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A wearable,rapidly manufacturable,stabilityenhancing microneedle patch for closed-loop diabetes management

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Microsystems & Nanoengineering 2024年第4期10卷 313-327页

作者： yiqun liu Li Yang Yue Cui School of Materials Science and Engineering Peking UniversityBeijing 100871China Renal Division Peking University First HospitalPeking University Institute of NephrologyKey Laboratory of Renal DiseaseMinistry of Health of ChinaKey Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University)Ministry of EducationBeijing 100034China

The development of a wearable,easy-to-fabricate,and stable intelligent minisystem is highly desired for the closedloop management of *** systems always suffer from large size,high cost,low stability,or complex ***,we show for the first time a wearable,rapidly manufacturable,stability-enhancing microneedle patch for diabetes *** patch consists of a graphene composite ink-printed sensor on hollow microneedles,a polyethylene glycol(PEG)-functionalized electroosmotic micropump integrated with the microneedles,and a printed circuit board for precise and intelligent control of the sensor and pump to detect interstitial glucose and deliver insulin through the hollow *** synthesizing and printing the graphene composite ink,the sensor fabrication process is fast and the sensing electrodes are *** PEG functionalization enables the micropump a significantly higher stability in delivering insulin,extending its lifetime from days to *** patch successfully demonstrated excellent blood glucose control in diabetic *** work may introduce a new paradigm for building new closedloop systems and shows great promise for widespread use in patients with diabetes.

关键词： patch stability wear

User behavior modeling for better Web search ranking

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Frontiers of Computer Science 2017年第6期11卷 923-936页

作者： yiqun liu Chao WANG Min ZHANG Shaoping MA Department of Computer Science and Technology Tsinghua University Beijing 100084 China

Modem search engines record user interactions and use them to improve search quality. In particular, user click-through has been successfully used to improve click- through rate （CTR）, Web search ranking, and query rec- ommendations and suggestions. Although click-through logs can provide implicit feedback of users＇ click preferences, de- riving accurate absolute relevance judgments is difficult be- cause of the existence of click noises and behavior biases. Previous studies showed that user clicking behaviors are bi- ased toward many aspects such as ＂position＂（user＇s attention decreases from top to bottom） and ＂trust＂（Web site reputa- tions will affect user＇s judgment）. To address these problems, researchers have proposed several behavior models （usually referred to as click models） to describe users？ practical browsing behaviors and to obtain an unbiased estimation of result relevance. In this study, we review recent efforts to construct click models for better search ranking and propose a novel convolutional neural network architecture for build- ing click models. Compared to traditional click models, our model not only considers user behavior assumptions as input signals but also uses the content and context information of search engine result pages. In addition, our model uses pa- rameters from traditional click models to restrict the meaning of some outputs in our model＇s hidden layer. Experimental results show that the proposed model can achieve consider- able improvement over state-of-the-art click models based on the evaluation metric of click perplexity.

关键词： user behavior click model Web search

Continuous monitoring of diabetes with an integrated microneedle biosensing device through 3D printing

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Microsystems & Nanoengineering 2021年第5期7卷 161-172页

作者： yiqun liu Qi Yu Xiaojin Luo Li Yang Yue Cui School of Materials Science and Engineering Peking University100871 BeijingP.R.China Renal Division Peking University Institute of NephrologyPeking University First Hospital100034 BeijingP.R.China

Diabetes is a prevalent chronic metabolic disease with multiple clinical manifestations and complications,and it is among the leading causes of *** and continuous monitoring of interstitial glucose is highly desirable for diabetes *** we unprecedentedly show continuous monitoring of diabetes with an integrated microneedle biosensing *** device was manufactured with a 3D printing process,a microfabrication process,an electroplating process,and an enzyme immobilization *** device was inserted into the dermis layer of mouse skin and showed accurate sensing performance for monitoring subcutaneous glucose levels in normal or diabetic *** detection results were highly correlated with those obtained from a commercial blood glucose *** anticipate that the study could open exciting avenues for monitoring and managing diabetes,alongside fundamental studies of subcutaneous electronic devices.

关键词： needle diabetes printing

Chronic deep brain stimulation of the subthalamic nucleus in a monkey model of hemiparkinsonian Dynamic alterations of extracellular fluid dopamine levels in corpus striatum

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Neural Regeneration Research 2009年第12期4卷 1037-1042页

作者： yiqun Cao Hanhua liu Xudong Zhao Xiaoping Zhou Jianmin liu Dongmei Li Department of Neurosurgery Changhai Hospital Second Military Medical University of Chinese PLA Shanghai 200433 China

BACKGROUND： Although experimental studies have utilized high-frequency stimulation in animal models, few reports have focused on long-term subthalamic nucleus deep brain stimulation （STN DBS） in Parkinson＇s disease （PD） animal models. OBJECTIVE： The present study simulated long-term DBS system and utilized microdialysis technology to study the influence of STN DBS on levels of extracellular dopamine （DA） and its metabolites, homovanillic acid （HVA） and dihydroxy phenyl acetic acid, in the corpus striatum of a hemiparkinsonian monkey model. DESIGN, TIME AND SETTING： A controlled animal study was performed at the Neurosurgery Laboratory, Changhai Hospital of the Second Military Medical University of Chinese PLA between January 2004 and December 2007. MATERIALS： 1-methy-4-phenyl-1, 2, 3, 6-tetrahydropyrindinewas （MPTP） purchased from Sigma, USA. Type-3389 DBS electrode and type-7246 pulse generator were provided by Medtronic, USA. METHODS： Hemiparkinsonism was induced in 2 male, adult Rhesus Macaque monkeys through unilateral internal carotid artery infusion of MPTP. Following model establishment, stimulation electrodes were implanted in the right STN, and chronic high-frequency stimulation （60 μs pulse width, 130 Hz frequency, and 1.5 2.0 V pressure） was performed. MAIN OUTCOME MEASURES： Prior to, and 2 hours, 8 hours, 1 week, 1 month, and 2 months after DBS, samples were collected from the caudate nucleus and putamen using microdialysis technology Extracellular levels of DA and its metabolites were measured using high-performance liquid chromatography and electrochemical detection （HPLC-ECD） methods. RESULTS： At 8 hours, 1 week, 1 month, and 2 months after DBS, DA levels in the putamen and caudate nucleus were increased on the electrode-implanted side by 39%, 91%, 111%, and 114% and 31%, 91%, 106%, and 102%, respectively. The DA turnover rate （HVA/DA） was increased in the putamen and caudate nucleus by 186% and 91%, respectively, at 8 hours after DBS, while there was

关键词： subthalamic nucleus deep brain stimulation Parkinson's disease microdialysis dopamine

A Microtube-Based Wearable Closed-Loop Minisystem for Diabetes Management

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Research 2023年第1期2022卷 399-412页

作者： yiqun liu Qi Yu Xiaojin Luo Le Ye Li Yang Yue Cui School of Materials Science and Engineering Peking UniversityChina First Hospital Interdisciplinary Research Center Peking UniversityBeijingP.RChina Renal Division Peking University First HospitalChina APeking University Institute of NephrologyChina Key Laboratory of Renal Disease Ministry of Health of ChinaChina Key Laboratoryof Chronic Kidney Disease Prevention and Treatment(Peking University) Ministry of EducationBejing P.R.China School of Integrated Circuits Peking UniversityBeijingP.R.China

Diabetes is a chronic metabolic disease with a high blood glucose level,leading to both seriously acute and chronic *** closed-loop system is an ideal system for diabetes ***,the large size and high cost of the commercial systems restrict their widespread ***,we present for the first time a microtube-based wearable closed-loop minisystem for diabetes *** closed-loop minisystem includes a biosensing device,an electroosmotic micropump,and a printed circuit board(PCB)with an *** microtube-based sensing device coated on the outer surface of the microtube is inserted into subcutaneous tissue for detecting interstitial glucose;the current signal for sensing glucose is processed by the PCB to power the electroosmotic micropump intelligently for the delivery of insulin into the subcutaneous tissue via the microtube *** closed-loop minisystem worn on a diabetic SD rat can successfully maintain its blood glucose level within a safe *** is expected that this new closed-loop paradigm could open up new prospects for clinical diabetes management.

关键词： Diabetes system pump

Versatile memristor implemented in van der Waals CuInP_(2)S_(6)

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Nano Research 2023年第7期16卷 10191-10197页

作者： yiqun liu Yonghuang Wu Bolun Wang Hetian Chen Di Yi Kai liu Ce-Wen Nan Jing Ma State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Memristors are playing an increasingly important role in developing in-memory *** memristors which offer both volatile and non-volatile performances can be employed as both memories and selectors,displaying unique advantages for developing novel electronic ***,the remarkable multifunctional memristor with switchable operating modes between volatile and non-volatile by regulating compliance currents is implemented in Ag/CIPS/Au(CIPS:CuInP_(2)S_(6))***-like volatile memristor performances with the rectification ratio of 10^(3) and an endurance of 500 switching cycles were ***,significant non-volatile memory performances with on/off ratio of 10^(3)and retention up to 10^(4)s were also developed,which enables it to be utilized as selectors and memories ***,such versatile memristor can emulate the short-term plasticity(STP)and long-term plasticity(LTP)of artificial synapse,demonstrating its advantages in neuromorphic computing applications.

关键词： CuInP_(2)S_(6)(CIPS) versatile memristor conductive filament synaptic plasticity

Bicontinuous porous membranes with micro-nano composite structure using a facile atomization-assisted nonsolvent induced phase separation method

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Frontiers of Chemical Science and Engineering 2022年第8期16卷 1268-1280页

作者： Jing Wang Guoyuan Pan Yu Li Yang Zhang Hongwei Shi Xuanbo liu Hao Yu Muhua Zhao yiqun liu Changjiang Wu College of Materials Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China SINOPEC Beijing Research Institute of Chemical Industry Beijing 100013China

The micro-nano composite structure can endow separation membranes with special surface properties,but it often has the problems of inefficient preparation process and poor structural *** this work,a novel atomization-assisted nonsolvent induced phase separation method,which is also highly efficient and very simple,has been *** using this method,a bicontinuous porous microfiltration membrane with robust micro-nano composite structure was obtained via commercially available polymers of polyacrylonitrile and *** formation mechanism of the micro-nano composite structure was *** microphase separation of polyacrylonitrile and polyvinylpyrrolidone components during the atomization pretreatment process and the hydrogen bonding between polyacrylonitrile and polyvinylpyrrolidone molecules should have resulted in the nano-protrusions on the membrane *** membrane exhibits superhydrophilicity in air and superoleophobicity *** membrane can separate both surfactant-free and surfactant-stabilized oil-in-water emulsions with high separation efficiency and permeation *** excellent antifouling property and robust microstructure,the membrane can easily be recycled for long-term ***,the scale-up verification from laboratory preparation to continuous production has been *** simple,efficient,cost-effective preparation method and excellent membrane properties indicate the great potential of the developed membranes in practical applications.

关键词： atomization nonsolvent induced phase

Three-Dimensional Hierarchical Ternary Nanostructures Bismuth/Polypyrrole/CNTs for High Performance Potassium-lon Battery Anodes

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Chinese Journal of Chemistry 2022年第13期40卷 1585-1591页

作者： Wenming Zhang Xiaoyu Chen Haoshan Xu yiqun liu Xiaohui Zhao Zisheng Zhang Ling Li National-Local Joint Engineering Laboratory of New Energy Photoelectric Devices College of Physics Science and TechnologyHebei UniversityBaodingHebei 071002China

In recent years,the anode materials of bismuth(Bi)-based potassium ion batteries with high theoretical capacity and suitable potassium ion insertion potential have attracted extensive ***,due to the volume expansion of Bi,the performance of Bi-based anode materials is not ideal during potassium ion(de)*** order to solve these problems,we report a three-dimensional(3D)ternary bismuth nanoparticles/conductive polymers/carbon nanotubes(Bi/PPy/CNT)hybrid anode material for K-ion *** a current density of 100 mA·g^(-1),its reversible capacity reaches 302 mAh·g^(-1) after 200 cycles,while it reaches 195.7 mAh·g^(-1) after 600 cycles at 1 A·g^(-1).Its excellent performance is attributed to the hydrogel network which provides a range of electron transport networks and high *** nanotubes are used as electron enhancers to reduce the volume expansion of Bi particles during the *** study provides a prerequisite for expanding the application of 3D ternary materials.

关键词： Bismuth Nanostructures Conducting materials Potassium ion battery Energy storage

Comparisons on Mineralogy and Lithology between Paleozoic Marine and Lacustrine Dolostones, Northern China

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Acta Geologica Sinica(English Edition) 2017年第S1期91卷 281-282页

作者： LI Hong liu yiqun NIU Yuanzhe FENG Shihai LEI Yun liu Yongjie State Key Laboratory of Continental Dynamics(Northwest University) Xi’an710069

1 Introduction Dolomite[Ca Mg(CO3)2],a common mineral in carbonate rocks,can be found in various geological settings from Precambrian to modern age,and is widely reported in almost all sedimentary and digenetic

关键词： Comparisons on Mineralogy and Lithology between Paleozoic Marine and Lacustrine Dolostones Northern China