rating Scale II, III and axial symptom scores were significantly lower with stimulation-on compared with the synchronous stimulation-off state in off-drug condition, and the motor symptoms of contralateral side limbs were effectively controlled. Only low Hoehn-Yahr stage was correlated with good long-term postoperative improvement in motor symptoms. The mean levodopa-equivalent daily dose after stimulation treatment was significantly lower than that before treatment, but dyskinesias became worse. Our experimental findings indicate that unilateral deep brain stimulation of the subthalamic nucleus is an effective treatment for improving motor symptoms in well selected asymmetrical Parkinson＇s disease patients presenting no severe axial symptoms and dyskinesias.

关键词： Parkinson's disease deep brain stimulation subthalamic nucleus neural regeneration

S100A8 promotes tumor progression by inducing phenotypic polarization of microglia through the TLR4/IL-10 signaling pathway in glioma

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Journal of the National Cancer Center

Journal of the National Cancer Center 2024年第4期4卷 369-381页

作者： Yuechao Yang Huanhuan Cui Deheng Li Lei Chen Yi Liu Changshuai Zhou Liangdong Li Mingtao Feng Xin Chen yiqun cao Yang Gao Department of Neurosurgery Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina School of Basic Medical Sciences Fudan UniversityShanghaiChina

Background:S100A8 is a member of the S100 protein family and plays a pivotal role in regulating inflammation and tumor *** study aimed to comprehensively assess the expression patterns and functional roles of S100A8 in glioma ***:Glioma tissues were collected from 98 patients who underwent surgical treatment at Fudan University Shanghai Cancer Center.S100A8 expression in glioma tissues was analyzed using immunohistochemistry(IHC)to establish its correlation with clinicopathological features in *** expression and prognostic effect of S100A8 in glioma were analyzed using TCGA and CGGA public ***,we investigated the role of S100A8 in glioma through a series of in vivo and in vitro experiments including Transwell,wound healing,CCK8,and intracranial tumor ***,bioinformatics analysis,single-cell sequencing and coimmunopre-cipitation(Co-IP)were used to explore the underlying ***:S100A8 was upregulated in gliomas compared to paracancerous tissues,and this phenotype was sig-nificantly correlated with poor *** analysis showed that S100A8 expression was higher in the high-grade glioma(HGG)group than that in the low-grade glioma(LGG)group.S100A8 overexpression in glioma cell lines promoted cell proliferation,migration and invasion,while silencing S100A8 reversed these *** vivo experiments showed that S100A8 knockdown can significantly reduce the tumor burden of glioma ***,S100A8 was observed to stimulate microglial M2 polarization by interacting with TLR4,which subse-quently induced NF-𝜅B signaling and IL-10 secretion within the tumor ***:S100A8 promotes tumor progression by inducing phenotypic polarization of microglia through the TLR4/IL-10 signaling pathway in *** might represent a therapeutic target for further basic research or clinical management of glioma.

关键词： S100A8 Glioma Microglia TLR4 IL-10

Is MRI Presenting “Enhancement with Multiple Microcystic Change and Focal Necrosis” a Potential Prognostic Implication of H3K27me3 Loss for WHO Grade I Meningioma of Meningeal-Epithelial Subgroup?

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Is MRI Presenting “Enhancement with Multiple Microcystic Ch...

An Overlay Network for Monitoring Activities of Computer Viruses

第十四届中国医师协会神经外科医师年会

作者： Yunhe Lu Liangdong Li Lei Chen Xin Chen yiqun cao Shanghai Cancer Center Fudan University

＜正＞Purposes: Loss of H3K27 trimethylation（H3K27me3） identifies a subset of meningiomas with increased risk of recurrence, particularly for cases with WHO grade Ⅱ histology or at the borderline between WHO grade I and Ⅱ. In our postoperative cases, it makes us curious that there are quite a few loss of H3K27me3 in WHO grade I meningioma of meningeal-epithelial subgroup. We hope to preliminarily identify the risk implications on MRI preoperatively so as to have better exchange with patients about risk of recurrence.

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Engineering Sciences 2008年第1期6卷 52-58页

作者： Li Ying cao yiqun Qiu Ben Jiao Jian Shan Xiuming Ren Yong School of Business SUN YAT-SEN University Guangzhou 510275 China Department of Electronic Engineering Tsinghua University Beijing 100084 China

To accurately track computer viruses,an overlay network that monitors the activities of viruses is *** and locating nodes infected by virus on network is achieved by a naming system in which a node in the network is mapped to a unique serial number of the *** carefully monitoring and recording sensitive communication between local system and remote nodes on the network,and suspicious operations on files that originate from remote nodes and entered via some form of file transfer,activities of viruses in both local and network level are recorded and ready for future *** data can also be used in analysis of the mechanism of a computer virus as well as its spreading mode and pattern.

关键词： overlay network virus observation DNS

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高超声速再入飞行器气动布局多目标优化

北京航空航天大学学报 2023年第7期49卷 1639-1650页

作者：樊博璇陈桂明曹逸群火箭军工程大学西安710025 火箭军装备部驻西安地区第一军事代表室西安710025

气动布局的多目标优化是飞行器设计中的关键技术。提出一种新的高超声速再入飞行器气动外形参数的多目标优化方法,证明外形优化对高超声速流下飞行器性能的影响。通过实例仿真对飞行器所受阻力和升力对制导性能影响进行详细验证分析,将... 详细信息

气动布局的多目标优化是飞行器设计中的关键技术。提出一种新的高超声速再入飞行器气动外形参数的多目标优化方法,证明外形优化对高超声速流下飞行器性能的影响。通过实例仿真对飞行器所受阻力和升力对制导性能影响进行详细验证分析,将飞行器落点圆概率偏差、末速大于500 m/s的占比、最大飞行过载小于60g的占比这3个性能指标作为优化目标,将升力特性作为中间参数,将气动布局优化问题分解为2个子问题,通过基于搜索算法的升力特性优化和基于改进的模拟退火算法的外形参数优化,减少优化计算时间、提升计算效率、实现对飞行器主体和襟翼的气动布局优化、获得高超声速流下的最佳飞行器外形。仿真结果表明:在确定的约束条件下,优化算法增加了飞行器在超音速流下的气动升力,有效提高了升阻比。在不影响最大飞行过载的前提下,优化后的飞行器表现出更高的气动性能,显著提升了命中精度,同时末速也满足指标要求,制导系统性能得到有效改善。

关键词：高超声速再入飞行器气动布局升力特性模拟退火组合优化算法优化设计

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SAW滤波器设计方法的研究

四川大学学报（自然科学版） 1996年第3期33卷 278-282页

作者：曹益群四川大学无线电电子学系四川成都

提出了一种时域奇偶分解积木式数字傅立叶变换ＳＡＷＦ设计方法．该方法计算的响应比单一常规方法的精度高，理论值与实际值吻合得更好，适用于信息处理系统使用的不同工作频率、对称和非对称频响、线性和非线性相位、高阻抗和低阻抗及... 详细信息

提出了一种时域奇偶分解积木式数字傅立叶变换ＳＡＷＦ设计方法．该方法计算的响应比单一常规方法的精度高，理论值与实际值吻合得更好，适用于信息处理系统使用的不同工作频率、对称和非对称频响、线性和非线性相位、高阻抗和低阻抗及不同带宽的ＳＡＷＦ波器的设计．

关键词：声表面波滤波器时域奇偶分解滤波器